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Документ Immunohistochemical characterization of mucosal glands of the human frontal sinus septum mucosa in normal state(WHO Office in Azerbaijan, 2023) Pronina, O. M.; Bilash, S. M.; Koptev, M. M.; Pirog-Zakaznikova, A. V.; Kononov, B. S.; Oliinichenko, Ya. O.; Donchenko, S. V.; Oleksiienko, V. V.; Mamai, O. V.; Проніна, Олена Миколаївна; Білаш, Сергій Михайлович; Коптев, Михайло Миколайович; Пирог-Заказнікова, Ангеліна Валеріївна; Кононов, Богдан Сергійович; Олійніченко, Ярина Олександрівна; Донченко, Світлана Владиславівна; Олексієнко, Владислав Віталійович; Мамай, Олександр ВолодимировичThe immunohistochemical characteristics of the glands of the mucous membrane of the septum of the human frontal sinus were studied in normal conditions. The study was conducted on 120 preparations of the glands of the mucous membrane of the septum of the frontal sinus in 52 corpses of people of both sexes aged from 30 to 87 years who died from causes not related to the pathology of the paranasal sinuses. Our study used such methods as collecting material from corpses and the subsequent method of preparing the material for histochemical studies, serial semi-thin sections, and immunohistochemical analysis. According to an immunohistochemical study, it was established that in the stroma of the septal glands, there are CD 3-positive cells, which are elements of the local protective barrier, as well as a large number of periacinar T-lymphocytes. The number of CD 20-positive cells is negligible in the periacinar connective tissue of the septum. The number of B lymphocytes in the periductal stroma was significant. Many plasma cells were identified in the periacinar stroma of both protein and mucous glands of the mucous membrane of the human frontal sinus. The cells formed chains of 10-12 cells along the basement membrane. The number of CD 138-positive cells in the periductal connective tissue was lower compared to the periacinar tissue.Документ Morphological changes in the arterioles of the haemomicrocirculatory bed of the gingival mucosa under prolonged exposure to food additives(Полтавський державний медичний університет, 2023) Oleksiienko, V. V.; Bilash, S. M.; Олексієнко, Владислав Віталійович; Білаш, Сергій МихайловичThis study investigates the effect of a complex of food additives, including monosodium glutamate, sodium nitrite and Ponceau 4R on the gums of rats. The study is aimed at identifying morphological changes in the walls of arterioles. The study was conducted on material from the gums of rats. Prepared sections were stained with such dyes as toluidine blue and polychrome. The main research methods were morphological, histological and static. The gums of rats in the control group were characterised by the presence of a mucous membrane without a submucosal base, being fused to its own lamina. The first layer was formed by narrow and high papillae, which seemed to grow into the epithelial layer of the mucosa. The next layer, the epithelial layer, was lined with multilayered squamous non-cornified epithelium. Arterioles, as the main vessels of our study, were defined as large-diameter, rounded structures with a thick wall and 3 layers. We studied 3 main parameters: total diameter, lumen of the canal and thickness of the arterioles walls. Particular attention was paid to changes in these values and their interpretation. At week 1, there were mainly decreases in the values relative to the control group, which increased or returned to the control group values by week 4 of the study. Further, the values increased until week 16, but these values were slightly higher than those of the control group. This indicates an insufficient effect of recovery processes in the arterioles due to the powerful effect of nutritional supplements on vascular morphology, especially with prolonged exposure. With this study, we demonstrate that the effects of a complex of food additives are much more powerful than those of individual additives. Given that all foods contain a complex of additives, this experiment will be of interest to food industry workers, as well as doctors and scientists conducting research in this area.Документ State of the autonomous nervous system and stress at outpatient appointment of dental-surgeon's patients with syncopathic conditions(Полтавський державний медичний університет, 2023) Mamai, O. V.; Bilash, S. M.; Boiko, D. I.; Svyryda, O. S.; Oleksiienko, V. V.; Kopytko, N. S.; Kolomiiets, S. V.; Мамай, Олександр Володимирович; Білаш, Сергій Михайлович; Бойко, Дмитро Іванович; Свирида, Олександр Сергійович; Олексієнко, Владислав Віталійович; Копитько, Назар Станіславович; Коломієць, Світлана Веніамінівнаt. In clinical practice, a dental surgeon encounters a wide range of emergencies, including epileptic seizures, cardiac arrest, fainting (or syncope), and others. At the same time, syncope is often overlooked against the background of more severe and dangerous conditions. The aim is to assess the level of perceived stress and the state of the autonomic nervous system in outpatients of a dental surgeon at the beginning of the appointment, depending on the further development of syncope. We conducted a pilot prospective study that included 33 outpatients of a dental surgeon, who were divided into 2 groups: group 1 – patients who developed syncope (n=11); group 2 – patients who did not develop syncope during the visit to the clinic (n=22). During the medical history, patients were asked to complete a questionnaire to assess perceived stress (PSS-10). Every patient received a hemodynamic assessment that included measuring their blood pressure and pulse, determining the Kerdo Index, and examining their autonomic nervous system by checking for demographism. The amount of time spent in the queue was also documented. If a patient fainted, emergency care was immediately given.There were no significant differences in gender, age, diagnosis, or wait time between patients in both groups. There were no statistically significant differences between the groups of patients in terms of perceived stress. A statistically significant higher Kerdo index was found in group 1 with a tendency to sympathicotonia. Conclusions. Thus, we have determined that it is the increased activity of the sympathetic nervous system before an outpatient visit to a dental surgeon, rather than the subjective level of perceived stress, that may be potentially associated with the likelihood of developing syncope, which requires more detailed research. Although syncopal states are generally considered benign, frequent episodes of syncope can harm the patient’s quality of life, morbidity, and compliance with the dentist. Therefore, for safe dental treatment, dentists need to know the state of the autonomic nervous system before treatment to ensure a better therapeutic alliance and treatment outcomesДокумент Професор Олена Миколаївна Проніна (До 65-річчя з дня народження)(Полтавський державний медичний університет, 2023) Білаш, Сергій Михайлович; Коптев, Михайло Миколайович; Пирог-Заказникова, Ангеліна Валеріївна; Кононов, Богдан Сергійович; Донченко, Світлана Владиславівна; Олексієнко, Владислав Віталійович; Олійніченко, Ярина Олександрівна; Мамай, Олександр Володимирович; Bilash, S. M.; Koptev, M. M.; Pirog-Zakaznikova, A. V.; Kononov, B. S.; Donchenko, S. V.; Oleksiienko, V. V.; Oliinichenko, Ya. O.; Mamai, O. V.Співробітники кафедри анатомії з клінічною ана томією та оперативною хірургією, а також науковці Полтавського осередку НТ АГЕТ України щиро вітають Олену Миколаївну Проніну з 65-річним ювілеєм і бажають їй великого натхнення, успіхів у подальшій роботі, міцного здоров’я і жіночої чарівності.