Diabetes therapy in wartime conditions

Abstract

The article highlights the most urgent problem of endocrinology - diabetes mellitus (DM), which is spreading at a catastrophic rate, becoming a real epidemic of the XXI century. Metformin is a hypoglycemic drug that has proven its effectiveness in the treatment of type 2 diabetes for many years. Therefore, it is metformin that is stable in the choice of the drug of the first line of glucose-lowering therapy. Type 2 diabetes is one of the most common diseases characterized by metabolic disorders as a result of many pathophysiological processes. The leading pathophysiological disorder of type 2 diabetes is insulin resistance of muscle and adipose tissue together with pancreatic β-cell dysfunction. Further processes take place in adipose tissue, organs of the gastrointestinal tract, α-cells of the pancreas, and kidneys. All this leads to the development of chronic hyperglycemia.