Наукові праці. Кафедра пропедевтики ортопедичної стоматології
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Перегляд Наукові праці. Кафедра пропедевтики ортопедичної стоматології за Автор "Demkovych, Andrii"
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Документ Biological compatibility of metal structures of dentures made from multiple melted alloys(2022) Hasiuk, Petro; Kindiy, Dmytro; Radchuk, Volodymyr; Kindiy, Viktor; Demkovych, Andrii; Yarkoviy, Vitaliy; Гасюк, Петро Анатолійович; Кіндій, Дмитро Данилович; Радчук, Володимир Богданович; Кіндій, Віктор Данилович; Демкович, Андрій Євгенович; Ярковий, Віталій ВасильовичThe issue of reuse of metal alloys in dentistry raises debatable questions about their impact on the human body. The aim of the study was the evaluation of the biocompatibility of metal structures of dentures made from cobalt-chromium and nickelchromium alloys Remanium GM 700 and Remanium CSe after repeated vacuum remelting. Materials and methods. Clinical study and treatment with fixed prostheses based on Remanium GM 700 and Remanium CSe were performed among 120 patients aged 25-60 years. The biocompatibility of the above-mentioned denture designs with oral tissues was studied. Results. Prostheses made from Remanium GM 700 and Remanium CSe alloys are biologically indifferent, which is confirmed by the indicators of alkaline and acid phosphatase activity within the physiological norm. Regardless of the number of remelts, these alloys do not cause dysbacteriosis. The obtained results do not depend on the terms of observation, which indicates the safe use of remolten alloys for dental prosthetics. Conclusions. The investigated alloys are biocompatible and can be used for the manufacture of solid structures of denturesДокумент Cytokinogenesis disorders in mechanisms of the experimental perodontitis development and their correction by flavonol(Aluna Publishing, 2022-01) Demkovych, Andrii; Bondarenko, Yurii; Hasiuk, Petro; Denefil, Olha; Zubchenko, Serhii; Kalashnikov, Dmytro; Демкович, Андрій Євгенович; Бондаренко, Юрій Іванович; Гасюк, Петро Анатолійович; Денефіль, Ольга Володимирівна; Зубченко, Сергій Григорович; Калашніков, Дмитро ВікторовичThe aim: Evaluation of changes in proinflammatory and anti-inflammatory units of the cytokine profile in the mechanisms of development of experimental bacterial-immune periodontitis and elucidation of the effect of flavonol quercetin on its parameters.Документ Dynamics of changes of c-reactive protein level in blood serum in the development and course of experimental periodontitis and their correction by flavonol(Aluna Publishing, 2022-02) Demkovych, Andrii; Hasiuk, Petro; Korobeinikova, Yuliia; Shcherba, Vitaliy; Korobeinikov, Leonid; Демкович, Андрій Євгенович; Гасюк, Петро Анатолійович; Коробейнікова, Юлія Леонідівна; Щерба, Віталій Володимирович; Коробейніков, Леонід СергійовичThe aim: To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin. Materials and methods: Modeling of periodontitis was performed by the following method: after thiopental anesthesia (at a dose of 40 mg / kg intramuscularly) rats were fixed. A subcostal injection of 0.01 ml of egg protein with cultures of Streptococcus hemolytic and Staphylococcus aureus at a dose of 4 CFU was performed in the area of periodontal tissues of the lower incisor as an initiating inflammatory factor. To enhance the immune process, a complete Freund’s adjuvant was introduced into the animal’s hind limb at the same time. Results: Analysis of the results of the study of the content of C-reactive protein in the blood serum of animals with experimental bacteria and immune periodontitis, receiving injections of quercetin, showed a significant decrease by 1.31 times, compared with animals with this simulated pathology on the 14th day of the experiment without the use of flavonol. When comparing this indicator on the 14th day of development of experimental periodontitis with correction, it was found that it remained slightly higher than the indicators of the intact group of rats. Conclusions: The level of C-reactive protein in the blood serum of experimental animals is an important indicator of the immune-inflammatory response, which increases its activation of the inflammatory system. The administration of flavonoid quercetin for 7 days helps to reduce the level of C-reactive protein in the blood serum of animals with experimental bacterial and immune periodontitis.