Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes

dc.contributor.authorSavchenko, L. G.
dc.contributor.authorDigtiar, N. I.
dc.contributor.authorSelіkhova, l. G.
dc.contributor.authorKaidasheva, E. I.
dc.contributor.authorShlykova, O. A.
dc.contributor.authorVesnina, l. E.
dc.contributor.authorKaidashev, I. P.
dc.contributor.authorСавченко, Людмила Гаврилівна
dc.contributor.authorДігтяр, Наталія Іванівна
dc.contributor.authorСеліхова, Людмила Григорівна
dc.contributor.authorКайдашева, Єльвіра Іллівна
dc.contributor.authorШликова, Оксана Анатоліївна
dc.contributor.authorВесніна, Людмила Едуардівна
dc.contributor.authorКайдашев, Ігор Петрович
dc.date.accessioned2021-05-14T11:53:07Z
dc.date.available2021-05-14T11:53:07Z
dc.date.issued2019
dc.description.abstractLiraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin l(SIRTl). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications. The aim of this study was to investigate L effects directed on the pro-inflammatory NF-kB pathway and expression of SIRT1 in obese patients with type 2 diabetes mellitus (DM).uk_UA
dc.identifier.citationLiraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes / L. G. Savchenko, N. I. Digtiar, l. G. Selikhova [et al.] // ROM. J. INTERN. MED. – 2019. –T. 57, № 3. – P. 233–240.uk_UA
dc.identifier.urihttps://repository.pdmu.edu.ua/handle/123456789/15807
dc.language.isoenuk_UA
dc.subjectglucagon-like peptide 1 (GLP-1)uk_UA
dc.subjectliraglutide; diabetesuk_UA
dc.subjectobesityuk_UA
dc.subjectNF-kBuk_UA
dc.subjectSIRT1uk_UA
dc.subjectmediators of inflammationuk_UA
dc.titleLiraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetesuk_UA
dc.typeArticleuk_UA

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