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Документ Vascular depression and cardiovascular complications of type 2 diabetes(Полтавський державний медичний університет, 2023) Kostrikova, U. A.; Myakinkova, L. O; Pustovoit, G. L.; Yarmola, T. I.; Кострікова, Юлія Анатоліївна; М'якінькова, Людмила Олександрівна; Пустовойт, Ганна Леонідівна; Ярмола, Тетяна ІванівнаThe paper highlights the scientific foundations that link the two-way pathophysiological mechanisms of the development of depression with the worsening of type 2 diabetes and coronary heart disease, congestive heart failure, and an increase in cardiovascular risk. The term "vascular depression" is defined as associated with organic changes in the brain characteristic of cerebrovascular diseases and type 2 diabetes; according to magnetic resonance imaging, they are identified as hyperintensity of the white matter of the brain. The development of white matter hyperintensity is facilitated by vascular dysregulation, transient ischemia, inflammation, and ischemic damage. Disturbances in the regulation of vascular tone that occur during the development of depressive states and their connection with somatic pathology, a decrease in cerebral blood flow, and the appearance of affective and cognitive symptoms are described. The importance of increased arterial stiffness and endothelial dysfunction in the development of depression is highlighted. The regulatory mechanisms of the influence of glucose, nitric oxide, pro-inflammatory cytokines, arachidonic acid, and eicosanoids on vascular regulation and their disturbances in patients with depression and type 2 diabetes are described. The features of astrocytic and neuronal homeostasis of the brain, the neurotoxicity of carbohydrate metabolism disorders and glutamate metabolism, their importance in the violation of vasoactive reactions, and the depression development in patients with type 2 diabetes are indicated. The mechanisms of neuro-endocrine, metabolic and enzymatic vascular regulation, their features in patients with type 2 diabetes and depression, their influence on the course, the prognosis of the disease and cardiovascular risk are considered.