Кафедра оториноларингології з офтальмологією

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https://repository.pdmu.edu.ua/handle/123456789/35

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Перегляд Кафедра оториноларингології з офтальмологією за Автор "Bezega, Mykhailo"

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  • Ескіз недоступний
    Документ
    Current views on the functional status of the palatine tonsils in chronic tonsillitis and alternatives in treatment strategies (literature review)
    (Index Copernicus Sp. z o.o., 2023) Bezega, Mykhailo; Zachepylo, Svitlana; Polianska, Valentyna; Podovzhnii, Olexander; Безега, Михайло Іванович; Зачепило, Світлана Вікторівна; Полянська, Валентина Павлівна; Подовжній, Олександр Григорович
    Aim: This article presents an analysis of a literature review, which highlights the causal aspects of the development of chronic tonsillitis (CHT). Material and method: The review contains statistical data on prevalence of this disease and high probability of local (tonsillar) and general (metatonsillar) complications development. Particular attention is paid to the issues of immunological reactivity of the macroorganism in conditions of chronic inflammation of the palatine tonsils (PT). The use of indicators of natural and acquired immunity in the diagnosis of CHT and in determining the direction of its treatment is justified. Data on the importance of biofilm in the genesis of chronic infectious processes, including PT, are systematized. In the etiology of inflammatory PT diseases, the development of their chronic course reflects the paramount importance of a wide range of microorganisms. The concept of biofilm, positioned by the authors as a specialized ecosystem that ensures maintenance of viability of the entire microbial association and preservation of its components, as well as a significant increase in the biomass of this population, has been developed. Results: The study of biofilms revealed fundamental differences between planktonic and biofilm forms of microbiota existence, including differences in bacterial behavior, biochemical processes, biosynthesis of various substances, and exchange of genetic information. It is clear that biofilms can contribute to the transmission of resistance genes to antibiotics, as well as to other antimicrobial agents. Conclusions: A study of the literature defines a new strategy for increasing the effectiveness of antimicrobial therapy for biofilm infections, which consists of the use of drugs from different pharmacotherapeutic groups acting to prevent biofilm formation and their morphofunctional destruction. There is experimental evidence that the use of drugs from these pharmaceutical groups can be effective in the complex treatment of diseases associated with biofilm formation.
  • Ескіз
    Документ
    The study of frontal recess configurations based on computed tomography data and their association with frontal sinusitis
    (2024) Loburets, Andriy; Loburets, Valeriy; Bezega, Mykhailo; Gasiuk, Iuriy; Лобурець, Андрій Валерійович; Лобурець, Валерій Васильович; Безега, Михайло Іванович; Гасюк, Юрій Анатолійович
    The anatomy of the frontal sinus (FS) is challenging for both radiologists and ENT surgeons. The IFAC (International Frontal Sinus Anatomy Classification) aims to simplify the classification of anatomical variations of the frontoethmoidal complex. Aim: The purpose of this study was to analyze, based on computed tomography (CT) data of the paranasal sinuses, the prevalence of frontal recess cells according to the IFAC classification in patients with chronic frontal sinusitis and those without signs of FS inflammation, as well as to determine the relationship between the configuration of frontal recess cells and FS inflammation. Materials and methods: An analysis of CT scans of the paranasal sinuses from 120 patients (233 sides) who were treated at the M.V. Sklifosovsky Poltava Regional Clinical Hospital between 2023 and 2024, was conducted. The prevalence of various types of frontoethmoidal cells (FEC) was studied according to the IFAC classification. A correlational analysis was performed between the presence of FS opacification and the configuration of FEC. Results: The prevalence of agger nasi cells was 97.42%, supra agger cells 48.07%, supra agger frontal cells 27.61%, supra bulla cells 81.97%, supra bulla frontal cells 22.75%, supraorbital ethmoidal cells 18.03%, and frontal septal cells 28.76%. The largest differences in the prevalence of FEC between patients with and without FS inflammation were observed in the presence of supraorbital ethmoidal cells (26.92% and 15.47%, respectively) and frontal septal cells (21.15% and 30.94%, respectively). However, these differences were not statistically significant. In 157 (67.38%) of the studied sides, we identified cells with pneumatization extending into the FS, while in the remaining cases, the FEC were located below the FS ostium. Conclusions: Received results demonstrate the need for a more detailed study of anatomical variations of the frontal recesses, especially in the context of surgical planning and treatment of chronic diseases of the nasal sinuses.