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Документ Radiographic changes in the bone grafts during guided bone regeneration with the use of titanium mesh on classical and authors' own methods for the mucosal flaps detachment(Ukrainian Medical Stomatological Academy, Poltava, 2018) Kaplun, D. V.; Avetikov, D. S.; Ivanytska, O. S.; Boiko, I. V.; Havryliev, V. M.; Каплун, Дмитро Володимирович; Аветіков, Давид Соломонович; Іваницька, Олена Сергіївна; Бойко, Ігор Васильович; Гаврильєв, Віктор Миколайович; Каплун, Дмитрий Владимирович; Аветиков, Давид Соломонович; Иваницкая, Елена Сергеевна; Бойко, Игорь Васильевич; Гаврильев, Виктор НиколаевичOne of the major problems in rehabilitation of bone volume loss in preparing patients for dental implantation is the bone graft exposure and its infection in the result of ischemic processes in the mucousal flap that covers it. We performed 27 surgical interventions for guided bone regeneration using titanium mesh according to the classical method of detachment of trapezoidal mucousal flap and 30 surgical interventions on authors' own method of detachment and mobilization of the mucousal flap. The augmentation was performed in the mandibular distal segments. Our studies have shown that the optimization of the limits of detachment and mobilization of mucousal and mucoperiosteal flaps, compared with the classical method of trapezoidal flaps, leads to a decrease in bone graft volume loss by 1.9%. The data indicate the possibility of improving the flap surgery efficiency during bone augmentation in patients with acquired edentulism;Документ Adaptation of polymerase chain reaction-restriction fragment length polymorphism method for polymorphism (rs2583988) analysis in alpha-synuclein gene(Українська медична стоматологічна академія, 2020) Tarianyk, K. A.; Lytvynenko, N. V.; Oliinychenko, V. K.; Byslik, T. V.; Pochernyaev, K. F.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Олійниченко, Є. К.; Буслик, Т. В.; Почерняєв, К. Ф.The article suggests the polymerase chain reaction-restriction fragment length polymorphism method for a single nucleotide polymorphism (rs2583988) detection for further prediction of Parkinson’s disease risks. Based on the meta-analysis results for the single nucleotide polymorphism rs2583988 (C>T) in αlpha-synuclein gene; current polymorphic variant was chosen by analyzing bioinformatical and genetic studies. We have designed a pair of primers and conditions for restriction analysis to detect different alleles in rs2583988. As a result, there was developed a simple and affordable method for detecting single nucleotide polymorphism rs2583988 alleles. The method is expected to be suitable for clinic laboratories, due to affordable cost and equipment, and to be used in further association studies.Документ The analysis of the change in ghrelin level in patients with different forms of parkinson’s disease(Полтавський державний медичний університет, 2020) Tarianyk, K. А; Kaidashev, I. P.; Shlykova, O. A.; Izmailova, O. V.; Таряник, Катерина Анатоліївна; Кайдашев, Ігор Петрович; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга ВіталіївнаThe aim of our study was to analyze diurnal fluctuations in hunger hormone level in patients with akinetic-rigid and mixed forms of Parkinson’s disease. The clinical studies have confirmed changes in the ghrelin level with a tendency to increase in the evening in patients of the control group and insignificant diurnal fluctuations in the level of ghrelin in patients with Parkinson’s disease with a tendency to decrease. It has been revealed that in patients with mixed form of the disease, the ghrelin level is lower compared to controls. The human circadian system regulates hunger independently of behavioral factors. There is a large endogenous circadian rhythm of hunger, with a peak in biological evening and a minimum in biological morning. However, the neuroendocrine mechanisms by which the circadian system regulates hunger and appetite remain unclear. Ghrelin, a peptide secreted primarily by the stomach, is the only known circulating orexigenic hormone and a key element in a complex energy balance signaling network. The authors insist thatfurther clinical research is needed to determine the relationship between the intake of antiparkinsonian drugs and the ghrelin level, whichcan significantly improve the clinical course of this diseaseДокумент Main goals of psychological rehabilitation of military servicemen in the Poltava region under the present conditions(Полтавський державний медичний університет, 2020) Havlovskyi, O. D.; Гавловський, Олександр Данилович; Гавловский, Александр ДаниловичThe outbreak of the war in the East of Ukraine has created new challenges for the psychological rehabilitation system. The purpose of the work was to analyse the main goals of psychological rehabilitation of military servicemen in the Poltava region in present conditions. The reports of the Rehabilitation Department of the Public Institution “Kremenchug Regional Clinical Hospital for Veterans of War” of the Poltava Regional Council were analysed for the 2014-2018. During 2014 and 2015 medical assistance to servicemen was provided only on an inpatient basis. Since 2016, it has become necessary to consult military personnel on an outpatient basis (2016 – 473 people (51.8%), 2017 – 570 people (48.3%), 2018 – 745 people (47.6%)) The highest percentage of treated military personnel was diagnosed with neurotic, stress-related and somatoform disorders, respectively in 2016 – 58.6%, in 2017 – 59.3%, and in 2018 – 56.7%. The presence among the military personnel of anti-terrorist operation / united forces operation of a constant increase in the number of patients with signs of impaired adaptation requires the earliest possible start of psychological rehabilitation.Документ State of gastrointestinal mucosal protection in neurological patients in cricical state(Полтавський державний медичний університет, 2020) Shkurupii, D. A.; Mogylnyk, A. I.; Sonnik, E. G.; Udovytska, N. O.; Шкурупій, Дмитро Анатолійович; Могильник, Антон Ігорович; Сонник, Євген Григорович; Удовицька, Наталія ОлегівнаAn observational clinical study was performed with 50 adult participants. The main group consisted of 30 patients with cerebrovascular diseases of the cerebrovascular diseases, which required the organization of intensive care. In the main group, on the 1st day of observation, the level of glycosaminoglycans was higher in 70% (21/30) cases. On the 7th day of observation, this indicator was higher in 100% (30/30) cases. Correlations between the increase in the concentration of glycosaminoglycans and their age, the severity of the condition in accordance with APACHE II, and the start time of enteral nutrition were established. Thus, in neurological patients in critical condition, the protection system of the gastrointestinal mucosa is in a state of functional tension.Документ Analysis of denture base impact on the denture foundation area tissues(Українська медична стоматологічна академія, 2020) Kalashnikov, D. V.; Kindiy, D. D.; Korol, D. M.; Kindiy, V. D.; Калашніков, Дмитро Вікторович; Кіндій, Дмитро Данилович; Король, Дмитро Михайлович; Кіндій, Віктор ДаниловичThe article presents the results of the study of the dental base impact on the denture foundation area tissues. The study was conducted in 149 patients aged 41 to 74 years. Removable partial laminar dentures for the upper and lower jaws were made of plastics "Ftorax" and "Etacryl-02" by three technologies: in a "water bath", in a dry polymerizer under the pressure and in an advanced injection molding machine. The results obtained allow us to recommend the technology of manufacturing removable partial laminar dentures in the advanced injection molding machine for using in dental orthopedics clinic.Документ Frequency and structure of benign soft tissue formations in the maxillofacial area(Українська медична стоматологічна академія, 2020) Ткаченко, Павло Іванович; Резвіна, Катерина Юріївна; Швець, Анатолій Іванович; Попело, Юлія Вікторівна; Ткаченко, Павел Иванович; Резвина, Екатерина Юрьевна; Швец, Анатолий Иванович; Попело, Юлия Викторовна; Tkachenko, P. I.; Rezvina, K. Yu.; Shvets, A. I.; Popelo, Yu. V.The article considered our own observation results and retrospective analysis of archival material of the Maxillofacial Department of M.V. Sklifosovsky Poltava Regional Clinical Hospital and Surgical Department of the Poltava City Children's Clinical Hospital from 2008 to 2018. It was found that among adults the number of patients with benign soft tissue formations of the face and neck is 4.9%, and in children – 7.8% of the total number of inpatients. Most of them were bronchiogenic cysts of the lateral part of the neck (152 – 26.3%) and atheromatous plaques (147 – 25.4%). They mostly occured at the age of 22 to 60 years, men suffered more often (205 - 35.5%). The largest number of discrepancies in the diagnosis at the prehospital phase were patients with epidermal cysts – 38 (7.9%). As for pediatric population, their number was 7.8% of the total number of inpatients. Neoplasms of dysontogenetic origin predominate, among which the most common were dermoid cysts – 92 patients (32.4%) and haemangiomas– 74 patients (26%). Less common were ranulae – 36 cases (12.7%), bronchiogenic cyst – 17 cases (6%) and atheromatous plaque – 16 cases (5.6%). They were found more often in the nursery age – from 1 to 3 years.Документ The role of arginine/citrulline cycle disorders in the pathogenesis of doxorubicin-induced liver injury associated with nonalcoholic steatohepatitis in rats(Українська медична стоматологічна академія, 2020) Maslova, G. S.; Skrypnyk, R. I.; Gopko, O. F.; Skrypnyk, I. M.; Маслова, Анна Сергеевна; Скрыпник, Роман Игоревич; Гопко, Александр Феликсович; Скрыпник, Игорь Николаевич; Маслова, Ганна Сергіївна; Скрипник, Роман Ігорович; Гопко, Олександр Феліксович; Скрипник, Ігор МиколайовичThe article presents the results of an experimental study aimed to investigate the features of arginine/citrulline cycle disorders associated with doxorubicin-induced liver injury in rats, concomitant with NASH. The study involved adult fertile outbred albino rats (n=30; male rats=15 (50%); female rats=15 (50%)) weighted 160-220 g. The rats were assigned into 3 groups: Group І (n=10) involved rats with NASH, administered with intraperitoneal 5 mg/kg doxorubicin for 3 days; Group ІІ (n=10) involved rats without NASH, administered with intraperitoneal doxorubicin similar to Group I regimen; Group ІІІ (n=10) – control group. It has been shown that administration of doxorubicin in rats with NASH leads to disorders of arginine/citrulline cycle, which are characterized by inhibition of arginase activity and activation of citrulline synthesis.Документ Assesment of the dietary energy intake of young people with normal weight and overweight(Українська медична стоматологічна академія, 2020) Vesnina, L. E.; Boriak, Kh. R; Sokolenko, V. М; Весніна, Людмила Едуардівна; Боряк, Христина Радиславівна; Соколенко, Валентина Миколаївна; Веснина, Людмила Эдуардовна; Боряк, Кристина Радиславовна; Соколенко, Валентина НиколаевнаThe problem of weight gain and obesity with the formation of energy imbalance remains relevant especially among children and young people. The paper was aimed at determining the dietary energy intake of young people with normal weight and overweight and its compliance with energy needs. The study involved 84 male and female subjects aged 18-25. Height, body weight, waist circumference, and thighs circumference, and their ratio was determined. According to the body mass index (BMI), 22 women and 22 men (BMI 18.50-24.99 kg/m2 ) have been assigned to the control group and the group with overweight involved 20 men and 20 women (BMI 25.00-29.99 kg/m2 ). Nutritional status has been studied by the method of 24-hour nutrition reproduction by making records in the food diary during a weekday and weekend day. The value of the basal metabolic rate was calculated by the Mifflin-St Jeor equation. Was determined the recommended daily energy dietary intake maintains the existing body weight. The obtained data were processed statistically. The development of energy imbalance in people with overweight of both genders, a significant increase in the energy value of the dietary intake compared to controls and in comparison with the recommended daily energy intake has been established. The increase in energy value is accompanied by the altered structure of nutrients due to increased consumption of mainly fats by male subjects with overweight and fats and carbohydrates by female subjects compared to the controls. In men of the control group, the increase in energy value of the dietary intake relative to the recommended daily energy intake is less pronounced compared to subjects with overweight. Prolonged existence of the positive energy balance is the risk factor for the development of obesity and metabolic disorders.Документ Morphofunctional characteristics of hemomicrocirculatory bed’s vessels of the pancreas in rats and at central deprivation of testosterone synthesis(Українська медична стоматологічна академія, 2020) Борута, Наталія Володимирівна; Борута, Наталия Владимировна; Boruta, N. V.In an experimental study of vessels of the hemomicrocirculatory bed of the exocrine pancreas in rats, it was found that the microvessels responded to the introduction of diferelin by persistent dilatation of arterioles during the first month of the experiment by 4.12% compared to the intact group of animals. The exchange component responded by increasing its average diameters, increasing its lumen by 1.93% compared to the intact animal group. The vessel capacity of the pancreas’ hemomicrocirculatory bed during the first month of the study responded with enlargement, increasing its lumens by 2.46% compared to the intact group of animals. The numbers recovery of the average diameters of microvessels with the introduction of tryptorelin embonate was not observed until the end of the experiment.Документ Structural organization of stromal and parenchymal components of rat testes during central deprivation of testosterone synthesis on the 180 day of the experiment(Українська медична стоматологічна академія, 2020) Стецук, Євген Валерійович; Стецук, Евгений Валерьевич; Stetsuk, Ye. V.; Акімов, Олег Євгенович; Акимов, Олег Евгеньевич; Akimov, O. Ye.; Шепітько, Костянтин Володимирович; Шепитько, Константин Владимирович; Shepitko, K. V.; Гольцев, Анатолій Миколайович; Гольцев, Анатолий Николаевич; Goltsev, A. M.Prolonged central deprivation of testosterone synthesis may lead to biochemical and morphological changes in testes. Influence of prolonged testosterone deficiency on reactive nitrogen and oxygen species production, morphological changes in interstitial endocrinocytes and sustentocytes is not yet fully understood. The number of interstitial endocrinocytes is reduced in comparison with the control group, there are interstitial spaces between the convoluted tubules with a complete absence of interstitial endocrinocytes. Interstitial endocrinocytes are reduced in size, their nuclei are heterochromic. When we studied the structural organization of rat sustentocytes from the experimental group in comparison with the control group, we found that hyperplasia of the elements of the smooth endoplasmic reticulum was observed in the cytoplasm of the sustentocytes. The number of mitochondria in the cytoplasm of the sustentocytes decreased, the electron density of the mitochondrial matrix was lowered, protein structures were present either inside the vacuoles or independently located in the cell cytoplasm. Biochemical studies revealed increased NO production from inducible NO-synthase and development of oxidative stress. Experimental central deprivation of testosterone synthesis with diphereline on the 180th day of the experiment leads to shift of NO synthesis from constitutive NO-synthases to inducible NO-synthase and intensification of oxidative stress due to increase of superoxide anion-radical production and decrease in antioxidant protection.Документ Functional state of cardiovascular and digestive systems in the body of students during fitness training(Українська медична стоматологічна академія, 2020) Sogokon, О. А.; Donets, O. V.; Donets, I. М.; Согоконь, O. A.; Донець, О. В.; Донець, Ілона Миколаївна; Согоконь, Е. А.; Донец, А. В.; Донец, Илона Николаевнаexercises effect the activation of internal systems’ work in the body. Analyzing the correlation of recreative fitness with students’ nutrition provides an opportunity to identify prospects for improving cardiovascular and digestive systems, improving general condition and achieving the desired student athletic performance. The study found that 92.5% of students were positive about the new content of training in modern fitness technology and only 7.5% said their attitude was uncertain. During the experiment, the dynamics of changes in the parameters of the cardiovascular and digestive systems’ functional state (experimental/control groups) were confirmed: the mean body weight decreased by 2.8 kg/1.5 kg, the pulse at rest decreased to 65.25 beats./min.+0.25/74.46 bpm+0.64; systolic pressure decreased to 112.75 mm Hg+0.35/118.21 mm Hg+0.79; diastolic pressure decreased to 72.21 mm Hg+0.39/76.57 mm Hg+0.43; the vital capacity of the lungs increased by 0.4 l/0.2 l, which is evidence of the cardiovascular system’s economic activity and confirms the feasibility of the applied methodology of health fitness technologies. Regarding the expediency of dietary change: 77% of students said they needed change, while 21% said they wanted it, and only 2% said they didn't want to change their diet.Документ A measure of the effect of complex food additives on rats’ adaptive responses(Українська медична стоматологічна академія, 2020) Yachmin, А. І.; Kononov, B. S.; Yeroshenko, G. А.; Bilash, S. М.; Bilash, V. P.; Ячмінь, Анастасія Ігорівна; Кононов, Богдан Сергійович; Єрошенко, Галина Анатоліївна; Білаш, Сергій Михайлович; Білаш, Валентина Павлівна; Ячминь, Анастасия Игоревна; Кононов, Богдан Сергеевич; Ерошенко, Галина Анатольевна; Билаш, Сергей Михайлович; Билаш, Валентина ПавловнаIn the paper was the investigation of the effect of consumed complex food additives on the rats’ adaptive response. 88 outbred mature male rats, housed in the common conditions, were involved into the study. Control rats consumed drinking water and received saline per os. The rats of the experimental group were given ad libitum access to water and, supplementary, consumed sodium nitrite solution. Sodium glutamate was administered at a dose of 20 mg/kg, Ponceau 4R at a dose of 5 mg/kg once daily per os. Doses of food additives were half less the allowable normal rate in food. After being exposed to open field test the rats were killed within 1, 4, 8, 12 and 16 weeks under thiopentone anesthesia overdose. Consumption of complex food additives at acceptable doses affects the behavioral responses of experimental animals. It has been established that just from the first week of observation, rats experienced increased anxiety, fear, blunting of adaptive responses, decreased activity and disturbance of the emotional state, which were intensified up to week 16 of the experiment.Документ Morphofunctional features of rat testes interstitial endocrinocytes and sustentocytes after 90 days of central testosterone synthesis deprivation(Українська медична стоматологічна академія, 2020) Stetsuk, Ye. V.; Akimov, O. Ye.; Shepitko, K. V.; Goltsev, A. N.; Стецук, Євген Валерійович; Стецук, Евгений Валерьевич; Акімов, Олег Євгенович; Акимов, Олег Евгеньевич; Шепітько, Костянтин Володимирович; Шепитько, Константин Владимирович; Гольцев, Анатолій Миколайович; Гольцев, Анатолий НиколаевичWith the social system development, there is a tendency to change attitudes towards family and family values. In developed European countries, there is a trend towards high sexual activity in elderly men and late creation of a family with children, which undergoes certain difficulties in connection with a decreased testosterone production in later years. The purpose of the study was to establish the microscopic organization of rat interstitial endocrinocytes and sustentocytes, to determine the sources of nitric oxide production and the intensity of oxidative stress in the testes with experimental central deprivation of testosterone synthesis with diphereline on the 90th day of the experiment. The experiments were carried out on 20 sexually mature male white rats of the Wistar line. Rats were divided into 2 groups: the control group (10) and the experimental group (10), which were injected subcutaneously with diphereline (Triptorelin embonate) at a dose of 0.3 mg / kg of the active substance for 90 days. Prolonged central deprivation of testosterone synthesis in animals leads to emergence of functional stress structural signs in population of sustentocytes and interstitial endocrinocytes, which are aimed to support testicular secretion. Central deprivation of testosterone synthesis within 90 days causes oxidative stress development owing to reactive oxygen species hyperproduction and nitrite accumulation in testicular tissue due to increased inducible NO-synthase activity;Документ Ultrastructural remodeling of rat submandibular glands in chronic ethanol intoxication(Українська медична стоматологічна академія, 2020) Yeroshenko, G. А.; Shevchenko, K. V.; Lisachenko, O. D.; Vilhova, O. V.; Yakushko, O. S.; Skotarenko, T. A.; Bilash, V. P.; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Вільхова, Олена Вікторівна; Якушко, Олена Святославівна; Скотаренко, Тетяна Анатоліївна; Білаш, Валентина Павлівна; Ерошенко, Галина Анатолиевна; Шевченко, Константин Васильевич; Лысаченко, Ольга Дмитриевна; Вильховая, Елена Викторововна; Якушко, Елена Святославовна; Скотаренко, Татьяна Анатольевна; Билаш, Валентина Павловна; Єрошенко, Галина АнатоліївнаThe study presents a detailed analysis of the ultramicroscopic structure of the rat submandibular glands in chronic ethanolintoxication at the later stages of the experiment. It has been established that prolonged exposure to ethanol at the later stages of the experiment was characterized by the appearance of signs of adaptive-compensatory responses of the parenchymal elements and vessels of the blood microvascular system with the emergence of dystrophic changes and apoptosis of ductal epithelium; however, no complete regeneration of the structure was detected.Документ Specific structure of the normal rat gastric fundus wall(Українська медична стоматологічна академія, 2020) Yachmin, А. І.; Vilkhova, O. V.; Boruta, N. V.; Bilash, S. M.; Skotarenko, T. A.; Bilash, V. P.; Kramarenko, D. R.; Ячмінь, Анастасія Ігорівна; Ячминь, Анастасия Игоревна; Борута, Наталія Володимирівна; Борута, Наталия Владимировна; Білаш, Сергій Михайлович; Билаш, Сергей Михайлович; Скотаренко, Тетяна Анатоліївна; Скотаренко, Татьяна Анатольевна; Білаш, Валентина Павлівна; Билаш, Валентина Павловна; Крамаренко, Денис Русланович; Крамаренко, Денис РуслановичAs a result of a comprehensive study, it was determined that the wall of the fundus of the stomach of rats according to the basic principles of structural organization corresponds to humans and can be used as an experimental model to study the effects of exogenous factors. By means of morphometric research the basic metric indicators of a wall of fundal department of a rats’ stomach and histotopographic features of own glands are established.Документ Glucocorticoids as immunostimulators in pathogenetic therapy of tuberculosis(Полтавський державний медичний університет, 2020) Yareshko, A. G.; Kulish, M. V.; Ярешко, Анатолий Григорьевич; Кулиш, Марина Владимировна; Ярешко, Анатолій Григорович; Куліш, Марина ВолодимирівнаВ статті обґрунтований імуностимулюючий ефект кортикостероїдів в комплексному лікуванні хворих на туберкульозу при введенні їх в подвійній фізіологічній дозі, через день з урахуванням добового біоритму функції гіпоталамо-гіпофізарно-наднирникової системи, тоді як при щоденному введенні вони проявляють імуносупресивний ефект. В-лімфоцити периферійної крові не чутливі до дії глюкокортикостероїдних препаратів.Документ Influence of prolonged central deprivation of testosterone synthesis on production of reactive oxygen and nitrogen species and morphological structure of rat testes(Українська медична стоматологічна академія, 2020) Stetsuk, Ye. V.; Akimov, O. Ye.; Shepitko, V. І.; Goltsev, A. М.; Стецук, Євген Валерійович; Акімов, Олег Євгенович; Шепітько, Володимир Іванович; Гольцев, Анатолій МиколайовичSome testicular diseases require long-term use of testosterone synthesis blockers. It is known that testosterone is a necessary component for the physiological cooperation of cell forms of the stroma and parenchyma of testes. The scientific literature contains a limited amount of data about the effect of long-term deprivation of testosterone synthesis on this cooperation. The aim of our study was to establish the effect of long-term (365 days) inhibition of hypothalamic-pituitary stimulation of spermatogenesis on morphological and biochemical parameters in rat testes. Central deprivation of testosterone synthesis leads to fibrosis with subsequent disruption of the structural organization of the convoluted seminiferous tubules, hemodynamic disorders, endothelial dysfunction, increased density of blood vessel walls and systemic congestion. A decrease in the activity of constitutive NO synthase isoforms plays a major role in the development of structural changes in the testes of rats.Документ Peculiarities of TLR9 expression on immune competent cells in reactive arthritis patients with chronic Epstein-Barr virus infection(Полтавський державний медичний університет, 2020) Lomikovska, M. P.; Hauduchok, I. G.; Potomkina, H. O.; Zubchenko, S. O.; Krill, I. Y.; Ischeykin, K. Y.; Chopyak, V. V.; Ламіковська, М. П.; Гайдучок, І. Г.; Потьомкіна, Г. О.; Зубченко, С. О; Кріль, І. Й.; Іщейкін, Костянтин Євгенович; Чопяк, В. В.; Ламиковская, М. П.; Гайдучок, И. Г.; Потёмкина, Г. О.; Зубченко, С. О.; Криль, И. Й.; Ищейкин, Константин Евгеньевич; Чопяк, В. В.The work presents the study findings on the TLR9 expression in immune competent cells in reactive arthritis patients with chronic Epstein-Barr virus infection, and considers the possibility of the reactive arthritis transformation into rheumatoid arthritis. It was established that expression of TLR9+CD123+ on monocytes was reliably higher in the blood of reactive arthritis patients as compared to healthy individuals, while in patients in active phase of EBV-infection the expression of this receptor was reliably higher as compared to similar indices of patients at the latent phase. At that, the number of TLR9+CD123+-monocytes in patients with reactive and rheumatoid arthritis was not reliably different. The number of TLR9+CD123+-lymphocytes as compared to indices of healthy individuals was reliably higher in patients with rheumatoid arthritis at both phases of chronic EBV-infection, while in patients with reactive arthritis it was only characteristic at the active phase of the infection. Expression of this receptor on lymphocytes turned out to be reliably higher in patients with rheumatoid arthritis as compared to patients with reactive arthritis, particularly at the active phase of chronic EBV infection.Документ Peculiarities of neurocognitive status of patients in the acute ischemic stroke phase of different hemispheric localization(Українська медична стоматологічна академія, 2020) Pushko, O.O.; Lytvynenko, N.V.; Пушко, Олександр Олександрович; Литвиненко, Наталія ВолодимирівнаThe article considers the peculiarities of neurocognitive status in patients after acute ischemic stroke of different hemispheric localization. Left-sided hemispheric stroke revealed a higher frequency and higher degree of cognitive impairment (mean score for Mini Mental State Examination was 21.3±0.61, for Montreal Cognitive Assessment – 18.22±0.9) compared with right-sided hemispheric localization of ischemic focus (mean score for MMSE – 24.05±0.52, for MoCa – 21.35±0.84) with a statistically significant difference between groups of patients as a whole and by specific blocks of subtests. It was also found that right-sided hemispheric strokes were characterized by a higher frequency and higher degree of anxiety and depressive disorders (mean score for Beck Depression Inventoянишенry was 15.1±0.87, for the state anxiety scale – 37.6±1.71, for the trait anxiety scale – 36.55±1.73) compared with the left-sided hemispheric localization of acute cerebrovascular accident (mean score for BDI was 11.61±0.71, for the state anxiety scale – 29.78±0.95, for the on the Spielberger-Khanin trait anxiety scale – 30.87±1.0) with a statistically significant difference between the groups.
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