Features of cytokine profile and endothelial function in comorbid course of essential hypertension

Abstract

Appearance of the new terminology such as “endothelial dysfunction” and “chronic systemic inflammation” has designated a new round in the study of essential hypertension (EH), namely – to defining the role of the immune inflammatory mechanisms in the development and progression of vascular pathology [1, 6, 8]. It should be noted that the peculiarity of internal pathology at present time is its comorbidity [2, 9, 10], besides EH comorbidity worsens disease on the whole [3, 4]. Combination of EH with duodenal peptic ulcer (DPU) is frequent. It can complicate diagnostics, modify clinical symptoms and worsen treatment quality [7]. The foregoing formed basis of this study. The study aimed to identify the features of the changes of the cytokine profile and endothelial function in patients with EH and comorbid DPU.