Вісник проблем біології і медицини, 2022, Випуск 2, Том 1 (164)

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Перегляд Вісник проблем біології і медицини, 2022, Випуск 2, Том 1 (164) за Ключові слова "chemoresistant tuberculosis"

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    Justification of the need for correction of immune and antioxidant system disorders in patients with first diagnosed chemoresistant pulmonary tuberculosis
    (Полтавський державний медичний університет, 2022) Filatova, O. V.; Філатова, Олена Вікторівна
    Today, tuberculosis is still an urgent social problem of humanity, mainly in countries with underdeveloped economies. Mortality rates from chemoresistant pulmonary tuberculosis are currently the highest among other dangerous diseases. Sixty patients with first diagnosed chemoresistant pulmonary tuberculosis were examined (30 patients were in main (I) and 30 – in control (II) groups. The main group included patients who were taking anti-TB drugs and tocopherol acetate and tincture of Echinacea purpurea). Patients in the main and control groups had had chemoresistant tuberculosis for the first time, and all patients had confirmed bacterial excretion. At the end of treatment in patients of the main group compared to the control, the immunogram significantly normalized. Namely: increase in the lymphocytes number from (12.3±1.12) to (17.2±1.5), (p<0.05), B-lymphocytes increased from (31.2±0.81) to (67.1±0.2) (p<0.05). The indicators of T-helpers were (29.4±1.81) vs (24.1±0.5), (p>0.05). The t-suppressors level was normal (16.3±1.05) vs (20.3±0.5), (p<0.05). HCT test data were (23.1±2.02) vs (15.3±3.5), (p<0.05). Immunoglobulin class A (1.4±0.8) vs (3.1±0.4), (p>0.05). Class M immunoglobulin increased after treatment, (26.2±3.21) vs (48.1±6.4), (p<0.05). Normalization of CEC concentration indicators (3.8±0.25) vs (7.1±0.2), (p<0.05) and natural killers from (22.2±1.25) to (45.1±1.4), (p<0.05). Therefore, according to the results of this study analysis, we can say that all given above immunogram indicators of patients in the main group compared to the control group normalized. Thus, it is necessary to correct changes in the immune and antioxidant systems in patients with first diagnosed chemoresistant pulmonary tuberculosis.