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    Dynamics of expression of carbohydrate determinants of fucosespecific lectin of the bark of golden rain in the mucosa of the attached part of the gums of rats under chronic ethanol intoxication
    (Полтавський державний медичний університет, 2023) Kazakova, K. S; Yeroshenko, G. A; Sheshukova, O. V.; Trufanova, V. P.; Polishchuk, T. V.; Maksymenko, A. I.; Bauman, S. S.; Казакова, Катерина Станіславівна; Єрошенко, Галина Анатоліївна; Шешукова, Ольга Вікторівна; Труфанова, Валентина Петрівна; Поліщук, Тетяна Вікторівна; Максименко, Аліна Іванівна; Бауман, Софія Сергіївна
    The purpose of the study was to determine the dynamics of expression of carbohydrate determinants of fucose-specificlectin of the bark of golden rain in the mucous membrane of the attached part of the gums of rats under chronic ethanol intoxication.The rats were administered 12 mg/kg of 40 % ethanol 4 times a day gastrointestinally. On days 5 and 12, the animals were removed from the experiment. Determination of carbohydrate components of the structural elements of the mucous membrane of the attached part of the gums was performed by lectin histochemistry. On the fifth day of observation, the study of the specificity ofreceptor binding to the fucose-specific lectin of the bark of the golden rain on the structural components of the epithelial plate ofthe attached part of the gums of rats revealed that the expression of receptors on the horny scales and basement membrane decreasedfrom moderate to weak. The reaction of receptors to the lectin of the bark of the golden rain on the basal membranes of the vessels of the hemomicrocirculatory channel increased from moderate to strong. On the 12th day of observation, the components of theepithelial plate of the attached part of the gums of rats showed a stable weak degree of expression of receptorsto the lectin of thebark of the golden rain in comparison with the previous period of the experiment.