Influence of quercetin on morphological changes in rats testes after 180 days during central deprivation of luteinizing hormone

Abstract

Central blockade of LH synthesis by the introduction of triptorelin with parallel administration of quercetin to the studied animals on the 180th day of the experiment causes changes in the structure of the interstitial space of the testes of rats and is characterized by high variability in the populations of interstitial endocrinocytes and macrophages, which affects the change in spermatogenesis in the testes of rats. Biochemical parameters on the 180th day of the experiment showed a shift in NO synthesis from constitutive NO synthases to inducible NO synthase and increased oxidative stress due to an increase in the production of superoxide anion radical and a decrease in antioxidant protection. 3. Quercetin protects rat testicular tissue from oxidative damage caused by the administration of triptorelin on the 180th day of the experiment by increasing the antioxidant defense and reducing reactive oxygen species.