Світ медицини та біології, 2023, № 1 (83)

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https://repository.pdmu.edu.ua/handle/123456789/20382

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Перегляд Світ медицини та біології, 2023, № 1 (83) за Автор "Boruta, N. V."

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    Morphofunctional characteristics of the structural components of the pancreas exocrine part in chemical castration
    (Полтавський державний медичний університет, 2023) Boruta, N. V.; Shepitko, V. I.; Stetsuk, Y. V.; Dubinin, D. S.; Levchenko, O. A.; Sydorenko, A. V.; Mykhaylenko, V. V.; Борута, Наталія Володимирівна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Дубінін, Дмитро Сергійович; Левченко, Ольга Анатоліївна; Сидоренко, Андрій Вячеславович; Михайленко, В. В.
    Throughout a person's life, the pancreas, which is the second largest gland (after the liver), is significantly affected by various adverse factors. It is a unique organ that combines external and internal secretory activity, playing an important role in the carbohydrate metabolism of the human body. Today, diseases of the pancreas are one of the most important problems in medicine. Established dystrophic changes of the gland, which were expressed by the formation of fibrous fields, the thickness of the capsule and interlobular connective tissue between the lobes visually increased, a decrease in the area of acini and exocrinocytes was observed, acini lost clear contours and shape due to swelling of the connective tissue. Exocrinocytes of acini lost apical eosinophilia and basal basophilia of the cytoplasm, there was a decrease in the area of the nuclei, which were changed in shape and location. The introduction of triptorelin causes destructive-degenerative changes in the exocrine apparatus of the pancreas, which are characterized by compensatory mechanisms in the early periods of observation, and in the later periods – dystrophic changes in the structural components of the gland are determined, which corresponds to the stage of partial decompensation, a decrease in the activity and functionality of the cellular component of the exocrine apparatus of the pancreas.
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    Документ
    Quantitative and qualitative changes in red bone marrow monocyte dipherone and microenvironmental cells during long-term triptorelin acetate administration in the experiment
    (Полтавський державний медичний університет, 2023) Martynenko, R. V.; Shepitko, V. I.; Pelypenko, L. B.; Boruta, N. V.; Martynenko, V. B.; Vilhova, O. V.; Stetsuk, Y. V.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Пелипенко, Лариса Борисівна; Борута, Наталія Володимирівна; Мартиненко, Віталій Борисович; Вільхова, Олена Вікторівна; Стецук, Євген Валерійович
    States. Huggins and Hodges demonstrated the therapeutic effect of testosterone deficiency in the gonads in the 1940s and thus confirmed the concept that prostate cancer is an androgen-dependent disease. Androgen deprivation therapy (ADT) is the main palliative treatment for men with locally advanced and metastatic prostate cancer, with the goal of reducing testosterone levels to the level obtained by surgical castration. The long-term chemical castration with triptorelin acetate leads to quantitative and qualitative changes in monocytic sprout cells at all levels of differentiation and proliferation with a complementary reaction of microenvironmental cells. The maximum quantitative changes in monocyte cells were observed at the 3rd month of the study, followed by a gradual recovery to the control group. Changes in the microenvironment cells: macrophages and reticular cells, were characterized by a stable reaction in the early stages of the study in the form of a decrease in the number and ratio of NSCs, with subsequent recovery of quantitative and qualitative changes to the level of the control group of animals. The adipocyte reacts at all stages of the study with a steady increase in quantitative and qualitative characteristics.