Вісник проблем біології і медицини, Випуск 3 (166)
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Перегляд Вісник проблем біології і медицини, Випуск 3 (166) за Ключові слова "chronic heart failure"
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Документ Influence of postmenopause on the formation of chronic heart failure in women with arterial hypertension(Полтавський державний медичний університет м.Полтава, Україна, 2022-11-02) Казаков, Юрій Михайлович; Чекаліна, Наталія Ігорівна; Плакса, Вікторія Михайлівна; Kazakov, Y. M.; Chekalina, N. I.; Plaksa, V. M.Chronic heart failure (CHF) is the leading cause of disability and mortality in the population, the prevalence of which is steadily increasing. CHF is three times more common in late postmenopausal women. The purpose of the work is the analysis of modern scientific ideas about the pathogenesis of CHF with arterial hypertension (AH) in postmenopausal conditions. The review presents the main ideas about the pathogenesis of CHF, the influence of hypoestrogeny on the molecular mechanisms of the development of hypertension, endothelial dysfunction, myocardial fibrosis, myocardial remodeling, and osteodysmetabolism. The leading role of the activation of systemic inflammation in the development of CHF, their importance in the postmenopausal period is indicated. The pro-inflammatory molecular cascades involved in the formation of CHF in postmenopausal women are presented. Common links were found in the pathogenesis of hypertension, CHF and processes accompanying postmenopause. Potential early markers of the development of CHF are presented, and possible directions of therapeutic influence are indicated. The review systematizes modern ideas about the pathogenetic mechanisms of the development of CHF in postmenopausal women against the background of hypertension, which determines the prospects for solving the problematic issues of diagnosis and treatment of CHF.