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100 лет жизни в борьбе. Взгляд на исторические события в СССР и Украине
("Дивосвіт", 2019) Дудченко, Максим Андрійович; Дудченко, Максим Андреевич
Книга професора М. А. Дудченка складається з двох частин. Перша, основна частина – це автобіографічна розповідь про віковий життєвий шлях у досить складних політично-економічних умовах, у яких довелося жити і трудитися. У другому розділі викладені переживання і думки про ті історичні події, які спостерігав, а в переважній більшості брав безпосередню участь автор. Перебуваючи часто у складних життєвих ситуаціях, він вийшов на прямий шлях реалізації своїх здібностей у воєнній, науковій, педагогічній та суспільній діяльності, маючи повне право на критичний огляд подій нової історії. Життєвий шлях професора М. А. Дудченка є прикладом досягнення фізичних, розумових і морально-етичних цінностей від народження до глибокої старості. Книга профессора М. А. Дудченко состоит как бы из двух частей. В первой, основной части изложено автобиографическое сообщение в форме рассказа о его вековом жизненном пути в довольно сложных політико-экономических условиях, в которых пришлось жить и трудиться. Во втором разделе изложены переживания и мысли о тех исторических событиях, которые созерцал, а в большинстве своем непосредственно участвовал автор. Находясь часто в тяжелых жизненных ситуациях, он вышел на прямой путь реализации своих способностей в военной, научной, педагогической и общественной деятельности, имея полное право на критическое обозрение событий новой истории. Жизненный путь профессора М. А. Дудченко служит примером достижения физических, умственных и морально-этических ценностей от рождения до глубокой старости.
75 лет уникальному выпуску врачей в Военно-медицинской академии им. С. М. Кирова
(Издательский дом Красная звезда, 2018-08) Дудченко, Максим Андрійович; Дудченко, Максим Андреевич; Dudchenko, M. A.
Уникальность 75-летнего юбилейного выпуска военных врачей в 1943 году в Кировской академии следует отнести к многофакторности. Впервые в 1939 году академия имела такой большой набор слушателей – 600 человек. Учебные занятия этот курс начал 1 сентября, с которым совпал день начала второй мировой войны, а выдача дипломов врача выпускникам 1943 года совпал с днем начала Великой Отечественной войны – 22 июня 1941 года. Этот курс 2 года обучался в условиях мирного времени и 2 года – в период Отечественной войны. В первый год войны учеба проходила в блокадном Ленинграде и сопровождалась голодом, холодом, артобстрелами и авиабомбежками с гибелью слушателей. Курс участвовал в защите Ленинграда в окопах фронтовых окраин города, отражая наступающих фашистов, за что слушатели были награждены медалью «За оборону Ленинграда». Эвакуация академии в Самарканд проходила в небывалых условиях. В Самарканде занятия проходили без выходных и праздников по 10 часов в день. Полноценная учеба, согласно учебному плану и программе, сопровождалась 4-х летним обучением с присвоением квалификации врача и выдачей полноценного диплома, чего не происходило ни в одном медицинском ВУЗе страны. Выпускникам присвоили воинские звания капитана медицинской службы, вручили предписание с указаним фронта прибытия для прохождения дальнейшей службы. Из прибывших в воинские части 37 (10%) однокусников погибли в боях, 50% получили ранения и контузии ; The uniqueness of the 75th anniversary issue of military doctors of the Military Medical Academy C.M. Kirov 1943 is emphasized by the following facts. For the first time in 1939 the academy itself had a large set of listeners - 600 people. This course started to study on September 1, the day of the beginning of the Second World War, and the date of graduation coincided with the date of the beginning of the Great Patriotic War - June 22, but in 1943. This course was taught for 2 years in peacetime and 2 years in the war period. In the first year of the war, studies took place in besieged Leningrad and was accompanied by famine, cold, shelling and air strikes with the death of students of the Academy. The listeners of the course participated in the defense of Leningrad in the trenches of the front lines of the city, fighting the advancing fascists, all the students were awarded by the medal "For the Defense of Leningrad".The evacuation of the academy to Samarkand was held in unprecedented conditions. In Samarkand, classes were held without vocations and holidays for 10 hours a day. Full-fledged study, according to the curriculum and the program, was accompanied by 4-year training with the assignment of a doctor's qualification and the issuance of a full-fledged diploma, which did not occur in any medical college in the country. Graduates were awarded the military rank of the medical service captain, handed the order with the indication of the front of arrival for further service. During the service in military units 37 graduates (10%) perished in combat, 50% were injured and had contussions
A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease
(Elsevier, 2023-06-22) Romero-Gómez, Manuel; Lawitz, Eric; Shankar, R Ravi; Chaudhri, Eirum; LH Lam, Raymond; Skrypnyk, Igor; Bassan, Isaac; Скрипник, Ігор Миколайович
Methods: This was a phase IIa, randomized, active-comparator-controlled, parallel-group, open-label study. A magnetic resonance imaging-estimated proton density fat fraction assessment was performed to determine LFC at screening and Week 24. Participants with an LFC of >− 10% at screening were randomized 1:1 to efinopegdutide 10 mg or semaglutide 1 mg, both administered subcutaneously once weekly for 24 weeks. Participants were stratified according to the concurrent diagnosis of type 2 diabetes mellitus (T2DM). Both drugs were titrated to the target dose over an 8-week time period. The primary efficacy endpoint was relative reduction from baseline in LFC (%) after 24 weeks of treatment. Results: Among 145 randomized participants (efinopegdutide n = 72, semaglutide n = 73), 33.1% had T2DM. At baseline, mean BMI was 34.3 kg/m2 and mean LFC was 20.3%. The least squares (LS) mean relative reduction from baseline in LFC at Week 24 was significantly (p <0.001) greater with efinopegdutide (72.7% [90% CI 66.8–78.7]) than with semaglutide (42.3% [90% CI 36.5–48.1]). Both treatment groups had an LS mean percent reduction from baseline in body weight at Week 24 (efinopegdutide 8.5% vs. semaglutide 7.1%; p = 0.085). Slightly higher incidences of adverse events and drug-related adverse events were observed in the efinopegdutide group compared with the semaglutide group, primarily related to an imbalance in gastrointestinal adverse events.
Alternative health insurance model in economically developed countries
(Academic journal of Health Sciences of the Royal Academy of Medicine of the Balearic Islands, 2025-03) Shevchenko, T. I.; Honchar, O. O.; Shaposhnyk, O. A.; Kudria, I. P.; Sorokina, S. I.; Tretiak, N. H.; Tretiak, I. M.; Шевченко, Тетяна Іванівна; Гончар, Ольга Олександрівна; Шапошник, Ольга Анатоліївна; Кудря, Ірина Павлівна; Сорокіна, Світлана Іванівна; Третяк, Наталія Григорівна; Третяк, Ігор Миколайович
The article explores the potential and dynamics of the non-profit health insurance model, emphasizing its organizational and legal structures, range of services, and factors influencing efficiency and competitiveness. It utilizes various methods, including structural, economic, and statistical analyses, to assess the viability of implementing non-profit insurance within Ukraine's healthcare system, drawing comparisons with practices in Western Europe, the United States, and Japan. Non-profit insurance companies, owned by their clients rather than investors, play a significant global role, accounting for about one-third of annual premiums and serving over 900 million policyholders. These entities blend features of financial and non-profit organizations: they manage statutory and insurance funds for financial operations while prioritizing member benefits over profit. Their unique approach allows for cost-effective premiums, tailored insurance conditions, democratic self-governance, and enhanced accessibility to a broad population. The study highlights the global relevance of non-profit insurance as a counterbalance to commercial insurers, fostering competition and mitigating unjustified price increases. It underscores the potential benefits for Ukraine in adopting this model, leveraging lessons from international practices, while considering national economic and social contexts. Collaborative integration of state, joint-stock, and non-profit insurers is proposed as an optimal solution to meet societal insurance needs. Further research is recommended to design a balanced health insurance mechanism incorporating diverse insurance models.
Analysis of the various teaching methods using effectiveness in the future doctors training
(Полтавський державний медичний університет, 2024-03-25) Sorokina, S. I.; Shevchenko, T. I.; Shaposhnyk, O. A.; Kudrya, I. P.; Prykhodko, N. P.; Сорокіна, Світлана Іванівна; Шевченко, Тетяна Іванівна; Шапошник, Ольга Анатоліївна; Кудря, Ірина Павлівна; Приходько, Наталія Петрівна
Under martial law, the introduction of a variety of modern educational opportunities is of particular importance. This requires not only the availability of high-tech equipment but also the effective use of traditional and modern interactive learning technologies. The article analyses students' attitudes to the introduction of certain interactive and traditional teaching methods and evaluates the effectiveness of their use in the training of future doctors. Based on the analysis of the student survey results, a fairly high assessment of the introduction of new technologies in the teaching process in the internal medicine clinic, in particular, the case-study method, was revealed. The simulation method was also recognised as optimal for learning the educational material, which has proved itself in recent years due to certain changes in the patient selection process at clinical sites.
Antiulcerogenic effect of lL-arginine of mucous membrane of stomach in experimental ulcer
(Programe-Abstract, 2000) Tarasenko, L.; Skrypnyk, I.; Neporada, K.; Скрипник, Ігор Миколайович; Тарасенко, Лідія Мусіївна; Непорада, Каріне Степанівна
Application of omeprasole in comprehensive curing of peptic ulcer patients
(BMJ, 2000) Skrypnyk, I.; Degitjaryova, I.; Скрипник, Ігор Миколайович
Aspects of the development of hypothyroid cardiomyopathy associated with chronic systemic inflammation
(Mìžnarodnij endokrinologìčnij žurnal, 2023) Horodynska, О. Yu.; Muravlova, О. V.; Shaienko, Z. О.; Dvornyk, I. L. ; Городинська, Олена Юріївна; Муравльова, Оксана Василівна; Шаєнко, Златослава Олексіївна; Дворник, Ірина Леонідівна
Cardiovascular manifestations are rated first among the symptoms of hypothyroidism. Since the highest prevalence of both coronary heart disease (CHD) and hypothyroidism is observed in the age group over 50 years old, the problem of combination of these nosologies in older people is increasing. Aim of the study is to investigate the structural and functional state of the left ventricular myocardium in hypothyroidism and CHD associated with chronic systemic inflammation. Materials and methods. To reach the objectives of the study, a randomized controlled clinical trial has been conducted in parallel groups of patients with hypothyroidism, CHD and combination of both. To form the main group, a screening analysis of 556 medical histories of patients with hypothyroidism and CHD during the period of 2006–2015 has been made, which were selected for further study.
Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity
(Wroclaw Medical University, Poland / Вроцлавський медичний університет, Польща, 2023) Skrypnyk, Maksym; Petrushanko, Tatiana; Neporada, Karine; Petrushanko, Vladymyr; Skrypnyk, Igor; Скрипник, Максим Ігорович ; Петрушанко, Тетяна Олексіївна; Непорада, Каріне Степанівна; Петрушанко, Володимир Миколайович; Скрипник, Ігор Миколайович
Background. Overweight and obesity are defined as abnormal or excessive fat accumulation that impairs health. The global prevalence of obesity has been increasing significantly among all age groups. Furthermore, obesity is a comorbid factor for numerous diseases, including cardiovascular and periodontal pathologies. Objectives. The present study aimed to investigate the influence of overweight and obesity on the periodontium of young adults in relation to the functional state of the cardiovascular system. Material and methods. The oral health status of 132 males and females aged 18–22 years was examined. They were divided into 4 groups according to their body mass index (BMI): normal weight; overweight; class I obesity; and class II obesity. A periodontal chart, the records on oral hygiene and caries, and periodontal indices were provided for each participant. The main functional parameters of the cardiovascular system were measured before and after the dental examination. Results. Overweight or obesity did not affect the intensity of caries in young adults. The prevalence and severity of gingivitis were significantly higher in obese individuals. A moderate correlation was found between gingivitis and BMI in patients with class I and II obesity. Disturbances in the cardiovascular system function and in the autonomic nervous system tone were also diagnosed in obese patients. An impaired vascular response and significant functional changes in the cardiovascular system developed against the background of obesity. These changes show the development of subcompensation in young adults with obesity. Conclusions. In obese individuals, significantly worse oral hygiene was observed as compared to normalBMI patients. Moreover, the clinical manifestation and intensity of gingivitis in obese individuals were high even in those with satisfactory oral hygiene. In young obese individuals, the periodontal disease manifested as gingivitis is due to significant adaptive and compensatory mechanisms.
Characteristics of disorders of the quality of life of young patients depending on the variant of the course of gastroesophageal reflux disease
(Полтавський державний медичний університет, 2023) Gorodnytska, I. M.; Skrypnyk, I. M.; Maslova, G. S.; Городницька, Інеса Михайлівна; Скрипник, Ігор Миколайович; Маслова, Ганна Сергіївна
The article represents the results of our research on determining the influence of esophageal symptoms of erosive and non-erosive forms of gastroesophageal reflux disease on indicators of the physical and mental components of quality of life according to the Medical Outcomes Study Questionnaire Short-Form 36. The presence and degree of severity of symptoms of gastroesophageal reflux disease were analyzed using the Gastroesophageal Reflux scale Disease Questionnaire. We examined 18 patients with an erosive form and 18 patients with a non-erosive form of gastroesophageal reflux disease. It is shown that against the background of the erosive form of gastroesophageal reflux disease, daily manifestations of the symptoms of the disease are more often observed, namely heartburn (RR=6.00 (0.80-44.95); p>0.05), regurgitation and pain in the epigastric region of the abdomen (RR=2.50 (0.56-11.25); p>0.05), which leads to violations of mainly physical components of quality of life. At the same time, the esophageal symptoms of the non-erosive form of gastroesophageal reflux disease change the quality of life of patients in categories that characterize mental health.
Clinical and diagnostic aspects of managing patients with valvular heart disease
(Полтавський державний медичний університет, 2022) Shaposhnyk, O. A.; Prykhodko, N. P.; Savchenko, L. V.; Shevchenko, T. I.; Sorokina, S. I.; Yakymyshyna, L. I.; Kudria, I. P.; Шапошник, Ольга Анатоліївна; Приходько, Наталія Петрівна; Савченко, Леся Володимирівна; Шевченко, Тетяна Іванівна; Сорокіна, Світлана Іванівна; Якимишина, Лариса Іллівна; Кудря, Ірина Павлівна
The article presents the results of examination of 47 patients with valvular heart disease. According to the research findings, when investigating the causes of severe mitral regurgitation, especially in young and middle-aged people, one should primarily consider Barlow's disease, myxomatous mitral valve degeneration, as the primary cause (having excluded fibroelastic deficiency). It was found that among all cases of detected mitral valve prolapse (even minor or moderate), which is currently diagnosed quite often with the development of modern technology, stratification of patients requires additional examinations to identify people at high risk of disease progression and complications, as well as to determine the prognosis.
Clinical case of acute kidney injury in a patient with dependent syndrome due to the use of opioids
(Вінницький національний медичний університет ім. М. І. Пирогова, 2024-04-19) Tupalo, A.; Sorokina, S. I.; Сорокіна, Світлана Іванівна
Acute kidney injury is a syndrome that occurs as a result of an acute decrease in glomerular filtration and is manifested by acute disorders of kidney-regulated indicators of homeostasis processes and is associated with a high risk of mortality. In particular,opiates can cause nephrotoxic kidney damage. Aim: The purpose of the study is to analyze the obtained data of an extraordinary clinical case with the determination of the main links of the polymorbid condition pathogenesis, to study individual patient management schemes depending on the nature of clinical manifestations, prognosis and risk of fatal complications.
Dependence of the Dental Status of Young Individuals with Different Body Weights on their Eating Behavior
(Faculty of Medicine Nis, 2022) Skrypnyk, Maksym; Petrushanko, Tatiana; Neporada, Karine; Skrypnyk, Roman; Petrushanko, Vladymyr; Skrypnyk, Igor; Скрипник, Максим Ігорович; Петрушанко, Тетяна Олексіївна; Непорада, Каріне Степанівна; Скрипник, Роман Ігорович; Петрушанко, Володимир Миколайович; Скрипник, Ігор Миколайович
Obesity is a global problem of modern society. According to the WHO, in 2016, more than 1.9 billion adults are overweight and about 650 million adults are obese. Numerous studies indicate the role of overweight, obesity and metabolic status on periodontal health, however, the mechanism of their development is not fully understood. The aim of the study was to explore the mechanism of periodontal disease development in patients with diverse body mass index and the mechanism of extra weight and obesity onset in these patients. The study involved 132 Ukrainian males and females, 18 - 22 years old. Body mass index was determined in all patients. Information on life history, illness and family history was collected. The assessment of dental status was conducted by indicating the oral and tongue hygiene indices and periodontal indices. Eating behaviour was assessed using the standardised Dutch eating behaviour questionnaire (DEBG) and the three-factor eating questionnaire (TFEQ R-18). Diet assessment was determined by standardized diet questionnaire. More than 60% of young people with the 1st and 2nd degree obesity had eating disorders, the most prevalent were disturbance of cognitive restraint and emotional eating components of eating behavior. The prevalence of periodontal disease was significantly higher in obese individuals, up to 87% in patients with the 1st and 2nd degree obesity. Eating behavior disturbances play a crucial role in the development of obesity in young adults and onset of gingivitis. The cause of non-plaque-induced gingivitis in patients with the 1st and 2nd degree obesity is a impaired general host response to the pathogenic factors of the oral cavity, caused by excess adipose tissue, which led to the development of chronic systemic mild inflammation. That is why these patients need a specific, integrated periodontal treatment.
Detection and assessment of disorders of the depressive spectrum in patients with acute myocardial infarction depending on the method of treatment
(Полтавський державний медичний університет, 2022) Kudria, I. P.; Shevchenko, T. I.; Voroshilova, T. A.; Tretiak, N. H.; Kryvoruchko, I. H.; Pushko, O. О.; Shaposhnyk, О. А.; Кудря, Ірина Павлівна; Шевченко, Тетяна Іванівна; Ворошилова, Тетяна Анатоліївна; Третяк, Наталія Григорівна; Криворучко, Іван Григорович; Пушко, Олександр Олександрович; Шапошник, Ольга Анатоліївна
The frequent combination of mental disorders of the depressive spectrum and cardiovascular diseases is one of the most urgent problems of modern medicine. The purpose of the study was to identify and assess, with the help of various psychodiagnostic methods, the degree of severity of depressive disorders in patients with acute myocardial infarction depending on the treatment method as a prerequisite for optimal drug therapy. 73 patients with the aforementioned pathology were studied and were divided into two groups. Group I included 44 patients who underwent urgent coronary angiography with subsequent stenting of the infarct-related coronary artery; Group II – included 29 patients who received only drug therapy. Examination of patients was carried out according to Ukrainian standards, in particular, a survey according to the scale of Beck and Zung. Patients with acute myocardial infarction after urgent coronary angiography with stenting of the infarct-dependent artery were more likely to have mild and moderate depression according to the Beck scale compared to patients who received only conservative medical treatment. The reverse pattern is observed for moderate and severe depression. 68.2% of patients with acute myocardial infarction after interventional intervention and 62.1% on the background of conservative treatment according to the Zung scale showed depression of various degrees of severity, mostly mild.
Diagnostic and Treatment Algorithms of Ulcerative Colitis in Ukraine
(KARGER, 2009) Skrypnyk, I.; Скрипник, Ігор Миколайович
Questions concerning the diagnosis and treatment of ulcerative colitis (UC) in Ukraine are described, in recent years, there has been considerable progress in conservative therapy and new drugs have been developed that provide persistent remission of the inflammatory process after long-term application in many cases. The results of our own investigation on the efficiency of rebamipide in the complex treatment of UC patients are presented. Optimization of treatment with substitution of mesalazine in tablet or granule form, especially with an additional rebamipide prescription and a once-daily administration of budesonide, leads to an increased effectiveness of treatment and improvement of quality of life in UC patients. In the future, development of new approaches in the pharmacotherapy of UC will use medications as a basic therapy with the purpose of achieving high-quality and effective 'convalescence of mucous membrane', including cytoprotectors, bilious acids, endogenous substances, stabilization of membranes, antihypoxantsand correction of microbiocenosis disorders.
Doxorubicin-induced arginine/citrulline cycle changes in rat model of non-alcoholic steatohepatitis
(Falk Foundation, 2023-05-18) Maslova, G.; Skrypnyk, I.; Lymanets, T.; Skrypnyk, R.; Маслова, Ганна Сергіївна; Скрипник, Ігор Миколайович; Лиманець, Тетяна Володимирівна
Introduction: Doxorubicin (Dox) belongs to the group of anthracycline antibiotics, which are widely used in oncological diseases treatment. The high risk of toxic effects is the basis for studying of the main mechanisms of organs and systems Dox-induced injury development. The aim - to investigate the peculiarities of Dox-induced arginine/citrulline cycle changes in rats with simulated non-alcoholic steatohepatitis (NASH). Methods: The studies were conducted on 30 white non-linear adult rats, weighing 160-220 g. The rats were divided into 3 groups: | (n = 10) - rats (5 males, 5 females), on which NASH was modeled during 63 days, then from the 64th till 66th day they were injected with 1 ml of 0.9% sodium chloride solution intraperitoneally; | (n = 10) - rats (S males, 5 females), on which NASH was modeled during 63 days, continued with Dox injections intraperitoneally 5 mg/kg/day from the 64th till the 66th day; Ill (n = 10) - rats (5 males, 5 females), which received a standard vivarium diet during 63 days, from the 64th to 66th day - 1 ml injections of 0,9% sodium chloride solution intraperitoneally. NASH modeling was hold using a diet containing a 42.8% fats mixture and a 4% fructose aqueous solution. On the 67th day, animals were euthanized under thiopental anesthesia at a dose of 50 mg/kg. A 10% liver homogenate was prepared, in which the concentration of arginine, citrulline, and arginase activity were determined.
Early progression as a predictor of survival in hodgkin and b-cell non hodgkin lymphoma, in the real world: the Ukrainian lymphoma registry-based study
(HemaSphere, 2024-06-13) Shokun, Nazar; Stepanishina, Yana; Skrypnyk, Igor; Lymanets, Tetiana; Gusachenko, Lulia; Шокун, Назар; Степанишина, Яна; Скрипник, Ігор Миколайович; Лиманець, Тетяна Володимирівна; Гусаченко, Юлія
Background: Lymphoma, being a relatively rare disease, benefits greatly from national-level data collection. It is important to study results of lymphoma treatment in different countries and with different healthcare systems to ensure that there is contemporary, geographically relevant data on lymphoma. Association of progression of disease at 24 months (POD 24) with overall survival (OS) has been confirmed in several types of lymphomas. Methods:The analysis refers to all newly diagnosed lymphoma cases identified at the National Cancer Institute (NCI) of Kyiv and seven other Ukrainian centers from September 2019 to December 2023. The diagnosis was classified according to WHO 2016 criteria, and registration was conducted in a secure, specialized database. The study received approval from the NCI Institutional Review Board. POD 24 was calculated for patients with the more frequent histology and adequate follow-up. Survival analysis distinguished between early progressors and those without early progression, adjusting OS calculations based on the timing of progression to refine outcome assessments. Results: A total of 1074 patients with newly diagnosed lymphoma were prospectively registered in ULR. The male-to-female ratio (M/F) for the entire population was 0.94, and the median age was 49 years (range 18-100). B-cell non-Hodgkin lymphoma represents the majority, comprising 740 cases (68.9%). Hodgkin lymphoma (HL) accounts for 296 cases (27.5%), predominantly represented by the Nodular sclerosis classical subtype in 207 cases (70%). The most frequent subtypes among B-NHL was Diffuse large B-cell lymphoma (DLBCL) with 259 cases (35%). In HL patients 3-year OS was 82% and 98% for patients with or without POD24 (HR 5,7 (CI95% 2,1-15,3), p=0,00042). In patients with DLBCL POD24 was 42% and 80%, with a HR 8,8 (CI95% 2,1-15,4, p = 0.00073). In Primary mediastinal large B-cell lymphoma patients 3-year OS was 25% and 88% for patients with or without POD24 (HR 8,8 (CI95% 2-38,4), p= 0.00073). In patients with Primary CNS lymphoma POD24 was 24% and 86% with a HR 42 (CI95% 4,4-399), p<0,0001. (Figure 1).
Efficacy profile daily injection filgrastim in chemotherapy-induced (ct) febrile neutropenia (fn) in patients with acute leukemia (al): ukranian retrospective study in a real-life cohort
(Clinical Limphoma, Myeloma & Leukemia, 2024-09-01) Lymanets, T.; Skrypnyk, I.; Maslova, G.; Gusachenko, I.; Лиманець, Тетяна Володимирівна; Скрипник, Ігор Миколайович; Маслова, Ганна Сергіївна; Гусаченко, Юлія володимирівна
Materials and methods: 59 primary patients with AL (median age: 53.8, range: 9.23 years; male 35 (59.3%), female 24 (40.7%); ECOG I-II) were included in the study during 2021-2023 and received the standard induction CT according to ESMO Clinical Practice Guidelines in our department. The patients were enrolled into two groups: 31(52.5%) and 28(47.5%) pts in control and study to Filgrastim groups, respectively. 21(35.6%) acute myeloid leukemia (AML) pts and 10(17%) acute lymphoblastic leukemia (ALL) pts were involved in IA and IIA control groups; 17(28.8%) AML-pts and 11(18.6%) ALL-pts were contained in IB and IIB study groups, respectively. Results. We verified Gr 4 neutropenia in 17(80.95%) pts of group IA and 14 (82.35%) pts of group IB which received regimen 7+3 with/without etoposide. Duration time of Gr 4 neutropenia in group IB versus group IA was 1.5 times less, t(38)= 3.65, р˂0.001. FN developed significantly rarer in IB group with G-CSFs, X2(1, N=38) = 4.87, p˂0.03. Among the patients with ALL was registered Gr 4 neutropenia in 6 (60%) pts of group IIA and 6 (54.5%) pts of group IIB. Duration time of FN was 2.7 times less in IIB group with G-CSFs than in group IIA, t(21)= 6.62, р˂0.00001. But there was no difference in the number of FN episodes developed in IIB vs IIA groups, p˃0.05. Conclusions. Filgrastim effectively prevents the development of FN in patients with AML against the background of severe cytostatic neutropenia. Thus, the use of Filgrastim made it possible to reduce the duration of severe neutropenia in patients with AL during induction CT.
Erosive and Ulcerative Lesions of Gastroduodenal Zone in Patients with Leukemias: Role of H. pylori
(WILEY-BLACKWELL, 2009) Skrypnyk, I.; Maslova, G.; Скрипник, Ігор Миколайович; Маслова, Ганна Сергіївна
Formation of clinical reasoning for quality improvement in medical education
(East European Institute of Psychology, 2016) Skrypnyk, Igor; Gopko, Oleksandr; Maslova, Ganna; Prykhodko, Nataliia; Скрипник, Ігор Миколайович; Гопко, Олександр Феліксович; Маслова, Ганна Сергіївна; Приходько, Наталія Петрівна
For successful implementation of the National Health Reform strategy problems of higher medical education in Ukraine should be solved. The problem of clinical reasoning is a cornerstone of competence in current medical education. The best methods for teaching and evaluating clinical reasoning skills among medical students have not yet been elucidated. The introduction of the test assessment system requires professional knowledge combined with increasing practical and theoretical training of medical students. It accomplishes through the introduction of role-playing games, improving material, technical base and means of distance education.

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