Possibility for non-invasive diagnosis of chronic endometrinis in women at risk during pregnavid preparation

Abstract

Introduction: Detection and treatment o f chronic endometritis (CE) is clinically significant, though involves intrauterine intervention to collect endometrium. The aim : To estimate the possibility to use fertility a2-m icroglobulin (FAMG) as the marker of the high risk for CE. Materials and m ethods: 70 women with CE who were planning pregnancy were tested for FAMG in menstrual blood. 40 of them received treatment of CE. The other 30 women refused from the proposed treatment. The control group involved 30 women who had neither CE nor luteal phase deficiency (LPD). Additional group (20 women) had LPD without CE. Results: The decrease of FAMG by 2.4 times was noted in women with CE (16.3 ± 3.9 |jg/ml against 39.8 ± 8.3 |jg/ml in the controls). In LPD the index was 5.6 times lower. After treatment the level of FAMG was increasing. Conclusions: The decrease o f the amount o f FAMG in menstrual blood is specific for women both with CE and LPD. Detection of abnorm ally low rates o f FAMG in all women with CE enables, with the exception of absolute hypoprogesteronemia and LPD, using it as a sim ple method of estimation of the functional state o f endometrium . Its application can be very useful both for non-invasive diagnosis of CE and subsequent evaluation of treatment of this pathology.