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Документ Applications of saliva in diagnostic of diseases - A comprehensive review(Вищий державний навчальний заклад України «Українська медична стоматологічна академія», 2015) Kiani, M.; Yanko, N.; Pankevich, A.; Панькевич, Артур ІвановичThe current development of diagnostic biomarkers in salivary diagnostics has led to the development of robust diagnostic tools for dentists to use in making clinical decisions and predicting treatment outcomes. An increasing number of systemic diseases and conditions have been shown to be reflected diagnostically in saliva. Along with these developments are technology advancements that have overcome barriers to the widespread implementation of salivary diagnostics. These barriers include technological problems related to achieving high sensitivity, high specificity, miniaturization, high throughput, automation, portability, low cost, high functionality and speed; overcoming them has enabled researchers to detect and measure multiple disease markers. These challenges have largely been met as a result of careful studies of salivary gland physiology, development of sensitive amplification methods (ELISA, RT-PCR), and education of the scientific community in the methodology for obtaining and dealing with salivary samples. Such miniaturized saliva based diagnostic technologies as OFNASET will enable the use of minute amounts of bodily fluids to yield critical patient information that reflects health and disease status. These technologies will allow clinicians to achieve real-time and simultaneous assessment of multiple diseases. Diagnostic molecular targets in saliva are the salivary proteome and the salivary transcriptome. Salivary analysis can be done for the diagnosis of the oral, infectious, systemic, autoimmune, and hereditary diseases, malignancy, monitoring of levels of hormones, detection of drugs, bone turnover marker in saliva, forensic evidence, genetic disorders, and occupational and environmental medicine. The ability to monitor health status, disease onset and progression, and treatment out come through non-invasive means is a highly desirable goal in health care promotion and delivery. An initiative catalyzed by the National Institute of Dental and Craniofacial Research (NIDCR) has created a roadmap to achieve this goal through the use of oral fluids as the diagnostic medium to scrutinize the health and disease status. The recent advances in oral fluid biomarker diagnostics has been fuelled by novel molecular approaches (e.g. proteomics, transcriptomics and genomics) and metagenomic analyses that have broadened the discovery of microbial pathogens associated with systemic and oral diseases. Similarly, these experimental approaches have been successfully used in the diagnosis of non-infectious systemic and oral conditions (e.g., cancers, autoimmune diseases, renal disease and diabetes). Diagnostic kits for S. mutans and Lactobacillus counting and salivary buffering capacity widely use in dental practice. The p53 antibodies and salivary defensin-1 level can be detected in the saliva of patients diagnosed with oral squamous cell carcinoma. Such biomarkers as Matrix metalloproteinase-8, Matrix metalloproteinase-9, Interleukin-1β (IL-1β), Interleukin- 6 (IL-6) alone and in combination, S100 proteins, Lactoferrin, Macrophage inflammatory protein-1α, 8-hydroxy- deoxyguanosine, and periodontopatogenic bacteria were successfully implementated in periodontal disease practice due to ELISA and PCR. The future of this field will depend on further validation of disease (and stage) specific biomarkers and their incorporation into state-of-the-art, multiplex assays that are versatile, quantitative, reliable, sensitive, specific, rapid, robust, and cost effective for broad implementation in diagnostic programs. Возможность контролировать состояние здоровья, начало, прогрессирование, и лечение за- болеваний с помощью неинвазивных методов является важной задачей в продвижении и оказании меди- цинской помощи. В этой статье представлены биологические и биохимические маркеры различных заболе- ваний в слюне и научно обосновано такое её использование. Технологии, работающие со слюной, прошли путь от ИФА и ПЦР до такого миниатюрного автоматизированного портативного теста как OFNASET c высокой пропускной способностью и сравнительно низкой стоимостью. Можливість контролювати стан здоров’я, початок та прогресування, а також лікування захво- рювання через неінвазивні методи є дуже важливим завданням у просуванні і наданні медичних послуг. У цій статті представлені біологічні та біохімічні маркери різних захворювань у слині та науково обґрунтоване таке її використання. Технології, що працюють зі слиною, пройшли шлях від ІФА та ПЦР до такого мініатюрного автоматизованого портативного тесту як OFNASET із високою пропускною здатністю та порівняно низькою вартістю.Документ Locus of control and behavioral strategies in HSEEU “UMSA” dental students from Iran and Iraq(Львівська медична спільнота, 2015) Tkachenko, E. V.; Kiani, M.; Almagri, A.; Ткаченко, Олена ВікторівнаAs it is known there exists a term «cognitive styles» including locus of control, behavioral strategies and reflectivity-impulsivity. They are studied in different countriesn part in Iran and Iraq. We met Iranian scientists work about interrelations between locus of control and academic degrees Other work touched necessity of determining theinternal and external locus of control in the patients with diabetes mellitus for thedoctor and the patient optimal conversation as well as following the therapy . Mother internal control locus in Iran is considered as positive for children creativity, for diabetes mellitus treatment in children in Yazd . Iranian scientists study locus of control in the students in gender aspect in Tabriz . Iranian scientists from Tarbiat Modares University as well asMedical school of Shahid Beheshti University proposed the term «creative defensivestrategies» for people with increased creativity. There is a work dedicated to comparison of Persian, Kurdish and Turkish ethnic groups in Iran on thissubject moreover in gender aspectДокумент Pulp Capping with Mineral Trioxide Aggregate at Pulp Exposure(Вищий державний навчальний заклад України «Українська медична стоматологічна академія», 2015) Kiani, M.; Yanko, N. V.; Ahmed, M. S.; Amanibeni, A.; Кіані, Масуд; Янко, Наталія Валентинівна; Ахмед, Моханад Сеєд; Аманібені, Алі; Киани, Масуд; Янко, Наталия Валентиновна; Ахмед, Моханад Сеед; Аманибени, АлиTo prevent the pulp from deteriorating when a dental restoration gets near the pulp, the dentist will place a small amount of a sedative dressing, such as MTA. This material, protect the pulp from noxious agents (heat, cold and bacteria) and stimulate the cell-rich zone of the pulp to lay down a bridge of reparative dentin. Dentin formation usually starts within 30 days of the pulp capping (there can be a delay in onset of dentin formation if the odontoblasts of the pulp are injured during cavity removal) and is largely completed by 130 days. MTA pulp capping was performed at open reversible pulpitis-presence of ulceration among carious dentin-pulp exposure. Teeth had no difficulty controlling bleeding from exposure, pin point should be up than 1mm exposure after caries has been removed, no treatment plan for a laboratory-fabricated prosthesis that is placed on the tooth, asymptomatic teeth without a history of pain. The procedure for pulp capping consisted of several steps. First, the dental cavity was drilled, if pulp was disclosed, the area was cleaned and the pulp point was covered with MTA to protect it from becoming infected. Once the pulp is capped, the dentist will place a temporary or permanent dental filling in the tooth. Of the 84 teeth with pulp exposure in 30 patients that were included in the current study by clinical evaluation. Performing a pulpectomy is typically suggested upon frank exposure of the pulp, but a pulp cap using MTA was used for 51 teeth in 11 patients. Patient ages ranged from 21 to 58 years. The current study estimated pulp vitality after MTA pulp caps with clinical and radiographical criteria. Follow up appointments were prescribed after 1,5, 2-3, 6, and 8 months. 20 from these 51 teeth dropouted after 1,5 months for irreversible pulpitis (n = 15) or restorative considerations required a more predictable foundation (n = 5). At recall after 6 months, 11 patients with pulp caps were clinically and radiographically assessed. Totally, 6 months pulp survival was 67.7%, while the 8 months survival rate was 56.2%. Within the limitations of the current study on procedures performed, it may be concluded that, for MTA pulp caps applied to carious exposures in adults, certain preoperative conditions patient age, exposure size and amount of bleeding are not predictive of clinical outcome. Considering the comparatively low success rate for the сurrent cohort, more studies are needed to define predictive criteria for successful pulp capping with MTA. The success measured as pulp survival over a period of one year of pulp caps performed may be low. This study provides data regarding the impact of exposure sizes and other preoperative variables on outcomes of MTA pulp caps in adults. Эффект минерал триоксид агрегата (МТА) при прямом покрытии пульпы состоит в стимуляции образования репаративного дентина в течение 1-4 месяцев. Наложение МТА на вскрытую точку пульпы диаметром до 1 мм при её вскрытии во время препарирования глубокого кариеса проводилось при возможности контролировать кровотечение из пульповой камеры и отсутствии болей в зубе в анамнезе. 23 из 31 зуба через 2-3 месяца после покрытия не имели симптомов (74%), все зубы не имели патологических изменений на рентгенограмме. Через 6 месяцев эффективность покрытия с МТА составила 67.7%, через 8 месяцев – 56.2%. Ефект мінерал триоксид агрегату (МТА) при прямому покритті пульпи полягає в стимуляції утворення репаративного дентину протягом 1-4 місяців. Накладення МТА на розкриту точку пульпи діаметром до 1 мм при її розкритті під час препарування глибокого карієсу проводилося при можливості контролювати кровотечу з пульпової камери і відсутності болю в зубі в анамнезі. 23 з 31 зуба через 2-3 місяці після покриття не мали симптомів (74%), всі зуби не мали патологічних змін на рентгенограмі. Через 6 місяців ефективність покриття з МТА склала 67,7%, через 8 місяців – 56,2%.Документ Pulse peculiarities in HSEEU «UMSA» iranian students(Київський медичний науковий центр, 2015) Tkachenko, E. V.; Kiani, M.; Ткаченко, Олена ВікторівнаArterial hypertension belongs to worldwide problems and Iran is nol an exception. Pulse study belongs to simple, informative and spread diagnostic method. It is possible to put diagnosis according to human pulse and some specialists do it successfully in the East in part. We met following scientific publications about pulse characteristics study in Iran. One work is dedicated to association between forced expiratory volume in one second and pulse oxymeiric measurements of arterial oxygen saturation. Pulse transit time is proposed to be used for arterial pressure measurement , pulseoximetry oxygen saturation is applied in open heart intensive care , new noninvasive method was introduced for measuring blood pressure continuously in operating room and during the anesthesia based on electrocardiograph and pulse oximetry signals .