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Документ Investigation of humoral immunity indicators of the oral cavity in patients depending on the degree of generalized chronic periodontitis(Полтавський державний медичний університет, 2021) Маrchenko, А. V.; Марченко, Алла ВолодимирівнаThe purpose of this research was to investigate the level of oral humoral immunity factors in patients depending on the degree of generalized chronic periodontitis. The study involved 60 patients. The material for the study was unstimulated oral fluid. Determination of lysozyme activity was carried out by the nephelometric method of V.G. Dorofeychuk. The level of sIgA in the oral fluid was identified by enzyme-linked immunosorbent assay according to the manufacturer's instructions. The correlation coefficient (Pearson's r) was computed to determine if a relationship exists between the levels of sIgA and lysozyme with the degree of generalized chronic periodontitis. It has been established an increase in the level of immune factors in the oral fluid of patients with generalized chronic periodontitis of I degree. A progressive significant decrease in lysozyme and sIgA was observed under conditions of generalized chronic periodontitis development of II and III degree. The lowest level of these indices was recorded in patients with generalized chronic periodontitis of III degree. We have established an inverse correlation between the levels of sIgA and lysozyme in the oral fluid of patients with the degree of generalized chronic periodontitis. Thus, the degree of generalized chronic periodontitis affects the level of humoral immune factors in the oral fluid and has an inverse correlation with them.Документ Особливості антенатального і постнатального періодів розвитку дітей з запальними процесами щелепно-лицевої локалізації(Українська медична стоматологічна академія, 2021) Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Попело, Юлія Вікторівна; Коротич, Наталія Миколаївна; Tkachenko, P. I.; Bilokon, S. O.; Lokhmatova, N. M.; Dolenko, O. B.; Popelo, Yu. V.; Korotych, N. M.За 7 років обстежено 537 дітей з гострими гнійними одонтогенними і неодонтогенними процессами щелепно-лицевої ділянки. Встановлено , що в їх структурі превалювали гострий гнійний лімфаденіт (29 %) та аденофлегмона і одонтогенний остеомієліт, на долю яких припадало по 18 %. Аналіз перебігу вагітності засвідчив, що в цей період у матерів обстежених дітей досить часто простежувалися випадки гострих інфекційних захворювань, наявність патологічних станів і це певною мірою відображалося на пологовій діяльності. Характерним є також те, що діти , які знаходилися на штучному та змішаному вигодуванні з місячного та шестимісячного віку частіше хворіли. Така ситуація вказує на необхідність включення цих дітей до групи ризику з метою своєчасно оздоровлення, що може звести нанівець вплив несприятливих чинників, дію яких вони відчували як в анте - так і постнатальному періодах їх розвитку.Документ The reaction of immunocompetent liver cells during chemical castration of male rats caused by the introduction of triptorelin acetate(Полтавський державний медичний університет, 2021) Rud, M. V.; Shepitko, V. I.; Stetsuk, Ye. V.; Akimov, O. Ye.; Vilkhova, O. V.; Skotarenko, T. A.; Рудь, Марія Володимирівна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Акімов, Олег Євгенович; Вільхова, Олена Вікторівна; Скотаренко, Тетяна АнатоліївнаThe purpose of our study was to elucidate the qualitative and quantitative changes in immunocompetent liver cells during chemical castration of male rats of central origin caused by the introduction of triptorelin acetate solution at different time intervals, to determine the sources of nitric oxide production as well as the effects of quercetin on morphological and quantitative changes of antigenpresenting liver cells. The morphological changes in the experimental groups with central testosterone deprivation and with its subsequent correction with quercetin on the 30th day of the experiment are identical and include signs of stromal ‒ vascular changes in the form of an increase in the thickness of the beam system and minor venous stasis with macrophage infiltration. Central 30 ‒ day deprivation of testosterone synthesis leads to a shift in the functioning of enzymes of the nitric oxide cycle in rat liver towards a predominance of the activity of inducible NO-synthase.Документ Blood gases and electrolytes under use of magnetite nanoparticles in blood loss(Полтавський державний медичний університет, 2021) Vazhnichaya, E. M.; Lutsenko, R. V.; Semaka, O. V.; Deviatkina, T. O.; Deviatkina, N. M.; Kurapov, Yu. A.; Litvin, S. Ye.; Важнича, Олена Митрофанівна; Луценко, Руслан Володимирович; Семака, Олександр Валентинович; Дев'яткіна, Тетяна Олексіївна; Дев'яткіна, Наталія Миколаївна; Курапов, Юрій Анатолійович; Литвин, Станіслав ЄгоровичBlood gases, acid-base balance, and electrolytes were studied under the conditions of correction of acute blood loss in abino rats with magnetite nanoparticles (5–8 nm) obtained by electron-beam technology and incorporated into sodium chloride crystals. It was shown that blood loss decreases total hemoglobin and the volumetric concentration of oxygen, diminishes sodium concentration and increases potassium concentration in the blood. Dissolved and injected intraperitoneally after the blood loss, magnetite nanoparticles (1.35–6.75 mg iron/kg) reduce the partial pressure of carbon dioxide, increase the partial pressure of oxygen, saturation of hemoglobin with oxygen and volumetric oxygen concentration, increase hydrogen index and sodium content, and reduce potassium concentration in the blood. These positive changes develop against the background of an increase in total hemoglobin. They surpass some effects of the traditional iron preparation and can be the basis for further research aimed at the use of magnetite nanoparticles in acute posthemorrhagic syndrome.Документ Assessment of adhesion to treatment of patients being on kidney replacement therapy taking into account the presence of type 2 diabetes mellitus(Полтавський державний медичний університет, 2021) Katerenchuk, I. P.; Rustamian, S. T.; Катеренчук, Іван Петрович; Рустамян, Сатєнік ТігранівнаThis article presents the results of the analysis of adherence to treatment of patients on renal replacement therapy, taking into account type 2 diabetes. It was found that the adherence index to treatment is directly proportional to the patient's age and does not depend on the article and duration of treatment on programmed hemodialysis. In turn, the presence of a history of diabetes increases patient compliance, which, in turn, has a positive effect on disease control by both the doctor and the patient. Patients with stage I-II chronic kidney disease have a low level of adherence, which may be an additional risk factor for renal failure progressionДокумент Pathomorphological changes of the optical nerve intracranial part in diabetes mellitus(Полтавський державний медичний університет, 2021) Pera-Vasylchenko, A. V.; Ryadnova, V. V.; Voskresenska, L. K.; Bezkorovayna, I. M.; Bezega, Н. М.; Пера-Васильченко, Анна Володимирівна; Ряднова, Вікторія Вікторівна; Воскресенська, Людмила Костянтинівна; Безкоровайна, Ірина Миколаївна; Безега, Ніна МихайлівнаРобота присвячена дослідженню морфологічних змін зорового нерва, переважно інтракраніального відділу, при діабетичній мікроангіопатії. Показано, що діабетична мікроангіопатія супроводжується проліферацією ендотеліоцитів капілярів, в результаті чого виникає звуження або облітерація просвіту судин. У свою чергу це призводить до ішемії нервових волокон з розвитком дистрофічних змін і часткового або повного руйнування астроцитів і олігодендроцитів. Очевидно, що при цукровому діабеті ці процеси відбуваються і в тканинах зорового нерва. Важка форма діабетичної мікроангіопатії зорового нерва схожа за морфологічними ознаками з проліферативною формою ретинопатіїДокумент The impact of the complex food additives on the glandular apparatus of the rat’s duodenal mucosa(Полтавський державний медичний університет, 2021) Bilash, V. P.; Grygorenko, A. S.; Yeroshenko, G. А.; Shevchenko, K. V.; Lysachenko, O. D.; Zviaholska, I. M.; Tymoshenko, Yu. V.; Khilinska, T. V.; Білаш, Валентина Павлівна; Григоренко, Альона Сергіївна; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Звягольська, Ірина Миколаївна; Тимошенко, Юлія Володимирівна; Хілінська, Тетяна ВолодимирівнаThe effect of a complex of food additives of monosodium glutamate, sodium nitrite and Ponceau 4R on the state of the crypt of the mucosa of the duodenum of rats in the early stages of the experiment leads to a decrease in mean morphometric values of crypt body components, which subsequently leads to disorders of microcirculation in blood vessels, the development of hypoxia and the occurrence of an inflammatory reaction. As a result, increasing dystrophic changes in the cells of the epithelium of the intestinal glands develop, which is manifested by a decrease in the average values of the quantitative indicator of the cellular composition of the epithelium of the crypts. Further, as a result of compensatory-restorative reactions, complete recovery does not occur, which is confirmed by a decrease in the mean values of the metric values of the crypt body with decreasing epithelial cell height, against a decrease in epithelial cell composition and local immunity during the experiment.Документ Remodeling of the gastric fundic vasculature under the effect of complex of monosodium glutamate, sodium nitrite and ponceau 4r(Полтавський державний медичний університет, 2021) Yachmin, А. І.; Yeroshenko, G. A; Shevchenko, K. V.; Bilash, S. M.; Lysachenko, O. D; Sokolenko, V. M; Sharlai, N. M.; Klepets, O. V.; Ячмінь, Анастасія Ігорівна; Шевченко, Костянтин Васильович; Білаш, Сергій Михайлович; Лисаченко, Ольга Дмитрівна; Соколенко, Валентина Миколаївна; Шарлай, Наталія Миколаївна; Клепець, Олена ВікторівнаThe paper presents the data of morphometric study of the effect of the food additives complex on the state of the vasculature of the stomach fundus under the action of the complex of monosodium glutamate, sodium nitrite and Ponceau 4R food additives. It was found that in the early stages of the experiment there was spasm of blood vessels of the hemomicrocirculatory bed due to the direct effect of food additives on the mucous membrane, which led to increased diameters of submucosal vessels as a result of hemodynamic conditions of the mucous membrane. Further development of the inflammatory reaction and the phenomenon of hypoxia led to compensatory-restorative reactions, but complete recovery did not occur, which at the end of the experiment was expressed by decompensation of the resistive link, metabolic spasm and increased lumen of the capacitive link.Документ The investigation of organoprotective properties of 2-hydroxy-n-naphthalene-1-yl -2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide(Полтавський державний медичний університет, 2021) Lutsenko, R. V.; Sydorenko, A. G.; Koiro, O. O.; Tsyvunin, Т. А.; Larinovska, Yu. B.; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Койро, Ольга Олегівна; Цивунін, Вадим Володимирович; Лар’яновська, Юлія БорисівнаIn experiments on 64 white male rats, the effect of 2-hydroxy-n-naphthalene-1-yl-2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide (12 mg/kg) compared to ethylmethylhydroxypyridine succinate (50 mg/ml) on the course of acute kidney injury caused by glycerol and tetrachloromethane hepatitis was studied. It has been found that the use of 2-hydroxy-n-naphthalene-1-yl-2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide against the background of tetrachloromethane hepatitis exhibits hepatoprotective properties, as evidenced by a decrease in the organ mass coefficient and the activity of enzymes-markers of damage to hepatocytes of alanine aminotransferase and aspartate aminotransferase in blood serum. The hepatoprotective effect of the studied compound is not inferior to ethylmethylhydroxypyridine succinate. In addition, a derivative of 2-oxyindoline-3-glyoxylic acid reduced the onset time of thiopental anesthesia. In acute glycerol-induced kidney injury, 2-hydroxy-n-naphthalene-1-yl-2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide had only the antiproteinuric action and did not show sufficient protective effect. This indicates the absence of the nephroprotective effect in the substance and possible side effects from the kidneys.Документ Folate cycle drugs in the complex preventive therapy for the miscarriage(Полтавський державний медичний університет, 2021) Mishchenko, V. P.; Rudenko, I. V.; Likhachov, V. K.; Gromova, A. M.; Tarasenko, K. V.; Міщенко, Валентина Павлівна; Руденко, І. В.; Ліхачов, Володимир Костянтинович; Громова, Антоніна Макарівна; Тарасенко, Костянтин Володимирович120 women of reproductive age were examined. Alleles of folate-related enzyme genes, the content of folic acid, cyanocobalamin, vitamins B1, B6 in the blood were determined. Prevention of miscarriage was based on preconception training of men and women (spouses). The pre-conceptual examination plan included a thorough study of the anamnesis, including family history; laboratory determination of folic acid, vitamins B12, B1, B6 in the blood of future parents (both woman and man). Decreased vitamin content or their level at the lower limit of normal was an indication for determining the folate-related enzyme genes (MTHFR: 1298A/C; 677C/T, MTR: 2756A/G, MTRR: 66A/G). Given the high (78.1 %) incidence of carriers of “functionally attenuated” (polymorphic) genes of folate cycle enzymes, both expectant parents were prescribed modern complexes of vitamins, microelements and amino acids containing Metafolin at the stage of preconception preparation 3-4 months before fertilization and during pregnancy according to the trimesters of gestation. Clinical and laboratory approach to the correction of vitamins, macro-, microelements, amino acids based on laboratory assessment of hereditary impairment of specific enzymes and by prescribing personalized therapy had a positive result in 57 (95.0 %) patients, which confirms its effectiveness.Документ Early cardiac rehabilitation in acute myocardial infarction patients and its features(Полтавський державний медичний університет, 2021) Teslenko, Y. V.; Myakinkova, L. O.; Teslenko, M. M.; Тесленко, Юрій Віталійович; М'якінькова, Людмила Олександрівна; Тесленко, Марина МиколаївнаPatients that have undergone myocardial infarction require inclusion in the treatment program of cardiac rehabilitation as a component of secondary prevention. Rehabilitation potential in patients with myocardial infarction was investigated according to a mathematical model that included indicators of hospital mortality, myocardial reperfusion, anxiety and depression, myocardial contractility, comorbidity and prehospital physical activity. The individual rehabilitation program according to the level of rehabilitation potential contributed to the early expansion of the physical exercise mode to the ward mode in patients of the experimental group for 2.83±0.13 days compared with 3.57±0.14 days in the control group, the baseline heart rate was 73.2±1.72 beats per minute, and 78.4±1.13 beats per minute, respectively. According to the results of submaximal testing, the distance in the experimental group was 694.7±38.4 m, in the control group – 584.2±40.7 m (p˂0.05). Assessment of rehabilitation potential provides determination of optimal terms and methods of cardiac rehabilitation.Документ Dynamics of oral hygiene indicators and salivity rate in children who frequently have acute respiratory and viral infections(Полтавський державний медичний університет, 2021) Pavlenkova, O. S.; Kaskova, L. F.; Павленкова, Оксана Сергіївна; Каськова, Людмила ФедорівнаBefore preventive interventions, the hygienic state in children, often ill, was unsatisfactory and ranged from 2.28±0.23– 2.29±0.12 points. A month after the appointment of preventive measures, this indicator improved to satisfactory in children of group 3 and to good in group 4 (who were assigned professional hygiene twice a year, individual hygiene using calcium paste, the use of calcium supplements and those that increase the body's protective properties and amounted to 1.68±0.06 points and 1.5±0.05 points, respectively. 6 months after the first survey, oral hygiene worsened in all children relative to the second survey, but it was better than to take preventive measures. The same picture was observed when determining the hygiene index according to the Green–Vermilion. There is a tendency to improve the rate of salivation after preventive measures.Документ Efficacy of percutaneous draining operations for simple renal cysts(Полтавський державний медичний університет, 2021) Sarychev, L. P.; Sarychev, Y. V.; Pustovoyt, A. L.; Suprunenko, S. M.; Savchenko, R. B.; Ustenko, R. L.; Sukhomlyn, S. A.; Саричев, Леонід Петрович; Саричев, Ярослав Володимирович; Пустовойт, Ганна Леонідівна; Супруненко, Сергій Миколайович; Савченко, Роман Борисович; Устенко, Роман Леонідович; Сухомлин, Сергій АдольфовичThe relevance of the work is due to the fact that the choice of the optimal method for minimally invasive treatment of simple renal cysts is controversial and there is no consensus. In order to assess the effectiveness of treatment, we carried out both a retrospective and prospective analysis of the documentation of 455 patients with simple renal cysts. Percutaneous draining operations performed in 402 (88.4 %) patients followed by sclerotherapy with 96 % ethanol have proven to be an effective treatment for progressive (>6 cm) and symptomatic simple renal cysts. Bosniak category II simple renal cysts are characterized by a significant increase in drainage time. Symptomatic parapelvical, multichambered, intraparenchymatous (Bosniak category IIFIII) and complicated (Bosniak category IV) simple renal cysts should be a subject for “open” surgical treatment.Документ New methods of dental hyperesthesia treatment(Полтавський державний медичний університет, 2021) Марченко, Алла Володимирівна; Дворник, Валентин Миколайович; Ніколішина, Елла Вячеславівна; Литовченко, Ірина Юріївна; Іленко, Наталія Миколаївна; Ніколішин, Ігор Анатолійович; Маrchenko, А. V.; Dvornik, V. М.; Nikolishyna, E. V.; Lytovchenko, I. Yu.; Ilenko, N. M.; Nikolishyn, І. А.The article presents the results of eliminating dental hyperesthesia by new effective methods of treatment developed and implemented in practical dentistry. Patients were divided into four groups: with hyperesthesia after professional or home teeth whitening; with hyperesthesia during the preparation of vital tissues for orthopedic structures; with hyperesthesia in pathological abrasion of the enamel and periodontitis. Analysis of the results and their comparison with previous studies showed that the use of drugs based on the eco-mineral complex bischofite is highly effective and ranges from 100 to 66.7 % depending on the observation group.Документ The effect of doxorubicin-induced oxidative stress on resistance of intestinal mucosa(Українська медична стоматологічна академія, 2021) Skrypnyk, R. І.; Maslova, G. S.; Скрипник, Роман Ігорович; Маслова, Ганна СергіївнаThe paper presents the findings of our own studies on the evaluation of the effect of anthracycline-induced oxidative stress on the level of N-acetylneuraminic acid and the state of the processes of free radical oxidation and antioxidant protection in the mucous membrane of rat small and large intestines depending on the presence of nonalcoholic steatohepatitis. 30 mature outbred albino rats were involved into studies. The cumulative dose of doxorubicin was 15 mg/kg. In the mucous membrane of the small intestine of rats with nonalcoholic steatohepatitis, administration of doxorubicin resulted in less pronounced oxidative damage and 1.2-fold decrease in N-acetylneuraminic acid concentration compared to rats without nonalcoholic steatohepatitis. It has been proved that administration of doxorubicin led to the development of doxorubicin-induced oxidative stress in the intestinal mucosa of rats with more severe lesions of the small intestine, regardless of the presence of nonalcoholic steatohepatitis.Документ Reactive changes in the vessels of the rat’s duodenal mucosa in response to the effect of complex food additives(Полтавський державний медичний університет, 2021) Yeroshenko, G. A.; Grygorenko, A. S.; Shevchenko, K. V.; Lysachenko, O. D.; Sokolenko, V. N.; Khilinska, T. V.; Bilash, V. P.; Solod, A. V.; Єрошенко, Галина Анатоліївна; Григоренко, Альона Сергіївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Соколенко, Валентина Миколаївна; Хілінська, Тетяна Володимирівна; Білаш, Валентина Павлівна; Солод, Анатолій ВікторовичВ роботі представлені дані морфометричного дослідження при комплексній дії харчових добавок на стан судин слизової оболонки. Встановлено, що дія глутамату натрію, нітриту натрію та Понсо 4R на ранніх термінах спостереження визначається зменшення середніх значень метричних показників судин гемомікроциркуляторного русла слизової оболонки, та розширення просвіту судин крупного калібру підслизової основи. В подальшому розвиток запальної реакції з виникненням набряку призвів до зменшення діаметрів просвіту резистивної та обмінної ланок з розширенням просвіту венул, викликав виникнення гіпоксії та дистрофічних змін, з наступним відновленням показників, внаслідок компенсаторно- пристосувальних реакцій на дію подразнюючого фактору, але повної нормалізації не відбулося. Зміни судин підслизового прошарку залежали від стану судин слизової оболонки протягом експерименту.Документ Morphometric analysis of placental and M1/M2 macrophages polarization in the detection of fetal growth restriction(Українська медична стоматологічна академія, 2021) Berezhna, V. A.; Gromova, A. M.; Mamontova, T. V.; Udovytska, N. O.; Starchenko, I. I.; Vesnina, L. E.; Бережна, Варвара Анатоліївна; Громова, Антоніна Макарівна; Мамонтова, Тетяна Василівна; Удовицька, Наталія Олегівна; Старченко, Іван Іванович; Весніна, Людмила ЕдуардівнаThe purpose of the present study was to analyzed the morphometric characteristics and CD68 and CD163 expression of macrophages in the placentas of women, whose pregnancies were complicated by fetal growth restriction. The study revealed low indices of the mass and area of the placentas, but high indices of the fetoplacental weight ratio. The level of CD68+ macrophages in fibrously altered terminal villi of the placenta was significantly higher in both groups women whose pregnancies were complicated by fetal growth restriction. There was significant increased CD163+ macrophages in fibrously altered terminal villi. Thus, in the placentas of women whose pregnancy was complicated by fetal growthrestriction and resulted preterm birth, there were disruptions of the vascular and stromal component of the chorionic villus with the changes to macrophage polarization from M1 to M2 types in fibrously altered terminal villi of the placenta.Документ Anemia in children in Ukraine: a 24-year retrospective analysis of morbidity and prevalence(Полтавський державний медичний університет, 2021) Volosovets, О. P.; Кryuchko, T. O.; Kryvopustov, S. P.; Hubenko, I. Ya.; Loboda, A. M.; Kiselova, M. M.; Volosovets, A. О.; Pavlyshyn, H. A.; Волосовець, О.П.; Крючко, Тетяна Олександрівна; Кривопустов, С. П.; Губенко, І. Я.; Лобода, О.Н.; Кисельова, М. Н.; Волосовець, А. О.; Павлишин, Г. А.The article is devoted to the growth of morbidity and prevalence of anemia in children of Ukraine in the period from 1994 to 2017. The methods of the system approach and epidemiological analysis of the MOH of Ukraine’s data in the period from 1994 to 2017 were used in the study. The retrospective study revealed that the incidence rate in children of Ukraine aged 0–17 inclusive increased by 31.4 % and by 59.8 % in the prevalence of anemia with their predominant detection in children affected by the Chernobyl accident and children constantly living in the areas with radiological control after the 1986 accident. A direct and noticeable relationship was established between the prevalence of anemia in children aged 0–14 years inclusive in 2011 and the population-weighted effective total radiation dose of the whole body in residents of different regions of Ukraine for the period 1997–2011 (p<0.05), which may indicate a possible impact of the accident consequences in combination with other factors on the incidence and prevalence of anemia in children.Документ Cytokines as mediators of the immune system and their role In the pathogenesis of community-acquired pneumonia(Полтавський державний медичний університет, 2021) Berezniakov, V. I.; Korzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Pyvovar, N. M.; Березняков, Владислав Ігорович; Корж, Олексій Миколайович; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Пивовар, Ніна МихайлівнаThe clinical and immunological examination of patients with community-acquired pneumonia has been carried out that included the study of the IL-2, IL-4, IL-6, IL-8 and TNFα cytokines’ system. Immune system disorders that determine the severity of pneumonia, the amount of inflammatory damage to the lung tissue, disrupted elimination of the immune complexes have been found. These tendencies to a decrease in the mmunoglobulins M and G result in a moderate course of community-acquired pneumonia and lobar lesions of the lungs, and the immune system disorders are reliably associated with imbalance of cytokines, with a predominance of their pro-inflammatory activity and a decrease in regulatory functions. The findings of the immunological monitoring indicate that standard antibiotic therapy in patients with community-acquired pneumonia leads to its clinical and radiological resolution, though it is not accompanied by the normalization of immunity parameters. The imbalance of the cytokine component of immunity justifies the need for further development of pathogenetic, as well as immunocorrective therapy, in patients with community-acquired pneumonia.Документ Clinical and psychopathological features of internally displaced women with adjustment disorders(Українська медична стоматологічна академія, 2021) Isakov, R. I.; Skrypnikov, A. M.; Herasymenko, L. O.; Hryn, K. V.; Kydon, P. V.; Vdovina, O. O.; Ісаков, Рустам Ісроїлович; Исаков, Рустам Исроилович; Скрипніков, Андрій Миколайович; Скрипников, Андрей Николаевич; Герасименко, Лариса Олександрівна; Герасименко, Лариса Александровна; Гринь, Катерина Вікторівна; Гринь, Екатерина Викторовна; Кидонь, Павло Володимирович; Кидонь, Павел Владимирович; Вдовіна, Олена Олександрівна; Вдовина, Елена АлександровнаVast numbers of internally displaced persons and the threatening growth rate of emigration create the need to pay increased attention to various aspects of psychopathological conditions that arise in response to changes in habitual living conditions. In addition to clinical consequences, the prevalence is accompanied by significant negative social and economic consequences both for society as a whole and for the patient himself, significantly deteriorating his quality of life and level of social functioning. There are significant gender differences in crisis response, in particular, women are the most vulnerable in the vast majority of stressful situations. We carried out a comprehensive clinical, psychopathological and psychodiagnostics examination of 48 internally displaced persons with the established adjustment disorder (F43.2) with studying and careful analysis of anamnestic data using a special questionnaire. The study found that the leading clinical manifestations of internally displaced women are the presence of anxiety and depression in the structure of adjustment disorders, social disintegration and the presence of psychosocial maladjustment. Clinical differences of internally displaced women with adjustment disorders affect the quality of life, change the system of social support and values, contribute to the reduction of productive activities in everyday life.
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