The case of leptospirosis in a female patient with Hodgkin’s lymphoma

Abstract

Introduction. Although we could not find the registered cases of leptospirosis co-occurring with lymphogranulomatosis, it is important to note that both diseases can affect the immune system. Therefore, the reported case is unique and will be interesting and useful for the physicians of various specialties. Case report. We report a case of icterohemorrhagic form of leptospirosis with a fatal outcome in a woman with postmortem diagnosis of Hodgkin’s lymphoma. Based on the findings of the autopsy, histological and immunohistochemical studies, it was established that the deceased suffered from Hodgkin’s lymphoma during her life, classical form, reticular subtype with depletion of lymphoid tissue and extranodal spread in the liver, ovaries, and epicardium. Conclusion. The combination of leptospirosis and lymphogranulomatosis was characterized by the complication of the diagnostic process, which should be taken into account by physicians of all specialties. Uvod. Iako nismo mogli pronaći registrovane slučajeve leptospiroze koja se javlja zajedno sa limfogranulomatozom, važno je napomenuti da obe bolesti mogu uticati na imunosistem; zbog toga je prijavljeni slučaj jedinstven i biće zanimljiv i koristan lekarima različitih specijalnosti. Prikaz slučaja. Predstavljamo slučaj ikterohemoragijske forme leptospiroze sa fatalnim ishodom kod bolesnice sa dijagnozom Hodžkinovog limfoma postavljenom post mortem. Na osnovu nalaza obdukcije, histoloških i imunohistohemijskih studija utvrđeno je da je preminula bolesnica tokom života patila od klasičnog oblika Hodžkinovog limfoma retikularnog podtipa, praćenog smanjenjem limfoidnog tkiva i ekstranodalnim širenjem u jetru, jajnike i epikard. Zaključak. Lekari svih specijalnosti treba da imaju na umu da kombinaciju leptospiroze i limfogranulomatoze karakteriše komplikacija dijagnostičkog procesa.