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Документ A German-Ukrainian partnership improved local routine diagnostics of infectious diseases in Ukraine(34 Annual Meeting th of the Society for Virology, 2025-03) Koval, T.; Bodnar, V.; Izuimska, O.; Marchenko, O.; Pryimenko, N.; Vatsenko, A.; Sidorenko, M.; Zelinskyy, G.; Schrammel, U.; Elsner, C.; Dziobaka, J.; Verhasselt, H. L.; Heintschel von Heinegg, E.; Dittmer, U.; Kaydashev, I.; Коваль, Тетяна Ігорівна; Боднар, Вадим Анатолійович; Ізюмська, Олена Михайлівна; Марченко, Олена Геннадіївна; Прийменко, Наталія Олегівна; Ваценко, Анастасія Ігорівна; Сидоренко, Марина Ігорівна; Кайдашев, Ігор ПетровичThe Ukraine currently experiences extremely challenging times in general and for their healthcare system in particular. The war leads to mass deaths and injuries, significant environmental damage, massive attacks on power supply systems, and the displacement of millions of people. These terrible circumstances inflict massive trauma to both civilians and combatants, and causes many social problems, predisposing for the spread of infectious diseases. At the same time, population migration, the destruction of medical facilities, and other challenges endanger the diagnosis of infectious diseases.Документ Allele С (rs5186) of at1r is associated with the severity of COVID-19 in the Ukrainian population(2022) Izmailova, O.; Shlykova, O.; Vatsenko, A.; Ivashchenko, D.; Dudchenko, M.; Koval, T.; Kaidashev, I.; Ізмайлова, Ольга Віталіївна; Шликова, Оксана Анатоліївна; Ваценко, Анжела Володимирівна; Іващенко, Дмитро Миколайович; Дудченко, Максим Олександрович; Коваль, Тетяна Ігорівна; Кайдашев, Ігор ПетровичThe severity of SARS-CoV-2 induced coronavirus disease 19 (COVID-19) depends on the presence of risk factors and the hosts’ gene variability. There are preliminary results that gene polymorphisms of the renin- angiotensin system can infuence the susceptibility to and mortality from COVID-19. Angiotensin II type 1 receptor (AT1R) might be a gene candidate that exerts such infuence. The aim of this study was to elaborate on the association between A1166C at1r polymorphic variants and the susceptibility to and severity of COVID-19 in the Ukrainian population. Methods: The study population consisted of the Ukrainian population (Poltava region) with COVID-19, divided into three clinical groups in accordance with oxygen requirement: patients without oxygen therapy (n = 110), with non-invasive (n = 136) and invasive (n = 36) oxygen therapy. The A1166C polymorphism of the at1r was determined by polymerase chain reaction with subsequent restrictase analysis. In an attempt to better explain the role of the A1166C at1r polymorphism we compared its association with COVID-19, essential hypertension (n = 79), renoparenchimal hypertension (n = 30) and dyscirculatory en- cephalopathy (n = 112). The data for this comparison were obtained by meta-analysis. Results: We observed signifcant differences in the frequency of AA, AC and CC genotypes in the groups of COVID- 19 patients with non-invasive and invasive oxygen therapy in comparison with control subjects as well as in the frequency of combined AC + CC genotype between the groups of COVID-19 patients with any types of oxygen therapy and patients without oxygen therapy. The frequency of the 1166C allele was higher in COVID-19 patients with invasive oxygen therapy (OR = 2.06; CI (1.20–3.53); p = 0.013). We obtained important results indicating that there were no differences between the frequency of at1r polymorphisms in patients with cardiovascular disease and severe COVID-19 with invasive oxygen therapy as well as those who died due to COVID-19. Conclusion: Our study indicated the presence of an association between the A1166C at1r polymorphisms and the severity of COVID-19 in the Ukrainian population. It seems that in carriers of 1166C at1r, the severity of COVID- 19 and oxygen dependency is higher as compared to the A allele carriers, possibly, due to cardiovascular disorders.Документ Anxiety, depression, and quality of life among HIV positive injection drug users in Ukraine, 2017(University of Sassari, 2019) Vasylyev, M.; Davtyan, H.; Denisiuk, O.; Jayaraj, J.; Koval, T.; Piddubna, А.; Sluzhynska, M.; Sluzhynska, O.; Mulcahy, F.; Коваль, Тетяна ІгорівнаIntroduction: People who inject drugs (PWID) are one of the key populations most vulnerable to HIV infection, with 28 times higher prevalence compared to the rest of the population. PWID are known to have many physical, psychological and lifestyle challenges that can influence access to care. Depression is common among PWID living with HIV. It has major effect on health-related quality of life (HRQoL) and is influencing adherence to antiretroviral therapy. This study was conducted to explore how anxiety and depression affect HRQoL among HIV-positive PWID in Ukraine. It will provide knowledge for the further policy development. Methodology: A descriptive cross-sectional study using data from interviewer- administrated questionnaires was performed. The questionnaire was based on the Hospital Anxiety and Depression Scale. The questionnaire on HRQoL was based on the SF-36. Results: Among the 90 HIV positive PWID 74% (67) and 61% (55) had anxiety and depression scores higher than 7 respectively, indicating that most patients had mental health problems. Average scores for general health (40), role limitations due to physical (44) and emotional health (34), vitality (41) and mental health (45) had mean scores less than 50 along with total physical (43) and mental health scores (35). Having an HIV positive partner or partner with unknown HIV status increases anxiety in HIV positive PWID. Conclusion: There are increased depressive and anxiety symptoms and poorer QoL among HIV-positive PWID in Ukraine. Strategies focusing on psychosocial support addressing QoL as part of HIV care could improve health outcomes for these comorbid and debilitating conditions.Документ Identifying the needs of older people living with HIV (≥ 50 years old) from multiple centres over the world: a descriptive analysis(ВМС, 2023) Grosso, T. M.; Hernández‑Sánchez, D.; Dragovic, G.; Vasylyev, M.; Saumoy, M.; Blanco, J. R.; García, D.; Koval, T.; Loste, C.; Westerhof, T.; Clotet, B.; Sued, O.; Cahn, P.; Negredo, E.; Коваль, Тетяна ІгорівнаBackground Older People Living with HIV (OPWH) combine both aging and HIV-infection features, resulting in ageism, stigma, social isolation, and low quality of life. This context brings up new challenges for healthcare professionals, who now must aid patients with a significant comorbidity burden and polypharmacy treatments. OPWH opinion on their health management is hardly ever considered as a variable to study, though it would help to understand their needs on dissimilar settings. Methods We performed a cross-sectional, comparative study including patients living with HIV aged ≥50 years old from multiple centers worldwide and gave them a survey addressing their perception on overall health issues, psychological problems, social activities, geriatric conditions, and opinions on healthcare. Data was analyzed through Chisquared tests sorting by geographical regions, age groups, or both. Results We organized 680 participants data by location (Center and South America [CSA], Western Europe [WE], Africa, Eastern Europe and Israel [EEI]) and by age groups (50- 55, 56-65, 66-75, >75). In EEI, HIV serostatus socializing and reaching undetectable viral load were the main problems. CSA participants are the least satisfied regarding their healthcare, and a great part of them are not retired. Africans show the best health perception, have financial problems, and fancy their HIV doctors. WE is the most developed region studied and their participants report the best scores. Moreover, older age groups tend to live alone, have a lower perception of psychological problems, and reduced social life. Conclusions Patients’ opinions outline region- and age-specific unmet needs. In EEI, socializing HIV and reaching undetectable viral load were the main concerns. CSA low satisfaction outcomes might reflect high expectations or profound inequities in the region. African participants results mirror a system where general health is hard to achieve, but HIV clinics are much more appealing to them. WE is the most satisfied region about their healthcare. In this context, age-specific information, education and counseling programs (i.e. Patient Reported Outcomes, Patient Centered Care, multidisciplinary teams) are needed to promote physical and mental health among older adults living with HIV/ AIDS. This is crucial for improving health-related quality of life and patient’s satisfaction.Документ New challenges of PrEP implementation during Russian-Ukrainian war(John Wiley & Sons Ltd, 2022) Koval, A.; Hetman, L.; Riabokon, S.; Bilets, A.; Koval, T.; Коваль, Тетяна ІгорівнаDevelopment of prevention programme and PrEP implementation in key population groups are highly important to achieve control of HIV epidemic especially in such a critical period for Ukraine. Despite significant disruptions in the provision of HIV prevention programme in the regions with military actions in Ukraine, through collaborative efforts the Center for Public Health and nongovernment organisations with the support of international partners, implementation of PrEP programme was able to continue in Ukraine. We aimed to assess of recruitment dynamics of new PrEP clients and changes in their geographic distribution in Ukraine during period of military actions.Документ Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population(Acta Biomed, 2023-02-13) Izmailova, O.; Shlykova, O.; Kabaliei, A.; Vatsenko, A.; Ivashchenko, D.; Dudchenko, M.; Volianskyi, A.; Zelinskyy, G.; Koval, T.; Dittmer, U.; Kaidashev, I.; Ізмайлова, Ольга Віталіївна; Дудченко, Максим Олександрович; Іващенко, Дмитро Миколайович; Кабалєй, Аліна Вікторівна; Волянський, Андрій Юрійович; Дітмер, Ульф; Зелінський, Геннадій; Шликова, Оксана Анатоліївна; Ваценко, Анастасія Ігорівна; Коваль, Тетяна Ігорівна; Кайдашев, Ігор ПетровичGene polymorphism, coding the host proteases, which are involved in the virus entry into the cells can influence the susceptibility to and mortality from coronavirus disease 19 (COVID-19). Angiotensin-converting enzyme 2 (ACE2), transmembrane serine 2 and serine 11A proteases (TMPRSS2, TMPRSS11A), and a cell surface cluster of differentiation 147 (CD147) might be a gene candidate that ex-erts such influence. The aim of this study was to investigate the associations between ace2, tmprss2, tmprss11a, and cd147 polymorphic variants and the severity of COVID-19 in the Ukrainian population. Methods: The study population consisted of the Ukrainian population with COVID-19: patients without oxygen therapy (n=62), with non-invasive (n=92) and invasive (n=35) oxygen therapy, as well as control subjects (n=92). Al-lelic polymorphisms of ace2 rs4240157, tmprss2 rs12329760, and tmprss11a rs353163 were determined by real-time PCR, and cd147 rs8259 polymorphism was detected by PCR with subsequent restrictase analysis. We compared investigated polymorphisms distribution with other populations by meta-analysis. Results: Our study is the first to obtain data about the distribution of investigated gene polymorphisms in the Ukrainian population: tmprss2 rs12329760 – CC 60.9%, CT 35.9%, TT 3.2%; tmprss11a rs353163 – CC 46.7%, CT 40.2%, TT 13.1%; ace2 rs4240157 – CC 7.6%, C 18.5%, CT 22.8%, TT 19.6%, T 31.5%; cd147 rs8259 – TT 60.9%, AT 32.6%, AA 6.5%. This distribution was similar to the Northern, Western and Southern European populations. There was a statistically significant difference in the frequency of tmprss2 polymorphic geno-types CC 57.1%, CT 28.6%, and TT 14.3% (P<0.05) in COVID-19 patients with invasive oxygen therapy in comparison with non-invasive oxygen therapy. This tmprss2 mutation occurs in the scavenger receptor cysteine-rich (SRCR) domain and might be important for protein-protein interaction in a calcium-depend-ent manner. Conclusions: Our study indicated the presence of an association between the tmprss2 rs12329760 polymorphism and the severity of COVID-19 in the Ukrainian population.Документ Predicting of the development of aidsindicating opportunistic infections in HIV-infected patients on antiretroviral therapy (retrospective cohort study)(Sumy State University, 2019) Marchenko, O.; Koval, T.; Sizova, L.; Kotelevska, Т.; Pryimenko, N.; Марченко, Олена Геннадіївна; Коваль, Тетяна Ігорівна; Сизова, Людмила Михайлівна; Котелевська, Тетяна Михайлівна; Прийменко, Наталія Олегівна; Dubynska, G.; Дубинська, Галина МихайлівнаДокумент Prevalence of herpesviruses among combatants during the Russian-Ukrainian war(34 Annual Meeting th of the Society for Virology, 2025-03) Koval, T.; Bodnar, V.; Zdor, O.; Loban, G.; Faustova, M.; Herasymenko, L.; Shlykova, O.; Izmailova, O.; Kabaliei, A.; Zelinskyy, G.; Schrammel, U.; Elsner, C.; Trilling, M.; Dittmer, U.; Kaidashev, I.; Коваль, Тетяна Ігорівна; Боднар, Вадим Анатолійович; Здор, Олег Іванович; Лобань, Галина Андріївна; Фаустова, Марія Олексіївна; Герасименко, Лариса Олександрівна; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга Віталіївна; Кабалєй, Аліна Вікторівна; Кайдашев, Ігор ПетровичThe war in the Ukraine is an unprecedented stressor that has negative consequences for the health of the Ukrainian population. A significant number of Ukrainian soldiers suffers from clinical symptoms of anxiety, depression, and sleep disorders. It has been shown that changes in the immune regulation under the influence of stress are quite significant and can lead to health consequences, including the reactivation of latent infections, including herpesviruses. However, there is no reliable information on the possible consequences of a war on the spread and reactivation of herpesviruses such as HSV-1/2; VZV, CMV, EBV, and HHV-6Документ Лимфаденопатия: алгоритм диагностики и тактика ведения пациента(УП «Профессиональные издания», 2021) Коваль, Татьяна Игоревна; Изюмская, Елена Михайловна; Марченко, Елена Геннадиевна; Прийменко, Наталья Олеговна; Котелевская, Татьяна Михайловна; Боднар, Вадим Анатольевич; Koval, T.; Iziumska, E.; Marchenko, E.; Pryimenko, N.; Kotelevskaya, T.; Bodnar, V.; Коваль, Тетяна Ігорівна; Ізюмська, Олена Михайлівна; Марченко, Олена Геннадіївна; Прийменко, Наталія Олегівна; Котелевська, Тетяна Михайлівна; Боднар, Вадим АнатолійовичВ статье подробно охарактеризован синдром лимфаденопатии, представлены терминоло- гия, причины, патофизиологические механизмы, классификация, варианты поражения лимфа- тических узлов при инфекционной и неинфекционной патологии. Приведен алгоритм диагно- стического поиска, который состоит из 3 этапов: оценки клинико-анамнестических данных, проведения рутинных лабораторных и инструментальных исследований и выполнения при необходимости дополнительных исследований согласно клинической ситуации. Предоставлены подходы к тактике ведения пациентов с неуточненной лимфаденопатией. Учитывая мультидисциплинарность синдрома лимфаденопатии, успешное решение проблемы дифференциальной диагностики этого состояния зависит от конструктивного взаимодействия многих специалистов (семейных врачей, инфекционистов, онкологов, гематологов, ревматологов, морфологов), их осведомленности о заболеваниях, проявляющихся увеличением лимфатических узлов, и понимания тактики ведения пациентов.