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Документ Adaptation of polymerase chain reaction-restriction fragment length polymorphism method for polymorphism (rs2583988) analysis in alpha-synuclein gene(Українська медична стоматологічна академія, 2020) Tarianyk, K. A.; Lytvynenko, N. V.; Oliinychenko, V. K.; Byslik, T. V.; Pochernyaev, K. F.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Олійниченко, Є. К.; Буслик, Т. В.; Почерняєв, К. Ф.The article suggests the polymerase chain reaction-restriction fragment length polymorphism method for a single nucleotide polymorphism (rs2583988) detection for further prediction of Parkinson’s disease risks. Based on the meta-analysis results for the single nucleotide polymorphism rs2583988 (C>T) in αlpha-synuclein gene; current polymorphic variant was chosen by analyzing bioinformatical and genetic studies. We have designed a pair of primers and conditions for restriction analysis to detect different alleles in rs2583988. As a result, there was developed a simple and affordable method for detecting single nucleotide polymorphism rs2583988 alleles. The method is expected to be suitable for clinic laboratories, due to affordable cost and equipment, and to be used in further association studies.Документ Chronotype and daily functioning of patients with different motor subtypes of parkinson disease(Полтавський державний медичний університет, 2024) Shkodina, A. D.; Bardhan, M.; Tarianyk, K. A.; Delva, M. Yu.; Шкодіна, Анастасія Дмитрівна; Бардхан, Майняк; Таряник, Катерина Анатоліївна; Дельва, Михайло ЮрійовичIntroduction. Sleep and circadian rhythm disturbances can occur at any stage of Parkinson disease (PD) and significantly affect quality of life. Chronotypes of patients with PD are associated with different phenotypes, in particular with the motor subtype. Thus, we hypothesized that patients with different motor subtypes of PD may have differences in the distribution of chronotypes and patterns of daily activity. Methods and materials. We conducted clinical research on the basis of the Centre for Parkinson Disease and Neurodegenerative Diseases of the Department of Neurological Diseases of Poltava State Medical University. PD was verified according to the recommendations of the International Movement Disorders and Parkinson's Disease Society. The motor subtype of PD was determined by the Stebbin method, which is based on the calculation of the Stebbins coefficient by the sum of the Unified PD Rating Scale scores. The examined patients were divided into 3 groups according to the motor subtype of PD: group 1 (n = 38) - patients with PD subtype with the predominance of postural instability and gait disorders (PIGD); group 2 (n = 26) - patients with PD subtype with the predominance of tremor and mixed subtype; control group (n = 30) - conditionally healthy individuals without CNS lesions. Circadian patterns were analyzed using the Munich Chronotype Questionnaire (MCTQ). Results. It was found that in PD patients sleep onset and time of getting out of bed was later (p<0.001 and p=0.042, respectively), sleep latency was longer (p<0.001), sleep duration was shorter (p=0.001), the mid-sleep corresponded to a later time (p<0.001). Patients with the PIGD subtype had a later time of getting out of bed (p=0.038), longer sleep inertia (p<0.001), shorter sleep duration (p<0.001), and later mid-sleep time (p=0.028). We have shown the tendency of patients with PD, mostly in the PIGD subtype, to later chronotypes (p<0.001). Light exposure indirectly moderately correlated with mid-sleep in all study groups. It was found that both the motor subtype (p<0.001) and the level of light exposure during the day (p<0.001) statistically significantly affect the mid-sleep. Conclusion. Thus, we have found that patients with PD differ from age-matched controls without neurodegenerative diseases by chronotype and circadian pattern of functioning. The motor subtype of the disease is associated with circadian differences, namely, the PIGD subtype is associated with shorter sleep duration, a predisposition to a later chronotype, and longer sleep inertia.Документ Circadian rhythm disorders and non-motor symptoms in different motor subtypes of Parkinson's disease(Georgian Association of Business Press, 2021) Tarianyk, K. A.; Shkodina, A. D.; Lytvynenko, N. V.; Таряник, Катерина Анатоліївна; Шкодіна, Анастасія Дмитрівна; Литвиненко, Наталія ВолодимирівнаThe phenotype of the disease depends not only on the prevalence of certain motor signs, but also on non-motor symptoms. Determination of different profiles of Parkinson's disease improves disease prognosis and management. A clinical study was conducted in patients with Parkinson's disease. For this purpose, 64 patients with various motor subtypes of the disease were examined. Diagnosis was made according to the UK Brain Bank Criteria. The patients were divided into groups according to the motor subtype verified by the results of interference electroneuromyography. In each group, demographic data were collected, staging according to the Hoehn-Yahr scale and the overall score of the unified UPDRS scale were studied. The study of gait was evaluated using the Nonmotor Symptom Rating Scale for Parkinson's Disease (NMSS). The Munich Chronotype Questionnaire (MCTQ) was used to determine sleep onset, wake-up time, sleep duration, mid-sleep, average sleep duration, average weekly light exposure, chronotype, and for working patients, relative jet lag and average weekly sleep deficit. Circadian rhythm disorders were diagnosed according to the international classification of sleep disorders-3. Patients with Parkinson's disease have a more characteristic evening chronotype and a shorter sleep duration due to late sleep onset. On the other hand, the tendency towards the morning or evening chronotype is not associated with the severity of the disease or the level of daytime sleepiness. It was found that PD patients are characterized by more pronounced disorders of the gastrointestinal, genitourinary systems, sleep and cognitive-affective disorders, and others. In patients with a mixed motor subtype, mood and cognitive impairments are more pronounced, and gait disorders are more pronounced in patients with a mixed motor subtype. Thus, different motor subtypes of Parkinson's disease have differences in the severity of motor manifestations and features of the circadian rhythm. Circadian dysregulation is associated with features of daily functioning and disorders of the motor sphere.Документ Cognitive and affective disturbances in patients with Parkinson's disease: Perspectives for classifying of motor/neuropsychiatric subtypes(Elsevier, 2022-06) Shkodina, A. D.; Tarianyk, K. A.; Boiko, D. I.; Zehravi, Mehrukh; Akter, Shamima; Ashraf, Ghulam Md.; Rahman, Md. Habibur; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро ІвановичParkinson’s disease (PD) is a neurological disorder, related to rigidity, bradykinesia, and resting tremors, among other motor symptoms. It is noticed in the increasing frequency of neuropsychiatric disorders, which may be also caused by non-motor symptoms of PD. Treatment of PD is usually based on the classification of motor subtypes; however, it remains unclear whether motor subtypes have differences in the severity of psychiatric symptoms. It determines the importance of discovering possible neuropsychiatric subtypes of PD. We conducted a clinical study, which included group 1 - patients with postural instability and gait disorders dominant (PIGD) subtype, group 2 - patients with tremor dominant (TD) and indeterminate subtypes (non-PIGD), and group 3 - people who did not have CNS damage. We used the Montreal Cognitive Assessment, Russified 20-point version of the Toronto Alexithymia Scale, State-Trait Anxiety Inventory, and Beck Depression Inventory for assessment of the mental status. It was the first time that neuropsychiatric subtypes of PD had been investigated based on the condition of cognition and mood. Cluster analysis gave us the possibility to classify our patients by the following subtype: affective-cognitive PIGD, anxious PIGD, affective-cognitive non-PIGD, and non-PIGD without psychiatric symptoms. This indicates a closed link between psychiatric and motor symptoms, which can be used for the improved treatment of PD.Документ Correction of non-motor vegetative fluctuations with Parkinson`s disease based on levodopa treatment(2014) Tarianyk, K. A.; Таряник, Катерина АнатоліївнаThe influence of dopamin receptors agonists in the transdermal and oral forms of drugs and amantadine for non-motor autonomic fluctuations of ptients with different duration of the disease during the treatment of Parkinson`s in a stable dose of levodopa were established. It was analysed, that the dopamin receptors agonists in the transdermal and oral forms of drugs reduce the frequency of duration of vegetative non-motor fluctuations in patients with Parkinson`s disease. The use of amantadine sulfate has little effect in a decrease non-motor autonomic fluctuations.Документ Devic’s opticomyelitis: a case report from the authors’ clinical practice(Журнал Польської медичної асоціації, Видавництво ALUNA, Польща, 2021) Purdenko, T. Y.; Lytvynenko, N. V.; Pushko, O. O.; Ostrovska, L. Y.; Hladka, V. M.; Tarianyk, K. A.; Sylenko, H. Ya.; Kolliakova, Y. A.; Пурденко, Тетяна Йосипівна; Литвиненко, Наталія Володимирівна; Пушко, Олександр Олександрович; Островська, Людмила Йосипівна; Гладка, Вікторія Михайлівна; Таряник, Катерина Анатоліївна; Силенко, Галина Ярославівна; Коллякова, Євгенія А.The aim was to analyze the contemporary scientific literature on Devic’s opticomyelitis and to present a case report from our clinical practice. Based on the patient’s complaints, case history and features of clinical course, objective neurological status, clinical laboratory and additional examination methods, characteristic MR-patterns, consultations of related specialists and differential diagnostics, we made the clinical diagnosis according to ICD-10: G36.0 Devic’s opticomyelitis, exacerbation, with a sustained bilateral lesion of the optic nerves in the form of retrobulbar neuritis with the development of partial atrophy of the optic nerves in both eyes, spinal cord lesions with common cystic, cicatrical and atrophic alterations at C1-Th8 level with moderate lower paraparesis, expressed by sensory ataxia, sensory disturbances by the descending conductive type from Th10, mpaired function of pelvic organs by the type of acute urinary retention, asthenic and neurotic syndrome. Widespread cases of demyelinating pathology in medical practice and complexity of differential diagnostics determine the need for a specific diagnostic algorithm. This algorithm should consider anamnestic data along with the course of the disease, clinical, laboratory and instrumental examination, including neuroimaging, analysis of CSF for oligoclonal bands, analysis for IgG antibodies to AQP4, which will allow to carry out diagnostics and to decide on tactics for further management of patients of this cohort. Further research is needed to conduct additional studies for optimization of tactics for dynamics monitoring and improvement of diagnostic, treatment and rehabilitation measures in patients with Devic’s opticomyelitis, including appropriate immunological control, given the complexity of differential diagnostics and the affinity of this pathology to multiple sclerosis.Документ Diagnostic errors during intramedullar processes(Українська медична стоматологічна академія, 2019) Zohaib, Ahmed; Tarianyk, K. A. ; Таряник, Катерина АнатоліївнаДокумент Diagnostic errors during intramedullar processes(Aluna Publishing, 2019) Tarianyk, K. A.; Lytvynenko, N. V.; Purdenko, T. Y.; Hladka, V. M.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Пурденко, Тетяна Йосипівна; Гладка, Вікторія МихайлівнаIntroduction: The article describes a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which remained undetected for many years and was treated as syringomyelia. Long-term exhausting examinations of the brain and spinal cord, dynamic follow-up of medical specialists, and repeated surgical interventions on the spine helped to differentiate this process and make the correct diagnosis. The aim: The objectives of the present paper are to analyze the existing classifications of syringomyelia; to examine its etiology, pathogenesis, diagnostic approaches and treatment tactics; to present a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which was misdiagnosed as syringomyelia. Materials and methods: The authors analyzed the existing classifications of syringomyelia and studied its etiology, pathogenesis, diagnostic approaches and treatment tactics using the method of content analysis, analyticalб comparative and contrastive methods. Clinical case: The described clinical case is a variant of the course of syringomyelia, associated with the spinal cord tumor, namely, in particular, anaplastic ependymoma. For a long time, the process remained undetected, despite the long-term examination and drainage of the syringomyelic cavity. Analyzing this case, it is highly important to pay attention to careful history collection, examination of the patient, analysis of the occurrence of certain disorders in order to conduct the neuroimaging examinations in time. Conclusions: Favorable outcome of the disease is directly related to the diagnosis at early stages, especially in young people, the clinical variant of the process, progression of the course, the degree of involvement of various parts of the nervous system and extraneural formations, the severity of the lesion. The treatment tactics and the ability to restore the functions will depend on all these factors.Документ Limb-girdle muscular dystrophy, type 2a (calpainopathy): clinical observation(Полтавський державний медичний університет, 2024) Synhaivskyi, A. M.; Delva, M. Yu.; Purdenko, T. Y.; Pushko, O. O.; Tarianyk, K. A.; Sylenko, H. Ya.; Hryn, K. V.; Сингаївський, А. М.; Дельва, Михайло Юрійович; Пурденко, Тетяна Йосипівна; Пушко, Олександр Олександрович; Таряник, Катерина Анатоліївна; Силенко, Галина Ярославівна; Гринь, Катерина ВікторівнаThe article illustrates a case study derived from our clinical observations, focusing on a patient diagnosed with limb-girdle muscular dystrophy, specifically type 2A, commonly known as calpainopathy. This is a group of rare genetic diseases of non-inflammatory genesis, which are based on a primary deficiency of muscle fibers due to their atrophy. To date, more than 30 different genetic forms of limb-girdle muscular dystrophies have been identified. The article outlines the clinical manifestations and diagnostic criteria associated with this condition. The disease has an autosomal recessive type of inheritance, accounting for about 30% of all cases, and occurs as a result of a point mutation in the CAPN3 gene (15q15.1 - q21.1). The normal product of the CAPN3 gene is the proteolytic protein calpain-3, which probably ensures cytoskeletal stability. Calpain-3 is the only member of the calpain family that is present in skeletal muscle and is involved in the regulation of various tissue processes. There are 2 clinical forms of calpainopathies 2A: Leyden-Möbius type is characterized by initial weakness of the pelvic girdle muscles, which eventually spreads to the shoulder girdle, while in Erb type, weakness first manifests itself in the shoulder girdle muscles, and after a few years - in the pelvic girdle muscles. In order to diagnose calpainopathy, the doctor should be guided by the anamnesis, clinical presentation, results of laboratory, functional and medical genetic studies, and histological examination of the affected muscle. Currently, there is no specific treatment for calpainopathy. Treatment is symptomatic in nature, aimed at normalizing the patient’s general condition, restoring lost functions and possibly slowing down the rate of disease progression. Dynamic patient monitoring and symptom management improve the possibility of extending the duration and quality of life. Метою дослідження було представлення клінічного випадку пацієнта з кальпаїнопатією з метою привертання уваги у сімейних лікарів, неврологів, фізичних терапевтів, педіатрів, травматологів та інших спеціалістів. Об’єкт і методи. Скарги, анамнез захворювання і життя, об’єктивний та неврологічний огляд, лабораторні, нейровізуалізаційні та нейрофізіологічні методи дослідження. Результати. Пацієнт А., 29 років, при госпіталізації скаржився на слабкість у кінцівках, особливо в ногах, схуднення мʼязів плечей, сідниць і стегон, збільшення в обʼємі гомілок, виражене порушення ходьби, труднощі при підйомах сходами та при вставанні з ліжка. Хворіє близько 5-ти років, коли почав відмічати слабкість у проксимальних мʼязах ніг, яка поступово наростала; близько 1,5 роки тому з’явилась слабкість у проксимальних мʼязах рук. Останні 2-ва роки відмічає прогресуючу зміну ходи. За медичною допомогою звернувся вперше. Хронічні захворювання заперечує. Рухові порушення в дитинстві не визначались. Відомо, що батько та мати пацієнта є родичами у третьому поколінні. У неврологічному статусі: зниження м’язового тонусу в проксимальних відділах кінцівок, переважно в ногах. Проба Барре «+» нижня. Сила в проксимальних відділах верхніх кінцівок, а саме у дельтоподібних м’язах та біцепсах, знижена до 4,0 балів. Сила в проксимальних відділах нижніх кінцівках, а саме, у привідних м’язах стегна, згиначах та розгиначах стегна, квадрицепсах знижена до 3,0-х балів. М’язова гіпотрофія лопаткових м’язів, більше справа, з формуванням «крилоподібних (виступаючих) лопаток». Також відмічається м’язова гіпотрофія проксимальних м’язів кінцівок із переважним ураженням біцепсів плечей, сіднично-стегнових м’язів, більше справа. Псевдогіпертрофія литкових мʼязів. Чутливість збережена. Хода утруднена, «качина». Відмічаються труднощі при підніманні сходами, при вставанні після присідання, позитивний симптом Говерса. Сколіотичні явища хребта, гіперлордоз поперекового відділу хребта. Когнітивні функції в нормі. У біохімічному аналізі крові: значне підвищення креатинфосфокинази, аланінамінотрансферази та аспартатамінотрансферази, інші показники – в межах норми. МРТ головного мозку: речовина головного мозку без змін сигнальних характеристик. На електронейроміограмі виявлено характерні зміни потенціалу рухових одиниць за міопатичним типом. Аналізи на активність альфа-галактозидази та альфа-1,4-глюкозидази: норма. Консультація ендокринологом та кардіологом: даних за патологію на час огляду не виявлено. Медичним генетиком поставлений діагноз: кінцівково-поясна м’язова дистрофія, тип 2А (кальпаїнопатія). Враховуючі вищеописані дані пацієнту встановлено діагноз: Кінцівково-поясна м’язова дистрофія, тип 2А (кальпаїнопатія) з периферичним проксимальним тетрапарезом (легким у руках, помірним у ногах), міопатичним синдромом, помірним порушенням функції ходьби. Пацієнту було проведено нейрометаболічну, антиоксидантну, загальнозміцнювальну терапії, вітамінотерапію та фізіотерапевтичне лікування. Висновки. На сьогодні не існує специфічного лікування кальпаїнопатії, тому терапія має симптоматичний характер, направлена на нормалізацію загального стану пацієнта, відновлення втрачених функцій та ймовірне сповільнення швидкості прогресування. А динамічне спостереження за пацієнтом і вчасний менеджмент симптомів поліпшує можливість продовження тривалості життя та покращення його якості.Документ Neurofibromatosis type I and its diagnostic criteria: a clinical observation(Aluna Publishing, 2022) Purdenko, T. Y.; Delva, M. Yu.; Ostrovskaya, L. I.; Tarianyk, K. A.; Sylenko, H. Ya.; Pushko, O. O.; Purdenko, S. V.; Пурденко, Тетяна Йосипівна; Дельва, Михайло Юрійович; Островська, Людмила Йосипівна; Таряник, Катерина Анатоліївна; Силенко, Галина Ярославівна; Пушко, Олександр Олександрович; Пурденко, Сергій ВолодимировичThe aim - to consider the etiopathogenesis, the main clinical manifestations, diagnostic criteria of NF1, and present a clinical case from their practice. The paper analyzes the research findings in recent publications, focused on the studied issue using the methods of continuous sampling, synthesis and generalization, bibliosemantic evaluation and content analysis. In order to attract the attention of family physicians, neurologists, dermatologists, ophthalmologists, surgeons and other specialists, we present our own clinical observation of NF1. The patient was examined using the methods of neurological examination, as well as other laboratory and instrumental methods of research. Early diagnosis and medical examination of patients with NF1 is crucial for predicting and improving the quality of life of patients. NF1 is a complex disease where the cooperation of doctors of different specialties is important. A favorable prognosis for patients is associated with the possibility of early diagnosis of malignant transformation and timely treatment.Документ Optimization the treatment of motor fluctuations in various forms of Parkinson’s Disease(Полтавський державний медичний університет, 2022) Tarianyk, K. A.; Lytvynenko, N. V.; Purdenko, T. Y.; Sylenko, H. Y.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Пурденко, Тетяна Йосипівна; Силенко, Галина ЯрославівнаLevodopa is one of the most effective drugs for the treatment of Parkinson's disease. However, the use of high doses of the drug has many adverse effects. Motor complications of levodopa, in the form of motor fluctuations and dyskinesia, occur in 30 to 40 percent of during the first five years of use and nearly 60 percent or more by 10 years. In the course of the study, an assessment of groups of patients with various forms of Parkinson's disease – akinetic-rigid and mixed, the nature of motor fluctuations, analysis of the relationship with the duration of the disease, levodopa therapy, drug dosage was carried out. Schemes for the treatment of motor fluctuations due to taking levodopa drugs in short-acting and long-acting drugs were analyzed. A positive effect was found in the form of a total intake of levodopa drugs. We can recommend to consider adding of long-release levodopa for management of motor complications in Parkinson’s disease patients with rigidity and akinetic-rigid and tremor-dominant forms of Parkinson’s disease. A proposed regimen for the addition of sustained-release levodopa for the treatment of motor complications in patients with various forms of Parkinson's disease.Документ Parry-romberg syndrome: difficulties of diagnosis and improvement of treatment(Українська медична стоматологічна академія, 2020) Hladka, V. M.; Purdenko, T. Y.; Tarianyk, K. A.; Гладка, Вікторія Михайлівна; Пурденко, Тетяна Йосипівна; Таряник, Катерина АнатоліївнаThe article described a case of a rare disease – progressive facial hemiatrophy in a patient of the Neurological Department of Poltava Regional Clinical Hospital. We reviewed a literature on the problem, analyzed the etiological factors, pathogenesis and clinical characteristics of the disease. There was defined a range of necessary examination methods of patients, which included examination by a neurologist, rheumatologist, endocrinologist, as well as the use of additional instrumental and laboratory research methods. Comprehensive treatment tactics include the use of trophotropic, vascular drugs, anabolic hormones, potassium supplements, massage, physical therapy.Документ Relationship between Sleep Disorders and Neuropsychiatric Symptoms in Parkinson's Disease: A Narrative Review(2022-10) Shkodina, A. D.; Iengalychev, T. R.; Tarianyk, K. A.; Boiko, D. I.; Lytvynenko, N. V.; Skrypnikov, A. M.; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро Іванович; Литвиненко, Наталія Володимирівна; Скрипніков, Андрій МиколайовичAim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completeness of the review, a second, more in-depth literature search was performed using the same electronic database with the search inquiries of increased specificity. Results: The information on pathophysiology, epidemiology, clinical features and risk factors was extracted and formed the basis for this review. Despite how widespread sleep disorders in Parkinson’s disease are, there is no systematic information about their association with neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment and psychosis. In this review, we described relationships between these non-motor symptoms of Parkinson’s disease, their timeline occurrence, gap in knowledge and perspectives for further research. We suppose that early treatment of sleep disorders in patients with Parkinson’s disease can reduce the incidence and extent of neuropsychiatric symptoms. Conclusion: We have demonstrated multiple, multidirectional relationships between sleep disorders and neuropsychiatric symptoms. However, some of them remain unexplored. The described knowledge can be applied to further study the possibility of influencing neuropsychiatric symptoms through the correction of sleep disorders in patients with different stages of Parkinson’s disease.Документ Roles of clock genes in the pathogenesis of Parkinson's disease(Elsevier, 2022-02) Shkodina, A. D.; Tan, S. Ch.; Hasan, M. M.; Abdelgawad, Mai; Chopra, Hitesh; Bilal, Muhammad; Boiko, D. I.; Tarianyk, K. A.; Alexiou, Athanasios; Шкодіна, Анастасія Дмитрівна; Бойко, Дмитро Іванович; Таряник, Катерина АнатоліївнаParkinson's disease (PD) is a common motor disorder that has become increasingly prevalent in the ageing population. Recent works have suggested that circadian rhythms disruption is a common event in PD patients. Clock genes regulate the circadian rhythm of biological processes in eukaryotic organisms, but their roles in PD remain unclear. Despite this, several lines of evidence point to the possibility that clock genes may have a significant impact on the development and progression of the disease. This review aims to consolidate recent understanding of the roles of clock genes in PD. We first summarized the findings of clock gene expression and epigenetic analyses in PD patients and animal models. We also discussed the potential contributory role of clock gene variants in the development of PD and/or its symptoms. We further reviewed the mechanisms by which clock genes affect mitochondrial dynamics as well as the rhythmic synthesis and secretion of endocrine hormones, the impairment of which may contribute to the development of PD. Finally, we discussed the limitations of the currently available studies, and suggested future potential studies to deepen our understanding of the roles of clock genes in PD pathogenesis.Документ The analysis of the change in ghrelin level in patients with different forms of parkinson’s disease(Полтавський державний медичний університет, 2020) Tarianyk, K. A. ; Kaidashev, I. P.; Shlykova, O. A.; Izmailova, O. V.; Таряник, Катерина Анатоліївна; Кайдашев, Ігор Петрович; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга ВіталіївнаThe aim of our study was to analyze diurnal fluctuations in hunger hormone level in patients with akinetic-rigid and mixed forms of Parkinson’s disease. The clinical studies have confirmed changes in the ghrelin level with a tendency to increase in the evening in patients of the control group and insignificant diurnal fluctuations in the level of ghrelin in patients with Parkinson’s disease with a tendency to decrease. It has been revealed that in patients with mixed form of the disease, the ghrelin level is lower compared to controls. The human circadian system regulates hunger independently of behavioral factors. There is a large endogenous circadian rhythm of hunger, with a peak in biological evening and a minimum in biological morning. However, the neuroendocrine mechanisms by which the circadian system regulates hunger and appetite remain unclear. Ghrelin, a peptide secreted primarily by the stomach, is the only known circulating orexigenic hormone and a key element in a complex energy balance signaling network. The authors insist thatfurther clinical research is needed to determine the relationship between the intake of antiparkinsonian drugs and the ghrelin level, whichcan significantly improve the clinical course of this diseaseДокумент The correction of non-motor symptoms in different forms of Parkinson’s disease by optimization therapy with levodopa(Полтавський державний медичний університет, 2022) Tarianyk, K. A.; Торяник, Катерина АнатоліївнаNon-motor symptoms in Parkinson’s disease (PD) are usually more complicated and difficult to manage than typical PD motor symptoms. However, they are usually overlooked and not properly treated. Physicians should be aware of the need to evaluate the neuropsychiatric, cognitive, autonomic, and sleep complications of PD. Early recognition of non-motor symptoms is essential, as effective treatment can reduce morbidity and improve the quality of life of PD patients. The aim of the study was to evaluate the impact of optimization levodopa therapy in patients with PD and motor fluctuations on severity of non-motor symptoms. The results of the examination of 80 patients with various forms of Parkinson's disease who were examined and treated at the Center for patients with CP and other neurodegenerative diseases of the Department of Neurological Diseases of Poltava State Medical University are presented. Patients were examined according to the UPDRS scale, the severity of non-motor symptoms was assessed according to the Non-motor symptoms scale (NMSS). We have found that optimization of the treatment by changing the regimen of the levodopa may significantly improve motor function. The improvement of motor function by usage of extended-release levodopa is associated with decreasing motor fluctuations severity. It has been established that the use of long-acting levodopa-containing drugs has a positive effect in the treatment of non-motor symptoms. Dominant reliable changes are more typical for patients with a akinetic-rigid form of the disease.Документ The role of circadian regulation of ghrelin levels in Parkinson's disease (literature review)(Aluna Publishing, 2021) Tarianyk, K. A.; Lytvynenko, N. V.; Shkodina, A. D.; Kaidashev, I. P. ; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Шкодіна, Анастасія Дмитрівна; Кайдашев, Ігор ПетровичThe paper is aimed at the analysis of the role of the circadian regulation of ghrelin levels in patients with Parkinson's disease. Based on the literature data, patients with Parkinson's disease have clinical fluctuations in the symptoms of the disease, manifested by the diurnal changes in motor activity, autonomic functions, sleep-wake cycle, visual function, and the efficacy of dopaminergic therapy. Biological rhythms are controlled by central and peripheral oscillators which links with dopaminergic neurotransmission - core of the pathogenesis of Parkinson`s disease. Circadian system is altered in Parkinson`s disease due to that ghrelin fluctuations may be changed. Ghrelin is potential food-entrainable oscillator because it is linked with clock genes expression. In Parkinson`s disease this hormone may induce eating behavior changing and as a result metabolic disorder. The "hunger hormone" ghrelin can be a biomarker of the Parkinson's disease, and the study of its role in the pathogenesis, as well as its dependence on the period of the day, intake of levodopa medications to improve the effectiveness of treatment is promising.Документ The usage of electroneuromyography for optimization diagnostic approaches to Parkinson’s disease(Полтавський державний медичний університет, м.Полтава, Україна, 2022) Shkodina, A. D.; Tarianyk, K. A.; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина АнатоліївнаMotor and sensory symptoms in patients with Parkinson’s disease are usually measured by clinical scales with subjective assessments. That is why the development of new techniques and improvement of objective methodology is necessary for clinical practice. We conducted an analytical cross-sectional study based on the Parkinson's disease and other neurodegenerative diseases centre based on Poltava State Medical University in the period 2020–2021. We performed a factor analysis of features of electroneuromyography. We determined indicators and their relationships that characterize the tremor and the severity of the cubital syndrome on the dominant side, as well as the severity of the carpal syndrome on the non-dominant side in patients with Parkinson`s disease. Thus, the usage of factor loads determined by the results of our study allows optimizing the diagnostic approach to peripheral lesions in Parkinson`s disease by calculating the severity of tremor and tunnel neuropathies in these patients.Документ Анализ показателей поверхностной и стимуляционной электронейромиографии у пациентов с разными формами болезни Паркинсона(Харківська медична академія післядипломної освіти, 2014) Таряник, Екатерина Анатольевна; Tarianyk, K. A.; Таряник, Катерина АнатоліївнаПроанализированы показатели электронейромиографии у пациентов с болезнью Паркинсона. Диагностировано уменьшение частоты осцилляций при выполнении координаторных проб у пациентов с дрожательной формой заболевания, повышение скорости проведения импульса по моторным волокнам периферических нервов у пациентов с его разными формами. У пациентов с акинетико-ригидной формой зарегистрирован "дистонический феномен", который характерен для раннего паркинсонизма с дрожательным компонентом. Electromyography findings were analysed in patients with Parkinson`s disease. Reduction of oscillation frequency during coordination tests, increased rate of pulse conduction along motor fibers of peripheral nerves was diagnosed in patients with tremor with different forms of disease. The patients with akinetic-rigid form demonstrated "dystonic phenomenon" typical for early parkinsonism with tremor component.Документ Використання нейромідину в комплексній терапії розсіяного склерозу(2012) Литвиненко, Наталія Володимирівна; Пінчук, Вікторія Анатоліївна; Таряник, Катерина Анатоліївна; Силенко, Галина Ярославівна; Литвиненко, Наталья Владимировна; Пинчук, Виктория Анатольевна; Таряник, Екатерина Анатольевна; Силенко, Галина Ярославовна; Lytvynenko, N. V.; Pinchuk, V. A.; Tarianyk, K. A.; Silenko, G. Ya.Доведена ефективність препарату нейромідин у пацієнтів з аксонально-демієлінізуючими і демієлінізуючими мотосенсорними або виключно моторними ураженнями, тоді як традиційні схеми лікування дають менший ефект при аксональних і моторних ураженнях. Доведена сприятлива дія препарату на проведення збудження і здат ність покращувати скоротливі здібності м'язів; Доказана эффективность препарата нейромидин у пациентов с аксонально-демиелинизирующими и демиелинизирующими мотосенсорными или исключительно моторными поражениями, тогда как традиционные схемы лечения вызывают меньший эффект при аксональных и моторных поражениях. Доказано благоприятное действие препарата на проведение возбуждения и способность улучшать сократительные способности мышц; Authors described good effects Neiromidin drug at patients with Multiple Sclerosis with axonal-demyelinative and demyelinative motor and sensory or only motory damage. Traditional charts treatment the patients with Multiple Sclerosis has smaller effect at axonal and motor damage. Neiromidin drugs had positive effect on transmission reactions and improvement flexor muscles ability.