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Документ Analysis of the corpus callosum myeloarchitectonics of mature people(Полтавський державний медичний університет, 2021) Boiagina, O. D.; Kostilenko, Yu. P.; Zharova, N. V.; Боягіна, Ольга Дмитрівна; Костиленко, Юрій Петрович; Жарова, Наталія Валентинівна; Боягина, Ольга Дмитриевна; Костиленко, Юрий Петрович; Жарова, Наталья ВалентиновнаSerial semi-thin sections of laminated preparations of the corpus callosum of mature people were studied. It was found out that there is a tunnel network of interstitial fissures between the blood exchange microvessels and myelinated nerve fibres, which closes around the cellular portions. This interstitial network is an intermediate compartment between the blood flowing through the microvessels and the cells in which the interfascicular oligodendrocytes are cellularly distributed. In the corpus callosum, the entire transport system is completely aimed at ensuring the structural and functional stability of only the myelin sheaths of nerve fibres due to the secretory activity of interfascicular oligodendrocytes.Документ Anatomical and topographic features of the structure of the cellular part of the mandible in patients with partial absence of teeth(Полтавський державний медичний університет, 2021) Stupnytsky, I. R.; Rozhko, M. M.; Stupnytskyi, R. M.; Silenko, Yu. I.; Yeroshenko, H. A.; Ступницький, І. Р.; Рожко, М. М.; Ступницький, Р. М.; Силенко, Юрій Іванович; Єрошенко, Галина Анатоліївна; Ступницкий, И. Р.; Рожко, М. М.; Ступницкий, Р. М.; Силенко, Юрий Иванович; Ерошенко, Галина АнатольевнаПроведене дослідження свідчить про те, що товщина слизової оболонки на верхівці коміркової частини нижньої щелепи у пацієнтів з включеними дефектами зубного ряду збільшувалася у напрямку зубів, які обмежували даний дефект. Верхівка коміркової частини, чітко видима в ротовій порожнині, не завжди співпадала з рентгенологічним зображенням коміркової частини, а була утворена потовщеною у даній ділянці слизовою оболонкою. Форма кісткової основи коміркової частини повторювала «клінічний» тип бокових поверхонь і форму верхівки гребеня у 87,5±6,8 % осіб. Неспівпадіння виявлено при ІV та VІІ типах бокових поверхонь коміркового відростка;Документ Anemia in children in Ukraine: a 24-year retrospective analysis of morbidity and prevalence(Полтавський державний медичний університет, 2021) Volosovets, О. P.; Кryuchko, T. O.; Kryvopustov, S. P.; Hubenko, I. Ya.; Loboda, A. M.; Kiselova, M. M.; Volosovets, A. О.; Pavlyshyn, H. A.; Волосовець, О.П.; Крючко, Тетяна Олександрівна; Кривопустов, С. П.; Губенко, І. Я.; Лобода, О.Н.; Кисельова, М. Н.; Волосовець, А. О.; Павлишин, Г. А.The article is devoted to the growth of morbidity and prevalence of anemia in children of Ukraine in the period from 1994 to 2017. The methods of the system approach and epidemiological analysis of the MOH of Ukraine’s data in the period from 1994 to 2017 were used in the study. The retrospective study revealed that the incidence rate in children of Ukraine aged 0–17 inclusive increased by 31.4 % and by 59.8 % in the prevalence of anemia with their predominant detection in children affected by the Chernobyl accident and children constantly living in the areas with radiological control after the 1986 accident. A direct and noticeable relationship was established between the prevalence of anemia in children aged 0–14 years inclusive in 2011 and the population-weighted effective total radiation dose of the whole body in residents of different regions of Ukraine for the period 1997–2011 (p<0.05), which may indicate a possible impact of the accident consequences in combination with other factors on the incidence and prevalence of anemia in children.Документ Assessment of adhesion to treatment of patients being on kidney replacement therapy taking into account the presence of type 2 diabetes mellitus(Полтавський державний медичний університет, 2021) Katerenchuk, I. P.; Rustamian, S. T.; Катеренчук, Іван Петрович; Рустамян, Сатєнік ТігранівнаThis article presents the results of the analysis of adherence to treatment of patients on renal replacement therapy, taking into account type 2 diabetes. It was found that the adherence index to treatment is directly proportional to the patient's age and does not depend on the article and duration of treatment on programmed hemodialysis. In turn, the presence of a history of diabetes increases patient compliance, which, in turn, has a positive effect on disease control by both the doctor and the patient. Patients with stage I-II chronic kidney disease have a low level of adherence, which may be an additional risk factor for renal failure progressionДокумент Blood gases and electrolytes under use of magnetite nanoparticles in blood loss(Полтавський державний медичний університет, 2021) Vazhnichaya, E. M.; Lutsenko, R. V.; Semaka, O. V.; Deviatkina, T. O.; Deviatkina, N. M.; Kurapov, Yu. A.; Litvin, S. Ye.; Важнича, Олена Митрофанівна; Луценко, Руслан Володимирович; Семака, Олександр Валентинович; Дев'яткіна, Тетяна Олексіївна; Дев'яткіна, Наталія Миколаївна; Курапов, Юрій Анатолійович; Литвин, Станіслав ЄгоровичBlood gases, acid-base balance, and electrolytes were studied under the conditions of correction of acute blood loss in abino rats with magnetite nanoparticles (5–8 nm) obtained by electron-beam technology and incorporated into sodium chloride crystals. It was shown that blood loss decreases total hemoglobin and the volumetric concentration of oxygen, diminishes sodium concentration and increases potassium concentration in the blood. Dissolved and injected intraperitoneally after the blood loss, magnetite nanoparticles (1.35–6.75 mg iron/kg) reduce the partial pressure of carbon dioxide, increase the partial pressure of oxygen, saturation of hemoglobin with oxygen and volumetric oxygen concentration, increase hydrogen index and sodium content, and reduce potassium concentration in the blood. These positive changes develop against the background of an increase in total hemoglobin. They surpass some effects of the traditional iron preparation and can be the basis for further research aimed at the use of magnetite nanoparticles in acute posthemorrhagic syndrome.Документ Changes in cell-mediated and humoral immunity indices and levels of pro- and anti-inflammatory cytokines in cervical mucus in pregnant women of high risk for preeclampsia(Полтавський державний медичний університет, 2021) Ліхачов, Володимир Костянтинович; Ващенко, Вікторія Леонідівна; Тарановська, Олена Олексіївна; Добровольська, Людмила Миколаївна; Макаров, Олег Геннадійович; Likhachov, V. K.; Vashchenko, V. L.; Taranovska, O. O.; Dobrovolska, L. M.; Makarov, O. G.62 pregnant women were examined, of which 30 were healthy pregnant ones (control group) and 32 women at high risk of preeclampsia (main group – MG) at 18–20 + 6 weeks and 28–32 weeks of pregnancy. The content of pro- and anti-inflammatory cytokines (TNFα, INFγ, IL10) in cervical mucus and indices of cellular-humoral immunity in the blood, including the concentration of circulating immune complexes (CIC) in the serum were studied. The analysis of the subpopulation composition of T - cells revealed a decrease in the concentration of T-helpers (CD4+) with a significant increase in the concentration of Tsuppressors/killers (CD8+) with a corresponding decrease in the immunoregulatory index. A significant decrease in the number of B cells (CD22+) was registered. An increase in CIC in the main group of subjects was demonstrated, and an increase in CIC levels above 100 IU/ml was closely associated with the development of preeclampsia. IgM in women with preeclampsia was significantly elevated, which may indicate the presence of trophoblastic stimulation of the immune system in these women. IgG levels were significantly reduced. In women with preeclampsia, a significant predominance of pro-inflammatory cytokines has been found in anti-inflammatory cytokine deficiency.Документ Changes in the intestinal microbiota in patients with ulcerative colitis and irritable bowel syndrome combined with urolithiasis(Полтавський державний медичний університет, Українська Академія наук національного прогресу, 2021-12) Kyrian, O. A.; Derkach, I. A.; Dorofeyev, A. E; Rudenko, M. M.; Кир'ян, Олена Анатоліївна; Дeркач, Ігор Анатолійович; Дорофєєв, Андрій Едуардович; Рудeнкo, Микола МиколайовичThe paper is devoted to the study of changes in the intestinal microbiome in patients with urolithiasis that occurred against the background of ulcerative colitis and irritable bowel syndrome. It was found that about 20 % of patients with urolithiasis have symptoms of irritable bowel syndrome, with more than half of the stones consisting of oxalates. In the study of fecal microflora in patients with the method of sequencing of the 16S gene of ribosomal RNA, compared with healthy, a significant decrease in Firmicutes, Faecalibacterium prausnitzii, Akkermansia muciniphila and the Firmicutes/Bacteroidetes ratio was revealed. The detected changes in the microflora can be associated both with direct changes in the intestine, inherent in nonspecific ulcerative colitis and irritable bowel syndrome, and with more frequent use of uroseptics/antibiotics in this category of patients;Документ Clinical and psychopathological features of internally displaced women with adjustment disorders(Українська медична стоматологічна академія, 2021) Isakov, R. I.; Skrypnikov, A. M.; Herasymenko, L. O.; Hryn, K. V.; Kydon, P. V.; Vdovina, O. O.; Ісаков, Рустам Ісроїлович; Исаков, Рустам Исроилович; Скрипніков, Андрій Миколайович; Скрипников, Андрей Николаевич; Герасименко, Лариса Олександрівна; Герасименко, Лариса Александровна; Гринь, Катерина Вікторівна; Гринь, Екатерина Викторовна; Кидонь, Павло Володимирович; Кидонь, Павел Владимирович; Вдовіна, Олена Олександрівна; Вдовина, Елена АлександровнаVast numbers of internally displaced persons and the threatening growth rate of emigration create the need to pay increased attention to various aspects of psychopathological conditions that arise in response to changes in habitual living conditions. In addition to clinical consequences, the prevalence is accompanied by significant negative social and economic consequences both for society as a whole and for the patient himself, significantly deteriorating his quality of life and level of social functioning. There are significant gender differences in crisis response, in particular, women are the most vulnerable in the vast majority of stressful situations. We carried out a comprehensive clinical, psychopathological and psychodiagnostics examination of 48 internally displaced persons with the established adjustment disorder (F43.2) with studying and careful analysis of anamnestic data using a special questionnaire. The study found that the leading clinical manifestations of internally displaced women are the presence of anxiety and depression in the structure of adjustment disorders, social disintegration and the presence of psychosocial maladjustment. Clinical differences of internally displaced women with adjustment disorders affect the quality of life, change the system of social support and values, contribute to the reduction of productive activities in everyday life.Документ Combination of ultraviolet radiation of autologous blood, negative pressure wound therapy, and endolymphatic antibacterial therapy in the treatment of post-traumatic wound infections(Полтавсьий державний медичний університет, 2021) Zubakha, A. B.; Lihonenko, O. V.; Chorna, I. O.; Shumejko, I. A.; Storozhenko, O. V.; Skotarenko, T. A.; Yaroshenko, R. A.; Зубаха, Анатолій Борисович; Стороженко, Олексій Володимирович; Лігоненко, Олексій Вікторович; Чорна, Ірина Олексіївна; Шумейко, Ігор Анатолійович; Скотаренко, Тетяна Анатоліївна; Ярошенко, Роман АнтоновичThe doctrine of the wound process is one of the current problems of surgery. It reflects the level of theoretical and practical medicine development. The purpose of this work was to study the improvement of treatment outcomes in patients with post-traumatic wound infections. A set of tools was used to treat patients: endolymphatic antibacterial therapy, ultraviolet irradiation of autologous blood and topical application of vacuum therapy. At the present stage, the best topical treatment method in bulky infected and purulent wounds is vacuum therapy using special technical equipment. The proposed complex of treatment reduces the severity of the disease and accelerates the debridement and regeneration of wounds. As a result, it allowed reducing the course of antibiotic administration by 1.8 times and the duration of inpatient treatment by 3.5 days compared to the traditional treatment methodsДокумент Comparative analysis of clinical manifestations of anxiety and depression in patients undergoing renal replacement therapy with concomitant type 2 diabetes mellitus(Полтавський державний медичний університет, 2021) Rustamian, S. T.; Katerenchuk, I. P.; Катеренчук, Іван Петрович; Рустамян, Сатєнік ТігранівнаThis article presents the comparative analysis results on clinical manifestations of anxiety and depression in patients undergoing renal replacement therapy, namely programmed hemodialysis, taking into account the concomitant type 2 diabetes mellitus. Patients undergoing renal replacement therapy, namely, program hemodialysis, have a higher risk of anxiety and depressive disorders than patients with chronic stage I-II kidney disease undergoing conservative therapy. Concomitant diabetes mellitus in patients undergoing renal replacement therapy causes an increase in the frequency of anxiety and depression.Документ Comparative characteristics of the dental diseases incidence in adolescents of Poltava and the village of Belozerie in the Cherkasy region(Полтавський державний медичний університет, 2021) Bublii, T. D.; Dubovaіa, L. I.; Бублій, Тетяна Дмитрівна; Дубовая, Людмила ІванівнаSocio-economic factors have a direct impact on the dental health of adolescents. Thus, the incidence of caries in senior pupils of the Belozerie village is by 1.49 times higher in comparison with the similar indices in Poltava. Their intensity of the carious process is exceeding the average value of 2.1±0.32 in urban residents by 2.08 times (p<0.05). The hygienic condition of the oral cavity in rural youngsters was significantly worse hygiene index=2.32±0.1 than 1.7±0.08 in adolescents living in the city. In the course of our study, it was found that periodontal tissue diseases were observed with the same frequency and amounted to 53.15±4.4 % in v. Belozerie and 56.7±9.32 % in Poltava (p>0.05). In adolescents of Poltava, with a satisfactory hygienic condition, the incidence of dental occlusion ano, malies is by 20.2% higher than in the rural youth.Документ Complex histological and immunohistochemical study of monocytopoiesis in rats with determination of proliferative activity by expression Ki67 and CD68+ in the experiment(Полтавський державний медичний університет, 2021) Martynenko, R. V.; Shepitko, V. I.; Stetsuk, Ye. V.; Boruta, N. V.; Yakushko, O. S.; Martynenko, V. B.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Борута, Наталія Володимирівна; Якушко, Олена Святославівна; Мартиненко, Віталій БорисовичKi67 is not only one of the markers of proliferation, but also an indirect determinant of the rate of cell division. CD68 is exploited as a valuable cytochemical marker to immunostain monocyte/macrophages in the histochemical analysis of inflamed tissues, tumor tissues, and other immunohistopathological applications. The purpose of the study was to determine the cell proliferation index of the monocytic line of red bone marrow using antibodies to CD68+ and Ki-67 in the control and intact groups of animals. There were established an equivalent degree of proliferative activity by progenitor cells with Ki-67 expression in the control and intact groups.Документ Current issues in diagnosing the respiratory manifestation of gastroesophageal reflux disease(Полтавський державний медичний університет, 2021) Osyodlo, G. V.; Bychkova, S. A.; Katerenchuk, I. P.; Seliuk, M. M.; Kazmirchuk, A. P.; Осьодло, Галина Василівна; Бичкова, С. А.; Катеренчук, Іван Петрович; Селюк, М. М.; Казмірчук, А. П.The purpose of the study was to determine the leading extraesophageal symptoms, disturbance of spirometric indices, changes in the immune system and production of nitric oxide in patients with gastroesophageal reflux disease. Bronchopulmonary manifestation of gastroesophageal reflux disease was a cough syndrome, which was characterized by the presence of non-intensive, unproductive cough with a small amount of mucous sputum and was combined, in most cases, with the hoarseness of the voice. Cough syndrome during gastroesophageal reflux disease was characterized by a lack of obstructive changes in the study of external respiration indices and elevated levels of proinflammatory cytokines in the blood serum. It was determined the higher nitric oxide content in platelets in patients with respiratory manifestations of gastroesophageal reflux disease.Документ Cytokines as mediators of the immune system and their role In the pathogenesis of community-acquired pneumonia(Полтавський державний медичний університет, 2021) Berezniakov, V. I.; Korzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Pyvovar, N. M.; Березняков, Владислав Ігорович; Корж, Олексій Миколайович; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Пивовар, Ніна МихайлівнаThe clinical and immunological examination of patients with community-acquired pneumonia has been carried out that included the study of the IL-2, IL-4, IL-6, IL-8 and TNFα cytokines’ system. Immune system disorders that determine the severity of pneumonia, the amount of inflammatory damage to the lung tissue, disrupted elimination of the immune complexes have been found. These tendencies to a decrease in the mmunoglobulins M and G result in a moderate course of community-acquired pneumonia and lobar lesions of the lungs, and the immune system disorders are reliably associated with imbalance of cytokines, with a predominance of their pro-inflammatory activity and a decrease in regulatory functions. The findings of the immunological monitoring indicate that standard antibiotic therapy in patients with community-acquired pneumonia leads to its clinical and radiological resolution, though it is not accompanied by the normalization of immunity parameters. The imbalance of the cytokine component of immunity justifies the need for further development of pathogenetic, as well as immunocorrective therapy, in patients with community-acquired pneumonia.Документ Dynamics of clinical and laboratory indicators in the treatment of patients with psoriasis and concomitant alimentary obesity(Полтавський державний медичний університет, 2021) Yemchenko, Ya. A.; Ishhejkin, K. Ye.; Kaidashev, I. P.; Ємченко, Яна Олександрівна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор ПетровичPsoriasis is the most common chronic, genetically determined autoimmune polyetiological inflammatory disease with impaired epidermal proliferation, which is provoked by exogenous and endogenous factors and is manifested by erythematous and scaly elements, papules and plaques. There is still no consensus on the pathogenesis of this dermatosis. To objectively understand the pathogenesis of psoriasis, it is necessary to take into account the insufficiently studied comorbidity of this pathology. Numerous studies have shown a clear link between psoriasis and obesity. Systemic inflammation is a common link in the pathogenesis of obesity and psoriasis. In this study, we determined the effectiveness of standard treatment for patients with psoriasis and concomitant grade I-II alimentary obesity, by clinical and immunological examination of systemic inflammation. Found that the treatment of patients was ineffective and further led to the deterioration of patient’s condition due to increased systemic inflammation, the progression of obesity and a more severe course of psoriasis.Документ Dynamics of oral hygiene indicators and salivity rate in children who frequently have acute respiratory and viral infections(Полтавський державний медичний університет, 2021) Pavlenkova, O. S.; Kaskova, L. F.; Павленкова, Оксана Сергіївна; Каськова, Людмила ФедорівнаBefore preventive interventions, the hygienic state in children, often ill, was unsatisfactory and ranged from 2.28±0.23– 2.29±0.12 points. A month after the appointment of preventive measures, this indicator improved to satisfactory in children of group 3 and to good in group 4 (who were assigned professional hygiene twice a year, individual hygiene using calcium paste, the use of calcium supplements and those that increase the body's protective properties and amounted to 1.68±0.06 points and 1.5±0.05 points, respectively. 6 months after the first survey, oral hygiene worsened in all children relative to the second survey, but it was better than to take preventive measures. The same picture was observed when determining the hygiene index according to the Green–Vermilion. There is a tendency to improve the rate of salivation after preventive measures.Документ Early cardiac rehabilitation in acute myocardial infarction patients and its features(Полтавський державний медичний університет, 2021) Teslenko, Y. V.; Myakinkova, L. O.; Teslenko, M. M.; Тесленко, Юрій Віталійович; М'якінькова, Людмила Олександрівна; Тесленко, Марина МиколаївнаPatients that have undergone myocardial infarction require inclusion in the treatment program of cardiac rehabilitation as a component of secondary prevention. Rehabilitation potential in patients with myocardial infarction was investigated according to a mathematical model that included indicators of hospital mortality, myocardial reperfusion, anxiety and depression, myocardial contractility, comorbidity and prehospital physical activity. The individual rehabilitation program according to the level of rehabilitation potential contributed to the early expansion of the physical exercise mode to the ward mode in patients of the experimental group for 2.83±0.13 days compared with 3.57±0.14 days in the control group, the baseline heart rate was 73.2±1.72 beats per minute, and 78.4±1.13 beats per minute, respectively. According to the results of submaximal testing, the distance in the experimental group was 694.7±38.4 m, in the control group – 584.2±40.7 m (p˂0.05). Assessment of rehabilitation potential provides determination of optimal terms and methods of cardiac rehabilitation.Документ Efficacy of percutaneous draining operations for simple renal cysts(Полтавський державний медичний університет, 2021) Sarychev, L. P.; Sarychev, Y. V.; Pustovoyt, A. L.; Suprunenko, S. M.; Savchenko, R. B.; Ustenko, R. L.; Sukhomlyn, S. A.; Саричев, Леонід Петрович; Саричев, Ярослав Володимирович; Пустовойт, Ганна Леонідівна; Супруненко, Сергій Миколайович; Савченко, Роман Борисович; Устенко, Роман Леонідович; Сухомлин, Сергій АдольфовичThe relevance of the work is due to the fact that the choice of the optimal method for minimally invasive treatment of simple renal cysts is controversial and there is no consensus. In order to assess the effectiveness of treatment, we carried out both a retrospective and prospective analysis of the documentation of 455 patients with simple renal cysts. Percutaneous draining operations performed in 402 (88.4 %) patients followed by sclerotherapy with 96 % ethanol have proven to be an effective treatment for progressive (>6 cm) and symptomatic simple renal cysts. Bosniak category II simple renal cysts are characterized by a significant increase in drainage time. Symptomatic parapelvical, multichambered, intraparenchymatous (Bosniak category IIFIII) and complicated (Bosniak category IV) simple renal cysts should be a subject for “open” surgical treatment.Документ Epigenetic and genetic aspects of the phenotypes of prader-willi and angelman syndromes(Українська медична стоматологічна академія, 2021) Fedoniuk, L. Ya.; Kovanova, E. N.; Remynetskii, B. Ya.; Yeroshenko, G. A.; Vatsenko, A. V.; Perederii, N. O.; Ulanovska–Tsiba, N. A.; Федонюк, Лариса Ярославівна; Кованова, Елеонора Миколаївна; Ремінецький, Борис Ярославович; Єрошенко, Галина Анатоліївна; Ваценко, Анжела Володимирівна; Передерій, Ніна Олександрівна; Улановська-Циба, Наталія АркадіївнаThe study of the epigenetic and genetic mechanisms of genomic imprinting and single-parent dysomia, as the most common disorders in Prader-Willi syndrome and Angelman syndrome, contributes to the discovery of the pathogenesis of these genetic anomalies and provides a basis for searching for new methods for their prevention and epigenetic therapy. Monoallelic expression of genes in genomic imprinting develops due to different methylation of 15 chromosome DNA, which is specific for different sexes. Prader-Willi syndrome develops as a result of microdeletion at the q11-q13 locus and the mutation of the candidate gene SNRPN of the paternal chromosomes. Angelman syndrome – as a result of microdeletion at the locus q11-q13 and mutation of the candidate gene UBE 3A in the maternal chromosome. The father's single-parent dysomia becomes the cause of Angelman syndrome, and the mother's single-parent dysomia is the cause of Prader-Willi syndrome. It can be assumed that similar Prader-Willi syndrome and Angelman syndrome disorders of genomic imprinting can arise as a result of demethylation of female and male chromosomes with the help of methyltransferases.Документ Evaluation of susceptibility of reference strains of microorganisms to the combined action of essential oils and mexidol(Полтавський державний медичний університет, 2021) Bobrova, N. A.; Vazhnichaya, E. M.; Loban, G. A.; Devyatkina, T. A.; Lugovaya, L. A.; Balyuk, O. Ye.; Bashtovenko, O. A.; Боброва, Нелля Олександрівна; Важнича, Олена Митрофанівна; Лобань, Галина Андріївна; Дев'яткіна, Тетяна Олексіївна; Лугова, Любов Олександрівна; Балюк, Олена Євгенівна; Баштовенко, Оксана АнатоліївнаThe susceptibility of the reference strains S. aureus ATCC 25923 and E. coli ATCC 25922 to 14 essential oils (EOs) and their combinations with mexidol (ethylmethylhydroxypyridine succinate) was studied using the disk diffusion method. It was shown that a combination of all EOs (with the exception of EOs of eucalyptus and ginger) with mexidol increases the susceptibility of S. aureus ATCC 25923 to these agents, with the most pronounced effect being observed with oils of lemon, lavender, fir, and rose. The susceptibility of E. coli ATCC 25922 to EOs of cinnamon, mint, tea tree, rose, eucalyptus, cloves, and sage significantly increases when combined with mexidol, and this effect is most pronounced when using combinations of mexidol with rose, eucalyptus, and clove oils. The discovered ability of mexidol to increase the susceptibility of microorganisms to EOs can be a basis for the development of pharmaceutical compositions with these substances in which an enhanced antimicrobial effect will accompanied by an antioxidant activity and low toxicity.
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