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Документ A three-stage therapeutic and diagnostic algorithm in mechanical jaundice of different genesis and the most effective mini-invasive method of its treatment(Полтавський державний медичний університет, 2022) Prykhidko, R. A.; Dudchenko, M. O.; Kravtsiv, M. I.; Zaiets, S. M.; Ivashchenko, D. M.; Chelishvili, A. L.; Shevchuk, M. P.; Прихідько, Роман Анатолійович; Дудченко, Максим Олександрович; Кравців, Микола Ігорович; Заєць, Сергій Миколайович; Іващенко, Дмитро Миколайович; Челішвілі, Анатолій Леонідович; Шевчук, Микола ПетровичThe paper analyzes the experience of treatment of mechanical jaundice with the use of minimally invasive surgical interventions in 176 patients. It has been found that the clinical presentation, laboratory parameters are of secondary importance in determining the etiology and level of biliary obstruction. For the differential diagnosis of etiological factors of obstructive jaundice, we used non-invasive and minimally invasive radiological methods: ultrasound – 203, magnetic resonance cholangiopancreatography – 98, multislice computed tomography – 74, endoscopic retrograde cholangiopancreatography - 138, percutaneous transhepatic cholangiography – 27. In order to determine the informativeness, we evaluated the detection of concretions, strictures of the bile ducts, mass lesions, dilation of intra- and extrahepatic bile ducts. Methods of elimination of biliary hypertension were various types of endoscopic decompression, which were performed in combination with endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography. We compared the following aspects: the possibility of performing these types of decompression of the bile ducts, their effectiveness in eliminating jaundice and complications. Based on our results, we developed a 3-stage diagnostic and treatment algorithm, whose efficiency in the elimination of mechanical jaundice was 96.0 %.Документ Analysis of clinical parameters of scar tissue of the scalp and neck depending on the circadian rhythm of the patient(Полтавський державний медичний університет, 2022) Skikevych, M. G.; Toropov, O. A.; Voloshyna, L. I.; Yatsenko, P. I.; Steblovskyi, D. V.; Boyko, I. V.; Avetikov, D. S.; Скікевич, Маргарита Георгіївна; Торопов, Олександр Анатолійович; Волошина, Людмила Іванівна; Яценко, Павло Ігорович; Стебловський, Дмитро Валерійович; Бойко, Ігор Васильович; Аветіков, Давид СоломоновичWound healing is a complex and dynamic process. It consists of phases that are closely related. The formation of the postoperative scar is influenced by: the topography of the surgical field, the duration of the inflammatory process, the method of surgical intervention, the time of surgical intervention and the patient's chronotype. In 1970, the Swedish psychologist Oscar Okvist began the scientific study of chronotypes. According to him, the term “chronotype” is used to define the individual characteristics of the circadian rhythm of man.Biological rhythms play an important role in adaptation and survival in the environment. According to previous research, biological rhythm affects not only the mental state, but also reparative functions during wound healing and rehabilitation in the postoperative period.Документ Anticholinergic burden in aging patients and its role in the development of bladder decompensation(Полтавський державний медичний університет, 2022) Pustovoit, G. L.; Sarychev, L. P.; Savchenko, R. B.; Sarychev, Y. V.; Ustenko, R. L.; Sukhomlin, S. A.; Пустовойт, Ганна Леонідівна; Саричев, Леонід Петрович; Савченко, Роман Борисович; Саричев, Ярослав Володимирович; Устенко, Роман Леонідович; Сухомлин, Сергій АдольфовичАнтихолінергічне навантаження розглядають як кумулятивний ефект від прийому препаратів з антихолінергічною активністю. У статті наведено дані про роль антихолінергічного навантаження в розвитку декомпенсації сечового міхура у хворих на доброякісну гіперплазію передміхурової залози. Обстежено 381 пацієнтів із доброякісною гіперплазією передміхурової залози в стадії субкомпенсації та декомпенсації сечового міхура. Антихолінергічне навантаження у пацієнтів літнього віку може розвиватися як в результаті прийому препаратів з високою потенційною антихолінергічної активністю, так і в результаті тривалого застосування препаратів з низькою потенційною антихолінергічної активністю. Препарати з високою потенційною антихолінергічною активністю зменшують симптоми гіперактивного сечового міхура у пацієнтів з доброякісною гіперплазією передміхурової залози, але антихолінергічне навантаження стає фактором поглиблення декомпенсації сечового міхура, що погіршує результати хірургічного лікування.Документ Biomechanical aspects of postural control of the human body(Полтавський державний медичний університет, 2022) Strashko, Ye.Yu.; Morokhovets, H. Yu.; Stetsenko, S. А.; Berezhna, V. А.; Kondratieva, Ye. О.; Horsha, O. V.; Stetsuk, Ye. V.; Страшко, Євген Юрійович; Мороховець, Галина Юріївна; Стеценко, Сергій Анатолійович; Бережна, Варвара Анатоліївна; Кондратьєва, Єлізавета Олександрівна; Горша, Оксана Вікторівна; Стецук, Євген ВалерійовичМатка являє собою м'язово-еластично-колагенову систему важелів, що беруть участь у стабілізації пози жінки під час вагітності, перебуваючи в нехарактерному стані внаслідок змін сполучнотканинних елементів як матки, так позаматкових структур. При збільшенні матки під час вагітності змінюється відновлення типової постави за рахунок змін в її м'язово-еластичному апараті, а також в еластично-коллагенових зв'язках з кістками таза. Важливо, що щільна ділянка зв’язок є колагеновою структурою і є найменш еластичним компонентом цього ланцюга. Матка прикріплюється до малого тазу зсередини, а ділянки зовнішніх спіроїдних динамічних м’язових ланцюгів прикріплюються ззовні, обплітаючи тіло як гомолатерально, так і гетеролатерально. Виходячи з вищесказаного, ми припускаємо, що це синергетичні та взаємоконкуруючі біомеханічні структури. Порушення балансу цих структур може призвести до неоптимального стану організму вагітної в статиці та динаміці.Документ Changes in corticosterocytes of the zona reticularis and сhromaffin cells of the adrenal gland in rats during the inhibition of testosterone synthesis(Полтавський державний медичний університет, 2022) Skotarenko, T. A.; Shepitko, V. I.; Stetsuk, E. V.; Boruta, N. V.; Скотаренко, Тетяна Анатоліївна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Борута, Наталія ВолодимирівнаMetabolic disorders, which are the main causes of many diseases and can be linked to the pathogenesis of other nosologies, remain relevant objects of scientific research. It has been proved that testosterone is an important biological regulator of metabolic processes in the male body. Modern studies are performed on the effect of testosterone deficiency on the state of neurons, testicles, liver and other body organs and tissues. The paper describes the main morphological changes of corticosterocytes of the reticular zone of the cortical substance and chromaffin cells of the medulla of the adrenal glands of white rats during central deprivation of testosterone synthesis through experimental blockade of gonadotropic hormones. It was established that inhibition of testosterone synthesis led to dystrophic changes and disruption of the synthetic function of corticosterocytes of the reticular zone, which was manifested at the microscopic level by the variability of morphometric indicators.Документ Changes in nitric oxide production and development of oxidative stress in rats heart during prolonged triptorelin-induced central deprivation of luteinizing hormone synthesis(Poltava State Medical University, Poltava, 2022) Voroshilova, T. A.; Shepitko, V. I.; Stetsuk, Ye. V.; Akimov, O. Ye.; Puzyryov, G. S.; Ворошилова, Тетяна Анатоліївна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Акімов, Олег Євгенович; Пузирьов, Гай СергійовичCentral deprivation of luteinizing hormone synthesis for 365 days leads to the development of oxidative stress in rat hearts. The peak of oxidative damage to the heart under these conditions happens on the 180th day of the central deprivation of luteinizing hormone synthesis. Production of nitric oxide during central deprivation of luteinizing hormone synthesis undergoes complex changes from an initial decrease of NO-synthase-dependent nitric oxide production on the 30th and 90th day to overproduction of nitric oxide from NO-synthases on the 365th day of the experiment.Документ Changes in the trigeminal ganglion of rats with acute carrageenaninduced inflammation(Полтавський державний медичний університет, 2022) Danyliv, О. D.; Shepitko, V. I.; Yakushko, O. S.; Stetsuk, Ye. V.; Boruta, N. V.; Данилів, Оксана Дмитрівна; Шепітько, Володимир Іванович; Якушко, Олена Святославівна; Стецук, Євген Валерійович; Борута, Наталія ВолодимирівнаThe purpose of the study was to establish the response of the components of the trigeminal ganglion in rats to aseptic inflammation under experimental conditions. The study was performed on 40 mature white male rats. Trigeminal ganglion of rats was the object of the study. The animals were divided into two groups: the control group of animals (5), which were injected with isotonic NaCl solution and the group of experimental animals (35), which were simulated acute carrageenan-induced inflammation. The rats were sacrificed within days 3, 5, 7, 10, 14, 21, and 30 under thiopental anesthesia overdose. Histological examination showed that carrageenan-induced inflammation in the trigeminal ganglion of rats had a staged course. Reactive changes in the vessels of the hemomicrocirculatory bed were most pronounced on the 5th day of observation. After that, the blood flow gradually stabilised until its complete normalization on the 14th day. Signs of reactive changes in neurons in the form of gradual oedema of the cytoplasm and nucleus and perinuclear chromatolysis were already noticed in the early stages of the experiment. The nature of the changes intensified with the increase in the observation period. Some cells showed signs of degenerative-dystrophic processes. The proliferative activity of glial cells increased in response to changes in neurons. The signs of inflammation in the parenchyma reached their maximum manifestation on the 14th day with an incomplete regeneration process for up to the 30th day.Документ Chronic periodontitis in patients with chronic duodenal ulce(Poltava State Medical University, 2022) Kharchenko, А. V.; Yelinska, A. M.; Shepitko, V. I.; Stetsuk, E. V.; Харченко, О. В.; Єлінська, Аліна Миколаївна; Шепітько, Володимир Іванович; Стецук, Євген ВалерійовичThe integumentary epithelium of the gastric mucosa, which is a continuous secretory field, serves to protect against gastric juice's aggressive properties, a product of the secretory activity of the gastric glands. The interdental papillae of the human gums do not contain any glandular structures. Their hydration is carried out due to the secretory activity of the salivary glands. But this does not exhaust the question of the similarities and differences between these two types of mucous membranes [9]. Summarizing our study of the mucous membranes of the gastric papillae and the gastric mucosa, we can note similar inflammatory processes in these two zones of the digestive tract, causing destructive changes and processes that distinguish the response to chronic inflammation of the gastric mucosa from the epithelium. Such differences are in the development of dystrophic processes, disturbance of regenerative and development of dysregenerative processes in the form of dysplasia of various degrees of expression in the gastric mucosa compared to the mucous membrane of the gingival papillae. There is a difference in the proliferative activity of these two mucous membranes. But the cellular immune response of these parts of the mucous membrane to the infectious factor Hp has common manifestations in the form of areas infiltrated by the lymphohistiocytic elements [5, 15], which demonstrates the connection between inflammatory processes in these parts of the digestive system. The formation of granulations and fibrous tissue occurs.Документ Clinical and diagnostic aspects of managing patients with valvular heart disease(Полтавський державний медичний університет, 2022) Shaposhnyk, O. A.; Prykhodko, N. P.; Savchenko, L. V.; Shevchenko, T. I.; Sorokina, S. I.; Yakymyshyna, L. I.; Kudria, I. P.; Шапошник, Ольга Анатоліївна; Приходько, Наталія Петрівна; Савченко, Леся Володимирівна; Шевченко, Тетяна Іванівна; Сорокіна, Світлана Іванівна; Якимишина, Лариса Іллівна; Кудря, Ірина ПавлівнаThe article presents the results of examination of 47 patients with valvular heart disease. According to the research findings, when investigating the causes of severe mitral regurgitation, especially in young and middle-aged people, one should primarily consider Barlow's disease, myxomatous mitral valve degeneration, as the primary cause (having excluded fibroelastic deficiency). It was found that among all cases of detected mitral valve prolapse (even minor or moderate), which is currently diagnosed quite often with the development of modern technology, stratification of patients requires additional examinations to identify people at high risk of disease progression and complications, as well as to determine the prognosis.Документ Clinical features of influence of different groups of bleaching agents in the oral cavity at different periods after the end of the treatment(Полтавський державний медичний університет, 2022) Dvornyk, A. V.; Dvornyk, V. M.; Vodoriz, Y. Y.; Skripnykov, P. M.; Tkachenko, I. M.; Дворник, Анна Валентинівна; Дворник, Валентин Миколайович; Водоріз, Ярослав Юрійович; Скрипников, Петро Миколайович; Ткаченко, Ірина МихайлівнаThe purpose of the study was to assess the clinical changes in the oral cavity after using teeth bleaching systems of different compositions. Totally 65 patients were examined. All patients were 20 to 40 years old and had no severe dental and somatic pathology. This clinical study evaluated the effectiveness and side effects of two products for teeth bleaching. The difference in clinical indicators after the bleaching procedure with the selected gels on the microelement structure of oral liquid was detected. We noticed a significant difference in calcium and sodium indices in the oral fluid. Teeth bleaching agents cause tooth sensitivity manifested by changes in the oral fluid viscosity, pH, and the micronutrient composition. Depending on the bleaching agent used, the teeth bleaching procedure should be completed with remineralizing therapy.Документ Comparison of the effect of antiseptics based on Decamethoxine, Chlorhexidine bigluconate and Iodophorm on the adhesive potential of bacteria of the genus Kocuria spp(2022) Лобань, Галина Андріївна; Фаустова, Марія Олексіївна; Чумак, Юлія Вікторівна; Ананьєва, Майя Миколаївна; Гаврильєв, Віктор Миколайович ; Аветіков, Давид Соломонович; Стебловський, Дмитро Валерійович; Loban', G. A.; Faustova, M. O.; Chumak, Yu. V.; Avetikov, D. S.; Ananieva, M. M.; Gavriliev, V. M.; Steblovskiy, D. V.Antiseptics can block the adhesion of bacteria, thus facilitating the course of the purulent-inflammatory process. Therefore, we investigated the adhesive properties of clinical isolates of the genus Kocuria isolated from the oral cavity of patients with infectious-inflammatory post-extraction complications. Remedies based on decamethoxine, chlorhexidine bigluconate and iodoform were used as test antiseptics. The adhesive properties of clinical isolates under the action of remedies based on decamethoxine, chlorhexidine bigluconate and iodoform were determined by V.I. Brillis. The adhesion index values of microorganisms of clinical isolates of the genus Kocuria under the action of subbacteriostatic concentration of remedy based on decamethoxine were 1.6 times (p<0.05) and 2.1 times (p<0.05) lower compared to those of the adhesion index of microorganisms after the action of remedies based on chlorhexidine bigluconate subbacteriostatic concentrations and iodoform respectively. In the presence of remedy based on chlorhexidine bigluconate SBsC, relative to the clinical isolates Kocuria kristinae 1 and Kocuria kristinae 2, IAM indices increased 1. 3 times, and IAM indices of Kocuria rosea increased 1.1 times compared to the IAM indices of the controls of these isolates. Considering the results of action remedy based on iodoform SBsC on clinical isolates Kocuria kristinae 1 and Kocuria kristinae 2, IAM increased in 2.1 times and in 1.5 times, IAM of clinical isolate Kocuria rosea also increased, but in 1.4 times, considering the control cultures.Документ Detection and assessment of disorders of the depressive spectrum in patients with acute myocardial infarction depending on the method of treatment(Полтавський державний медичний університет, 2022) Kudria, I. P.; Shevchenko, T. I.; Voroshilova, T. A.; Tretiak, N. H.; Kryvoruchko, I. H.; Pushko, O. О.; Shaposhnyk, О. А.; Кудря, Ірина Павлівна; Шевченко, Тетяна Іванівна; Ворошилова, Тетяна Анатоліївна; Третяк, Наталія Григорівна; Криворучко, Іван Григорович; Пушко, Олександр Олександрович; Шапошник, Ольга АнатоліївнаThe frequent combination of mental disorders of the depressive spectrum and cardiovascular diseases is one of the most urgent problems of modern medicine. The purpose of the study was to identify and assess, with the help of various psychodiagnostic methods, the degree of severity of depressive disorders in patients with acute myocardial infarction depending on the treatment method as a prerequisite for optimal drug therapy. 73 patients with the aforementioned pathology were studied and were divided into two groups. Group I included 44 patients who underwent urgent coronary angiography with subsequent stenting of the infarct-related coronary artery; Group II – included 29 patients who received only drug therapy. Examination of patients was carried out according to Ukrainian standards, in particular, a survey according to the scale of Beck and Zung. Patients with acute myocardial infarction after urgent coronary angiography with stenting of the infarct-dependent artery were more likely to have mild and moderate depression according to the Beck scale compared to patients who received only conservative medical treatment. The reverse pattern is observed for moderate and severe depression. 68.2% of patients with acute myocardial infarction after interventional intervention and 62.1% on the background of conservative treatment according to the Zung scale showed depression of various degrees of severity, mostly mild.Документ Diagnostic and treatment approaches to acute pancreatitis in pregnant women(Полтавський державний медичний університет, 2022) Mishchenko, V. V.; Mishchenko, V. P.; Rudenko, I. V.; Pustovoyt, P. I.; Likhachov, V. K.; Dobrovolʹsʹka, L. M.; Makarov, O. H.; Міщенко, Василь Васильович; Міщенко, Валентина Павлівна; Руденко, І. В.; Пустовойт, Павло Іванович; Ліхачов, Володимир Костянтинович; Добровольська, Людмила Миколаївна; Макаров, Олег ГеннадійовичЧастота виникнення гострого панкреатиту складає від 1:1500 до 1:10000 вагітностей. Мета дослідження полягала у вдосконаленні діагностичних та лікувальних підходів при гострому панкреатиті у вагітних. Під наглядом була 21 вагітна жінка з гострим панкреатитом. Постановка діагнозу гострого панкреатиту у вагітних ґрунтувалась на критеріях класифікації Atlanta (2013). Комплексне консервативне лікування гострого панкреатиту у вагітних полягало у призначені октреотиду, інгібіторів протонної помпи, у II триместрі ‒ інгібіторів протеаз, напівсинтетичних пеніцилінів, цефалоспоринів III‒IV поколінь. Слід проводити корекцію водно‒електролітного балансу, відшкодування втрати плазми, порушень мікроциркуляції, боротьбу з набряком підшлункової залози та парапанкреатичної клітковини. Перебіг гострого панкреатиту у вагітних у 52,4 % випадків характеризувався середнім та тяжким ступенем тяжкості, що супроводжувалось дистресом плода. Летальних випадків не було. Впровадження застосованих нами діагностичних та лікувальних підходів при гострому панкреатиті у вагітних дозволило уникнути летальності, хірургічних та акушерсько-перинатальних ускладнень. Ведення вагітних із гострим панкреатитом є вкрай складним завданням і в першу чергу залежить від ступеня тяжкості гострого панкреатиту у таких хворих. Ведення вагітних, які хворіють на гострий панкреатит, вимагає мультидисциплінарного підходу для прогнозування перебігу панкреатиту, визначення тактики ведення вагітності при цьому, способу і термінів розродження.Документ Extracellular matrix of rat liver under the conditions of combining systemic inflammatory response syndrome and chronic alcohol intoxication(Полтавський державний медичний університет, 2022) Mykytenko, A. O.; Akimov, O. Ye.; Yeroshenko, G. A.; Neporada, K. S.; Микитенко, Андрій Олегович; Акімов, Олег Євгенович; Єрошенко, Галина Анатоліївна; Непорада, Каріне СтепанівнаThe aim of this study was to establish the effect of systemic inflammatory response syndrome on the background of chronic alcohol intoxication on the concentration of oxyproline, glycosaminoglycans and sialic acids in the liver of rats. The study was performed on 24 male Wistar rats. Animals were divided into 4 groups of 6 animals: I – control; II – systemic inflammatory response syndrome group; III – alcoholic hepatitis groupand IV – animals with a combination of systemic inflammatory response syndrome and chronic alcohol intoxication. The concentrations of glycosaminoglycans, heparin-heparan, keratan-dermatan and chondroitin fractions of glycosaminoglycans, free oxyproline and sialic acids were studied in the liver tissue homogenate. The combination of systemic inflammatory response syndromeand chronic alcohol intoxication leads to ncreased intensity of collagenolysis, glycoprotein catabolism and reduced intensity of breakdown of proteoglycans of connective tissue of the liver. However, it changes the ratio of individual fractions of glycosaminoglycans in the direction of reducing тtheconcentration of anti-inflammatory and increasing regenerative.Документ General description of patients with community-acquired pneumonia Who passed an open comparative study(Полтавський державний медичний університет, 2022) Berezniakov, V. I.; Кorzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Zvyagolska, І. М.; Sharlay, N. М.; Березняков, Владислав Ігорович; Корж, А. Н.; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Звягольська, Ірина Миколаївна; Шарлай, Наталія МиколаївнаThe article provides a general description of the etiology and pathogenesis of patients with community-acquired pneumonia who passed an open comparative study at the Kharkiv Municipal Clinical Hospital No. 25. The most likely causative agents of community-acquired pneumonia in patients of the Therapeutic Department of the Kharkiv Municipal Clinical Hospital No 25 are Streptococcus pneumoniae and mixed cultures of bacteria, with an increase in the proportion of Staphylococcus aureus. In modern conditions, when choosing the tactics of antimicrobial therapy for community-acquired pneumonia, it is necessary to consider not only the spectrum of the most likely pathogens, but also the trends in the formation of antibiotic resistance in the leading etiological groups. It is impractical to prescribe empirical antibiotic therapy for community-acquired pneumonia without establishing an etiological diagnosis.Документ Influence of behavioral factors on health indicators оf school students at the regional level(Полтавський державний медичний університет, 2022-12) Holovanova, I. A.; Lesko, O. M.; Obrevko, N. O.; Liakhova, N. O.; Bielikova, I. V.; Голованова, Ірина Анатоліївна; Лесько, О. М.; Обревко, Н. О.; Ляхова, Наталія Олександрівна; Бєлікова, Інна ВолодимирівнаThe article analyzes the state of health of schoolchildren aged 10–15 in Kremenchuk and investigates the influence of behavioral risk factors. It was established that the movement activity of schoolchildren is insufficient, 19.2 % have an increased BMI. Detected violations of food behavior, manifested in the replacement of a “healthy snack” with sweets in 30.8 % or refusal of snacks in 12.2 %. 12.8 % of schoolchildren note insufficient duration of night sleep, which leads to overtiredness. It has been established that children 13–15 years are significantly less engaged in physical education; do not follow the rest regime, reducing the time of night sleep; they use fruits, vegetables or yogurts for snacks much less often, preferring snacks and sweets. It was found that 56.4 % of children get sick more than once a year, the influence of behavioral risk factors on the frequency of colds was proven: children who did not do physical education were 3 times more getting colds than those who did active lifestyle; “unhealthy” snacking on sweets and snacks increased the risk of frequent colds by 2 times.Документ Influence of food additives complex on the morphology of villi of the rats’ duodenum mucosa(Полтавський державний медичний університет, 2022) Yeroshenko, G. A.; Grygorenko, A. S.; Shevchenko, K. V.; Lysachenko, O. D.; Riabushko, O. B.; Pyvovar, N. M.; Klepets, O. V.; Єрошенко, Галина Анатоліївна; Григоренко, Альона Сергіївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Рябушко, Олена Борисівна; Клепець, Олена Вікторівна; Пивовар, Ніна МихайлівнаThe study presents the findings of the study of the effect of food additives, namely, monosodium glutamate, sodium nitrite and Ponceau-4R on the morphological state of the components of the villi of the rats’ duodenal mucosa. The study was aimed at establishing the dynamics of changes in the metric parameters of the components of the villi of rats’ duodenal mucosa in normal conditions and under the action of the complex of food additives. It has been found that consumption of the complex of food additives leads to changes in the metric values of the height and width of the villi, which at the early stages of the experiment leads to a decrease in their mean values due to the immediate direct action on the mucous membrane with subsequent development of inflammatory reaction and edema, which will lead to an increase in metric values and a decrease in the number of epithelial cells of the villus. Adaptive mechanisms do not fully restore the values of the morphometric study, which is manifested by a decrease in the height of the villi by 20.25 % compared with the control group with an increase in the number of enterocytes with brush border and a decrease in the number of goblet cells by 44.41 %.Документ Influence of transcription factor κB on remodeling of extracellular matrix of rat liver under conditions of chronic alcohol intoxication(Полтавський державний медичний університет, 2022) Mykytenko, A. O.; Akimov, O. Ye.; Yeroshenko, G. A.; Neporada, K. S.; Микитенко, Андрій Олегович; Акімов, Олег Євгенович; Єрошенко, Галина Анатоліївна; Непорада, Каріне СтепанівнаLiver fibrosis is a common tissue reaction associated with chronic liver damage resulting from prolonged parenchymal cell damage and inflammation. The fibrogenic response is characterized by the progressive accumulation of extracellular matrix components enriched in collagen fibrils and impaired extracellular matrix remodeling. The aim of this study was to establish the effect of transcriptional factor κB on the concentration of oxyproline, glycosaminoglycans and sialic acids in the liver of rats under conditions of chronic alcohol intoxication. The study was performed on 24 male Wistar rats. The animals were divided into 4 groups of 6 animals: І – control; II – animals with inhibition of κB; ІІI – animals with chronic alcohol hepatitis and ІV – animals with κB inhibition on the background of chronic alcohol intoxication. We studied the total concentration of glycosaminoglycans, concentration of heparin-heparan, keratan-dermatan and chondroitin fractions of glycosaminoglycans, free oxyproline and sialic acids in the liver tissue homogenate. Prolonged alcohol intoxication of rats leads to remodeling of the extracellular matrix as evidenced by increased collagenolysis and catabolism of glycoconjugates of amorphous connective tissue of the liver. The use of the inhibitor of the transcription factor κB in the background of prolonged alcohol intoxication of animals reduced the concentration of GAG by 1.43 times, lowered oxyproline concentration by 1.6 times and decreased the concentration of sialic acids by 1.14 times compared to chronic alcohol intoxication group. Transcriptional factor NF-κB under conditions of chronic alcohol intoxication affects the architectural remodeling of connective tissue of rat liver by increasing degradation of collagen fibers and destruction of glycoproteins and proteoglycans of the extracellular matrix.Документ Influence of vacuum instillations with intravenous introduction of nitrogen oxide donators on the healing of purulent soft tissue wounds(Полтавський державний медичний університет, 2022-02) Gorodova-Andreeva, T. V.; Lyakhovskiy, V. I.; Sydorenko, A. V.; Городова-Андрєєва, Тамара Валер'янівна; Ляховський, Віталій Іванович; Сидоренко, Архип ВолодимировичThe efficacy of vacuum therapy with instillations of L-arginine was studied in combination with its intravenous infusion. Results were in 89 patients, treated for purulent-necrotic soft tissue diseases. Patients were emergency operated on. The main group - 44 patients, got the same therapy and intravenous 100 ml of arginine hydrochloride solution daily. 2-3 courses of vacuum therapy, 3 days each were performed. In the main group, signs of intoxication and body temperature returned to normal by an average of 3.1 days. Normalization of the level of leukocytes was observed in 5.4 days. pH-metry from the wound surface, it was found that significant changes in the average pH of patients in the main group were observed for 7-10 days - the beginning of the regeneration phase. The therapy in the main group in comparison with typical local treatment provided accelerated wound cleansing, reduction of microbial contamination and faster transition of purulent-necrotic phase to regeneration.Документ Molecular and genetic characteristics of adenovirus as causes of acute diarrhea in the people of southern Ukraine(Полтавський державний медичний університет, 2022) Appelkhans, O. L.; Kozishkurt, O. V.; Hrytsenko, K. S.; Boruta, N. V.; Shablii, T. P.; Hruzevskyi, O. A.; Naidich, O. V.; Аппельханс, Олена Леонідівна; Козішкурт, Олена Володимирівна; Гриценко, К. С.; Борута, Наталія Володимирівна; Шаблій, Тетяна Петрівна; Грузевський, Олександр Анатолійович; Найдіч, Ольга ВолодимирівнаThe etiological role of adenoviruses as causative agents of acute diarrhea in the southern region of Ukraine was studied. Adenovirus DNA was detected in 10.61±1.05 % of clinical stool samples. Serotypes of two gene groups: C and F were identified during genotyping and sequencing of genetic material of detected adenovirus isolates. Gene group F (HAdV41), proves their role in the occurrence of this infectious pathology. HAdV41 isolates had a significant advantage 75.0±15.31 % and had a pronounced genetic heterogeneity, showed similarities with serotypes circulating in previous years in different regions of the world: Sweden (1978), Japan (2003, 2006), South Africa (2009–2014), Iraq (2016). The obtained results allowed to establish the geographical origin of circulating adenoviruses, as well as to predict a further increase in the intensity of the epidemic process of adenoviral infections in southern Ukraine.