Наукові праці. Кафедра ендокринології з дитячими інфекційними хворобами
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Перегляд Наукові праці. Кафедра ендокринології з дитячими інфекційними хворобами за Автор "Bobyreva, L. Ye."
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Документ Chronic systemic inflammation in the pathogenesis of comorbid pathology and its correction(2018) Shaienko, Z. О.; Vynnyk, N. I.; Bobyreva, L. Ye.; Popruga, A. O.; Шаєнко, Златослава Олексіївна; Винник, Наталія Іванівна; Бобирьова, Людмила Єгорівна; Попруга, Алла ОлександрівнаThe paper presents the findings of our own study on the changes of the systemic inflammation in patients with type 2 diabetes mellitus (DM2) and ischemic heart disease (IHD) during the combination treatment with metformin and pioglitazone. 95 patients with IHD concomitant with DM2 have been treated. Patients, enrolled into study, have been randomized into 2 groups: the comparison group (n=37) treated with metformin and sulphonylureas, and the study group (n=58) treated with metformin and pioglitazone. The proposed course of therapy lasted 6 months. Before, after 3 and 6 months of treatment the control over the state of inflammatory responses was made and C-reactive protein, tumor necrosis factor-alpha, Interleukin-6 was assessed. The resulting data confirmed a statistically significant reduction under the effect of the combined treatment with the proposed combination of marker drugs and the degree of chronic systemic inflammation that is specific for IHD and DM2, which has a positive impact on the development and progress of IHD in DM2 patients, is well tolerated and can be considered as a pathogenic factor in the therapy of the presented comorbid nosologies.Документ Combination of Metformin and Pioglitazone and its Effect in Treatment of Comorbid Pathology(Wiadomosci Lekarskie, 2018) Shaienko, Z. O.; Bobyreva, L. Ye.; Шаєнко, Златослава Олексіївна; Бобирьова, Людмила ЄгорівнаIntroduction: The early development and high incidence of cardiovascular lesion in patients with type 2 diabetes mellitus is one of the most serious challenges for the diabetology worldwide. Aim: The purpose of the paper is to determine the dynamics of the insulin resistance indices in patients with type 2 diabetes mellitus concomitant with coronary heart disease in the combination therapy with metformin and pioglitazone during 3 and 6 months. Materials and Methods: 95 patients with type 2 diabetes mellitus and coronary heart disease have been treated and randomized into two groups: the comparison group (n=37), treated with metformin and sulfonylureas, and the study group (n=58), treated with metformin in combination with pioglitazone. Prior, after 3 and 6 months of treatment C-peptide was assessed and index of the insulin resistance was calculated. Results: The resulting data proved the statistically significant lowering of the markers and level of the insulin resistance under the effect of combination treatment with metformin and pioglitazone. Conclusions: The proposed variant of the combination therapy has a positive effect on the clinical course of the coronary heart disease in patients with type 2 diabetes mellitus, well tolerated by the patients and can be considered as the pathogenetic factor in the treatment of these diseases.Документ Features of the myocardium remodeling in patients with hypothyroidism, coronary heart disease and provided comorbidity(Проблеми ендокринної патології спеціальний випуск, 2019) Bobyreva, L. Ye.; Horodynska, O. Y.; Бобирьова, Людмила Єгорівна; Городинська, Олена Юріївна; Бобырева, Людмила Егоровна; Городинская, Елена ЮрьевнаIn modern medical science the thyroid gland dysfunction is one of the risk factors for cardiovascular disease. Many studies, devoted to the mechanisms of the influence of reduced function of the thyroid gland on the cardiovascular system, have been organized. Slight disorders of the thyroid function may be accompanied by an increasing of cardiometabolic risk This leads to the search for additional influence on the pathogenetic mechanisms of the hypothyroidism in order to treat effectively these threatening manifestations and consequences of the disease.Документ Problems of nitrate water pollution in Poltava region(Wiadomosci Lekarskie, 2018) Pikul, K. V.; Bobyreva, L. Ye.; Kotelevska, T. M.; Pryimenko, N. О.; Tarasenko, K. V.; Пікуль, Катерина Вікторівна; Бобирьова, Людмила Єгорівна; Котелевська, Тетяна Михайлівна; Прийменко, Наталія Олегівна; Тарасенко, Костянтин Володимирович; Пикуль, Екатерина Викторовна; Бобырева, Людмила Егоровна; Котелевская, Татьяна Михайловна; Прийменко, Наталья Олеговна; Тарасенко, Константин ВладимировичThe topicality is determined bypriority and importance of researches that have preventive referral directed on provision of harmonious growth and early childhood development, children’s resistance to the infection’s effects and other unfavorable external factors. There are problems about the role of permanent nitrate load in the formation of children health issues, especially children who live in the area with high nitrate levels in drinking well water.Документ Изучение распространенности сахарного диабета по Полтавской, Житомирской областям и по Украине в целом(Полтавський державний медичний університет, 2001) Бобырева, Людмила Егоровна; Дворник, Ирина Леонидовна; Муравлева, Оксана Васильевна; Гончаренко, Александр Викторович; Бобирьова, Людмила Єгорівна; Дворник, Ірина Леонідівна; Муравльова, Оксана Василівна; Гончаренко, Олександр Вікторович; Bobyreva, L. Ye.; Dvornyk, I. L.; Muravleva, O. V.; Goncharenko, O. V.The purpose of this investigation was to study the epidemiological states of diabetes mellitus in Poltava, Zhutomir regions and in the whole Ukraine for the 15 years (Poltava — the so called „clean« region and Zhutomir — the so called „dirty« one). There was revealed the increasing of diabetes mellitus sick-rate in these regions and in Ukraine both in adults and children. There is a tendency of a permanent increasing of the lethality of those suffers from This disease. All this shows the vitality of this problem nowadays and acute necessity to find the new methods of treatment of the patients suffering from the diabetes mellitus.