Вісник проблем біології і медицини, Випуск 3 (166)
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Документ Подагрична нефропатія: вибір стартової терапії у коморбідного пацієнта(Полтавський державний медичний університет, 2022-10-19) Ждан, Вячеслав Миколайович; Ткаченко, Максим Васильович; Бабаніна, Марина Юріївна; Волченко, Григорій Вілійович; Кітура, Євдокія Михайлівна; Кир'ян, Олена Анатоліївна; Zhdan, V. M.; Tkachenko, M. V.; Babanina, M. Yu.; Volchenko, G. V.; Kitura, Ye. M.; Kyrian, O. A.The increase in the prevalence of gout leads to an increase in the frequency of concomitant diseases associated with a persistent increase in the level of uric acid (UA), the degree of decompensation associated with the frequency of arthritis exacerbations. A complex cascade of events is formed the pathogenetic mechanisms of which are closely related to the progress of each of its components. Ukrainian and international recommendations define the standards for the treatment of gouty arthritis, which provide for the mandatory achievement of the target level of UA in the blood serum. The need for a steady decrease to the target level is justified by the desire to influence the process of UA dissolution, the violation of which leads to the formation of urate crystals with their subsequent deposition in the joint cavity and soft tissues, exacerbation of arthritis and an increase in the probability of an undesirable result. Hypouricemic therapy is a mandatory component of standard drug therapy for patients with gout. The literature provides data on the severe febuxostat advantages over other hypouricemic agents. This work aimed to determine the possibility of obtaining a clinical and laboratory effect in a short time after the start of febuxostat therapy (up to 3 months) in patients with gouty nephropathy who have concomitant pathology. Achieving normouricemia in a patient with gout and comorbidities is essential for controlling the course of gout, preventing new gout attacks, and reducing the threat to life and health caused by comorbidities. Analysis of the use of febuxostat in our patients demonstrated the achievement of target values or a significant reduction in UA levels within 3 months of therapy.