Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease

Abstract

The aim of this study was to determine the effect of quercetin on the indicators of chronic systemic inflammation (CSI) in stable coronary artery disease (CAD). Methods: This study included 85 patients with CAD, stable angina pectoris, functional class (FC) II, and heart failure (=F) 0-y. Each patient was prescribed beta-blockers, statins, and aspirin. In addition, a total of 30 patients, forming the study group received quercetin at a daily dose of 120 mg for two months, while the remaining 55 patients made up the control group. The levels of cytokines, such as tumor necrosis factor (TNF-a), interleukin-1b (IL-1b), and interleukin-10 (IL-10) in serum and the expression of the inhibitor of kappa B a (IkBa) gene in blood mononuclear cells, were determined.