Histochemical polymorphism of keratin pearls in squamous cell carcinoma of the lung
Ескіз недоступний
Дата
2014
Назва журналу
Номер ISSN
Назва тому
Видавець
Canadian Scientific Journal
Анотація
The aim of the research is to study histochemical features of keratin pearls in keratinizing
squamous cell carcinoma of lung irrespective of its localization. Methods: histochemical
methods of staining have been also used during the investigation: neutral fats stained
with Sudan III and with finish hematoxylin staining. Combined histochemical staining
has been also used: neutral mucoproteins and acid glycosaminoglycans with PASreaction-
alcian blue and PAS-reaction with tionine blue. The results of histological and
histochemical analyses detected three types of keratin pearls of different structures and
tinctorial features: eosinophilic or tionine-positive, PAS-positive (containing glycogen)
and light or sudanophilic (containing lipids). Taking into consideration the obtained data,
it can be assumed that tumor clusters with heterogenous keratin pearls by tinctorial
features are differed according to the degree of cells’ differentiation, keratinization
and related to various stages of tumor progression. Histochemical analyses of keratin
pearls are not normally taken into consideration during morphological studies and it is
regarded as differentiated keratinizing cancer. However, the results of morphological
investigations show that it is necessary to consider histochemical features of cancerous
clusters for adequate morphological analysis of tumor progression.
Опис
Ключові слова
squamous cell carcinoma, keratin pearls, histochemistry, polymorphism
Бібліографічний опис
Gasyuk Y. Histochemical polymorphism of keratin pearls in squamous cell carcinoma of the lung / Y. Gasyuk, B. Filenko // Canadian Scientific Journal. – 2014. – Vol. 1, № 2. – С. 18–24.