2022
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Документ The influence of anxiety level and past COVID-19 on sleep quality and insomnia severity(2022) Boiko, D. I.; Zhyvotovska, A. I.; Skrypnikov, A. M.; Бойко, Дмитро Іванович; Животовська, Лілія Валентинівна; Скрипніков, Андрій МиколайовичBased on recent studies, we put forward a hypothesis about the synergistic effect of anxiety disorders and previous COVID-19 on the deterioration of the quality of sleep and occurring of insomnia. The purpose of the study was to investigate the impacts of anxiety disorders, and COVID-19 on anamnesis and its combined effect on sleep disturbances. We conducted a case-control study, which included 60 patients, who were divided into 3 groups depending on the occurrence of anxiety disorders and COVID-19 in their medical history during the last 6 months. Patients were assessed by the Beck anxiety inventory, Pittsburgh Sleep Quality Index, and the Insomnia Severity Index. We found a worsening sleep quality and a higher frequency of insomnia in patients with COVID-19. Along with this, concomitant anxiety disorders worsened both the quality of sleep and the level of insomnia in these respondents. It was determined that patients with an anxiety disorder with a history had a lower subjective assessment of sleep quality, higher sleep latency, and more pronounced diurnal dysfunction, while patients without a history had better sleep efficiency and a lower frequency of sleeping pills. Anxiety disorders and having experienced COVID-19 are associated with poorer sleep quality and more severe insomnia. Their combination significantly reduces the quality of sleep and increases the degree of insomnia. These findings suggest a potential role for COVID-19 in exacerbating the association between anxiety and sleep disorders.Документ A three-stage therapeutic and diagnostic algorithm in mechanical jaundice of different genesis and the most effective mini-invasive method of its treatment(Полтавський державний медичний університет, 2022) Prykhidko, R. A.; Dudchenko, M. O.; Kravtsiv, M. I.; Zaiets, S. M.; Ivashchenko, D. M.; Chelishvili, A. L.; Shevchuk, M. P.; Прихідько, Роман Анатолійович; Дудченко, Максим Олександрович; Кравців, Микола Ігорович; Заєць, Сергій Миколайович; Іващенко, Дмитро Миколайович; Челішвілі, Анатолій Леонідович; Шевчук, Микола ПетровичThe paper analyzes the experience of treatment of mechanical jaundice with the use of minimally invasive surgical interventions in 176 patients. It has been found that the clinical presentation, laboratory parameters are of secondary importance in determining the etiology and level of biliary obstruction. For the differential diagnosis of etiological factors of obstructive jaundice, we used non-invasive and minimally invasive radiological methods: ultrasound – 203, magnetic resonance cholangiopancreatography – 98, multislice computed tomography – 74, endoscopic retrograde cholangiopancreatography - 138, percutaneous transhepatic cholangiography – 27. In order to determine the informativeness, we evaluated the detection of concretions, strictures of the bile ducts, mass lesions, dilation of intra- and extrahepatic bile ducts. Methods of elimination of biliary hypertension were various types of endoscopic decompression, which were performed in combination with endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography. We compared the following aspects: the possibility of performing these types of decompression of the bile ducts, their effectiveness in eliminating jaundice and complications. Based on our results, we developed a 3-stage diagnostic and treatment algorithm, whose efficiency in the elimination of mechanical jaundice was 96.0 %.Документ Influence of food additives complex on the morphology of villi of the rats’ duodenum mucosa(Полтавський державний медичний університет, 2022) Yeroshenko, G. A.; Grygorenko, A. S.; Shevchenko, K. V.; Lysachenko, O. D.; Riabushko, O. B.; Pyvovar, N. M.; Klepets, O. V.; Єрошенко, Галина Анатоліївна; Григоренко, Альона Сергіївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Рябушко, Олена Борисівна; Клепець, Олена Вікторівна; Пивовар, Ніна МихайлівнаThe study presents the findings of the study of the effect of food additives, namely, monosodium glutamate, sodium nitrite and Ponceau-4R on the morphological state of the components of the villi of the rats’ duodenal mucosa. The study was aimed at establishing the dynamics of changes in the metric parameters of the components of the villi of rats’ duodenal mucosa in normal conditions and under the action of the complex of food additives. It has been found that consumption of the complex of food additives leads to changes in the metric values of the height and width of the villi, which at the early stages of the experiment leads to a decrease in their mean values due to the immediate direct action on the mucous membrane with subsequent development of inflammatory reaction and edema, which will lead to an increase in metric values and a decrease in the number of epithelial cells of the villus. Adaptive mechanisms do not fully restore the values of the morphometric study, which is manifested by a decrease in the height of the villi by 20.25 % compared with the control group with an increase in the number of enterocytes with brush border and a decrease in the number of goblet cells by 44.41 %.Документ Detection and assessment of disorders of the depressive spectrum in patients with acute myocardial infarction depending on the method of treatment(Полтавський державний медичний університет, 2022) Kudria, I. P.; Shevchenko, T. I.; Voroshilova, T. A.; Tretiak, N. H.; Kryvoruchko, I. H.; Pushko, O. О.; Shaposhnyk, О. А.; Кудря, Ірина Павлівна; Шевченко, Тетяна Іванівна; Ворошилова, Тетяна Анатоліївна; Третяк, Наталія Григорівна; Криворучко, Іван Григорович; Пушко, Олександр Олександрович; Шапошник, Ольга АнатоліївнаThe frequent combination of mental disorders of the depressive spectrum and cardiovascular diseases is one of the most urgent problems of modern medicine. The purpose of the study was to identify and assess, with the help of various psychodiagnostic methods, the degree of severity of depressive disorders in patients with acute myocardial infarction depending on the treatment method as a prerequisite for optimal drug therapy. 73 patients with the aforementioned pathology were studied and were divided into two groups. Group I included 44 patients who underwent urgent coronary angiography with subsequent stenting of the infarct-related coronary artery; Group II – included 29 patients who received only drug therapy. Examination of patients was carried out according to Ukrainian standards, in particular, a survey according to the scale of Beck and Zung. Patients with acute myocardial infarction after urgent coronary angiography with stenting of the infarct-dependent artery were more likely to have mild and moderate depression according to the Beck scale compared to patients who received only conservative medical treatment. The reverse pattern is observed for moderate and severe depression. 68.2% of patients with acute myocardial infarction after interventional intervention and 62.1% on the background of conservative treatment according to the Zung scale showed depression of various degrees of severity, mostly mild.Документ Influence of transcription factor κB on remodeling of extracellular matrix of rat liver under conditions of chronic alcohol intoxication(Полтавський державний медичний університет, 2022) Mykytenko, A. O.; Akimov, O. Ye.; Yeroshenko, G. A.; Neporada, K. S.; Микитенко, Андрій Олегович; Акімов, Олег Євгенович; Єрошенко, Галина Анатоліївна; Непорада, Каріне СтепанівнаLiver fibrosis is a common tissue reaction associated with chronic liver damage resulting from prolonged parenchymal cell damage and inflammation. The fibrogenic response is characterized by the progressive accumulation of extracellular matrix components enriched in collagen fibrils and impaired extracellular matrix remodeling. The aim of this study was to establish the effect of transcriptional factor κB on the concentration of oxyproline, glycosaminoglycans and sialic acids in the liver of rats under conditions of chronic alcohol intoxication. The study was performed on 24 male Wistar rats. The animals were divided into 4 groups of 6 animals: І – control; II – animals with inhibition of κB; ІІI – animals with chronic alcohol hepatitis and ІV – animals with κB inhibition on the background of chronic alcohol intoxication. We studied the total concentration of glycosaminoglycans, concentration of heparin-heparan, keratan-dermatan and chondroitin fractions of glycosaminoglycans, free oxyproline and sialic acids in the liver tissue homogenate. Prolonged alcohol intoxication of rats leads to remodeling of the extracellular matrix as evidenced by increased collagenolysis and catabolism of glycoconjugates of amorphous connective tissue of the liver. The use of the inhibitor of the transcription factor κB in the background of prolonged alcohol intoxication of animals reduced the concentration of GAG by 1.43 times, lowered oxyproline concentration by 1.6 times and decreased the concentration of sialic acids by 1.14 times compared to chronic alcohol intoxication group. Transcriptional factor NF-κB under conditions of chronic alcohol intoxication affects the architectural remodeling of connective tissue of rat liver by increasing degradation of collagen fibers and destruction of glycoproteins and proteoglycans of the extracellular matrix.Документ Diagnostic and treatment approaches to acute pancreatitis in pregnant women(Полтавський державний медичний університет, 2022) Mishchenko, V. V.; Mishchenko, V. P.; Rudenko, I. V.; Pustovoyt, P. I.; Likhachov, V. K.; Dobrovolʹsʹka, L. M.; Makarov, O. H.; Міщенко, Василь Васильович; Міщенко, Валентина Павлівна; Руденко, І. В.; Пустовойт, Павло Іванович; Ліхачов, Володимир Костянтинович; Добровольська, Людмила Миколаївна; Макаров, Олег ГеннадійовичЧастота виникнення гострого панкреатиту складає від 1:1500 до 1:10000 вагітностей. Мета дослідження полягала у вдосконаленні діагностичних та лікувальних підходів при гострому панкреатиті у вагітних. Під наглядом була 21 вагітна жінка з гострим панкреатитом. Постановка діагнозу гострого панкреатиту у вагітних ґрунтувалась на критеріях класифікації Atlanta (2013). Комплексне консервативне лікування гострого панкреатиту у вагітних полягало у призначені октреотиду, інгібіторів протонної помпи, у II триместрі ‒ інгібіторів протеаз, напівсинтетичних пеніцилінів, цефалоспоринів III‒IV поколінь. Слід проводити корекцію водно‒електролітного балансу, відшкодування втрати плазми, порушень мікроциркуляції, боротьбу з набряком підшлункової залози та парапанкреатичної клітковини. Перебіг гострого панкреатиту у вагітних у 52,4 % випадків характеризувався середнім та тяжким ступенем тяжкості, що супроводжувалось дистресом плода. Летальних випадків не було. Впровадження застосованих нами діагностичних та лікувальних підходів при гострому панкреатиті у вагітних дозволило уникнути летальності, хірургічних та акушерсько-перинатальних ускладнень. Ведення вагітних із гострим панкреатитом є вкрай складним завданням і в першу чергу залежить від ступеня тяжкості гострого панкреатиту у таких хворих. Ведення вагітних, які хворіють на гострий панкреатит, вимагає мультидисциплінарного підходу для прогнозування перебігу панкреатиту, визначення тактики ведення вагітності при цьому, способу і термінів розродження.Документ Changes in the trigeminal ganglion of rats with acute carrageenaninduced inflammation(Полтавський державний медичний університет, 2022) Danyliv, О. D.; Shepitko, V. I.; Yakushko, O. S.; Stetsuk, Ye. V.; Boruta, N. V.; Данилів, Оксана Дмитрівна; Шепітько, Володимир Іванович; Якушко, Олена Святославівна; Стецук, Євген Валерійович; Борута, Наталія ВолодимирівнаThe purpose of the study was to establish the response of the components of the trigeminal ganglion in rats to aseptic inflammation under experimental conditions. The study was performed on 40 mature white male rats. Trigeminal ganglion of rats was the object of the study. The animals were divided into two groups: the control group of animals (5), which were injected with isotonic NaCl solution and the group of experimental animals (35), which were simulated acute carrageenan-induced inflammation. The rats were sacrificed within days 3, 5, 7, 10, 14, 21, and 30 under thiopental anesthesia overdose. Histological examination showed that carrageenan-induced inflammation in the trigeminal ganglion of rats had a staged course. Reactive changes in the vessels of the hemomicrocirculatory bed were most pronounced on the 5th day of observation. After that, the blood flow gradually stabilised until its complete normalization on the 14th day. Signs of reactive changes in neurons in the form of gradual oedema of the cytoplasm and nucleus and perinuclear chromatolysis were already noticed in the early stages of the experiment. The nature of the changes intensified with the increase in the observation period. Some cells showed signs of degenerative-dystrophic processes. The proliferative activity of glial cells increased in response to changes in neurons. The signs of inflammation in the parenchyma reached their maximum manifestation on the 14th day with an incomplete regeneration process for up to the 30th day.Документ Morphological features of the stromal component of the liver in experimental supplement of rations with food additives(Полтавський державний медичний університет, 2022) Mustafina, Н. M.; Starchenko, I. I.; Koka, V. М.; Fylenko, B. М.; Roiko, N. V.; Cherniak, V. V.; Prylutskyi, O. K.; Мустафіна, Галія Міркатівна; Старченко, Іван Іванович; Кока, Володимир Миколайович; Филенко, Борис Миколайович; Ройко, Наталія Віталіївна; Черняк, Валентина Володимирівна; Прилуцький, Олексій КостянтиновичThe purpose of this study was to study in an experiment the morphological features of the structural organization of the periportal connective tissue of the liver of white rats after the introduction into the diet of a complex of food additives (sodium glutamate, sodium nitrite, Ponceau 4R) for 8 weeks. The study was performed on 30 outbred white rats of both sexes, weighing 204 ±0.67 g. The experimental animals were additionally fed a combination of food additives – monosodium glutamate, Ponceau R-4, sodium nitrate for 1 and 8 weeks. The study of the stromal component of the liver was carried out on traditional histological preparations. To differentiate immunocompetent cells of connective tissue structures, immunohistochemical reactions with antibodies to CD68 and CD3 were performed. It was established that the addition of a complex of food additives (sodium glutamate, sodium nitrite, ponzo 4R) to the standard diet of laboratory animals for 8 weeks leads to excessive development of connective tissue in the liver and changes in the relative number of CD3+ and CD68+ cellular elements.Документ Results of complex treatment of maxillofacial hemangiomas in children(Полтавський державний медичний університет, 2022) Tkachenko, P. I.; Bilokon, S. O.; Lokhmatova, N. M.; Popelo, Y. V.; Dolenko, O. B.; Korotych, N. M.; Bilokon, N. P.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Попело, Юлія Вікторівна; Доленко, Ольга Борисівна; Коротич, Наталія Миколаївна; Білоконь, Наталія ПавлівнаЗа останні роки частота виявлення гемангіом щелепно-лицевої ділянки у дітей в Україні значно збільшилась. З метою визначення ефективності їх комплексного лікування узагальнено зміст 32 стаціонарних історій хвороб та 47 амбулаторних карт тематичних дітей. Капілярні гемангіоми діагностовано у 20 % випадків (у 19 % у вигляді винних плям). В 25 % спостережень вони самостійно редукувалися протягом 7-12 місяців. Незначні за обсягом і глибиною пухлини (56 % випадків) ліквідовано діатермокоагуляцією чи місцевим введенням малих доз преднізолону. Для усунення «великих плям» застосовувалась фракційна лазеротерапія. Кавернозні гемангіоми діагностовано в 23 % випадків. У 72 % пацієнтів проведено лікування дипроспаном у вигляді чотирьохразової інфільтрації по периферії утворення. У 23 % спостережень проводилось черезшкірне прошивання пухлини, пункція новоутворення з подальшим введенням в порожнини 70 % розчину спирту. Змішані гемангіоми (46 % пацієнтів) лікували застосуванням анаприліну. У 33 % пацієнтів піогенну гранульому видалено радикальним хірургічним втручанням, а у 67 % – діатермокоагуляцією. По завершенню лікування гемангіом всі діти пройшли курс реабілітаційних заходів.Документ The choice of a method for surgical treatment of internal chronic hemorrhoids(Полтавський державний медичний університет, 2022) Kravtsiv, M. I.; Dudchenko, M. O.; Ivashchenko, D. M.; Prykhidko, R. A.; Shevchuk, M. P.; Zaiets, S. M.; Ivanova, G. O.; Кравців, Микола Ігорович; Дудченко, Максим Олександрович; Іващенко, Дмитро Миколайович; Прихідько, Роман Анатолійович; Шевчук, Микола Петрович; Заєць, Сергій Миколайович; Іванова, Галина ОлегівнаHaemorrhoids are one of the most common diseases in the anorectal zone. Often this disease requires surgical treatment, so the study of types of operations for treatment of hemorrhoids is very important in our time. The aim of our study was to compare Rafaelo radiofrequency ablation of hemorrhoids and Milligan-Morgan hemorrhoidectomy to determine the best method of surgical treatment of chronic hemorrhoids. Our study included 135 patients divided into two groups. The first group consisted of 75 patients operated on by radiofrequency ablation, the second group consisted of 60 patients who underwent classical Milligan-Morgan hemorrhoidectomy. Obtained results showed that the method of radiofrequency ablation of hemorrhoids using the Rafaelo method is less traumatic, easier to perform for surgeons, has an insignificant level of postoperative pain, low frequency of early and late postoperative complications and recurrence, does not require additional drug therapy and is characterized by a short postoperative period and recovery.Документ Changes in corticosterocytes of the zona reticularis and сhromaffin cells of the adrenal gland in rats during the inhibition of testosterone synthesis(Полтавський державний медичний університет, 2022) Skotarenko, T. A.; Shepitko, V. I.; Stetsuk, E. V.; Boruta, N. V.; Скотаренко, Тетяна Анатоліївна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Борута, Наталія ВолодимирівнаMetabolic disorders, which are the main causes of many diseases and can be linked to the pathogenesis of other nosologies, remain relevant objects of scientific research. It has been proved that testosterone is an important biological regulator of metabolic processes in the male body. Modern studies are performed on the effect of testosterone deficiency on the state of neurons, testicles, liver and other body organs and tissues. The paper describes the main morphological changes of corticosterocytes of the reticular zone of the cortical substance and chromaffin cells of the medulla of the adrenal glands of white rats during central deprivation of testosterone synthesis through experimental blockade of gonadotropic hormones. It was established that inhibition of testosterone synthesis led to dystrophic changes and disruption of the synthetic function of corticosterocytes of the reticular zone, which was manifested at the microscopic level by the variability of morphometric indicators.Документ Overweight and obesity as risk factors for chemotherapy-induced hepatotoxicity in patients with acute lymphoblastic leukemia(Полтавський державний медичний університет, 2022) Skrypnyk, I. M.; Maslova, G. S.; Lymanets, T. V.; Скрипник, Ігор Миколайович; Маслова, Ганна Сергіївна; Лиманець, Тетяна ВолодимирівнаObesity is one of the proven risk factors for all types of tumors and is one of the reasons for reducing the effectiveness of specific chemotherapy and the development of chemotherapy-induced injury of liver. This article presents the results of functional liver state monitoring in patients with acute lymphoblastic leukemia during remission induction chemotherapy, taking into account the overweight and obesity. High toxicity of acute lymphoblastic leukemia chemotherapy regimens with a general tendency to hypoproteinemia development has been demonstrated. The overweight and obesity potentiate cytostatic-induced liver injury in patients with acute lymphoblastic leukemia with maximum risk in case of primary liver injury due to tumor exposure.Документ Clinical and diagnostic aspects of managing patients with valvular heart disease(Полтавський державний медичний університет, 2022) Shaposhnyk, O. A.; Prykhodko, N. P.; Savchenko, L. V.; Shevchenko, T. I.; Sorokina, S. I.; Yakymyshyna, L. I.; Kudria, I. P.; Шапошник, Ольга Анатоліївна; Приходько, Наталія Петрівна; Савченко, Леся Володимирівна; Шевченко, Тетяна Іванівна; Сорокіна, Світлана Іванівна; Якимишина, Лариса Іллівна; Кудря, Ірина ПавлівнаThe article presents the results of examination of 47 patients with valvular heart disease. According to the research findings, when investigating the causes of severe mitral regurgitation, especially in young and middle-aged people, one should primarily consider Barlow's disease, myxomatous mitral valve degeneration, as the primary cause (having excluded fibroelastic deficiency). It was found that among all cases of detected mitral valve prolapse (even minor or moderate), which is currently diagnosed quite often with the development of modern technology, stratification of patients requires additional examinations to identify people at high risk of disease progression and complications, as well as to determine the prognosis.Документ Pathomorphosis of diseases of the digestive system allergic and non-allergic genesis in children of Ukraine in the dynamics of 25 years of observation(Полтавський державний медичний університет, 2022) Volosovets, O. P.; Kryuchko, T. O.; Marushko, Yu. V.; Shadrin, O. Н.; Volosovets, T. M.; Pochynok, T. V.; Churylina, A. V.; Волосовець, Олександр Петрович; Крючко, Тетяна Олександрівна; Марушко, Юрій Володимирович; Шадрін, Олег Геннадійович; Волосовець, Тетяна Миколаївна; Починок, Тетяна Вікторівна; Чуриліна, Аліна ВасилівнаThe purpose of the study was a retrospective 25-year analysis of the incidence and prevalence of the digestive system diseases of allergic and non-allergic genesis in children of Ukraine to determine the possibility of environmental factors’ influence on their development. We have used methods of system approach, epidemiological, correlation and cluster analysis of medical statistics data of the Ministry of Health of Ukraine. A retrospective study from 1993 to 2017 have revealed that among children of Ukraine (aged 0–17 years included) there was a tendency of increasing the prevalence of diseases of the digestive system by 13.6 %, as well as their incidence – by 12.1 %, еspecially it is related to the children, affected by the Chernobyl accident. Over 25 years there have been significant changes in their structure, which requires careful attention to the above contingent of children.Документ The normal architectonics of the greater omentum vasculature in elderly people of both gender(Полтавський державний медичний університет, 2022) Stepanchuk, A. P.; Fedorchenko, I. L.; Pryshliak, A. M.; Piliuhin, A. V.; Shepitko, K. V.; Степанчук, Алла Петрівна; Федорченко, Ігор Леонідович; Пришляк, Антоніна Михайлівна; Пілюгін, Андрій Валентинович; Шепітько, Костянтин ВолодимировичVariability of topography of arteries and veins of the greater omentum, taken from 20 cavaders of elderly people was investigated by the methods of anatomical preparation and morphometry. The right and left gastro-omental arteries form the superior arterial arch in 15 of 18 cases, and did not anastomose in 3 cases. The inferior arterial arch was present in 1 of 20 cases. The left gastro-omental artery was absent in 2 of 20 cases. The central artery has a greater length and outer diameter both in women and men. The veins, in comparison with the arteries, have a larger outer diameter and one vein accompanies the artery of the same name. The zone of the central, and in its absence – the right and left medial arteries of the greater omentum can be used for obtaining the graft for transplantation in the quadrangular and triangular shapes of the greater omentum of the elderly people.Документ Pathogenetic prevention of prosthetics stomatitis in persons with internal diseases(Полтавський державний медичний університет, 2022) Dvornyk, V. M.; Marchenko, A. V.; Ponomarenko, В. О.; Kovalenko, V. V.; Litovchenko, I. Yu.; Teslenko, O. I.; Jerys, L. B.; Дворник, Валентин Миколайович; Марченко, Алла Володимирівна; Пономаренко, Віктор Олегович; Коваленко, Віктор Вікторович; Литовченко, Ірина Юріївна; Тесленко, Олександра Іванівна; Єрис, Любов БорисівнаPrimary and secondary prevention of prosthetic stomatitis in patients using removable dentures remains a topical and priority area of dentistry. The methods of prevention of chronic prosthetic stomatitis developed in the background of their internal diseases developed and tested by the authors of the article are effective, reduce the number of visits for prosthesis correction, are accessible and easy to perform for elderly and senile patients. They improve the adaptation of the oral mucosa to the basis of a removable prosthesis, adjust the general condition of the body and thus improve the quality of life of patients, as evidenced by the normalization of their psycho-emotional status. An individualized and differentiated approach to maintenance therapy prevents exacerbation of prosthetic stomatitis during the year in 78 % of patients.Документ The degree of involvement of the level of circulating immune complexes and red blood cells in the pathogenesis of community-acquired pneumonia(Полтавський державний медичний університет, 2022) Bereznyakov, V. I.; Korzh, A. M.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Vatsenko, A. V.; Ulanovska-Tsyba, N. A.; Березняков, Володимир Іванович; Корж, Андрій Миколайович; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Ваценко, Анжела Володимирівна; Улановська-Циба, Наталія АркадіївнаThe paper presents the findings of the study of the degree of involvement of the level of circulating immune complexes and red blood cells in the pathogenesis of community-acquired pneumonia. Marked disorders in immunological indices of the severity degree of the disease in patients with community-acquired pneumonia have been established, which must be taken into ccount when diagnosing the disease: elevated circulating immune complexes level in the blood serum of patients and an increase in the total circulating immune complexes level, mainly due to an increase in the most toxigenic small- (<11 S) and medium molecular weight (11 S–19 S) fractions of the immune complexes. The higher the level of circulating immune complexes, especially small molecular weight ones, the more likely a severe course of community-acquired pneumonia is. In community-acquired pneumonia, oxidative stress and intensified generation of reactive oxygen specie develop. Changes in the quantity and quality of blood corpuscles necessitate the inclusion of agents that improve blood oxygenation into standard antibacterial therapy.Документ Morphological and metric changes of the glandular apparatus of the rat stomach fundus under the effect of a complex of food additives(Полтавський державний медичний університет, 2022) Yeroshenko, G. А.; Yachmin, А. І.; Shevchenko, K. V.; Lysachenko, O. D.; Riabushko, O. B.; Sokolenko, V. M.; Sharlai, N. M.; Єрошенко, Галина Анатоліївна; Ячмінь, Анастасія Ігорівна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Рябушко, Олена Борисівна; Соколенко, Валентина Миколаївна; Шарлай, Наталія МиколаївнаThe paper presents the data of morphometric and histological examination in the complex action of food additives on the glandular apparatus of the stomach fundus. It was found that the complex action of dietary supplements of sodium nitrite, sodium glutamate and Ponceau 4R leads to changes in morphometric parameters of the fundus glands with the development of a complex reaction, followed by inflammatory reaction and edema. Reconstructive reactions aimed at neutralizing the alternative factor and restoring the morphofunctional state of the glands of the stomach fundus do not lead to complete recovery of structural components due to the predominance of constant negative stimuli with dystophic changes, expressed by changes in morphometric parameters and morphological structure.Документ General description of patients with community-acquired pneumonia Who passed an open comparative study(Полтавський державний медичний університет, 2022) Berezniakov, V. I.; Кorzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Zvyagolska, І. М.; Sharlay, N. М.; Березняков, Владислав Ігорович; Корж, А. Н.; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Звягольська, Ірина Миколаївна; Шарлай, Наталія МиколаївнаThe article provides a general description of the etiology and pathogenesis of patients with community-acquired pneumonia who passed an open comparative study at the Kharkiv Municipal Clinical Hospital No. 25. The most likely causative agents of community-acquired pneumonia in patients of the Therapeutic Department of the Kharkiv Municipal Clinical Hospital No 25 are Streptococcus pneumoniae and mixed cultures of bacteria, with an increase in the proportion of Staphylococcus aureus. In modern conditions, when choosing the tactics of antimicrobial therapy for community-acquired pneumonia, it is necessary to consider not only the spectrum of the most likely pathogens, but also the trends in the formation of antibiotic resistance in the leading etiological groups. It is impractical to prescribe empirical antibiotic therapy for community-acquired pneumonia without establishing an etiological diagnosis.Документ Molecular and genetic characteristics of adenovirus as causes of acute diarrhea in the people of southern Ukraine(Полтавський державний медичний університет, 2022) Appelkhans, O. L.; Kozishkurt, O. V.; Hrytsenko, K. S.; Boruta, N. V.; Shablii, T. P.; Hruzevskyi, O. A.; Naidich, O. V.; Аппельханс, Олена Леонідівна; Козішкурт, Олена Володимирівна; Гриценко, К. С.; Борута, Наталія Володимирівна; Шаблій, Тетяна Петрівна; Грузевський, Олександр Анатолійович; Найдіч, Ольга ВолодимирівнаThe etiological role of adenoviruses as causative agents of acute diarrhea in the southern region of Ukraine was studied. Adenovirus DNA was detected in 10.61±1.05 % of clinical stool samples. Serotypes of two gene groups: C and F were identified during genotyping and sequencing of genetic material of detected adenovirus isolates. Gene group F (HAdV41), proves their role in the occurrence of this infectious pathology. HAdV41 isolates had a significant advantage 75.0±15.31 % and had a pronounced genetic heterogeneity, showed similarities with serotypes circulating in previous years in different regions of the world: Sweden (1978), Japan (2003, 2006), South Africa (2009–2014), Iraq (2016). The obtained results allowed to establish the geographical origin of circulating adenoviruses, as well as to predict a further increase in the intensity of the epidemic process of adenoviral infections in southern Ukraine.