Світ медицини та біології, № 2 (72)

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State of gastrointestinal mucosal protection in neurological patients in cricical state
(Полтавський державний медичний університет, 2020) Shkurupii, D. A.; Mogylnyk, A. I.; Sonnik, E. G.; Udovytska, N. O.; Шкурупій, Дмитро Анатолійович; Могильник, Антон Ігорович; Сонник, Євген Григорович; Удовицька, Наталія Олегівна
An observational clinical study was performed with 50 adult participants. The main group consisted of 30 patients with cerebrovascular diseases of the cerebrovascular diseases, which required the organization of intensive care. In the main group, on the 1st day of observation, the level of glycosaminoglycans was higher in 70% (21/30) cases. On the 7th day of observation, this indicator was higher in 100% (30/30) cases. Correlations between the increase in the concentration of glycosaminoglycans and their age, the severity of the condition in accordance with APACHE II, and the start time of enteral nutrition were established. Thus, in neurological patients in critical condition, the protection system of the gastrointestinal mucosa is in a state of functional tension.
Bioelectrical impedance determining body composition and hardware-software recording of heart rate variability during an objective structured clinical examination as a diagnostic tool
(Українська медична стоматологічна академія, 2020) Nevoit, G. V.; Potiazhenko, М. М.; Mintser, О. P.; Ignatenko, N. I.; Kаbernik, Yu. А.; Невойт, Ганна Володимирівна; Потяженко, Максим Макарович; Мінцер, Озар Петрович; Ігнатенко, Н. І.; Кабернік, Юлія Анатоліївна; Невойт, Анна Владимировна; Потяженко, Максим Макарович; Минцер, Озар Петрович; Игнатенко, Н. И.; Каберник, Юлия Анатольевна
Practical issues of studying the role of electromagnetic phenomena of cardiac activity and impedance of body tissues in the diagnosis of the functional state of the human body are presented in the article. The purpose of the publication is to determine the clinical diagnostic potential and the appropriateness of applying the computerized methodology for a short record of heart rate variability and the body impedance measurement technique as an instrumental Objective Structured Clinical Examination. The article presents the results of a survey of functionally healthy people of different levels of fitness.
Condition and structural organization of the glandular area mucous membrane of albino rat hard palate under the 30-day-long effect of acrylic monomer
(Українська медична стоматологічна академія, 2020) Khilinich, Ye. S.; Starchenko, І.І.; Davydenko, V. Yu.; Nidzelskiy, M. Ya.; Davydenko, G. М.; Хілініч, Євгеній Сергійович; Старченко, Іван Іванович; Давиденко, Вадим Юрійович; Нідзельський, Михайло Якович; Давиденко, Ганна Миколаївна; Хилинич, Евгений Сергеевич; Старченко, Иван Иванович; Давыденко, Вадим Юрьевич; Нидзельский, Михаил Яковлевич; Давыденко, Анна Николаевна
Currently, the problem of the impact of removable laminar denture frames, including residual monomer, on the condition of the minor salivary glands, which play an important role in maintaining the balance in the oral cavity, remains poorly understood. Therefore, the paper was aimed at the experimental study of the effect of the monomer of the base acrylic resin “Ftoraks” on the condition and structural organization of the salivary glands of hard palate of albino rats. The findings of the study show that the monomer disrupts homeostasis of the oral cavity and causes irritation of the mucous membrane, manifested by dystrophy of the epithelial plate on day 30 of the experiment, as well as thickening of the corneal layer due to hypertrophy, which indicates the presence of hyperkeratosis. On day 30 of the experiment, thickening of the entire epithelial layer and the phenomena of hyper- and diskeratosis was detected in the experimental group; the phenomena of plethora, high lymphocyte, neutrophilic and eosinophilic leukocyte count were noted in the lamina propria of the mucous membrane and growing of relative amount of connective tissue can be regarded as the manifestation of a compensatory-adaptive reaction in response to the action of the monomer. 30-day-long experimental studies have shown insignificant effect of the monomer of the base acrylic resin “Ftoraks” on the cumulative size of the salivary glands in the submucous layer of the hard palate. Since the average recommended period of use of full removable laminar dentures is 3-5 years, it was considered necessary to continue the experiment and investigate the effect of the monomer of the base acrylic resin “Ftoraks” on the condition and structural organization of salivary glands of the hard palate of albino rats after 3, 6 and 9 months to further extrapolate the findings of the study to the human body.
Clinical and morphological aspects of complex treatment of generalized periodontitis
(Українська медична стоматологічна академія, 2020) Savchuk, O. V.; Gasyuk, N. V.; Klytynska, O. V.; Yeroshenko, G. A.; Zaliznyak, M. S.; Савчук, О. В.; Гасюк, Наталія Володимирівна; Клітинська, Оксана Василівна; Єрошенко, Галина Анатоліївна; Залізняк, М. С.; Савчук, О. В.; Гасюк, Наталия Владимировна; Клитинская, Оксана Васильевна; Ерошенко, Галина Анатольевна; Зализняк, М. С.
The article presents scientific data on the substantiation of clinical effectiveness of the effectiveness of the use of the drug “Jen-metrohelur” in the complex treatment of generalized periodontitis. Thus, according to our clinical and morphological studies, the use of “Jen-metrohelur” in the treatment of generalized periodontitis is clinically effective. The justification for this provision is the results of complex clinical and morphological observations, positive dynamics of changes in PMA index (49.32 ±1.98) and periodontal Russell index (3,89±0,54) and changes in the functional status of segmental leukocytes in the dynamics of treatment. So, according to the results of our clinical and morphological studies, the use of the medication “Jen-metrohelur” in the treatment of generalized periodontitis is clinically effective. This provision suggests that in the generalized periodontitis, cells of the inflammatory process together with disorganized cells of the epithelium, connective tissue of the gums and periodontium and bacteria form specific kinds of infiltrates in the periodontal tissues, the nature of these infiltrate initiates the incidence of relapses in the generalized periodontitis in patients.
Structural organization of stromal and parenchymal components of rat testes during central deprivation of testosterone synthesis on the 180 day of the experiment
(Українська медична стоматологічна академія, 2020) Стецук, Євген Валерійович; Стецук, Евгений Валерьевич; Stetsuk, Ye. V.; Акімов, Олег Євгенович; Акимов, Олег Евгеньевич; Akimov, O. Ye.; Шепітько, Костянтин Володимирович; Шепитько, Константин Владимирович; Shepitko, K. V.; Гольцев, Анатолій Миколайович; Гольцев, Анатолий Николаевич; Goltsev, A. M.
Prolonged central deprivation of testosterone synthesis may lead to biochemical and morphological changes in testes. Influence of prolonged testosterone deficiency on reactive nitrogen and oxygen species production, morphological changes in interstitial endocrinocytes and sustentocytes is not yet fully understood. The number of interstitial endocrinocytes is reduced in comparison with the control group, there are interstitial spaces between the convoluted tubules with a complete absence of interstitial endocrinocytes. Interstitial endocrinocytes are reduced in size, their nuclei are heterochromic. When we studied the structural organization of rat sustentocytes from the experimental group in comparison with the control group, we found that hyperplasia of the elements of the smooth endoplasmic reticulum was observed in the cytoplasm of the sustentocytes. The number of mitochondria in the cytoplasm of the sustentocytes decreased, the electron density of the mitochondrial matrix was lowered, protein structures were present either inside the vacuoles or independently located in the cell cytoplasm. Biochemical studies revealed increased NO production from inducible NO-synthase and development of oxidative stress. Experimental central deprivation of testosterone synthesis with diphereline on the 180th day of the experiment leads to shift of NO synthesis from constitutive NO-synthases to inducible NO-synthase and intensification of oxidative stress due to increase of superoxide anion-radical production and decrease in antioxidant protection.
Correlation analysis between metric parameters of parenchymatous components of rat submandibular glands under the effect of ethanol
(Українська медична стоматологічна академія, 2020) Shevchenko, K. V.; Yeroshenko, G. А.; Solod, A. V.; Lysachenko, O. D.; Yakushko, O. S.; Boruta, N. V.; Lichman, D. V.; Kramarenko, D. R.; Шевченко, Костянтин Васильович; Шевченко, Константин Васильевич; Єрошенко, Галина Анатоліївна; Ерошенко, Галина Анатольевна; Солод, Анатолій Вікторович; Солод, Анатолий Викторович; Лисаченко, Ольга Дмитрівна; Лисаченко, Ольга Дмитриевна; Якушко, Олена Святославівна; Якушко, Елена Святославовна; Борута, Наталія Володимирівна; Борута, Наталия Владимировна; Лічман, Діана Володимирівна; Личман, Диана Владимировна; Крамаренко, Денис Русланович; Крамаренко, Денис Русланович
The effect of ethanol on the salivary glands is manifested by changes in morphometric parameters of both the final departments and excretory ducts. But taking into account that the obtained large number of morphometric indicators is rather complicated, then there is a need for a correlation analysis, where the presence of dependencies between morphometric indicators was determined using the Bravais – Pearson coefficient. It was established that diagnostic criteria for assessing the functional state of rat submandibular glands after ethanol is manifested by the dependence of the outer diameter, lumen diameter and epithelial cell height on day 12 in all parenchymal components, which corresponds to the formation of chronic alcohol dependence in rats.
Peculiarities of neurocognitive status of patients in the acute ischemic stroke phase of different hemispheric localization
(Українська медична стоматологічна академія, 2020) Pushko, O.O.; Lytvynenko, N.V.; Пушко, Олександр Олександрович; Литвиненко, Наталія Володимирівна
The article considers the peculiarities of neurocognitive status in patients after acute ischemic stroke of different hemispheric localization. Left-sided hemispheric stroke revealed a higher frequency and higher degree of cognitive impairment (mean score for Mini Mental State Examination was 21.3±0.61, for Montreal Cognitive Assessment – 18.22±0.9) compared with right-sided hemispheric localization of ischemic focus (mean score for MMSE – 24.05±0.52, for MoCa – 21.35±0.84) with a statistically significant difference between groups of patients as a whole and by specific blocks of subtests. It was also found that right-sided hemispheric strokes were characterized by a higher frequency and higher degree of anxiety and depressive disorders (mean score for Beck Depression Inventoянишенry was 15.1±0.87, for the state anxiety scale – 37.6±1.71, for the trait anxiety scale – 36.55±1.73) compared with the left-sided hemispheric localization of acute cerebrovascular accident (mean score for BDI was 11.61±0.71, for the state anxiety scale – 29.78±0.95, for the on the Spielberger-Khanin trait anxiety scale – 30.87±1.0) with a statistically significant difference between the groups.
Changes in indices of chemical composition and mineralizing properties of oral fluid in children with intestinal dysbiosis
(Українська медична стоматологічна академія, 2020) Kaskova, L. F.; Novikova, S. C.; Anopriyeva, N. M.; Akzhitova, A. A.; Каськова, Людмила Федорівна; Новікова, Світлана Чеславна; Анопрієва, Наталія Михайлівна; Акжитова, Ганна Олександрівна; Каськова, Людмила Фёдоровна; Новикова, Светлана Чеславна; Аноприева, Наталья Михайловна; Акжитова, Анна Александровна
The purpose of our work was to study the indices of calcium, inorganic phosphorus and mineralizing properties of oral fluid in 2-3 year-old children with intestinal dysbiosis. The results obtained allowed us to conclude that in the oral fluid of 2-3 years old children with intestinal dysbiosis there was a decrease in the content of calcium and inorganic phosphorus compared to similar indicators in healthy children. Thus, the rate of ionized calcium in the oral fluid was 0.23±0.01 mmol/l, which is 1.6 times less than the corresponding indice in children of the control group (0.37±0.02 mmol/l). The content of inorganic phosphorus in the oral fluid in children with intestinal dysbiosis was 4.38±0.03 mmol/l, and in somatically healthy children it was 4.66±0.03 mmol/l, which is correspondingly lower by 0.28 mmol/l. They also showed a decrease in the mineralizing potential of the oral fluid, which indicates the tendency of the erupted teeth to the enamel demineralization and increasing the prevalence of dental caries. The distribution of children by the level of mineralizing potential indicated that only 6.6% of children with intestinal dysbiosis have a high rate, which is more than 2 times worse than in the control group. The cooperation of a dentist and a pediatrician is necessary for the timely detection and prevention of dysbiosis emergence in children and, as a consequence, dental pathology – dental caries.
Parry-romberg syndrome: difficulties of diagnosis and improvement of treatment
(Українська медична стоматологічна академія, 2020) Hladka, V. M.; Purdenko, T. Y.; Tarianyk, K. A.; Гладка, Вікторія Михайлівна; Пурденко, Тетяна Йосипівна; Таряник, Катерина Анатоліївна
The article described a case of a rare disease – progressive facial hemiatrophy in a patient of the Neurological Department of Poltava Regional Clinical Hospital. We reviewed a literature on the problem, analyzed the etiological factors, pathogenesis and clinical characteristics of the disease. There was defined a range of necessary examination methods of patients, which included examination by a neurologist, rheumatologist, endocrinologist, as well as the use of additional instrumental and laboratory research methods. Comprehensive treatment tactics include the use of trophotropic, vascular drugs, anabolic hormones, potassium supplements, massage, physical therapy.
The role of arginine/citrulline cycle disorders in the pathogenesis of doxorubicin-induced liver injury associated with nonalcoholic steatohepatitis in rats
(Українська медична стоматологічна академія, 2020) Maslova, G. S.; Skrypnyk, R. I.; Gopko, O. F.; Skrypnyk, I. M.; Маслова, Анна Сергеевна; Скрыпник, Роман Игоревич; Гопко, Александр Феликсович; Скрыпник, Игорь Николаевич; Маслова, Ганна Сергіївна; Скрипник, Роман Ігорович; Гопко, Олександр Феліксович; Скрипник, Ігор Миколайович
The article presents the results of an experimental study aimed to investigate the features of arginine/citrulline cycle disorders associated with doxorubicin-induced liver injury in rats, concomitant with NASH. The study involved adult fertile outbred albino rats (n=30; male rats=15 (50%); female rats=15 (50%)) weighted 160-220 g. The rats were assigned into 3 groups: Group І (n=10) involved rats with NASH, administered with intraperitoneal 5 mg/kg doxorubicin for 3 days; Group ІІ (n=10) involved rats without NASH, administered with intraperitoneal doxorubicin similar to Group I regimen; Group ІІІ (n=10) – control group. It has been shown that administration of doxorubicin in rats with NASH leads to disorders of arginine/citrulline cycle, which are characterized by inhibition of arginase activity and activation of citrulline synthesis.
Frequency and structure of benign soft tissue formations in the maxillofacial area
(Українська медична стоматологічна академія, 2020) Ткаченко, Павло Іванович; Резвіна, Катерина Юріївна; Швець, Анатолій Іванович; Попело, Юлія Вікторівна; Ткаченко, Павел Иванович; Резвина, Екатерина Юрьевна; Швец, Анатолий Иванович; Попело, Юлия Викторовна; Tkachenko, P. I.; Rezvina, K. Yu.; Shvets, A. I.; Popelo, Yu. V.
The article considered our own observation results and retrospective analysis of archival material of the Maxillofacial Department of M.V. Sklifosovsky Poltava Regional Clinical Hospital and Surgical Department of the Poltava City Children's Clinical Hospital from 2008 to 2018. It was found that among adults the number of patients with benign soft tissue formations of the face and neck is 4.9%, and in children – 7.8% of the total number of inpatients. Most of them were bronchiogenic cysts of the lateral part of the neck (152 – 26.3%) and atheromatous plaques (147 – 25.4%). They mostly occured at the age of 22 to 60 years, men suffered more often (205 - 35.5%). The largest number of discrepancies in the diagnosis at the prehospital phase were patients with epidermal cysts – 38 (7.9%). As for pediatric population, their number was 7.8% of the total number of inpatients. Neoplasms of dysontogenetic origin predominate, among which the most common were dermoid cysts – 92 patients (32.4%) and haemangiomas– 74 patients (26%). Less common were ranulae – 36 cases (12.7%), bronchiogenic cyst – 17 cases (6%) and atheromatous plaque – 16 cases (5.6%). They were found more often in the nursery age – from 1 to 3 years.
State of the palate tissues reparative regeneration in children after radical uranostaphyloplasty
(Українська медична стоматологічна академія, 2020) Ткаченко, Павло Іванович; Доленко, Ольга Борисівна; Лохматова, Наталія Михайлівна; Білоконь, Сергій Олександрович; Попело, Юлія Вікторівна; Ткаченко, Павел Иванович; Доленко, Ольга Борисовна; Лохматова, Наталия Михайловна; Белоконь, Сергей Александрович; Попело, Юлия Викторовна; Tkachenko, P. I.; Dolenko, O. B.; Lokhmatova, N. M.; Bilokon, S. O.; Popelo, Yu. V.
Метою роботи стало вивчення стану репаративної регенерації м'яких тканин піднебіння після проведення радикальної ураностафілопластики шляхом оцінки клінічної ситуації і морфологічних структур піднебінних слизово- окісних клаптів. Комплекс взаємообумовлених порушень гомеостазу, який виникає після проведення ураностафілопластики, значно впливає на процес формування рубця і характер загоєння рани. Вивчення процесів репаративної регенерації м'яких тканин піднебіння на 13-14 і 29-30 добу після проведення радикальної ураностафілопластики дає можливість на ранніх етапах спрогнозувати ймовірність формування грубого рубця і вплинути на цей процес шляхом підбору індивідуального плану лікувально-профілактичних і реабілітаційних заходів для цієї категорії хворих.
Specific structure of the normal rat gastric fundus wall
(Українська медична стоматологічна академія, 2020) Yachmin, А. І.; Vilkhova, O. V.; Boruta, N. V.; Bilash, S. M.; Skotarenko, T. A.; Bilash, V. P.; Kramarenko, D. R.; Ячмінь, Анастасія Ігорівна; Ячминь, Анастасия Игоревна; Борута, Наталія Володимирівна; Борута, Наталия Владимировна; Білаш, Сергій Михайлович; Билаш, Сергей Михайлович; Скотаренко, Тетяна Анатоліївна; Скотаренко, Татьяна Анатольевна; Білаш, Валентина Павлівна; Билаш, Валентина Павловна; Крамаренко, Денис Русланович; Крамаренко, Денис Русланович
As a result of a comprehensive study, it was determined that the wall of the fundus of the stomach of rats according to the basic principles of structural organization corresponds to humans and can be used as an experimental model to study the effects of exogenous factors. By means of morphometric research the basic metric indicators of a wall of fundal department of a rats’ stomach and histotopographic features of own glands are established.

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