2022

Постійне посилання на фонд

https://repository.pdmu.edu.ua/handle/123456789/17898

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The influence of anxiety level and past COVID-19 on sleep quality and insomnia severity
(2022) Boiko, D. I.; Zhyvotovska, A. I.; Skrypnikov, A. M.; Бойко, Дмитро Іванович; Животовська, Лілія Валентинівна; Скрипніков, Андрій Миколайович
Based on recent studies, we put forward a hypothesis about the synergistic effect of anxiety disorders and previous COVID-19 on the deterioration of the quality of sleep and occurring of insomnia. The purpose of the study was to investigate the impacts of anxiety disorders, and COVID-19 on anamnesis and its combined effect on sleep disturbances. We conducted a case-control study, which included 60 patients, who were divided into 3 groups depending on the occurrence of anxiety disorders and COVID-19 in their medical history during the last 6 months. Patients were assessed by the Beck anxiety inventory, Pittsburgh Sleep Quality Index, and the Insomnia Severity Index. We found a worsening sleep quality and a higher frequency of insomnia in patients with COVID-19. Along with this, concomitant anxiety disorders worsened both the quality of sleep and the level of insomnia in these respondents. It was determined that patients with an anxiety disorder with a history had a lower subjective assessment of sleep quality, higher sleep latency, and more pronounced diurnal dysfunction, while patients without a history had better sleep efficiency and a lower frequency of sleeping pills. Anxiety disorders and having experienced COVID-19 are associated with poorer sleep quality and more severe insomnia. Their combination significantly reduces the quality of sleep and increases the degree of insomnia. These findings suggest a potential role for COVID-19 in exacerbating the association between anxiety and sleep disorders.
Morphological features of the stromal component of the liver in experimental supplement of rations with food additives
(Полтавський державний медичний університет, 2022) Mustafina, Н. M.; Starchenko, I. I.; Koka, V. М.; Fylenko, B. М.; Roiko, N. V.; Cherniak, V. V.; Prylutskyi, O. K.; Мустафіна, Галія Міркатівна; Старченко, Іван Іванович; Кока, Володимир Миколайович; Филенко, Борис Миколайович; Ройко, Наталія Віталіївна; Черняк, Валентина Володимирівна; Прилуцький, Олексій Костянтинович
The purpose of this study was to study in an experiment the morphological features of the structural organization of the periportal connective tissue of the liver of white rats after the introduction into the diet of a complex of food additives (sodium glutamate, sodium nitrite, Ponceau 4R) for 8 weeks. The study was performed on 30 outbred white rats of both sexes, weighing 204 ±0.67 g. The experimental animals were additionally fed a combination of food additives – monosodium glutamate, Ponceau R-4, sodium nitrate for 1 and 8 weeks. The study of the stromal component of the liver was carried out on traditional histological preparations. To differentiate immunocompetent cells of connective tissue structures, immunohistochemical reactions with antibodies to CD68 and CD3 were performed. It was established that the addition of a complex of food additives (sodium glutamate, sodium nitrite, ponzo 4R) to the standard diet of laboratory animals for 8 weeks leads to excessive development of connective tissue in the liver and changes in the relative number of CD3+ and CD68+ cellular elements.
Results of complex treatment of maxillofacial hemangiomas in children
(Полтавський державний медичний університет, 2022) Tkachenko, P. I.; Bilokon, S. O.; Lokhmatova, N. M.; Popelo, Y. V.; Dolenko, O. B.; Korotych, N. M.; Bilokon, N. P.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Попело, Юлія Вікторівна; Доленко, Ольга Борисівна; Коротич, Наталія Миколаївна; Білоконь, Наталія Павлівна
За останні роки частота виявлення гемангіом щелепно-лицевої ділянки у дітей в Україні значно збільшилась. З метою визначення ефективності їх комплексного лікування узагальнено зміст 32 стаціонарних історій хвороб та 47 амбулаторних карт тематичних дітей. Капілярні гемангіоми діагностовано у 20 % випадків (у 19 % у вигляді винних плям). В 25 % спостережень вони самостійно редукувалися протягом 7-12 місяців. Незначні за обсягом і глибиною пухлини (56 % випадків) ліквідовано діатермокоагуляцією чи місцевим введенням малих доз преднізолону. Для усунення «великих плям» застосовувалась фракційна лазеротерапія. Кавернозні гемангіоми діагностовано в 23 % випадків. У 72 % пацієнтів проведено лікування дипроспаном у вигляді чотирьохразової інфільтрації по периферії утворення. У 23 % спостережень проводилось черезшкірне прошивання пухлини, пункція новоутворення з подальшим введенням в порожнини 70 % розчину спирту. Змішані гемангіоми (46 % пацієнтів) лікували застосуванням анаприліну. У 33 % пацієнтів піогенну гранульому видалено радикальним хірургічним втручанням, а у 67 % – діатермокоагуляцією. По завершенню лікування гемангіом всі діти пройшли курс реабілітаційних заходів.
The choice of a method for surgical treatment of internal chronic hemorrhoids
(Полтавський державний медичний університет, 2022) Kravtsiv, M. I.; Dudchenko, M. O.; Ivashchenko, D. M.; Prykhidko, R. A.; Shevchuk, M. P.; Zaiets, S. M.; Ivanova, G. O.; Кравців, Микола Ігорович; Дудченко, Максим Олександрович; Іващенко, Дмитро Миколайович; Прихідько, Роман Анатолійович; Шевчук, Микола Петрович; Заєць, Сергій Миколайович; Іванова, Галина Олегівна
Haemorrhoids are one of the most common diseases in the anorectal zone. Often this disease requires surgical treatment, so the study of types of operations for treatment of hemorrhoids is very important in our time. The aim of our study was to compare Rafaelo radiofrequency ablation of hemorrhoids and Milligan-Morgan hemorrhoidectomy to determine the best method of surgical treatment of chronic hemorrhoids. Our study included 135 patients divided into two groups. The first group consisted of 75 patients operated on by radiofrequency ablation, the second group consisted of 60 patients who underwent classical Milligan-Morgan hemorrhoidectomy. Obtained results showed that the method of radiofrequency ablation of hemorrhoids using the Rafaelo method is less traumatic, easier to perform for surgeons, has an insignificant level of postoperative pain, low frequency of early and late postoperative complications and recurrence, does not require additional drug therapy and is characterized by a short postoperative period and recovery.
Anticholinergic burden in aging patients and its role in the development of bladder decompensation
(Полтавський державний медичний університет, 2022) Pustovoit, G. L.; Sarychev, L. P.; Savchenko, R. B.; Sarychev, Y. V.; Ustenko, R. L.; Sukhomlin, S. A.; Пустовойт, Ганна Леонідівна; Саричев, Леонід Петрович; Савченко, Роман Борисович; Саричев, Ярослав Володимирович; Устенко, Роман Леонідович; Сухомлин, Сергій Адольфович
Антихолінергічне навантаження розглядають як кумулятивний ефект від прийому препаратів з антихолінергічною активністю. У статті наведено дані про роль антихолінергічного навантаження в розвитку декомпенсації сечового міхура у хворих на доброякісну гіперплазію передміхурової залози. Обстежено 381 пацієнтів із доброякісною гіперплазією передміхурової залози в стадії субкомпенсації та декомпенсації сечового міхура. Антихолінергічне навантаження у пацієнтів літнього віку може розвиватися як в результаті прийому препаратів з високою потенційною антихолінергічної активністю, так і в результаті тривалого застосування препаратів з низькою потенційною антихолінергічної активністю. Препарати з високою потенційною антихолінергічною активністю зменшують симптоми гіперактивного сечового міхура у пацієнтів з доброякісною гіперплазією передміхурової залози, але антихолінергічне навантаження стає фактором поглиблення декомпенсації сечового міхура, що погіршує результати хірургічного лікування.
The role of sulfide anion in the developmen of oxidatives stress in the liver under conditions of chronic alcoholic hepatitis
(Полтавський державний медичний університет, 2022) Mykytenko, A. O.; Akimov, O. E.; Eroshenko, G. A.; Neporada, K. S.; Микитенко, Андрій Олегович; Акімов, Олег Євгенович; Єрошенко, Галина Анатоліївна; Непорада, Каріне Степанівна
The pathogenesis of alcoholic hepatitis is multifactorial and is the final result of a complex interaction of ethanol metabolism, inflammation and immunological reactions. The molecular mechanisms of H2S action in alcoholic hepatitis have not been sufficiently studied, and its protective role has not been proven. The experiments were carried out on 30 white, sexually mature outbred male rats, weighing 180–220 g. The animals were divided into 2 groups: І – control (n=6); ІІ group – animals on which we simulated alcoholic hepatitis. In the homogenate of the liver of rats, the activity of superoxide dismutase and catalase, the concentration of malondialdehyde and oxidatively modified proteins, sulfide anion concentration and the production of superoxide anion were determined. A decrease in the concentration of sulfide anion against the background of an increase in the activity of superoxide dismutase and the presence of an inversely proportional strong correlation between them indicates the effect of alcohol on the thioredoxin system, namely, on the increase of expression of a protein that interacts with thioredoxin, stimulating the reaction of the latter with reactive oxygen species. Chronic alcohol intoxication leads to the development of oxidative stress in the liver of rats due to an increase in the production of reactive oxygen species. The decrease in the concentration of sulfide anion on the 28th day of the experiment is connected with its usage as an antioxidant.
Changes in nitric oxide production and development of oxidative stress in rats heart during prolonged triptorelin-induced central deprivation of luteinizing hormone synthesis
(Poltava State Medical University, Poltava, 2022) Voroshilova, T. A.; Shepitko, V. I.; Stetsuk, Ye. V.; Akimov, O. Ye.; Puzyryov, G. S.; Ворошилова, Тетяна Анатоліївна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Акімов, Олег Євгенович; Пузирьов, Гай Сергійович
Central deprivation of luteinizing hormone synthesis for 365 days leads to the development of oxidative stress in rat hearts. The peak of oxidative damage to the heart under these conditions happens on the 180th day of the central deprivation of luteinizing hormone synthesis. Production of nitric oxide during central deprivation of luteinizing hormone synthesis undergoes complex changes from an initial decrease of NO-synthase-dependent nitric oxide production on the 30th and 90th day to overproduction of nitric oxide from NO-synthases on the 365th day of the experiment.
A three-stage therapeutic and diagnostic algorithm in mechanical jaundice of different genesis and the most effective mini-invasive method of its treatment
(Полтавський державний медичний університет, 2022) Prykhidko, R. A.; Dudchenko, M. O.; Kravtsiv, M. I.; Zaiets, S. M.; Ivashchenko, D. M.; Chelishvili, A. L.; Shevchuk, M. P.; Прихідько, Роман Анатолійович; Дудченко, Максим Олександрович; Кравців, Микола Ігорович; Заєць, Сергій Миколайович; Іващенко, Дмитро Миколайович; Челішвілі, Анатолій Леонідович; Шевчук, Микола Петрович
The paper analyzes the experience of treatment of mechanical jaundice with the use of minimally invasive surgical interventions in 176 patients. It has been found that the clinical presentation, laboratory parameters are of secondary importance in determining the etiology and level of biliary obstruction. For the differential diagnosis of etiological factors of obstructive jaundice, we used non-invasive and minimally invasive radiological methods: ultrasound – 203, magnetic resonance cholangiopancreatography – 98, multislice computed tomography – 74, endoscopic retrograde cholangiopancreatography - 138, percutaneous transhepatic cholangiography – 27. In order to determine the informativeness, we evaluated the detection of concretions, strictures of the bile ducts, mass lesions, dilation of intra- and extrahepatic bile ducts. Methods of elimination of biliary hypertension were various types of endoscopic decompression, which were performed in combination with endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography. We compared the following aspects: the possibility of performing these types of decompression of the bile ducts, their effectiveness in eliminating jaundice and complications. Based on our results, we developed a 3-stage diagnostic and treatment algorithm, whose efficiency in the elimination of mechanical jaundice was 96.0 %.
Influence of food additives complex on the morphology of villi of the rats’ duodenum mucosa
(Полтавський державний медичний університет, 2022) Yeroshenko, G. A.; Grygorenko, A. S.; Shevchenko, K. V.; Lysachenko, O. D.; Riabushko, O. B.; Pyvovar, N. M.; Klepets, O. V.; Єрошенко, Галина Анатоліївна; Григоренко, Альона Сергіївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Рябушко, Олена Борисівна; Клепець, Олена Вікторівна; Пивовар, Ніна Михайлівна
The study presents the findings of the study of the effect of food additives, namely, monosodium glutamate, sodium nitrite and Ponceau-4R on the morphological state of the components of the villi of the rats’ duodenal mucosa. The study was aimed at establishing the dynamics of changes in the metric parameters of the components of the villi of rats’ duodenal mucosa in normal conditions and under the action of the complex of food additives. It has been found that consumption of the complex of food additives leads to changes in the metric values of the height and width of the villi, which at the early stages of the experiment leads to a decrease in their mean values due to the immediate direct action on the mucous membrane with subsequent development of inflammatory reaction and edema, which will lead to an increase in metric values and a decrease in the number of epithelial cells of the villus. Adaptive mechanisms do not fully restore the values of the morphometric study, which is manifested by a decrease in the height of the villi by 20.25 % compared with the control group with an increase in the number of enterocytes with brush border and a decrease in the number of goblet cells by 44.41 %.
Influence of transcription factor κB on remodeling of extracellular matrix of rat liver under conditions of chronic alcohol intoxication
(Полтавський державний медичний університет, 2022) Mykytenko, A. O.; Akimov, O. Ye.; Yeroshenko, G. A.; Neporada, K. S.; Микитенко, Андрій Олегович; Акімов, Олег Євгенович; Єрошенко, Галина Анатоліївна; Непорада, Каріне Степанівна
Liver fibrosis is a common tissue reaction associated with chronic liver damage resulting from prolonged parenchymal cell damage and inflammation. The fibrogenic response is characterized by the progressive accumulation of extracellular matrix components enriched in collagen fibrils and impaired extracellular matrix remodeling. The aim of this study was to establish the effect of transcriptional factor κB on the concentration of oxyproline, glycosaminoglycans and sialic acids in the liver of rats under conditions of chronic alcohol intoxication. The study was performed on 24 male Wistar rats. The animals were divided into 4 groups of 6 animals: І – control; II – animals with inhibition of κB; ІІI – animals with chronic alcohol hepatitis and ІV – animals with κB inhibition on the background of chronic alcohol intoxication. We studied the total concentration of glycosaminoglycans, concentration of heparin-heparan, keratan-dermatan and chondroitin fractions of glycosaminoglycans, free oxyproline and sialic acids in the liver tissue homogenate. Prolonged alcohol intoxication of rats leads to remodeling of the extracellular matrix as evidenced by increased collagenolysis and catabolism of glycoconjugates of amorphous connective tissue of the liver. The use of the inhibitor of the transcription factor κB in the background of prolonged alcohol intoxication of animals reduced the concentration of GAG by 1.43 times, lowered oxyproline concentration by 1.6 times and decreased the concentration of sialic acids by 1.14 times compared to chronic alcohol intoxication group. Transcriptional factor NF-κB under conditions of chronic alcohol intoxication affects the architectural remodeling of connective tissue of rat liver by increasing degradation of collagen fibers and destruction of glycoproteins and proteoglycans of the extracellular matrix.
Detection and assessment of disorders of the depressive spectrum in patients with acute myocardial infarction depending on the method of treatment
(Полтавський державний медичний університет, 2022) Kudria, I. P.; Shevchenko, T. I.; Voroshilova, T. A.; Tretiak, N. H.; Kryvoruchko, I. H.; Pushko, O. О.; Shaposhnyk, О. А.; Кудря, Ірина Павлівна; Шевченко, Тетяна Іванівна; Ворошилова, Тетяна Анатоліївна; Третяк, Наталія Григорівна; Криворучко, Іван Григорович; Пушко, Олександр Олександрович; Шапошник, Ольга Анатоліївна
The frequent combination of mental disorders of the depressive spectrum and cardiovascular diseases is one of the most urgent problems of modern medicine. The purpose of the study was to identify and assess, with the help of various psychodiagnostic methods, the degree of severity of depressive disorders in patients with acute myocardial infarction depending on the treatment method as a prerequisite for optimal drug therapy. 73 patients with the aforementioned pathology were studied and were divided into two groups. Group I included 44 patients who underwent urgent coronary angiography with subsequent stenting of the infarct-related coronary artery; Group II – included 29 patients who received only drug therapy. Examination of patients was carried out according to Ukrainian standards, in particular, a survey according to the scale of Beck and Zung. Patients with acute myocardial infarction after urgent coronary angiography with stenting of the infarct-dependent artery were more likely to have mild and moderate depression according to the Beck scale compared to patients who received only conservative medical treatment. The reverse pattern is observed for moderate and severe depression. 68.2% of patients with acute myocardial infarction after interventional intervention and 62.1% on the background of conservative treatment according to the Zung scale showed depression of various degrees of severity, mostly mild.
Changes in the trigeminal ganglion of rats with acute carrageenaninduced inflammation
(Полтавський державний медичний університет, 2022) Danyliv, О. D.; Shepitko, V. I.; Yakushko, O. S.; Stetsuk, Ye. V.; Boruta, N. V.; Данилів, Оксана Дмитрівна; Шепітько, Володимир Іванович; Якушко, Олена Святославівна; Стецук, Євген Валерійович; Борута, Наталія Володимирівна
The purpose of the study was to establish the response of the components of the trigeminal ganglion in rats to aseptic inflammation under experimental conditions. The study was performed on 40 mature white male rats. Trigeminal ganglion of rats was the object of the study. The animals were divided into two groups: the control group of animals (5), which were injected with isotonic NaCl solution and the group of experimental animals (35), which were simulated acute carrageenan-induced inflammation. The rats were sacrificed within days 3, 5, 7, 10, 14, 21, and 30 under thiopental anesthesia overdose. Histological examination showed that carrageenan-induced inflammation in the trigeminal ganglion of rats had a staged course. Reactive changes in the vessels of the hemomicrocirculatory bed were most pronounced on the 5th day of observation. After that, the blood flow gradually stabilised until its complete normalization on the 14th day. Signs of reactive changes in neurons in the form of gradual oedema of the cytoplasm and nucleus and perinuclear chromatolysis were already noticed in the early stages of the experiment. The nature of the changes intensified with the increase in the observation period. Some cells showed signs of degenerative-dystrophic processes. The proliferative activity of glial cells increased in response to changes in neurons. The signs of inflammation in the parenchyma reached their maximum manifestation on the 14th day with an incomplete regeneration process for up to the 30th day.
Diagnostic and treatment approaches to acute pancreatitis in pregnant women
(Полтавський державний медичний університет, 2022) Mishchenko, V. V.; Mishchenko, V. P.; Rudenko, I. V.; Pustovoyt, P. I.; Likhachov, V. K.; Dobrovolʹsʹka, L. M.; Makarov, O. H.; Міщенко, Василь Васильович; Міщенко, Валентина Павлівна; Руденко, І. В.; Пустовойт, Павло Іванович; Ліхачов, Володимир Костянтинович; Добровольська, Людмила Миколаївна; Макаров, Олег Геннадійович
Частота виникнення гострого панкреатиту складає від 1:1500 до 1:10000 вагітностей. Мета дослідження полягала у вдосконаленні діагностичних та лікувальних підходів при гострому панкреатиті у вагітних. Під наглядом була 21 вагітна жінка з гострим панкреатитом. Постановка діагнозу гострого панкреатиту у вагітних ґрунтувалась на критеріях класифікації Atlanta (2013). Комплексне консервативне лікування гострого панкреатиту у вагітних полягало у призначені октреотиду, інгібіторів протонної помпи, у II триместрі ‒ інгібіторів протеаз, напівсинтетичних пеніцилінів, цефалоспоринів III‒IV поколінь. Слід проводити корекцію водно‒електролітного балансу, відшкодування втрати плазми, порушень мікроциркуляції, боротьбу з набряком підшлункової залози та парапанкреатичної клітковини. Перебіг гострого панкреатиту у вагітних у 52,4 % випадків характеризувався середнім та тяжким ступенем тяжкості, що супроводжувалось дистресом плода. Летальних випадків не було. Впровадження застосованих нами діагностичних та лікувальних підходів при гострому панкреатиті у вагітних дозволило уникнути летальності, хірургічних та акушерсько-перинатальних ускладнень. Ведення вагітних із гострим панкреатитом є вкрай складним завданням і в першу чергу залежить від ступеня тяжкості гострого панкреатиту у таких хворих. Ведення вагітних, які хворіють на гострий панкреатит, вимагає мультидисциплінарного підходу для прогнозування перебігу панкреатиту, визначення тактики ведення вагітності при цьому, способу і термінів розродження.
Morphometric characteristics of the rat small bronchi in consumption of the complex of food additives
(Полтавський державний медичний університет, 2022) Eroshenko, G. A.; Donets, I. M.; Shevchenko, K. V.; Lysachenko, O. D.; Solod, A. V.; Vatsenko, A. V.; Ulanovska-Tsyba, N. A.; Єрошенко, Галина Анатоліївна; Донець, Ілона Миколаївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Солод, Анатолій Вікторович; Ваценко, Анжела Володимирівна; Улановська-Циба, Наталія Аркадіївна
The paper presents the data of the morphometric study of the small bronchi of the lungs of rats under the complex effect of food additives. It has been established that consumption of the complex of food additives leads to a change in the morphometric parameters of the structural components of the small bronchi of the rat lungs, which at the early stages is manifested by a significant decrease in the morphometric parameters of the outer diameter and lumen with a significant increase in the height of the epitheliocytes in the small bronchi of all orders due to the primary endogenous impact of the components of the food additive complex, which is associated with spasm of the exchange blood vessels and the progressive phenomena of hypoxia. Subsequently, the impact of the alterative factor, which prevails over the protective mechanisms of the body, is manifested by the development of bronchospasm in the small bronchi of the 3rd order, the appearance of inflammatory infiltration in the bronchial walls and the formation of bronchial hyperreactivity, which is characteristic of the development of diseases of the respiratory system, including asthma.
General description of patients with community-acquired pneumonia Who passed an open comparative study
(Полтавський державний медичний університет, 2022) Berezniakov, V. I.; Кorzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Zvyagolska, І. М.; Sharlay, N. М.; Березняков, Владислав Ігорович; Корж, А. Н.; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Звягольська, Ірина Миколаївна; Шарлай, Наталія Миколаївна
The article provides a general description of the etiology and pathogenesis of patients with community-acquired pneumonia who passed an open comparative study at the Kharkiv Municipal Clinical Hospital No. 25. The most likely causative agents of community-acquired pneumonia in patients of the Therapeutic Department of the Kharkiv Municipal Clinical Hospital No 25 are Streptococcus pneumoniae and mixed cultures of bacteria, with an increase in the proportion of Staphylococcus aureus. In modern conditions, when choosing the tactics of antimicrobial therapy for community-acquired pneumonia, it is necessary to consider not only the spectrum of the most likely pathogens, but also the trends in the formation of antibiotic resistance in the leading etiological groups. It is impractical to prescribe empirical antibiotic therapy for community-acquired pneumonia without establishing an etiological diagnosis.
Molecular and genetic characteristics of adenovirus as causes of acute diarrhea in the people of southern Ukraine
(Полтавський державний медичний університет, 2022) Appelkhans, O. L.; Kozishkurt, O. V.; Hrytsenko, K. S.; Boruta, N. V.; Shablii, T. P.; Hruzevskyi, O. A.; Naidich, O. V.; Аппельханс, Олена Леонідівна; Козішкурт, Олена Володимирівна; Гриценко, К. С.; Борута, Наталія Володимирівна; Шаблій, Тетяна Петрівна; Грузевський, Олександр Анатолійович; Найдіч, Ольга Володимирівна
The etiological role of adenoviruses as causative agents of acute diarrhea in the southern region of Ukraine was studied. Adenovirus DNA was detected in 10.61±1.05 % of clinical stool samples. Serotypes of two gene groups: C and F were identified during genotyping and sequencing of genetic material of detected adenovirus isolates. Gene group F (HAdV41), proves their role in the occurrence of this infectious pathology. HAdV41 isolates had a significant advantage 75.0±15.31 % and had a pronounced genetic heterogeneity, showed similarities with serotypes circulating in previous years in different regions of the world: Sweden (1978), Japan (2003, 2006), South Africa (2009–2014), Iraq (2016). The obtained results allowed to establish the geographical origin of circulating adenoviruses, as well as to predict a further increase in the intensity of the epidemic process of adenoviral infections in southern Ukraine.
Reaction of rat hepatocytes during correction of acute experimental aseptic inflammation of the peritoneum by the administration of cryopreserved placenta
(Poltava State Medical University, 2022) Voloshyna, O. V.; Shepitko, V. I.; Pelipenko, L. B.; Raskaley, V. B.; Волошина, Олена Валеріївна; Шепітько, Володимир Іванович; Пелипенко, Лариса Борисівна; Раскалєй, В. Б.
Analyzing the results of the experimental study, it should be noted that the method of treatment of acute experimental aseptic peritonitis, which we proposed, can be attributed to the effectiveness and, in terms of performance, easily accessible, which is practically uncomplicated. The morphometric study revealed that the mean large diameter of hepatocytes, small cell diameter and their area tended to increase from the 10th day of the experiment. From the 3–5th day of the experiment, the large and small diameters of the hepatocyte nuclei slowly increased, and on the 7th and 10th days, the values were the largest. The value of the nuclear-cytoplasmic index from the 2nd to the 14th day of the experiment was greater than that of the intact group. On the 30th day of the experiment, all indices were equal to the values of the intact group.It is proved that the use of a complex of biologically active substances contained in cryopreserved placenta in acute experimental aseptic peritoneal inflammation leads to the normalization of the morphological state of hepatocytes’ structural components. When using cryopreserved placenta, the anti- inflammatory effect of biologically active substances is manifested by the restriction of alternative and increased reparative phenomena. Thus, based on this study, we can assume that the introduction of cryopreserved placenta not only implements its multiple properties, such as immunomodulatory and immunostimulatory, desensitizing, antitoxic, hepatoprotective, stimulation of regeneration but also affects its influence and reduces recovery time.
Comparison of the effect of antiseptics based on Decamethoxine, Chlorhexidine bigluconate and Iodophorm on the adhesive potential of bacteria of the genus Kocuria spp
(2022) Лобань, Галина Андріївна; Фаустова, Марія Олексіївна; Чумак, Юлія Вікторівна; Ананьєва, Майя Миколаївна; Гаврильєв, Віктор Миколайович ; Аветіков, Давид Соломонович; Стебловський, Дмитро Валерійович; Loban', G. A.; Faustova, M. O.; Chumak, Yu. V.; Avetikov, D. S.; Ananieva, M. M.; Gavriliev, V. M.; Steblovskiy, D. V.
Antiseptics can block the adhesion of bacteria, thus facilitating the course of the purulent-inflammatory process. Therefore, we investigated the adhesive properties of clinical isolates of the genus Kocuria isolated from the oral cavity of patients with infectious-inflammatory post-extraction complications. Remedies based on decamethoxine, chlorhexidine bigluconate and iodoform were used as test antiseptics. The adhesive properties of clinical isolates under the action of remedies based on decamethoxine, chlorhexidine bigluconate and iodoform were determined by V.I. Brillis. The adhesion index values of microorganisms of clinical isolates of the genus Kocuria under the action of subbacteriostatic concentration of remedy based on decamethoxine were 1.6 times (p<0.05) and 2.1 times (p<0.05) lower compared to those of the adhesion index of microorganisms after the action of remedies based on chlorhexidine bigluconate subbacteriostatic concentrations and iodoform respectively. In the presence of remedy based on chlorhexidine bigluconate SBsC, relative to the clinical isolates Kocuria kristinae 1 and Kocuria kristinae 2, IAM indices increased 1. 3 times, and IAM indices of Kocuria rosea increased 1.1 times compared to the IAM indices of the controls of these isolates. Considering the results of action remedy based on iodoform SBsC on clinical isolates Kocuria kristinae 1 and Kocuria kristinae 2, IAM increased in 2.1 times and in 1.5 times, IAM of clinical isolate Kocuria rosea also increased, but in 1.4 times, considering the control cultures.
Overweight and obesity as risk factors for chemotherapy-induced hepatotoxicity in patients with acute lymphoblastic leukemia
(Полтавський державний медичний університет, 2022) Skrypnyk, I. M.; Maslova, G. S.; Lymanets, T. V.; Скрипник, Ігор Миколайович; Маслова, Ганна Сергіївна; Лиманець, Тетяна Володимирівна
Obesity is one of the proven risk factors for all types of tumors and is one of the reasons for reducing the effectiveness of specific chemotherapy and the development of chemotherapy-induced injury of liver. This article presents the results of functional liver state monitoring in patients with acute lymphoblastic leukemia during remission induction chemotherapy, taking into account the overweight and obesity. High toxicity of acute lymphoblastic leukemia chemotherapy regimens with a general tendency to hypoproteinemia development has been demonstrated. The overweight and obesity potentiate cytostatic-induced liver injury in patients with acute lymphoblastic leukemia with maximum risk in case of primary liver injury due to tumor exposure.
Clinical and diagnostic aspects of managing patients with valvular heart disease
(Полтавський державний медичний університет, 2022) Shaposhnyk, O. A.; Prykhodko, N. P.; Savchenko, L. V.; Shevchenko, T. I.; Sorokina, S. I.; Yakymyshyna, L. I.; Kudria, I. P.; Шапошник, Ольга Анатоліївна; Приходько, Наталія Петрівна; Савченко, Леся Володимирівна; Шевченко, Тетяна Іванівна; Сорокіна, Світлана Іванівна; Якимишина, Лариса Іллівна; Кудря, Ірина Павлівна
The article presents the results of examination of 47 patients with valvular heart disease. According to the research findings, when investigating the causes of severe mitral regurgitation, especially in young and middle-aged people, one should primarily consider Barlow's disease, myxomatous mitral valve degeneration, as the primary cause (having excluded fibroelastic deficiency). It was found that among all cases of detected mitral valve prolapse (even minor or moderate), which is currently diagnosed quite often with the development of modern technology, stratification of patients requires additional examinations to identify people at high risk of disease progression and complications, as well as to determine the prognosis.

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