Polymorphism of the nfatc1 gene family as a marker of arterial hypertension progression in adolescents

Abstract

Arterial hypertension (AH) and its complications at the present stage occupy a leading place in the structure of polymorphism of vascular diseases. The aim of the research is to determine the variability of the NFATCI and NFATC4 genes for the development and progression of hypertension in adolescents. The analysis of the data revealed that the expression rate of the NFATC1 gene in patients with hypertension was 3.06 ± 0.52, and the NFATC4 gene was 18.32 ± 5.62, that is, the expression of these genes significantly exceeded the reference values that were taken for a unit. The study of rs11665469 genotypes of the NFATC1 gene in patients with hypertension: CC– 58%, TT – 25%, CT – 21%. Any significant differences in the group of adolescents with hypertension and in the control group depending on the listed genotypes (p ≥ 0.05) were not found out. The rf222909 genotypes of the NFATC4 gene in adolescents with AH were detected in the ratios: CC– 39%, GG – 21%, CG – 46%, and in adolescents in the control group: CC – 24%, GG – 20%, CG – 54%.