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Документ Biological Properties of Streptococcus pluranimalium as the New Human Pathogen(Open Access Macedonian Journal of Medical Sciences, 2023-01-17) Ananieva, M.; Faustova, M.; Loban, G.; Avetikov, D.; Tkachenko, P.; Bobyr, V.; Dobrovolska, O.; Ананьєва, Майя Миколаївна; Фаустова, Марія Олексіївна; Лобань, Галина Андріївна; Аветіков, Давид Соломонович; Ткаченко, Павло Іванович; Бобир, В. В.; Добровольська, Оксана ВолодимирівнаBackground: The limited amount of information available today does not fully reflect the biological properties of Streptococcus pluranimalium as a pathogen new to humans, its pathogenicity factors, and, as a consequence, the pathogenesis of diseases, which is causes Aim: The aim of this research was to study the biological properties of S. pluranimalium, its sensitivity to antibiotics and antiseptics, as well as its adhesive properties. Methods: Two hundred samples were collected from the coronal pockets in patients with acute purulent pericoronitis during 2019–2021 years. Among them, five clinical strains of S. pluranimalium were isolated. Final identification was carried out using a Vitec-2compact bioMérieux automatic bacteriological analyzer. The sensitivity of the studied microbial strains to antibiotics of various groups was determined by the disk diffusion method. The adhesive properties of S. pluranimalium were determined according to the standard Brilis method. Results: It possesses typical morphological and cultural properties characteristics of the genus Streptococcus representatives. This microorganism virtually does not break down carbohydrates, but it produces arylamidases that enables it to be differentiated from other streptococci. S. pluranimalium demonstrates variable sensitivity to antibiotics; the lowest sensitivity has been found out to the second-generation fluoroquinolones. In addition, the clinical isolates studied show high adhesive properties to human red blood cells.Документ CCL2/MCP-1 Serum Chemokine Level in Patients with Odontogenic Infectious and Inflammatory Diseases of the Soft Tissues of the Maxillofacial Area and Mediastinum(Acta Facultatis Medicae Naissensis, 2022) Faustova, M.; Nazarchuk, O.; Dmytriiev, D.; Avetikov, D.; Loban, G.; Babina, Yu.; Ananieva, M.; Фаустова, Марія Олексіївна; Аветіков, Давид Соломонович; Лобань, Галина Андріївна; Ананьєва, Майя МиколаївнаAim. The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum. Methods. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients’ plasma CCL2/MCP-1 level was determined using a kit for specific ELISA.Документ Forecasting the development of antimicrobial resistance of S. aureus(Frontiers Media SA, 2025-01-09) Shemetov, O.; Faustova, M.; Perepelova, T.; Balia, H.; Pavlish, I.; Loban, G.; Шеметов, Олег Валентинович; Фаустова, Марія Олексіївна; Перепелова, Тетяна Василівна; Баля, Геннадій Миколайович; Павліш, Ігор Вікторович; Лобань, Галина АндріївнаToday, about 15.0% of odontogenic pathology is caused by Staphylococcus aureus (S. aureus). The aim of the study was to predict the development of antimicrobial resistance of S. aureus based on retrospective data. Methods: A total of 425 patients undergoing treatment for odontogenic infectious diseases of the facial area during 2019–2023 were involved in the study. The object of the study was 106 clinical isolates of S. aureus that were isolated and identified from patients. Determining the sensitivity of the obtained isolates to antimicrobial drugs was carried out using Vitek antimicrobial susceptibility testing (Biomerioux, France) and analyzed according to the breackpoint tables of the EUCAST. Prediction of the development of antimicrobial resistance of S. aureus to various antibiotics was carried out on the basis of the received sensitivity data of the studied isolates in 2019–2023 using the exponential smoothing method. Results: The antimicrobial resistance of S. aureus isolates to various antibiotics changed annually during 2019–2023. The level of resistance of S. aureus isolates to benzylpenicillin wavered between 40%–50% from 2019 to 2023 with the trend of an 18.0% increase over the next five years. A uniform plateau of antimicrobial resistance of S. aureus to cefoxitin is predicted at the level of 32.0% during 2024–2028. We recorded the highest portions of S. aureus resistant to norfloxacin (33.3%) and ciprofloxacin (16.7%) in 2023 with prediction of its increasing in the next five years within the range of 20.0%. It was established that S. aureus may reach 100.0% resistance to gentamicin in 2027. According to exponential smoothing, the level of S. aureus resistance to amikacin will increase by 22.7% over the next five-year period. Moreover, representatives of this species of bacteria can develop complete (100.0%) resistance to tetracycline as early as 2027. Conclusions: Mathematical prediction of the development of antimicrobial sensitivity of S. aureus isolates showed a high probability of its development to antibiotics of all groups in the next five years.Документ Prevalence of herpesviruses among combatants during the Russian-Ukrainian war(34 Annual Meeting th of the Society for Virology, 2025-03) Koval, T.; Bodnar, V.; Zdor, O.; Loban, G.; Faustova, M.; Herasymenko, L.; Shlykova, O.; Izmailova, O.; Kabaliei, A.; Zelinskyy, G.; Schrammel, U.; Elsner, C.; Trilling, M.; Dittmer, U.; Kaidashev, I.; Коваль, Тетяна Ігорівна; Боднар, Вадим Анатолійович; Здор, Олег Іванович; Лобань, Галина Андріївна; Фаустова, Марія Олексіївна; Герасименко, Лариса Олександрівна; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга Віталіївна; Кабалєй, Аліна Вікторівна; Кайдашев, Ігор ПетровичThe war in the Ukraine is an unprecedented stressor that has negative consequences for the health of the Ukrainian population. A significant number of Ukrainian soldiers suffers from clinical symptoms of anxiety, depression, and sleep disorders. It has been shown that changes in the immune regulation under the influence of stress are quite significant and can lead to health consequences, including the reactivation of latent infections, including herpesviruses. However, there is no reliable information on the possible consequences of a war on the spread and reactivation of herpesviruses such as HSV-1/2; VZV, CMV, EBV, and HHV-6Документ Trends in underlying causes of death in HIV - infected patients from 2016 to 2018 in Ukraine: a cohort study(Wiley-Blackwell, 2019-11-09) Kyrychenko, T.; Loban, G.; Klorfayn, V.; Holubieva, T.; Marchenko, P.; Legkostup, L.; Marchenko, A.; Mykhailova, K.; Korshenko, V.; Кириченко, Тетяна Станіславівна; Лобань, Галина Андріївна; Клорфайн, Вадим Йосипович; Голубєва, Тетяна Миколаївна; Марченко, Павло Сергійович; Легкоступ, Л.; Марченко, Алла Володимирівна; Михайлова, Катерина Іванівна; Коршенко, Володимир ОлександровичDeath level in PLHIV in Ukraine remains high. We aimed to examine changes in causes of death in PLHIV over the period 2016–2018. A retrospective cohort study was conducted at Poltava Regional HIV Center which routinely collected data for PLHIV enrolled.Документ Virological efficacy of first-line regimens, resistance profile and factors influencing adherence to ART in clinical practice in Ukraine(Virology Education, 2019. Vilnius, Lithuania., 2019-09-20) Kyrychenko, T.; Loban, G.; Korshenko, V.; Кириченко, Тетяна Станіславівна; Лобань, Галина Андріївна; Коршенко, Володимир ОлександровичIntegrase inhibitors (INI) have recently been recommended for first-line therapy (FLT) in Ukraine, but non-nucleoside reverse transcriptase inhibitors (NNRTI) based regimens present a majority of FLT cases, even though testing for NNRTI mutation has not been routinely performed. Data regarding virological efficacy of ART and prevalence of drug resistance mutations in Ukraine is scarce. We evaluated the virological response, resistance profile, factors influencing adherence to treatment in patients starting a first-line regimen in clinical settings in Ukraine.Документ Спосіб визначення протигрибкової дії емульсії евгенолу в полісорбаті-80 на еталонний штам Candida albicans(2022) Полянська, Валентина Павлівна; Федорченко, Віра Іванівна; Зачепило, Світлана Вікторівна; Боброва, Нелля Олександрівна; Лобань, Галина Андріївна; Polanska, V.; Zachepilo, S.; Fedorchenko, V.; Bobrova, N.; Loban, G.Проведені авторами спостереження під час комплексного вивчення дії евгенолу дозволили розробити та запропонувати новий спосіб визначення дії евгенолу, який включає застосування еталонного штаму Candida albicans.