Вісник проблем біології і медицини, Випуск 3 (166)
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Документ Optimization the treatment of motor fluctuations in various forms of Parkinson’s Disease(Полтавський державний медичний університет, 2022) Tarianyk, K. A.; Lytvynenko, N. V.; Purdenko, T. Y.; Sylenko, H. Y.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Пурденко, Тетяна Йосипівна; Силенко, Галина ЯрославівнаLevodopa is one of the most effective drugs for the treatment of Parkinson's disease. However, the use of high doses of the drug has many adverse effects. Motor complications of levodopa, in the form of motor fluctuations and dyskinesia, occur in 30 to 40 percent of during the first five years of use and nearly 60 percent or more by 10 years. In the course of the study, an assessment of groups of patients with various forms of Parkinson's disease – akinetic-rigid and mixed, the nature of motor fluctuations, analysis of the relationship with the duration of the disease, levodopa therapy, drug dosage was carried out. Schemes for the treatment of motor fluctuations due to taking levodopa drugs in short-acting and long-acting drugs were analyzed. A positive effect was found in the form of a total intake of levodopa drugs. We can recommend to consider adding of long-release levodopa for management of motor complications in Parkinson’s disease patients with rigidity and akinetic-rigid and tremor-dominant forms of Parkinson’s disease. A proposed regimen for the addition of sustained-release levodopa for the treatment of motor complications in patients with various forms of Parkinson's disease.