New look at the etiology of chronic pyelonephritis among children with polymorphism of TLR2 gene

Abstract

Currently the mechanisms of recognition of alien agents, which is implemented by Toll-like receptor innate immune system has become one of the main tasks of clinical immunology. The aim of our research was to analyze the association between polymorphism of the gene Toll-like receptor 2 (Arg753Gln) of the main pathogens of the urinary system. These results confirm the important role of Toll-like receptors in the realization of innate immune and allow considering polymorphism Toll-like receptor gene 2 as an additional prognostic indicator in genetic researches.