Predictors of myocardial ischemia and central hemodynamic disorders in patients with coronary heart disease

Abstract

Materials and methods. One-time, open-label, single group clinical trial involved 115 patients with CHD: stable angina pectoris, FC II, НF 0-І (62 men and 53 women aged 54±6.2). Patients were given laboratory and instrumental studies. The levels of total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), triglycerides (TG) by sedimentation, fibrinogen (Fg) concentration in blood by gravimetric analysis, the level of cytokines (CK) in the blood (interleukin 1β (IL-1β), tumor necrosis factor (TNFα), interleukin 10 (IL-10)) by the immune enzyme method, the content of circulating endothelial microparticles (EMP) of CD32+CD40+ in blood by cytofluorometry, mRNA gene expression of kappa B-alpha inhibitor (IkBα) of the nuclear kappa B transcription factor (NF-kB) in mononuclear cells of the peripheral blood by real-time polymerase chain reaction (Real-time PCR) were being determined [4, 5, 6]. Echocardiography and the 24 hour Holter ECG monitoring were performed by the standard method. A correlation and regression analysis was conducted.