Перегляд за Автор "Cherniavska, Yuliia"

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  • Ескіз
    Документ
    Preliminary study of the influence of maternal and neonatal NOS3 (rs1799983), IL1B (rs1143634) genes variants and their intergenic interaction on the development of hypoxic-ischemic encephalopathy in newborns in the context of treatment planning
    (Aluna Publishing, 2024-12) Cherniavska, Yuliia; Davydenko, Alina; Pokhylko, Valerii; Fishchuk, Liliia; Rossokha, Zoia; Чернявська, Юлія Ігорівна; Давиденко, Аліна Володимирівна; Похилько, Валерій Іванович; Фіщук, Лілія Євгенівна; Россоха, Зоя Іванівна
    Aim: To determine the influence of maternal and neonatal variants of the eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) genes and their intergenic interactions on the development of HIE in newborns. Materials and Methods: The study included a cohort of 105 newborns and their 99 mothers. Determination of variants of the genes eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) was carried out for the patients of study groups. Results: The frequency of detection of the 894TT genotype by the eNOS gene was increased in newborns with severe asphyxia (p=0.018) and in their mothers (p=0,0057). Further analysis of intergenic interactions, performed in mother-child pairs, revealed an increased frequency of the neonatal 894GG (eNOS)/ maternal 3953С (IL-1B) genotype combination in the comparison group versus the group of newborns with HIE (p=0.007). Conclusions: The significance of the intergenic maternal combination of 894GG/3953CT genotypes for the eNOS and IL1B genes and the intergenic combination of neonatal 894GG (eNOS)/maternal 3953CT (IL-1B) genotypes in the development of HIE in newborns has been proven. Associations of maternal and neonatal 894TT genotypes for the eNOS gene with the development of severe asphyxia, bradycardia, and respiratory failure were found in newborns with HIE.
  • Ескіз
    Документ
    The I/D variant of the ACE gene affects the clinical characteristics ofCOVID-19 course in intensive care unit patients
    (Taylor & Francis Group, 2025) Pokhylko, Valerii; Cherniavska, Yuliia; Fishchuk, Liliia; Rossokha, Zoiia; Popova, Olena; Vershyhora, Victoriia; Dubytska, Olha; Zhuk, Liudmyla; Tsvirenko, Svitlana; Kovtun, Serhii; Horovenko, Nataliia; Похилько, Валерій Іванович; Чернявська, Юлія Ігорівна; Фіщук, Лілія Євгенівна; Россоха, Зоя Іванівна; Попова, Олена Федорівна; Вершигора, Вікторія Олександрівна; Дубицька, О. М.; Жук, Людмила Анатоліївна; Цвіренко, Світлана Миколаївна; Ковтун, Сергій Іванович; Горовенко, Наталія Григорівна
    Aim: The purpose of our study was to investigate the prevalence of the I/D variant of the ACE gene among intensive care unit patients and its potential impact on the course, severity, and mortality of COVID-19. Patients and methods: The study group included 117 patients with severe COVID-19 and 100 with mild COVID-19. All patients underwent testing for the I/D variant of the ACE gene. Results: The genotype frequencies in the group of patients with severe and mild COVID-19 were as follows: II – 23.1% and 20.0%, ID – 50.4% and 52.0%, DD – 26.6% and 28.0%. These frequencies did not significantly differ from each other, nor did they differ in the population frequencies for the Ukrainian population. The study revealed that the level of diuresis in carriers of the ID genotype was significantly higher than that in patients with the II genotype (p = 0.009). Patients with the DD genotype had prolonged activated partial thromboplastin time compared with those with the ID genotype (p = 0.023). Conclusions: The I/D variant of the ACE gene is associated with certain clinical indicators in severe COVID-19 patients, but no significant relationship was found with severity or mortality.