Світ медицини та біології. 2021

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New methods of dental hyperesthesia treatment
(Полтавський державний медичний університет, 2021) Марченко, Алла Володимирівна; Дворник, Валентин Миколайович; Ніколішина, Елла Вячеславівна; Литовченко, Ірина Юріївна; Іленко, Наталія Миколаївна; Ніколішин, Ігор Анатолійович; Маrchenko, А. V.; Dvornik, V. М.; Nikolishyna, E. V.; Lytovchenko, I. Yu.; Ilenko, N. M.; Nikolishyn, І. А.
The article presents the results of eliminating dental hyperesthesia by new effective methods of treatment developed and implemented in practical dentistry. Patients were divided into four groups: with hyperesthesia after professional or home teeth whitening; with hyperesthesia during the preparation of vital tissues for orthopedic structures; with hyperesthesia in pathological abrasion of the enamel and periodontitis. Analysis of the results and their comparison with previous studies showed that the use of drugs based on the eco-mineral complex bischofite is highly effective and ranges from 100 to 66.7 % depending on the observation group.
The effect of doxorubicin-induced oxidative stress on resistance of intestinal mucosa
(Українська медична стоматологічна академія, 2021) Skrypnyk, R. І.; Maslova, G. S.; Скрипник, Роман Ігорович; Маслова, Ганна Сергіївна
The paper presents the findings of our own studies on the evaluation of the effect of anthracycline-induced oxidative stress on the level of N-acetylneuraminic acid and the state of the processes of free radical oxidation and antioxidant protection in the mucous membrane of rat small and large intestines depending on the presence of nonalcoholic steatohepatitis. 30 mature outbred albino rats were involved into studies. The cumulative dose of doxorubicin was 15 mg/kg. In the mucous membrane of the small intestine of rats with nonalcoholic steatohepatitis, administration of doxorubicin resulted in less pronounced oxidative damage and 1.2-fold decrease in N-acetylneuraminic acid concentration compared to rats without nonalcoholic steatohepatitis. It has been proved that administration of doxorubicin led to the development of doxorubicin-induced oxidative stress in the intestinal mucosa of rats with more severe lesions of the small intestine, regardless of the presence of nonalcoholic steatohepatitis.
Assessment of adhesion to treatment of patients being on kidney replacement therapy taking into account the presence of type 2 diabetes mellitus
(Полтавський державний медичний університет, 2021) Katerenchuk, I. P.; Rustamian, S. T.; Катеренчук, Іван Петрович; Рустамян, Сатєнік Тігранівна
This article presents the results of the analysis of adherence to treatment of patients on renal replacement therapy, taking into account type 2 diabetes. It was found that the adherence index to treatment is directly proportional to the patient's age and does not depend on the article and duration of treatment on programmed hemodialysis. In turn, the presence of a history of diabetes increases patient compliance, which, in turn, has a positive effect on disease control by both the doctor and the patient. Patients with stage I-II chronic kidney disease have a low level of adherence, which may be an additional risk factor for renal failure progression
Pathomorphological changes of the optical nerve intracranial part in diabetes mellitus
(Полтавський державний медичний університет, 2021) Pera-Vasylchenko, A. V.; Ryadnova, V. V.; Voskresenska, L. K.; Bezkorovayna, I. M.; Bezega, Н. М.; Пера-Васильченко, Анна Володимирівна; Ряднова, Вікторія Вікторівна; Воскресенська, Людмила Костянтинівна; Безкоровайна, Ірина Миколаївна; Безега, Ніна Михайлівна
Робота присвячена дослідженню морфологічних змін зорового нерва, переважно інтракраніального відділу, при діабетичній мікроангіопатії. Показано, що діабетична мікроангіопатія супроводжується проліферацією ендотеліоцитів капілярів, в результаті чого виникає звуження або облітерація просвіту судин. У свою чергу це призводить до ішемії нервових волокон з розвитком дистрофічних змін і часткового або повного руйнування астроцитів і олігодендроцитів. Очевидно, що при цукровому діабеті ці процеси відбуваються і в тканинах зорового нерва. Важка форма діабетичної мікроангіопатії зорового нерва схожа за морфологічними ознаками з проліферативною формою ретинопатії
Investigation of humoral immunity indicators of the oral cavity in patients depending on the degree of generalized chronic periodontitis
(Полтавський державний медичний університет, 2021) Маrchenko, А. V.; Марченко, Алла Володимирівна
The purpose of this research was to investigate the level of oral humoral immunity factors in patients depending on the degree of generalized chronic periodontitis. The study involved 60 patients. The material for the study was unstimulated oral fluid. Determination of lysozyme activity was carried out by the nephelometric method of V.G. Dorofeychuk. The level of sIgA in the oral fluid was identified by enzyme-linked immunosorbent assay according to the manufacturer's instructions. The correlation coefficient (Pearson's r) was computed to determine if a relationship exists between the levels of sIgA and lysozyme with the degree of generalized chronic periodontitis. It has been established an increase in the level of immune factors in the oral fluid of patients with generalized chronic periodontitis of I degree. A progressive significant decrease in lysozyme and sIgA was observed under conditions of generalized chronic periodontitis development of II and III degree. The lowest level of these indices was recorded in patients with generalized chronic periodontitis of III degree. We have established an inverse correlation between the levels of sIgA and lysozyme in the oral fluid of patients with the degree of generalized chronic periodontitis. Thus, the degree of generalized chronic periodontitis affects the level of humoral immune factors in the oral fluid and has an inverse correlation with them.
Early cardiac rehabilitation in acute myocardial infarction patients and its features
(Полтавський державний медичний університет, 2021) Teslenko, Y. V.; Myakinkova, L. O.; Teslenko, M. M.; Тесленко, Юрій Віталійович; М'якінькова, Людмила Олександрівна; Тесленко, Марина Миколаївна
Patients that have undergone myocardial infarction require inclusion in the treatment program of cardiac rehabilitation as a component of secondary prevention. Rehabilitation potential in patients with myocardial infarction was investigated according to a mathematical model that included indicators of hospital mortality, myocardial reperfusion, anxiety and depression, myocardial contractility, comorbidity and prehospital physical activity. The individual rehabilitation program according to the level of rehabilitation potential contributed to the early expansion of the physical exercise mode to the ward mode in patients of the experimental group for 2.83±0.13 days compared with 3.57±0.14 days in the control group, the baseline heart rate was 73.2±1.72 beats per minute, and 78.4±1.13 beats per minute, respectively. According to the results of submaximal testing, the distance in the experimental group was 694.7±38.4 m, in the control group – 584.2±40.7 m (p˂0.05). Assessment of rehabilitation potential provides determination of optimal terms and methods of cardiac rehabilitation.
Особливості антенатального і постнатального періодів розвитку дітей з запальними процесами щелепно-лицевої локалізації
(Українська медична стоматологічна академія, 2021) Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Попело, Юлія Вікторівна; Коротич, Наталія Миколаївна; Tkachenko, P. I.; Bilokon, S. O.; Lokhmatova, N. M.; Dolenko, O. B.; Popelo, Yu. V.; Korotych, N. M.
За 7 років обстежено 537 дітей з гострими гнійними одонтогенними і неодонтогенними процессами щелепно-лицевої ділянки. Встановлено , що в їх структурі превалювали гострий гнійний лімфаденіт (29 %) та аденофлегмона і одонтогенний остеомієліт, на долю яких припадало по 18 %. Аналіз перебігу вагітності засвідчив, що в цей період у матерів обстежених дітей досить часто простежувалися випадки гострих інфекційних захворювань, наявність патологічних станів і це певною мірою відображалося на пологовій діяльності. Характерним є також те, що діти , які знаходилися на штучному та змішаному вигодуванні з місячного та шестимісячного віку частіше хворіли. Така ситуація вказує на необхідність включення цих дітей до групи ризику з метою своєчасно оздоровлення, що може звести нанівець вплив несприятливих чинників, дію яких вони відчували як в анте - так і постнатальному періодах їх розвитку.
The reaction of immunocompetent liver cells during chemical castration of male rats caused by the introduction of triptorelin acetate
(Полтавський державний медичний університет, 2021) Rud, M. V.; Shepitko, V. I.; Stetsuk, Ye. V.; Akimov, O. Ye.; Vilkhova, O. V.; Skotarenko, T. A.; Рудь, Марія Володимирівна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Акімов, Олег Євгенович; Вільхова, Олена Вікторівна; Скотаренко, Тетяна Анатоліївна
The purpose of our study was to elucidate the qualitative and quantitative changes in immunocompetent liver cells during chemical castration of male rats of central origin caused by the introduction of triptorelin acetate solution at different time intervals, to determine the sources of nitric oxide production as well as the effects of quercetin on morphological and quantitative changes of antigenpresenting liver cells. The morphological changes in the experimental groups with central testosterone deprivation and with its subsequent correction with quercetin on the 30th day of the experiment are identical and include signs of stromal ‒ vascular changes in the form of an increase in the thickness of the beam system and minor venous stasis with macrophage infiltration. Central 30 ‒ day deprivation of testosterone synthesis leads to a shift in the functioning of enzymes of the nitric oxide cycle in rat liver towards a predominance of the activity of inducible NO-synthase.
Folate cycle drugs in the complex preventive therapy for the miscarriage
(Полтавський державний медичний університет, 2021) Mishchenko, V. P.; Rudenko, I. V.; Likhachov, V. K.; Gromova, A. M.; Tarasenko, K. V.; Міщенко, Валентина Павлівна; Руденко, Ірина Василівна ; Ліхачов, Володимир Костянтинович; Громова, Антоніна Макарівна; Тарасенко, Костянтин Володимирович
120 women of reproductive age were examined. Alleles of folate-related enzyme genes, the content of folic acid, cyanocobalamin, vitamins B1, B6 in the blood were determined. Prevention of miscarriage was based on preconception training of men and women (spouses). The pre-conceptual examination plan included a thorough study of the anamnesis, including family history; laboratory determination of folic acid, vitamins B12, B1, B6 in the blood of future parents (both woman and man). Decreased vitamin content or their level at the lower limit of normal was an indication for determining the folate-related enzyme genes (MTHFR: 1298A/C; 677C/T, MTR: 2756A/G, MTRR: 66A/G). Given the high (78.1 %) incidence of carriers of “functionally attenuated” (polymorphic) genes of folate cycle enzymes, both expectant parents were prescribed modern complexes of vitamins, microelements and amino acids containing Metafolin at the stage of preconception preparation 3-4 months before fertilization and during pregnancy according to the trimesters of gestation. Clinical and laboratory approach to the correction of vitamins, macro-, microelements, amino acids based on laboratory assessment of hereditary impairment of specific enzymes and by prescribing personalized therapy had a positive result in 57 (95.0 %) patients, which confirms its effectiveness.
Dynamics of oral hygiene indicators and salivity rate in children who frequently have acute respiratory and viral infections
(Полтавський державний медичний університет, 2021) Pavlenkova, O. S.; Kaskova, L. F.; Павленкова, Оксана Сергіївна; Каськова, Людмила Федорівна
Before preventive interventions, the hygienic state in children, often ill, was unsatisfactory and ranged from 2.28±0.23– 2.29±0.12 points. A month after the appointment of preventive measures, this indicator improved to satisfactory in children of group 3 and to good in group 4 (who were assigned professional hygiene twice a year, individual hygiene using calcium paste, the use of calcium supplements and those that increase the body's protective properties and amounted to 1.68±0.06 points and 1.5±0.05 points, respectively. 6 months after the first survey, oral hygiene worsened in all children relative to the second survey, but it was better than to take preventive measures. The same picture was observed when determining the hygiene index according to the Green–Vermilion. There is a tendency to improve the rate of salivation after preventive measures.
Efficacy of percutaneous draining operations for simple renal cysts
(Полтавський державний медичний університет, 2021) Sarychev, L. P.; Sarychev, Y. V.; Pustovoyt, A. L.; Suprunenko, S. M.; Savchenko, R. B.; Ustenko, R. L.; Sukhomlyn, S. A.; Саричев, Леонід Петрович; Саричев, Ярослав Володимирович; Пустовойт, Ганна Леонідівна; Супруненко, Сергій Миколайович; Савченко, Роман Борисович; Устенко, Роман Леонідович; Сухомлин, Сергій Адольфович
The relevance of the work is due to the fact that the choice of the optimal method for minimally invasive treatment of simple renal cysts is controversial and there is no consensus. In order to assess the effectiveness of treatment, we carried out both a retrospective and prospective analysis of the documentation of 455 patients with simple renal cysts. Percutaneous draining operations performed in 402 (88.4 %) patients followed by sclerotherapy with 96 % ethanol have proven to be an effective treatment for progressive (>6 cm) and symptomatic simple renal cysts. Bosniak category II simple renal cysts are characterized by a significant increase in drainage time. Symptomatic parapelvical, multichambered, intraparenchymatous (Bosniak category IIFIII) and complicated (Bosniak category IV) simple renal cysts should be a subject for “open” surgical treatment.
The impact of the complex food additives on the glandular apparatus of the rat’s duodenal mucosa
(Полтавський державний медичний університет, 2021) Bilash, V. P.; Grygorenko, A. S.; Yeroshenko, G. A. ; Shevchenko, K. V.; Lysachenko, O. D.; Zviaholska, I. M.; Tymoshenko, Yu. V.; Khilinska, T. V.; Білаш, Валентина Павлівна; Григоренко, Альона Сергіївна; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Звягольська, Ірина Миколаївна; Тимошенко, Юлія Володимирівна; Хілінська, Тетяна Володимирівна
The effect of a complex of food additives of monosodium glutamate, sodium nitrite and Ponceau 4R on the state of the crypt of the mucosa of the duodenum of rats in the early stages of the experiment leads to a decrease in mean morphometric values of crypt body components, which subsequently leads to disorders of microcirculation in blood vessels, the development of hypoxia and the occurrence of an inflammatory reaction. As a result, increasing dystrophic changes in the cells of the epithelium of the intestinal glands develop, which is manifested by a decrease in the average values of the quantitative indicator of the cellular composition of the epithelium of the crypts. Further, as a result of compensatory-restorative reactions, complete recovery does not occur, which is confirmed by a decrease in the mean values of the metric values of the crypt body with decreasing epithelial cell height, against a decrease in epithelial cell composition and local immunity during the experiment.
Remodeling of the gastric fundic vasculature under the effect of complex of monosodium glutamate, sodium nitrite and ponceau 4r
(Полтавський державний медичний університет, 2021) Yachmin, А. І.; Yeroshenko, G. A.; Shevchenko, K. V.; Bilash, S. M.; Lysachenko, O. D. ; Sokolenko, V. M.; Sharlai, N. M.; Klepets, O. V.; Ячмінь, Анастасія Ігорівна; Шевченко, Костянтин Васильович; Білаш, Сергій Михайлович; Лисаченко, Ольга Дмитрівна; Соколенко, Валентина Миколаївна; Шарлай, Наталія Миколаївна; Клепець, Олена Вікторівна
The paper presents the data of morphometric study of the effect of the food additives complex on the state of the vasculature of the stomach fundus under the action of the complex of monosodium glutamate, sodium nitrite and Ponceau 4R food additives. It was found that in the early stages of the experiment there was spasm of blood vessels of the hemomicrocirculatory bed due to the direct effect of food additives on the mucous membrane, which led to increased diameters of submucosal vessels as a result of hemodynamic conditions of the mucous membrane. Further development of the inflammatory reaction and the phenomenon of hypoxia led to compensatory-restorative reactions, but complete recovery did not occur, which at the end of the experiment was expressed by decompensation of the resistive link, metabolic spasm and increased lumen of the capacitive link.
The investigation of organoprotective properties of 2-hydroxy-n-naphthalene-1-yl -2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide
(Полтавський державний медичний університет, 2021) Lutsenko, R. V.; Sydorenko, A. G.; Koiro, O. O.; Tsyvunin, Т. А.; Larinovska, Yu. B.; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Койро, Ольга Олегівна; Цивунін, Вадим Володимирович; Лар’яновська, Юлія Борисівна
In experiments on 64 white male rats, the effect of 2-hydroxy-n-naphthalene-1-yl-2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide (12 mg/kg) compared to ethylmethylhydroxypyridine succinate (50 mg/ml) on the course of acute kidney injury caused by glycerol and tetrachloromethane hepatitis was studied. It has been found that the use of 2-hydroxy-n-naphthalene-1-yl-2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide against the background of tetrachloromethane hepatitis exhibits hepatoprotective properties, as evidenced by a decrease in the organ mass coefficient and the activity of enzymes-markers of damage to hepatocytes of alanine aminotransferase and aspartate aminotransferase in blood serum. The hepatoprotective effect of the studied compound is not inferior to ethylmethylhydroxypyridine succinate. In addition, a derivative of 2-oxyindoline-3-glyoxylic acid reduced the onset time of thiopental anesthesia. In acute glycerol-induced kidney injury, 2-hydroxy-n-naphthalene-1-yl-2-(2-oxy-1,2-dihydro-indole-3-yliden)-acetamide had only the antiproteinuric action and did not show sufficient protective effect. This indicates the absence of the nephroprotective effect in the substance and possible side effects from the kidneys.
The state of the temporomandibular joint in patients with a cross bite and mandible displacement based on x-ray methods
(Українська медична стоматологічна академія, 2021) Smaglyuk, L. V.; Kulish, N. V.; Liakhovska, A. V.; Смаглюк, Любов Вікентіївна; Куліш, Неля Володимирівна; Ляховська, Анастасія Віталіївна
У статті представлені дані щодо удосконалення методів діагностики стану скронево-нижньощелепного суглобу на етапах планування ортодонтичного лікування у пацієнтів із перехресним прикусом у поєднанні зі зміщенням нижньої щелепи. На основі аналізу даних рентгенологічного методу досліджень, а саме ортопантомограми визначені анатомічні особливості розташування елементів скронево-нижньощелепного суглобу при перехресному букальному прикусі зі зміщенням нижньої щелепи незалежно від сторони локалізації. Змінюється форма та ширина суглобових ямок і відповідно трансформується форма та ширина суглобових голівок. Визначається різний рівень розташування суглобових голівок в ямках, як з боку зміщення нижньої щелепи так і з протилежної сторони. Встановлено, що чим більший ступінь зсуву нижньої щелепи вбік тим більший градус невідповідності розташування суглобових голівок. Тому потрібно ретельно аналізувати будову суглобів, паралельність розташування голівок, диференціювати характер змін з метою сприяння звуження кола потенційних ускладнень в період ортодонтичного лікування.
Актуальні питання діагностики респіраторних проявів гастроезофагеальної рефлюксної хвороби
(ТОВ "Видавничий Дім "Здоров'я України", 2021) Osyodlo, G. V.; Bychkova, S. A.; Katerenchuk, I. P.; Seliuk, M. M.; Kazmirchuk, A. P.; Осьодло, Г. В.; Бичкова, С. А.; Катеренчук, Іван Петрович; Селюк, Михайло Миколайович ; Казмірчук, А. П.
The purpose of the study was to determine the leading extraesophageal symptoms, disturbance of spirometric indices, changes in the immune system and production of nitric oxide in patients with gastroesophageal reflux disease. Bronchopulmonary manifestation of gastroesophageal reflux disease was a cough syndrome, which was characterized by the presence of non-intensive, unproductive cough with a small amount of mucous sputum and was combined, in most cases, with the hoarseness of the voice. Cough syndrome during gastroesophageal reflux disease was characterized by a lack of obstructive changes in the study of external respiration indices and elevated levels of proinflammatory cytokines in the blood serum. It was determined the higher nitric oxide content in platelets in patients with respiratory manifestations of gastroesophageal reflux disease.
Dynamics of clinical and laboratory indicators in the treatment of patients with psoriasis and concomitant alimentary obesity
(Полтавський державний медичний університет, 2021) Yemchenko, Ya. A.; Ishhejkin, K. Ye.; Kaidashev, I. P.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович
Psoriasis is the most common chronic, genetically determined autoimmune polyetiological inflammatory disease with impaired epidermal proliferation, which is provoked by exogenous and endogenous factors and is manifested by erythematous and scaly elements, papules and plaques. There is still no consensus on the pathogenesis of this dermatosis. To objectively understand the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidity of this pathology. Numerous studies have shown a clear link between psoriasis and obesity. Systemic inflammation is a common link in the pathogenesis of obesity and psoriasis. In this study, we determined the effectiveness of standard treatment for patients with psoriasis and concomitant grade I-II alimentary obesity, by clinical and immunological examination of systemic inflammation. Found that the treatment of patients was ineffective and further led to the deterioration of patient’s condition due to increased systemic inflammation, the progression of obesity and a more severe course of psoriasis.
Influence of prolonged tripterelin-induced central deprivation of testosterone synthesis on morphological structure of rat’s liver
(Українська медична стоматологічна академія, 2021) Polyvyana, O. A.; Shepitko, K. V.; Stetsuk, Ye. V.; Akimov, O. Ye.; Dubinin, D. S.; Полив'яна, Олександра Анатоліївна; Шепітько, Костянтин Володимирович; Стецук, Євген Валерійович; Акімов, Олег Євгенович; Дубінін, Дмитро Сергійович
In recent years, the incidence of prostate cancer has increased worldwide. For example, in 2012, the GLOBOCAN project found that prostate cancer was the second most commonly diagnosed cancer and the fifth leading cause of cancer deaths among men worldwide. Insufficient testosterone can exacerbate liver damage caused by obesity. The aim of our study was to identify morphological changes in the liver of rats at the tissue and cellular levels, to study the processes of formation of reactive oxygen species and the intensity of lipid peroxidation during prolonged central deprivation of testosterone synthesis caused by triptereline. Triptorelin-induced central deprivation of testosterone synthesis leads to oxidative damage to hepatocytes due to increased production of reactive oxygen species and decreased activity of antioxidant enzymes. Oxidative damage to liver cells begins at the molecular and cellular levels and becomes apparent at the tissue level on day 180 of the central deprivation of testosterone synthesis.
The role of L-ornithine-L-aspartate in prophylaxis of cytostatic-induced liver injury in patients with multiple myeloma
(Полтавський державний медичний університет, 2021) Maslova, G. S.; Skrypnyk, R. I.; Skrypnyk, I. N.; Маслова, Ганна Сергіївна; Скрипник, Роман Ігорович; Скрипник, Ігор Миколайович
The paper presents the findings of our studies on the assessment of the effectiveness of L-ornithine-L-aspartate in the prophylactic of chemotherapy-induced liver injury in patients with multiple myeloma. 24 patients with multiple myeloma were examined (11 females and 13 males, ages 46–78). The condition assessment was conducted twice: before chemotherapy and after 3 courses of chemotherapy. Patients were analyzed for the following biochemical parameters: the activity of alanine and asparagines aminotransferases, gamma-glutamyltranspeptidase, alkaline phosphatase, total bilirubin, total protein, creatinine, urea, total blood calcium level. Depending on the inclusion of L-ornithine-L-aspartate as an adjuvant treatment, patients were divided into 2 groups: group I (n=12) – patients with multiple myeloma, who underwent only chemotherapy; group II (n=12) – patients with multiple myeloma, who during chemotherapy received L-ornithine-L-aspartate at a dose of 10 g/day intravenously for 10 days, then 5 g 2 twice a day for 20 days. Group ІІІ (n=20) the control group, included 20 practically healthy persons. It was established, that application of L-ornithine-L-aspartate as an adjuvant treatment in patients with multiple myeloma that undergo chemotherapy provides the effective prophylactic of pathological alterations in liver and kidney functional state.
Cytokines as mediators of the immune system and their role In the pathogenesis of community-acquired pneumonia
(Полтавський державний медичний університет, 2021) Berezniakov, V. I.; Korzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Pyvovar, N. M.; Березняков, Владислав Ігорович; Корж, Олексій Миколайович; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Пивовар, Ніна Михайлівна
The clinical and immunological examination of patients with community-acquired pneumonia has been carried out that included the study of the IL-2, IL-4, IL-6, IL-8 and TNFα cytokines’ system. Immune system disorders that determine the severity of pneumonia, the amount of inflammatory damage to the lung tissue, disrupted elimination of the immune complexes have been found. These tendencies to a decrease in the mmunoglobulins M and G result in a moderate course of community-acquired pneumonia and lobar lesions of the lungs, and the immune system disorders are reliably associated with imbalance of cytokines, with a predominance of their pro-inflammatory activity and a decrease in regulatory functions. The findings of the immunological monitoring indicate that standard antibiotic therapy in patients with community-acquired pneumonia leads to its clinical and radiological resolution, though it is not accompanied by the normalization of immunity parameters. The imbalance of the cytokine component of immunity justifies the need for further development of pathogenetic, as well as immunocorrective therapy, in patients with community-acquired pneumonia.

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