Вісник проблем біології і медицини, Випуск 3 (166)
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Перегляд Вісник проблем біології і медицини, Випуск 3 (166) за Ключові слова "antibody-dependent enhancement of infection"
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Документ Progress and problems of vaccination against coronavirus infection Covid-19(Полтавський державний медичний університет, 2022-09-16) Karatash, A. V.; Bilanova, L. P.; Bilash, S. M.; Pronina, O. M.; Bilash, V. P.; Hryn, K. V.; Hryn, V. G.; Oliinichenko, Ya. O.; Караташ, Андрій Вячеславович; Біланова, Лариса Павлівна; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Білаш, Валентина Павлівна; Гринь, Катерина Вікторівна; Гринь, Володимир Григорович; Олійніченко, Ярина ОлександрівнаThis article is devoted to the main achievements and problems associated with vaccination against the COVID-19 coronavirus infection. This problem remains relevant as the coronavirus infection is a highly contagious disease that spreads widely worldwide. Vaccination is currently the most effective way to prevent the occurrence of a coronavirus infection or its severe consequences. The difficulty is that vaccination against COVID-19 is effective only when the antigenic structure of the circulating virus matches the antigens contained in the vaccine (or, in the case of RNA and DNA vaccines, the viral antigens programmed into the genetic code). However, the coronavirus is constantly changing its genetic structure, resulting in new strains that differ from circulating variants and have pandemic potential, against which existing vaccines may be ineffective. This study aimed to determine the main approaches to creating a vaccine's advantages and disadvantages of vaccination through bibliographic analysis. A literature search was conducted among published peer-reviewed articles, books, textbooks, and monographs. The obtained data were systematized and processed. Attention was paid to the main approaches to creating vaccines against COVID-19; the problems of immunological imprinting and antibody-dependent enhancement of infection were assessed. It was established that strategies based on the use of DNA and RNA vaccines to solve the problem of their low immunogenicity in humans are a real alternative for the future development of medicine in the prevention of infectious diseases.