Вісник проблем біології і медицини, Випуск 2, Том 2 (165)
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Документ A clinical case of multisystem inflammatory syndrome in a 12-year-old child(Полтавський державний медичний університет, 2022) Tsvirenko, S. M.; Ananevych, O. I.; Voloshyna, V. V.; Laktionova, V. M.; Savchenko, L. V.; Цвіренко, Світлана Миколаївна; Ананевич, Олена Іванівна; Волошина, Вікторія Валеріївна; Лактіонова, В. М.; Савченко, Леся ВолодимирівнаThe fourth wave of the SARS-CoV-2 virus pandemic was characterized by an incidence increase of the disease in all ages children. In most cases, the disease course in children was much easier than in adults. However, an increase in the cases number of children with coronavirus showed that some pediatric patients with SARS-CoV-2 infection developed a nonspecific hyperinflammatory syndrome. According to most observations, a multisystem inflammatory syndrome in children (MIS-C) usually occurs 2-6 weeks after coronavirus disease in previously healthy children and adolescents. It is characterized by clinical and laboratory evidence of multiorgan inflammation. The article presents a clinical case of a pediatric multisystem inflammatory syndrome associated with coronavirus infection in school-age children. The patient developed a gradual MIS-C development after asymptomatic coronavirus infection. The disease onset was characterized by nonspecific symptoms resembling the clinic of a respiratory infection. In the dynamics of the MIS-C formation, there was a lesion of the respiratory, cardiovascular, hepatobiliary systems, and skin, with the development of poly-organ failure syndrome. Therapy conducted by current recommendations contributed to the complete disease regression, and examination three months after recovery showed no abnormalities in the child's health.Документ Establishing the relationship between the level of interleukin-18 and the state of periodontium in children of primary-school-age with chronic catarrhal gingivitis and insulin-dependent diabetes mellitus(Полтавський державний медичний університет, 2022) Sheshukova, O. V.; Kuz, I. O.; Maksymenko, A. I.; Trufanova, V. P.; Polishchuk, T. V.; Mosiienko, A. S.; Kazakova, K. S.; Шешукова, Ольга Вікторівна; Кузь, Ірина Олексіївна; Максименко, Аліна Іванівна; Труфанова, Валентина Петрівна; Поліщук, Тетяна Вікторівна; Мосієнко, Анна Сергіївна; Казакова, Катерина СтаніславівнаInsulin-dependent diabetes mellitus is a significant risk factor for inflammatory periodontal disease in children and adolescents. The study aimed to determine the dental status and study the content of pro-inflammatory IL-18 in oral fluid in primary school children with insulin-dependent diabetes mellitus and to develop an algorithm for predicting IL-18 levels in oral fluid of children with chronic catarrhal gingivitis in type I diabetes mellitus background by establishing a relationship between the level of IL-18 and the assessment index of periodontal tissues according to the Sillness scale, Loe. The study examined 82 children aged six to fourteen years, including 56 with type I diabetes and 26 without concomitant somatic diseases. The IL-18 amount in the oral fluid to characterize the inflammation in the oral cavity organs was determined. The IL-18 value increases with the periodontal index and bleeding gums during probing. It is consistent with the data of scientific studies on IL-18 amount in the oral fluid of adults without diabetes. Our study results also show that an increase in the IL-18 value in oral fluid is closely related to type I diabetes in children. Moreover, in our opinion, IL-18 can be considered a potential biomarker of inflammation in periodontal disease in children with type I diabetes mellitus, the clinical manifestations of which are not yet visible. We found that IL-18 levels are elevated even in the absence of clinical gingivitis manifestations. Therefore, establishing IL-18 pathogenetic significance in chronic catarrhal gingivitis on the background of type I diabetes is extremely important.