Periodontal disease and salivary oxidative stress in children with lymphogranulomatosis

dc.contributor.authorYanko, N. V.
dc.contributor.authorKaskova, L. F.
dc.contributor.authorVashchenko, I. Yu.
dc.contributor.authorNovikova, S. Ch.
dc.contributor.authorЯнко, Наталія Валентинівна
dc.contributor.authorКаськова, Людмила Федорівна
dc.contributor.authorВащенко, Ірина Юріївна
dc.contributor.authorНовікова, Світлана Чеславна
dc.date.accessioned2023-10-09T07:17:29Z
dc.date.available2023-10-09T07:17:29Z
dc.date.issued2023-07-30
dc.description.abstractThe aim: To investigate the impact of lymphogranulomatosis (LGM) and periodontal disease on salivary lipid peroxidation and enzymatic antioxidants` levels in children. Materials and methods: 45 children aged 6–16 years with LGM were examined before hematologic therapy (group LGM 1), after therapy (group LGM 2), and at the remission (group LGM 3). The control group included 70 healthy children. Periodontal state of children, saliva thiobarbituric acid reacting substances (TBARS), superoxide dismutase (SOD) and catalase were examined. Results: 6-11 years old children from LGM 1 group showed a higher frequency of periodontal disease (50,0%), as well as 12-15 year olds (80,8%) compared to healthy children (17,4% and 42,8% accordingly, p<0,05). TBARS levels were higher in LGM 1-3 groups of children with periodontal disease (9,79, 12,3 and 12,6 umol/l, р<0,01) compared to counterparts without it (8,01, 10,1 and 11,6 umol/l, р<0,01) and healthy children with periodontal disease (7,9 umol/l, р<0,01). SOD activity was higher in LGM 1-3 groups of children with periodontal disease (-0,075, -0,086, -0,074 units) compared to children without it (-0,048, -0,059, -0,04 units, р<0,01) and healthy children with periodontal disease (-0,04 units, р<0,01). Catalase activity was lower in LGM 1-3 groups of children with periodontal disease (6,72, 5,2 and 6,7 units) compared to counterparts without it (7,3, 3,7 and 4,7 units, р<0,01) and healthy children with periodontal disease (7,1 units, р<0,01). Conclusions: Children with periodontal disease related to LGM had higher TBARS levels, SOD activity and lower catalase activity in saliva. Both LGM and periodontal disease altered lipid peroxidation and antioxidant protection in saliva of children.uk_UA
dc.identifier.citationPeriodontal disease and salivary oxidative stress in children with lymphogranulomatosis / N. V. Yanko, L. F. Kaskova, I. Yu. Vashchenko, S. Ch. Novikova // Wiadomosci Lekarskie. – 2023. – Vol. LXXVI, issue 7. – P. 1569–1565.uk_UA
dc.identifier.doi10.36740/WLek202307109
dc.identifier.issn0043-5147
dc.identifier.urihttps://repository.pdmu.edu.ua/handle/123456789/21855
dc.language.isoenuk_UA
dc.publisherAlunauk_UA
dc.subjectchildrenuk_UA
dc.subjectperiodontal diseaseuk_UA
dc.subjectantioxidantuk_UA
dc.subjectoxidative stressuk_UA
dc.subjectlymphogranulomatosisuk_UA
dc.titlePeriodontal disease and salivary oxidative stress in children with lymphogranulomatosisuk_UA
dc.typeArticleuk_UA

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