Світ медицини та біології. 2022

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https://repository.pdmu.edu.ua/handle/123456789/17898

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Перегляд Світ медицини та біології. 2022 за Автор "Bereznyakov, V. I."

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    The degree of involvement of the level of circulating immune complexes and red blood cells in the pathogenesis of community-acquired pneumonia
    (Полтавський державний медичний університет, 2022) Bereznyakov, V. I.; Korzh, A. M.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Vatsenko, A. V.; Ulanovska-Tsyba, N. A.; Березняков, Володимир Іванович; Корж, Андрій Миколайович; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Ваценко, Анжела Володимирівна; Улановська-Циба, Наталія Аркадіївна
    The paper presents the findings of the study of the degree of involvement of the level of circulating immune complexes and red blood cells in the pathogenesis of community-acquired pneumonia. Marked disorders in immunological indices of the severity degree of the disease in patients with community-acquired pneumonia have been established, which must be taken into ccount when diagnosing the disease: elevated circulating immune complexes level in the blood serum of patients and an increase in the total circulating immune complexes level, mainly due to an increase in the most toxigenic small- (<11 S) and medium molecular weight (11 S–19 S) fractions of the immune complexes. The higher the level of circulating immune complexes, especially small molecular weight ones, the more likely a severe course of community-acquired pneumonia is. In community-acquired pneumonia, oxidative stress and intensified generation of reactive oxygen specie develop. Changes in the quantity and quality of blood corpuscles necessitate the inclusion of agents that improve blood oxygenation into standard antibacterial therapy.