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Документ Morphological Changes of Dental Pulp in Experimental Deep Caries with Perforation of the Pulp Chamber in Rats(AURIS Kommunikations- und Verlagsgesellschaft mbH, 2014) Grinishin, O. B.; Filenko, B. M.; Филенко, Борис МиколайовичPulpitis is inflammation of soft tissues of dental cavity caused by pathogenic microorganisms that penetrate mostly through the carious cavity. The purpose of the research was to study morphological changes of dental pulp in experimental deep caries with perforation of the pulp chamber in rats. In the coronal and cervical portions of the pulp in deep caries with perforation of pulp chamber irreversible necrotic processes of odontoblasts have been noted. At the same time significant circulatory disorders in the form of thrombosis and hemorrhage have been detected in the root portion of pulp. Moreover, necrobiotic changes in the root portion of the pulp are combined with the inflammatory infiltrates, which can further affect periodontium.Документ Морфологічні зміни пульпи при експериментальному поверхневому карієсі(Вищий державний навчальний заклад України «Українська медична стоматологічна академія», 2013) Гринишин, Ольга Богданівна; Филенко, Борис Миколайович; Гринишин, Ольга Богдановна; Филенко, Борис Николаевич; Grinishin, O. B.; Filenko, B. M.Характер враження та ступінь розвитку запального процесу в пульпі зуба обумовлює визначення тактики ендодонтичного лікування – пульпотомію чи пульпектомію. В роботі описані морфологічні зміни дентину та пульпи зуба при експериментальному поверхневому карієсі у щурів. Встановлено, що при поверхневому карієсі розвиваються оборотні зміни в коронковій частині пульпи зуба, в той час як цервікальна та коренева ділянки не змінюються у порівнянні з нормою.; The main reason of pulpitis development is carious process. The nature of lesion and extent of inflammatory process development causes endodontiс treatment approach i.e. pulpotomy or pulpectomy. The research objective is to study morphological changes of dental pulp in case of experimental superficial caries in rats. The research has been conducted on histochemically stained thick sections of teeth and decalcified cuts of usually stained teeth. Dental deposits and plaque are combined with the sites of superficial caries. Superficial caries is characterized by deep lesion of enamel up to enamel-dentin junction. It is observed in rats for 42-52 day of research. Microscopic researches have shown the expressed destructive changes in dentin underlying enamel: granular disintegration, dead ways existence. Uneven accumulation of basophilic granules as calcified deposits has been noted within predentin zone. Hypostasis of odontoblasts processes has been observed between predentin and odontoblasts nuclei in a site of coronal pulp. The zone of odontoblasts processes hypostasis is characterized by accumulation of edematous liquid between odontoblasts and predentin. Dentinal tubules have perpendicular orientation to a pulp and are light pink stained due to calcified deposits. Single odontoblasts processes don't reach dentinal tubules. We consider the described morphological changes to be connected with blood circulation disorders as arterial hyperemia observed directly in the pulp. Thus odontoblasts nuclei are at different distance from the apical surface of their cytoplasm. The expansion of fissures between odontoblasts promotes accumulation of edematous liquid within overodontoblasts area. There is a formation of transparent dentin in dentinal tubules. The transparent dentin is a pulp adaptation reaction, reparation sealing of separate dentinal tubules. The sites of the ostium and radicular pulp in case of superficial caries are not changed compared with the norm. Odontoblasts in the ostium have a perpendicular course to predentin. There is an imbricate arrangement of odontoblasts in radicular part. We came to the conclusion that precarious processes turn into superficial caries with its distribution on enamel-dentin junction. There is an accumulation of edematous liquid with partial destruction of odontoblasts processes in overodontoblasts space due to the local blood circulation disorders as arterial hyperemia. The formation of a transparent dentin as pulp adaptation reaction has been noted. Therefore, morphological changes of dentin and coronal pulp are reversible while there are no changes within the ostium and the root areas.Документ Морфологічні зміни тканин зуба при експериментальному глибокому карієсі у щурів(Вищий державний навчальний заклад України «Українська медична стоматологічна академія», 2014) Гринишин, О. Б.; Филенко, Борис Миколайович; Гринишин, О. Б.; Филенко, Борис Николаевич; Grinishin, O. B.; Filenko, B. N.Вивчення морфологічних змін дентину та пульпи при карієсі є обґрунтуванням тактики ендодонтичного лікування. В роботі описані запальні та адаптаційні зміни пульпи при експериментальному глибокому карієсі без перфорації пульпової камери у щурів. Встановлено, що в кореневій та цервікальній частинах пульпи визначаються розлади місцевого кровообігу та дистрофія одонтобластів, що носять частково зворотній характер. В кореневій частині розвиваються зворотні зміни.; Pulpitis is the stage of carious progression that develops in the form of hyperergic inflammation against the background of previous pulp sensitization, caused by the decay products of organic substances of hard tooth tissues and microorganisms’ endotoxins of carious focus. In deep caries the significant destructive changes of dentin, reaching to pulp chamber, as well as progression of inflammatory pulp reaction are observed. Deep caries originates mainly on the 111-140 day of the experiment and is characterized by the complete enamel decay and partial dentin destruction, but is separated from pulp by the preserved predentin area. In the experiment, stipulated by cariogenic diet, no bacterial clumps, penetrating into dentinal fibers, have been identified. This makes evident that in presented experimental model aseptic caries is being developed. It has been established that bulbous portion of pulp, adjoining to carious focus, is microscopically characterized by odontoblasts’ proliferation, evident by numerous mitosis. It should be noted that odontoblasts’ nuclei are located at the level, different to the level of multilayered structures’ formation. Among individual odontoblasts, light lumens, filled with hydropic fluid that separates odontoblasts and penetrates into superdontoblastic space, causing atrophy and destruction of odontoblasts’ processes, are found. Right under the odontoblastic layer around hyperemic vessels, multiple cells of fibroblastic type are identified, providing pulp with replacing dentin. In deep caries, pulp of cervical portion of tooth is also reactive. It has been established that in this area bodies of odontoblasts, being of smaller sizes, penetrate into individual dentinal tubules. This is due to the fact that hydropic fluid accumulates in subodontal space, formed by odontoblasts and basal layer of Weil. This layer is located between odontoblasts and microvessels and characterized by the presence of numerous cells of odontoblastic type and fibrous structures. Due to proliferation and differentiation of fibroblasts, the secondary replacing dentin can be formed in the cervical portion of pulp chamber. However, its formation, filling the lumen of cervical portion of pulp chamber, may be shifted onto the root one. It should be noted that, unlike the norm, odontoblasts of root portion change its spatial orientation. So, they are located perpendicularly relative to predentin with its bigger diameter, and its big processes penetrate into individual dentinal tubules. This perpendicular location of odontoblasts is obviously connected with minor edema of super- and subodontoblastic spaces. Unlike cervical portion, in the root portion a miotic activity of fibroblasts is less evident. The formation of replacing dentin in deep caries without perforation of pulp chamber is to be considered as adaptive pulp reaction on enamel and dentin’s destructive processes. In the root and cervical portions of pulp local blood circulation disorders and odontoblasts’ dystrophy, which are of partially reversible nature, are identified. In the root portion the reversible changes are developed.