Кафедра оториноларингології з офтальмологією
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Перегляд Кафедра оториноларингології з офтальмологією за Автор "Avetikov, D. S."
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Документ Effect of quercetin on lipid peroxidation state in experimental chemical rhinitis caused by alkaline burn(Полтавський державний медичний університет, 2024-03-20) Netyukhailo, L. G.; Avetikov, D. S.; Hasiuk, Yu. A.; Нетюхайло, Лілія Григорівна; Аветіков, Давид Соломонович; Гасюк, Юрій АнатолійовичTreating inflammatory diseases of the nasal mucosa, particularly rhinitis, is one of the most pressing issues in medicine. Rhinitis is usually infectious and often seen in influenza and respiratory viral infections. This pathology can lead to dangerous complications, such as inflammation of the nasal cavity and paranasal sinuses, meningoencephalitis, brain abscess, and others. It is well known that inflammation is the basis for developing rhinitis. Inflammation involves several complex molecular reactions aimed at tissue repair and the fight against harmful factors. A significant amount of scientific research has been conducted to investigate the potential of antioxidants to prevent diseases that occur in the context of inflammation. However, the results have led to considerable uncertainty about the impact of antioxidants on inflammation. This prompted the need to study this issue as part of our work. In view of the above, there is a need to conduct studies using quercitin as a potential antioxidant agent. It will allow us to determine the effect of antioxidant properties on the course of the disease, particularly on the development of rhinitis. Quercitin, due to its antioxidant properties, protects the body from free radical damage and may be useful in treating various diseases. This study aimed to investigate the effect of quercetin on lipid peroxidation (LPO) during experimental chemical rhinitis. Chemical rhinitis was induced using a wet swab moistened with a 40% caustic soda solution inserted into each nostril. The drug is a bioflavianoid with the active ingredient quercetin. Assessment of the state of lipid peroxidation in the blood was performed by the following indicators: the content of diene conjugates (DC) - the initial products of lipid peroxidation, TBA-reagents. Indicators were studied in blood serum on the third and fourteenth days of the experiment.Документ Polyps-changed mucosa of the ostiomeatal complex in chronic rhinosinusitis(Полтавський державний медичний університет, 2024-03-20) Hasiuk, Yu. A.; Avetikov, D. S.; Netyukhailo, L. G.; Гасюк, Юрій Анатолійович; Аветіков, Давид Соломонович; Нетюхайло, Лілія ГригорівнаThe purpose of the study was to determine the morphological changes that occur in the polypoidal mucosa of the osteomeatal complex in chronic rhinosinusitis. For the study, the surgical material was used - polypomatous mucosa of the osteomeatal complex obtained during FESS. In many cases, modern treatment methods are unable to provide long-term remission of the disease. This prompts the search for new methods of surgical and medical rehabilitation of the mucous membrane in chronic rhinosinusitis, the polypoidal mucosa of the osteomeatal complex is covered with goblet-transformed epithelium, which is unable to perform the transport function of the mucociliary apparatus in themeatus. In the intrinsic layer of the mucous membrane, edema occurs first, which has a vascular origin, and then leukocyte infiltration occurs, which blocks the ostiomeatal complex. Inhibition of mucociliary transport and blockade of the osteomeatal complex are the main pathogenetic factors in the occurrence of exacerbation of chronic rhinosinusitis. Dysregenerative processes in the stromal component also play an essential role in the genesis of polyposis changes in the mucous membrane. Our studies indicate that in chronic rhinosinusitis, the polypoidal mucosa of the ostiomeatal complex is covered with goblet-transformed epithelium, which is unable to perform the transport function of the mucociliary apparatus in the middle nasal meatus. The obtained materials were used to make histological preparations according to generally accepted methods, which were stained with histological and histochemical stains. In chronic rhinosinusitis, the polyposis-altered mucosa of the osteomeatal complex is covered with goblet-transformed epithelium. The mucosa has edema with a pronounced vascular genesis. Blockade of the ostiomeatal complex is the main pathogenetic factor in the occurrence of exacerbation of chronic rhinosinusitis.