Antimicrobial properties of the new combined dental gel

Abstract

Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. RotrinDenta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. RotrinDenta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov’ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.