Наукові праці. Кафедра хірургічної стоматології та щелепно-лицевої хірургії
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Перегляд Наукові праці. Кафедра хірургічної стоматології та щелепно-лицевої хірургії за Автор "Avetikov, David"
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Документ Biological Properties of Streptococcus pluranimalium as the New Human Pathogen(Open Access Macedonian Journal of Medical Sciences, 2023-01-17) Ananieva, Maiia; Faustova, Mariia; Loban, Galina; Avetikov, David; Tkachenko, Pavlo; Bobyr, Vitalii; Dobrovolska, Oksana; Ананьєва, Майя Миколаївна; Фаустова, Марія Олексіївна; Лобань, Галина Андріївна; Аветіков, Давид Соломонович; Ткаченко, Павло Іванович; Бобир, В. В.; Добровольська, Оксана ВолодимирівнаBackground: The limited amount of information available today does not fully reflect the biological properties of Streptococcus pluranimalium as a pathogen new to humans, its pathogenicity factors, and, as a consequence, the pathogenesis of diseases, which is causes Aim: The aim of this research was to study the biological properties of S. pluranimalium, its sensitivity to antibiotics and antiseptics, as well as its adhesive properties. Methods: Two hundred samples were collected from the coronal pockets in patients with acute purulent pericoronitis during 2019–2021 years. Among them, five clinical strains of S. pluranimalium were isolated. Final identification was carried out using a Vitec-2compact bioMérieux automatic bacteriological analyzer. The sensitivity of the studied microbial strains to antibiotics of various groups was determined by the disk diffusion method. The adhesive properties of S. pluranimalium were determined according to the standard Brilis method. Results: It possesses typical morphological and cultural properties characteristics of the genus Streptococcus representatives. This microorganism virtually does not break down carbohydrates, but it produces arylamidases that enables it to be differentiated from other streptococci. S. pluranimalium demonstrates variable sensitivity to antibiotics; the lowest sensitivity has been found out to the second-generation fluoroquinolones. In addition, the clinical isolates studied show high adhesive properties to human red blood cells.Документ CCL2/MCP-1 Serum Chemokine Level in Patients with Odontogenic Infectious and Inflammatory Diseases of the Soft Tissues of the Maxillofacial Area and Mediastinum(Acta Facultatis Medicae Naissensis, 2022) Faustova, Mariia; Nazarchuk, Oleksandr; Dmytriiev, Dmytro; Avetikov, David; Loban, Galina; Babina, Yuliana; Ananieva, Maiia; Фаустова, Марія Олексіївна; Аветіков, Давид Соломонович; Лобань, Галина Андріївна; Ананьєва, Майя МиколаївнаAim. The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum. Methods. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients’ plasma CCL2/MCP-1 level was determined using a kit for specific ELISA.Документ Comparative characteristics of the properties of dental implants depending on the design, shape and surface in the experiment(Ausra, Kaunas, Lithuania, 2023) Kaplun, Dmytro; Avetikov, David; Lokes, Kateryna; Ivanytska, Olena; Каплун, Дмитро Володимирович; Аветіков, Давид Соломонович; Локес, Катерина Петрівна; Іваницька, Олена СергіївнаThe aim of the study. Compare the properties of different dental implants depending on the design, shape and surface area in the experiment. Materials and methods. Dental implants with similar sizes (5.5×10 mm) were selected: Vitaplant VPKS, Mega Gen AnyRidge and Alpha Dent Superior Active. The calculation of the total area of the implants was performed and the implants were immersed in a ferromagnetic substance. Results and discussion. The small number of turns and their small length of the Vitaplant implant cannot create a large surface area (this size of the implant has an area of 174.7 mm2 ). On the thin, slightly conical body of the MegaGen implant (North Korea), the developer placed 10 turns of thread with wide blades. Due to the data design features, this implant has the largest surface area (276.5 mm2 ), which is an advantage in implant integration. The same number of turns (10) and a very similar frequency bring Alpha Dent implants (Germany) closer to the implant described above, but the design implements an innovative anti-rotation system. This implant size has a total surface area of 210.5 mm2 . Conclusions. The implant Vitaplant VPKS is inferior in effi ciency of the geometry of the implant Mega Gen AnyRidge by 24%, and the implant Alpha Dent Superior Active in turn ahead of the effi ciency of the representative of the Korean company by 8.9%. The shape of the geometry of the implant affects the effectiveness of counteracting the masticatory load more than its surface area.Документ Expression of periferal core molecular clock genes in oral mucosa depends on the chronotype in patients with maxillofacial cellulitis(Journal of Oral Biology and Craniofacial Research, 2023-09) Lokes, Kateryna; Lychman, Vitaliy; Izmailova, Olga; Shlykova, Oksana; Avetikov, David; Kaidashev, Igor; Локес, Катерина Петрівна; Личман, Віталій Олександрович; Ізмайлова, Ольга Віталіївна; Шликова, Оксана Анатоліївна; Аветіков, Давид Соломонович; Кайдашев, Ігор ПетровичIntroduction: Accurate determination of the patient’s chronotype is one of the problems of personalized medicine. Recent studies have shown that determining of the expression of timing genes is a valuable method that can help gain molecular insight into a patient’s intrinsic circadian timing. Odontogenic cellulitis is very common pathology. Since acute inflammatory diseases are an urgent pathology, the time of surgical intervention can correspond depend on the time of the patient’s hospitalization. Materials and methods: The level of mRNA expression of peripheral circadian clock genes clock and bmal1, per1, cry1 in buccal epithelial cells in patients with odontogenic purulent inflammatory diseases of maxillofacial area in the morning and evening was investigated.Документ Microbiological substantiation of the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic phlegmon and maxillofacial abscesses(2024-01-19) Lokes, Kateryna; Kiptilyi, Anatolii; Skikevych, Margaryta; Steblovskyi, Dmytro; Lychman, Vitaliy; Bilokon, Serhii; Avetikov, David; Локес, Катерина Петрівна; Кіптілий, Анатолій Васильович; Скікевич, Маргарита Георгіївна; Стебловський, Дмитро Валерійович; Личман, Віталій Олександрович; Білоконь, Сергій Олександрович; Аветіков, Давид СоломоновичOdontogenic infections can become life-threatening. The aim of the study was to determine the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic infections by assessing the microbial population of the infection site