Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes
dc.contributor.author | Savchenko, L. G. | |
dc.contributor.author | Digtiar, N. I. | |
dc.contributor.author | Selіkhova, l. G. | |
dc.contributor.author | Kaidasheva, E. I. | |
dc.contributor.author | Shlykova, O. A. | |
dc.contributor.author | Vesnina, l. E. | |
dc.contributor.author | Kaidashev, I. P. | |
dc.contributor.author | Савченко, Людмила Гаврилівна | |
dc.contributor.author | Дігтяр, Наталія Іванівна | |
dc.contributor.author | Селіхова, Людмила Григорівна | |
dc.contributor.author | Кайдашева, Єльвіра Іллівна | |
dc.contributor.author | Шликова, Оксана Анатоліївна | |
dc.contributor.author | Весніна, Людмила Едуардівна | |
dc.contributor.author | Кайдашев, Ігор Петрович | |
dc.date.accessioned | 2021-05-14T11:53:07Z | |
dc.date.available | 2021-05-14T11:53:07Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin l(SIRTl). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications. The aim of this study was to investigate L effects directed on the pro-inflammatory NF-kB pathway and expression of SIRT1 in obese patients with type 2 diabetes mellitus (DM). | uk_UA |
dc.identifier.citation | Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes / L. G. Savchenko, N. I. Digtiar, l. G. Selikhova [et al.] // ROM. J. INTERN. MED. – 2019. –T. 57, № 3. – P. 233–240. | uk_UA |
dc.identifier.uri | https://repository.pdmu.edu.ua/handle/123456789/15807 | |
dc.language.iso | en | uk_UA |
dc.subject | glucagon-like peptide 1 (GLP-1) | uk_UA |
dc.subject | liraglutide; diabetes | uk_UA |
dc.subject | obesity | uk_UA |
dc.subject | NF-kB | uk_UA |
dc.subject | SIRT1 | uk_UA |
dc.subject | mediators of inflammation | uk_UA |
dc.title | Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes | uk_UA |
dc.type | Article | uk_UA |
Файли
Контейнер файлів
1 - 1 з 1
Ескіз недоступний
- Назва:
- Liraglutide.pdf
- Розмір:
- 5.98 MB
- Формат:
- Adobe Portable Document Format
- Опис:
Ліцензійна угода
1 - 1 з 1
Ескіз недоступний
- Назва:
- license.txt
- Розмір:
- 4.3 KB
- Формат:
- Item-specific license agreed upon to submission
- Опис: