Вісник проблем біології і медицини, Випуск 4 (167)
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Перегляд Вісник проблем біології і медицини, Випуск 4 (167) за Ключові слова "616.857:616.831-005.1"
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Документ Migraine and cerebrovascular diseases(Полтавський державний медичний університет, 2022) Delva, I. I.; Дельва, Ірина ІванівнаIn the last decade, much attention is paid to migraine as a risk factor of cerebrovascular pathology. There is increased risk of stroke and transient ischemic attack in females who have migraine with aura, this risk is highest in women under 45 years who use oral contraceptives and (or) smoke. The mechanisms that mediate in- creased risk of stroke in migraine patients up to now are still not completely defined and, most likely, are multifacto- rial. Drugs for the abortive therapy of migraine – ergotamine alkaloids and triptans have vasoconstrictor properties and by that way may increase the risk of ischemic stroke. Spreading cortical depression is an intense depolariza- tion of neurons and glial cells membranes that spreads in a wave-like manner throughout the cerebral cortex with secondary decreasing of cerebral perfusion; decreased cerebral blood flow during cortical depression may exceed a critical threshold and lead to migrainous infarction. According to polygenomic search, it was found the common hereditary predisposition to migraine and ischemic stroke, highest in atherothrombotic and cardioembolic strokes. In patients with migraine with aura, the prevalence of patent foramen ovale is significantly increased; it is assumed that through patent foramen ovale mechanical or chemical stimuli can directly come from venous system to the arterial system and cause a migraine attack with aura. There are associations between migraine without aura and the risk of cerebral arteries dissections, particularly in males and younger patients. Also it was revealed associations between migraine attacks and paroxysms of atrial fibrillation, especially in females who have migraine with aura. Thus, migraine, especially migraine with aura, is associated with an increased risk of strokes, mainly ischemic stroke. Understanding the relationships between migraine and cerebrovascular pathology is important for effective primary prevention of cerebrovascular diseases in migraine patients.