Influence of chronic nitrate intoxication on the concentration of lipid hydroperoxides in the gastric mucosa

dc.contributor.authorAkimov, O. Y.
dc.contributor.authorАкімов, Олег Євгенович
dc.date.accessioned2018-10-22T05:28:08Z
dc.date.available2018-10-22T05:28:08Z
dc.date.issued2018-10
dc.description.abstractThe excessive alimentary intake of nitrates into human and animal body can cause a cascade of changes in their organism. The sources of nitrates can be either products of vegetable origin (especially beetroot) or groundwater and drinking water (regions with developed agriculture). The first system of organs, which experiences the negative effect of nitrates, is the digestive system. The purpose of this work was to establish the effect of chronic nitrate intoxication on the content of lipid hydroperoxides in rat stomach mucous membrane. Materials and methods. We carried out experiment on 24 white rats. We divided animals into 2 groups: the control group (10) and the group of chronic nitrate intoxication (14). We modeled chronic nitrate intoxication by intragastric administration of sodium nitrate at a dose of 500 mg / kg for 30 days. The content of lipid hydroperoxides in 10% of the mucous membrane homogenate was determined by the method of VB Gavrilov. and MI Mishkorudnaya (1983). We analyzed the obtained results for normality by the Shapiro-Wilk method. Further, we compared data by the Student method. The difference was considered statistically significant if p <0.05. Results and discussion. Chronic nitrate intoxication reduces the content of dien conjugates (DC) in the gastric mucosa by 8% relative to the control group. The concentration of triene conjugates (TC) increases by 20.51%. The content of octadiene conjugates (ODC) increases by 52.2%. Decrease in the concentration of DC under conditions of nitrate intoxication, we can explain by the increase in activity of superoxide dismutase [1]. The remaining hydroperoxides are products of the later stages of lipid peroxidation (LPO), which is controlled by the glutathione system. Thus, it can be argued that the excessive intake of nitrates in the body leads to a disruption in the functioning of the glutathione system. Conclusion. Excess intake of nitrates in the body prevents the activation of LPO on early stages, but enhances lipid oxidation that has already begun.uk_UA
dc.identifier.citationAkimov O. Y. Influence of chronic nitrate intoxication on the concentration of lipid hydroperoxides in the gastric mucosa / O. Y. Akimov // Інтегративні механізми патологічних процесів: від експериментальних досліджень до клінічної практики : матеріали VII Пленуму наукового товариства патофізіологів та наук.-практ. конф., присвячених 110-річчю з дня народження члена-кореспондента АМН СРСР, професора М. Н. Зайка. – Полтава, 2018. – С. 4–5.uk_UA
dc.identifier.otherУДК 616-092.4
dc.identifier.urihttps://repository.pdmu.edu.ua/handle/123456789/8766
dc.language.isoen_USuk_UA
dc.publisherУкраїнська медична стоматологічна академіяuk_UA
dc.titleInfluence of chronic nitrate intoxication on the concentration of lipid hydroperoxides in the gastric mucosauk_UA
dc.typeThesisuk_UA

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