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Документ Daily monitoring of arterial pressure as a method of early diagnosis of arterial hypertension in young patients(HSEE of Ukraine “Ukrainian Medical Stomatological Academy”, 2018) Ivanytska, T.; Burmak, Y.; Petrov, Ye.; Treumova, S.; Ivanytskyi, I.; Іваницька, Тетяна Анатоліївна; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Треумова, Світлана Іванівна; Іваницький, Ігор ВалерійовичThus, it can be concluded that daily monitoring of blood pressure is a highly sensitive method that allows diagnosing arterial hypertension in young patients in the early stages. It should be noted that the majority of patients with arterial hypertension had pathological daily profiles, which indicates an unfavorable prognosis and it needs for more careful management of such patients. It seems that we should change our traditional practice to diagnose and manage BP according to office measurements and more broadly use 24-h ABPM, particularly in young patients, to optimize BP control.Документ Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease(Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy” — Poltava, Ukraine, 2017) Chekalina, N.; Shut`, S.; Trybrat, T.; Burmak, Yu.; Petrov, Ye.; Manusha, Y.; Kazakov, Yu.; Чекаліна, Наталія Ігорівна; Шуть, Світлана Володимирівна; Трибрат, Тетяна Анатоліївна; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Мануша, Юлія Іванівна; Казаков, Юрій МихайловичThe aim: The aim of our research was to study the effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease (CHD). Material and methods: The research involved 85 patients with CHD: stable angina pectoris, FC II, and 30 healthy individuals made up the control group. After 1.5 months of stabilizing therapy (β-blockers, statins, aspirin) patients with CHD were randomized into 2 groups — the research group (30 people) and the comparison group (55 people). Quercetin at a dose of 120 mg per os daily was added to standard treatment of the patients of the research group (with CHD), patients of the comparison group continued receiving the same treatment. The day before randomization and 2 months after prescribing differentiation therapy to the patients, echocardiography (echo) and 24 hour Holter ECG monitoring were made. Results: Clinical evaluation of echocardiography revealed that diastolic dysfunction of the left ventricle (LV) had been found in 100% of patients studied: in 97.6% — in the form of violation of relaxation (type I), in 2.4% of patients — in the form of pseudonormalization (type II). The 24 hour Holter ECG monitoring revealed episodes of myocardial ischemia (10.7+2.7 episodes a day), premature atrial contractions (PACs) and premature ventricular contractions (PVCs) in patients with stable CHD. After a two-month term of therapy in patients of both research and comparison groups left ventricular systolic function in terms of ejection fraction (EF) of LV significantly improved (by 4.5% and 3.2% respectively). LV diastolic function improved in both groups in terms of the ratio of the phases of the transmitral flow E/A, also IVRT significance decreased (p<0.05). DT value dropped significantly influenced by quercetin, in the comparison group it didn`t change. According to the 24 hour Holter ECG monitoring, the total time and number of episodes of ST segment depression decreased with dominative results in quercetin group. PVC number was significantly reduced only by influence of therapy with quercetin (р=0.0022). Conclusions: The data have shown cardioprotective properties of quercetin in conditions of CHD.Документ Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease(Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Str. Shevchenka, 23, 36000, Poltava, Ukraine, 2018) Chekalina, N.; Burmak, Y.; Petrov, Ye.; Borisova, Z.; Manusha, Y.; Kazakov, Yu.; Kaidashev, I. P.; Кайдашев, Ігор Петрович; Чекаліна, Наталія Ігорівна; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Борисова, Зінаїда Олексіївна; Мануша, Юлія Іванівна; Казаков, Юрій МихайловичThe aim of this study was to determine the effect of quercetin on the indicators of chronic systemic inflammation (CSI) in stable coronary artery disease (CAD). Methods: This study included 85 patients with CAD, stable angina pectoris, functional class (FC) II, and heart failure (=F) 0-y. Each patient was prescribed beta-blockers, statins, and aspirin. In addition, a total of 30 patients, forming the study group received quercetin at a daily dose of 120 mg for two months, while the remaining 55 patients made up the control group. The levels of cytokines, such as tumor necrosis factor (TNF-a), interleukin-1b (IL-1b), and interleukin-10 (IL-10) in serum and the expression of the inhibitor of kappa B a (IkBa) gene in blood mononuclear cells, were determined.Документ Некоторые особенности клинической картины и патогенетических мехaнизмов язвенной болезни двенадцатиперстной кишки у лиц пожилого и старческого возраста(Высшее государственное учебное заведение Украины “Украинская медицинская стоматологическая академия”, 2012) Петров, Евгений Евгеньевич; Казаков, Юрий Михайлович; Чекалина, Наталья Игоревна; Петров, Євген Євгенович; Казаков, Юрій Михайлович; Чекаліна, Наталія Ігорівна; Petrov, Ye.; Kazakov, Yu.; Chekalina, N.В обзоре представлены клинические и патогенетические особенности язвенной болезни двенадцатиперстной кишки у лиц пожилого и старческого возраста; В огляді представлено клінічні та патогенетичні особливості виразкової хвороби дванадцятипалої кишки у осіб похилого і старечого віку; Clinical and pathogenetic peculiarities of peptic duodenal ulcer in patients of elderly and senile age are presented in the review.