Вісник проблем біології і медицини, Випуск 1 (172)
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Документ The effect of quercetin on the structural organisation of the testicular interstitial space in the dyshormonal state induced by tryptorelin at day 270 in the experiment(Полтавський державний медичний університет, 2024) Stetsuk, Ye. V.; Shepitko, V. I.; Zaporozhets, T. M.; Pronina, O. M.; Boruta, N. V.; Стецук, Євген Валерійович; Шепітько, Володимир Іванович; Запорожець, Тетяна Миколаївна; Проніна, Олена Миколаївна; Борута, Наталія ВолодимирівнаThe objective of this study was to assess the morphological changes in the interstitial space of rat testes, determine the sources of nitric oxide production, and evaluate the intensity of oxidative stress in the rat testes during longterm experimental central blocking of the synthesis of luteinising hormone by tryptorelin, with the addition of quercetin to the diet. The experimental group of ten animals received a subcutaneous injection of tryptorelin at a dose of 0.3 mg/kg of active ingredient for 270 days, with simultaneous addition of quercetin to the diet, to model central blocking of luteinising hormone synthesis. Morphologically, the number of macrophages on day 270 was increased at the expense of perivascular macrophages. During the biochemical study of the testicular interstitium, we found that the main production of superoxide anion radical on the 270th day of observation was slightly reduced. The addition of quercetin to the diet reduces changes in the structure of the interstitial space of the testes and impaired nitric oxide production by constitutive isoforms of NO synthase induced by tryptorelin on the 270th day of observation.