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Androgen imbalance in gouty arthritis in men with obesity
(Wydawnictvo POLIHYMNIA Sp. z o.o., Lublin, 2016) Kapustianska, A.; Zhdan, V.; Bobyriov, V. M.; Chelishvili, A.; Shepitko, V.; Капустянська, Анна Анатоліївна; Ждан, Вячеслав Миколайович; Бобирьов, Віктор Миколайович; Челішвілі, Анатолій Леонідович; Шепітько, Володимир Іванович; Капустянская, Анна Анатольевна; Ждан, Вячеслав Николаевич; Бобырев, Виктор Николаевич; Челишвили, Анатолий Леонидович; Шепитько, Владимир Иванович
Mostly men suffer from gouty arthritis (95% of cases). The most frequent comorbid condition is obesity in men who suffer from gouty arthritis. In men for gouty arthritis obesity found an increase in the level of erythrocyte sedimentation rate (35,5 ± 1,2) and C-reactive protein (13,0 ± 1,2). Found that when gouty arthritis in patients with obesity inflammatory process is not limited to local changes in the joints, but also causes a reaction of the whole organism. There was a decrease the testosterone levels in obese men. It confirms the importance of determining the level of testosterone for gouty arthritis patients with obesity. Thus, the decrease in testosterone levels, especially in the presence of obesity II and III, characterized by maximum hyperuricemia, confirming evidence for an association of abdominal obesity with levels of testosterone in patients with gouty arthritis. A course of gouty arthritis, a form of arthritis and the presence of peripheral tophi affects on hyperuricemia. In turn, the levels of testosterone and uricemia affect the severity of obesity in patients with gouty arthritis. The severity of obesity depends on the indicators of testosterone. We established pathogenetic role of testosterone in the development and progression of gouty arthritis and obesity in men. It is proved that the aggravation of gouty arthritis is accompanied by changes in testosterone levels, depending on the degree of obesity. We find a strong link between the concentration of testosterone and uric acid, as well as stage of disease. It is shown that obesity contributes to the development of degenerative changes in osteo-articular apparatus in violation of motor function. In turn, promotes the development of gouty arthritis, overweight and obesity.
Anhedonia as behavioral marker of experimental neurosis and its correction
(Czech Republic, 2018) Sydorenko, A. H.; Lutsenko, R. V.; Сидоренко, Антоніна Григорівна; Луценко, Руслан Володимирович
Anhedonia at experimental models of chronic stress and its correction
(Aluna, 2017) Lutsenko, R.; Sydorenko, A.; Bobyriov, V. M.; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Бобирьов, Віктор Миколайович
Different types of chronic stress lead to neurotic and depressive disorders. Key symptoms of these disorders are anhedonia and correction of which will indicate the efficacy of proposed therapy. The aim of the paper is to investigate the influence of amide 2-hydroxy-N-naftalen- 1-il-2-(2-oxo-1,2-dihidro-indole-3-iliden) and ethyl ether 4-[2-hydroxy-2-(2-oxo-1,2-dihidro- indole-3-iliden)-acetamin]-butyric acid on anhedonia after the experimental neurosis and chronic moderate stress in rats. Materials and methods. It was studied the influence of therapeutic and preventive administration of substances 18 and E-38 in the dosage of 12mg/kg during chronic mild stress “conflict of afferent activation” during 30 days and depression-like behavior chronic mild stress that modeled 8 weeks. Results of investigation. Experimental neurosis caused decrease of number of comings to drinking-bowl, decrease of total number of drank sucrose and decrease of the percent of drank water with sugar in comparison with intact animals. Analogical but more significant changes were noticed during depression-like behavior. The use of amide 2- oxoindolin-3-glyoxylic acid based on neurosis counters effectively the development of anhedonia. Substance 18 increased the number of comings to drinking-bowl with sucrose and increased the amount of the number of drank water with sucrose in comparison with control pathology without correction. The substance possibly assists in use of solution with sucrose among water and does not compromise reference-preparation such as diazepam. The administration of ethyl ether of 2-oxoindolin-3-glyoxylic acid at chronic mild stress possibly increased the number of comings to the drinking-bowl and increased the number of drank sucrose in comparison with control pathology and it was more effective than imipramine and countered anhedonia. Conclusions. It was indicated that during 30 day experimental neurosis and 8 week depression-like behavior cause the development of anhedonia. Therapeutic use of amide 2- hydroxy-N-naftalen-1-il-2-(2-oxo-1,2-dihidro-indole-3-iliden) and ethyl ether 4-[2-hydroxy- 2-(2-oxo-1,2-dihidro-indole-3-iliden)-acetamin]-butyric acid corrected effectively anhedonia after experimental neurosis and chronic mild stress in rats. Różne rodzaje przewlekłego stresy prowadzą do zaburzeń neurotycznych i depresyjnych, kluczowym objawem których jest anhedonia, korekcja której świadczyć będzie o efektywności zaproponowanej terapii. Cel pracy ‒ zbadanie wpływu amida 2-hydroxy-N-naftalen-1-il-2-(2-oxo-1,2-dihydro- indol-3-ilidenu) (związek 18) oraz esteru etylowego 4-[2-hydroxy-2-(2-oxo-1,2-dihydro- indol-3-iliden)-acetamino]-masłowego kwasu (związek E-38) na anhedonię po eksperymentalnej neurozie i przewlekłym umiarkowanym stresie u szczurów. Materiały i metody badania. w eksperymentach na dojrzałych płcioso szczurach linii Wistar badano wpływ profilaktyczno-leczniczego podania związków 18 i E-38 w dawce 12 mg/kg przy przewlekłej neurozi “ekonfliktu impulsów aferentnych” w ciągu 30 dób oraz stanie przypominającym depresję (przewlekły umiarkowany stres), który był modelowany przez 8 tygodni. Wyniki badania. Eksperymentalna neuroza wywołała zmniejszenie ilości podejść do poidła, zmniejszenie łącznej ilości wypitej sacharozy oraz zmnieszyła odsetek wypitej wody z cukrem w porównaniu ze zwierzętami nienaruszonymi. Analogiczne, lecz bardziej wyraźne zmiany obserwowane były przy odtwarzaniu stanu przypominającego depresję. Stosowanie amidu 2-oxoindolin-3-dioksylowego kwasu na tle neurozy efektywnie zapobiegało rozwojowi stanu anhedonii. Związek 18 zwiększał ilość podejść do poidła z sacharozą oraz zwiększał ilość wypitej sacharozy w porównaniu z patologią kontrolną bez korekcji. Substancja prawdopodobnie sprzyjała preferowaniu spożywania właśnie sacharozy wśród wody, a pod względem aktywności nie odbiegała od preparatu referencyjnego diazepamu. Podanie eteru etylowego 2-oxoindolin-3-gioksylowego kwasu przy przewlekłym umiarkowanym stresie prawdopodobnie zwiększało ilość podejść do poidła i zwiększało ilość wypitej sacharozy w porównaniu z patologią kontrolną oraz efektywniej od imipraminu zapobiegało anhedonii. Wniosek. Ustalono, że 30-dzienna neuroza eksperymentalna oraz 8-tygodniowy stan przypominający depresję wywołują rozwój anhedonii. Leczniczo-profilaktyczne stosowanie amida2-hydroxy-N-naftalen-1-il-2-(2-oxo-1,2-dihydro-indol-3-ilidenu) oraz esteru etylowego 4-[2-hydroxy-2-(2-oxo-1,2-dihydro-indol-3-iliden)-acetamino]-masłowego kwasu efektywnie korygowało anhedonię po neurozie eksperymentalnej i przewlekłym umiarkowanym stresie u szczurów.
Anhedonia correction at different types of chronic stress
(Росія, Санкт-Петербург, 2018) Lutsenko, R. V.; Sydorenko, A. H.; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Луценко, Руслан Владимирович; Сидоренко, Антонина Григорьевна
Экспериментальный невроз и хронический умеренный стресс вызывают развитие ангедонии. Лечебно-профилактическое применение производных 2-оксииндолин-3-глиоксиловой кислоты эффективно корректировало ангедонию при экспериментальной патологии.
Antidepressive activity of 2-oksoindolin-3-glycolic acid derivatives in Numero’s test
(Харків, Національний фармацевтичний університет, 2012) Sydorenko, A. G.; Lutsenko, R. V.; Сидоренко, Антоніна Григорівна; Луценко, Руслан Володимирович
Antimicrobial properties of the new combined dental gel
(2023) Devіatkina, Nataliia; Дев'яткіна, Наталія Миколаївна
Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. RotrinDenta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. RotrinDenta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov’ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.
Blood gases and electrolytes under use of magnetite nanoparticles in blood loss
(Полтавський державний медичний університет, 2021) Vazhnichaya, E. M.; Lutsenko, R. V.; Semaka, O. V.; Deviatkina, T. O.; Deviatkina, N. M.; Kurapov, Yu. A.; Litvin, S. Ye.; Важнича, Олена Митрофанівна; Луценко, Руслан Володимирович; Семака, Олександр Валентинович; Дев'яткіна, Тетяна Олексіївна; Дев'яткіна, Наталія Миколаївна; Курапов, Юрій Анатолійович; Литвин, Станіслав Єгорович
Blood gases, acid-base balance, and electrolytes were studied under the conditions of correction of acute blood loss in abino rats with magnetite nanoparticles (5–8 nm) obtained by electron-beam technology and incorporated into sodium chloride crystals. It was shown that blood loss decreases total hemoglobin and the volumetric concentration of oxygen, diminishes sodium concentration and increases potassium concentration in the blood. Dissolved and injected intraperitoneally after the blood loss, magnetite nanoparticles (1.35–6.75 mg iron/kg) reduce the partial pressure of carbon dioxide, increase the partial pressure of oxygen, saturation of hemoglobin with oxygen and volumetric oxygen concentration, increase hydrogen index and sodium content, and reduce potassium concentration in the blood. These positive changes develop against the background of an increase in total hemoglobin. They surpass some effects of the traditional iron preparation and can be the basis for further research aimed at the use of magnetite nanoparticles in acute posthemorrhagic syndrome.
Chronic obstructive pulmonary disease and comorbidities: management of somatoform disorders
(Aluna Publishing, Польща, 2021) Burya, Liliia V.; Kapustianska, Anna A.; Moiseieva, Nataliia V.; Vakhnenko, Andrii V.; Rumiantseva, Mariia O.; Zviagolska, Iryna M.; Буря, Лілія Володимирівна; Капустянська, Анна Анатоліївна; Моісєєва, Наталія Віталіївна; Вахненко, Андрій Вікторович; Рум'янцева, Марія Олександрівна; Звягольська, Ірина Миколаївна
The aim: To perform a comprehensive evaluation of the effect of paroxetine on the degree of somatoform disorders in exacerbation of severe COPD in women. Materials and methods: The study involved 53 female patients with severe COPD (Group D), confirmed by instrumental methods of study. At hospitalization, patients were divided into 2 groups. Patients of Group 1 (n = 21; aged 52.5 ± 0.8 years old) underwent basic exacerbation therapy. Patients of Group 2 (n = 22; aged 57.9 ± 0.4 years old) underwent basic exacerbation therapy supplemented with paroxetine for 14 days, 1 tablet (0.20 g) once a day. Results: The basic therapy for treatment of COPD exacerbations, supplemented with paroxetine, led to a positive clinical effect, confirmed by increase in skeletal and respiratory muscular system, increased parameters of pulmonary ventilation, increased tolerance to physical load, increased oxygen saturation, decreased heart rate and breathing rate. Conclusions: The strategy for choosing an antidepressant to provide multidisciplinary care for somatoform disorders in women with exacerbation of severe COPD (group D) should take into account the efficacy and favorable safety profile and personalization of the drug. In exacerbation of severe COPD, the degree of somatoform disorders in patients correlates with the severity of the main criteria: FVC1, the distance walked during the 6-minute step test, oxygen saturation after the 6-minute step test, end-expiratory pressure in the oral cavity.
Circadian rhythms: physiological and pathophysiological aspects
(Springer Nature, 2022) Drogovoz, S. M.; Seredyns’ka, N. M.; Shtroblya, A. L.; Luk’yanchyuk, V. D.; Lutsenko, R. V.; Krutskykh, T. V.; Panfilova, A. L.; Derymedvid’, L. V.; Shtroblya, M. V.; Луценко, Руслан Володимирович
Physiological and pathophysiological aspects of the functioning of the cerebral system (hypothalamus and cerebral epiphysis) providing the circadian rhythm in humans are described with special attention to the involvement of disorders in this system in the pathogenesis of some neurodegenerative diseases and epilepsy.
Clinical, pharmacotherapeutic and biorhythmological peculiarities of depressive disorders, comorbid with cardiovascular pathology
(м. Тбілісі, 2021) Hryn, K.; Sydorenko, A.; Vlasova, O.; Kolot, E.; Martynenko, Y.; Гринь, Катерина Вікторівна; Сидоренко, Антоніна Григорівна; Власова, Олена Вікторівна; Колот, Еліна Георгіївна; Мартиненко, Яніна Павлівна
The spread of depressive disorders is extra high nowadays. Depressive disorders are widespread mental disorders in the structure of mental pathology, both causes of psychiatrists’ visit, and causes of medical aid. The presence of depressive syndrome in patients with cardiovascular system leads to deterioration patient’s condition and adaptive abilities and aggravates somatic abnormality. Adequate therapy causes their reduction, prevention of recurrence and decompansation of comorbid somatic pathology, and eliminates severe medical and prevents social consequences. The study of clinical aspects of depressive conditions which are accompanied with pathology is one of the direction not only psychiatric, but also common pharmacotherapeutic investigations. The aim of the investigation was to determine clinical, pharmacotherapeutic and biorhythmic peculiarities of depressive disorders in patients with comorbid cardiac pathology. And also assessment of efficacy of complex therapy based on chronotherapy principle was used. 50 patients (female patients) with depressive disorders were involved in this investigation. This was performed based on “Depressive disorders of organic genesis, characterized by somatic pathology” (F 06.35), “Somatoform disorder” of heart and cardiovascular system (F 45.30), “Mild depressive episode” (F 32.00), and also comorbid arterial hypertension confirmed by physician. Clinical, laboratory, clinical and psychopathological investigations using psychodiagnostic scales (scale HAMD-21, CGI-S, CGI-І) were used. Individual biorhythmic status was established and it requires medicamentous therapy. Comparing patients of both groups, it has been detected a group of patients in whom principles of chronotherapy, especially antihypertensive and antidepressive therapy were prescribed, dynamics of patient’s improvement was better than in the investigated group where the principle of chronotherapy was observed.
Combined pharmacological therapy including several antiarrhythmic agents for treatment of different disorders of cardiac rhythm
(Грузія, м. Тбілісі, 2021-06) Kapustnick, Yu. ; Lutsenko, R.; Sуdorenko, A.; Капустник, Юрій Олексійович; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна; Капустник, Юрий Алексеевич; Луценко, Руслан Владимирович; Сидоренко, Антонина Григорьевна
Combined therapy using several antiarrhythmic agents can be useful for treatment of different disorders of cardiac rhythm, including their hazardous and stable forms. It is especially re-quired in case of insufficient efficacy after using one antiarrhythmic agent. As a combined therapy one can use the administra-tion of several preparations e.g. 1) preparations of IA subclass and β-blocker adrenergic agents; 2) antiarrhythmic agents of I class and calcium channel blocker agents (verapamil and dil-thiazem); 3) III class (amiodarone or sotalol) together with β-blocker drugs; 4) antiarrhythmic agents of III class and calcium antagonists; 5) antiarrhythmic agents of I and III classes. The latter combination has especially strong effect for treatment of arrhythmias caused by re-entry mechanism with or without a short excitability period. Antiarrhythmic agents of II class (β-blocker drugs) and III classes (amiodarone or sotalol) cause reduction of development risk of arrhythmias with trigger mechanism, including bidirectional spindle-shaped ventricular (torsade de pointes) tachycardia. Thus, combinations including preparations of II class together with III class and simultaneous using of antiarrhythmic agents of I and III classes should be administered to prevent hazardous potentially lethal arrhythmias. The authors of this article have developed a new method of combined therapy of paroxysmal supraventricular tachyarrhythmias in patients with ischemic heart disease, including the use of allapinin and cardiac glycosides. The author’s certificate of invention was obtained for this method. The efficacy of this combined therapy for suppression of supraventricular paroxysmal tachyarrhythmias was analyzed compared to treatment with allapinin alone. It was proved that combined therapy has bigger effectiveness in comparison with therapy with help allapinin only. It is forbidden to use of such combinations of antiarrhythmic agents: β-adrenergic blocker agent + verapamil; β-adrenergic blocker agent + dilthizem; propafenone + verapamil; propafenone + dilthizem; propafenone + β-adrenergic blocker agent. After administration of such combined therapy, it is possible the occurrence medicinal (toxic) disfunction of sinus node. The administration of propafenone together with β-adrenergic blocker agent is impossible because propafenone has properties of β-blocker preparation. It is connected with similar chemical structure of propafenone and non-selective β-blocker agent propranolol.
Comprehensive patterns of comorbidity: copd and depression
(Wydawnictwo Aluna, 2018) Moisieieva, N. V.; Burya, L. V.; Kapustianska, A.; Kolenko, I. O.; Rumyantseva, M. A.; Shumeiko, O. H.; Моісєєва, Наталія Віталіївна; Буря, Лілія Володимирівна; Капустянська, Анна Анатоліївна; Коленко, Ірина Олексіївна; Рум'янцева, Марія Олександрівна; Шумейко, Олексій Григорович
Introduction: Data on the prevalence of psychopathological disorders in the exacerbation of chronic obstructive pulmonary disease (COPD) are very heterogeneous. COPD and depression have common predisposing factors. The aim: The aim of the research is to conduct a comprehensive assessment of the e»ect of paroxetine on the level of depressive disorders in the exacerbation of severe degree COPD in women. Materials and methods: The study included patients with severe degree COPD and depressive disorder. A step-by-step test, dynamometry of muscular strength of muscle groups and calculation of the percent ratio of muscular strength to mass were performed for all patients, and the strength of the respiratory muscles was measured. To assess the level of depression, the HADS questionnaire and the CES-D self-questionnaire were used. Assessment of the severity of the patient’s condition was conducted according to the Hospital Alert and Depression Scale (HADS). Results: In exacerbation of severe COPD, the level of depression in patients correlates with the severity of the main criteria: FEV1, the 6-minute step test distance, oxygen saturation after the 6-minute step test, expiratory pressure in the oral cavity. Conclusions: Upon the synchronization of the standard therapy, the level of depression in patients with exacerbation of severe COPD e»ectively decreases. Paroxetine is a valid choice in the comprehensive treatment of COPD. According to the data of evidence-based medicine, the medication demonstrates high eÈciency and favorable safety pro le, without exerting a negative e»ect on COPD, which is of key signi cance in the combined pathology treatment.
Correction of movement stereotype in patients with spastic forms of cerebral palsy
(Polish Academy of Sciences, 2014) Strashko, Ye. Yu.; Bobyrova, L. E.; Kapustianska, A. A.; Yushkovska, O. G.; Fedorovych, L. O.; Страшко, Євген Юрійович; Бобирьова, Людмила Єгорівна; Капустянська, Анна Анатоліївна; Юшковська, Ольга Геннадіївна; Федорович, Людмила Олександрівна; Страшко, Евгений Юрьевич; Бобырева, Людмила Егоровна; Капустянская, Анна Анатольевна
In this article, the author proposed a rehabilitation program, which includes the impact on the body of patients with cerebral palsy throughout the bio muscle kinematic chain, taking into account the construction of the spiral body muscles during rehabilitation procedures.
Current strategy for treatment of comorbid states: complicated community-acquired pneumonia with arterial hypertension
(Wydawnictwo Aluna, Polska, 2020) Burya, L. V.; Vakhnenko, A. V.; Moiseieva, N. V.; Kapustianska, A. A.; Zviagolska, I. M.; Буря, Лілія Володимирівна; Вахненко, Андрій Вікторович; Моісєєва, Наталія Віталіївна; Капустянська, Анна Анатоліївна; Звягольська, Ірина Миколаївна; Буря, Лилия Владимировна; Вахненко, Андрей Викторович; Моисеева, Наталья Витальевна; Капустянская, Анна Анатольевна; Звягольская, Ирина Николаевна
The aim: To optimize the treatment of CAP patients with hypertension, complicated by exudative pleuritis. Materials and methods: The study included 43 CAP patients, aged 46 to 65 years, with viral lesions along with hypertension. The average age of the patients was 52.5 ± 4.5 years. Veri cation of the CAP diagnosis and its formulation was performed in accordance with the order of the Ministry of Health of Ukraine No. 128 of 19.03.2007 “On the approval of clinical protocols of medical care in “Pulmonology” in all patients, pneumonia was complicated by exudative pleuritis, which was con rmed by X-ray examination. Results: The use of combination drugs, namely, torasemide with prolonged e ect and tivortin aspartate in the treatment of patients with community-acquired pneumonia, complicated by exudative pleuritis, combined with hypertension led to more signi cant positive changes in the values of saturation, blood biochemical parameters, as well as accelerated recovery of patients, which was con rmed by the positive dynamics of X-ray examination. Conclusions: As a result of the treatment, all parameters of the quality of life of the patients were greatly improved, which resulted in a signi cant reduction in functional limitations and high social activity of the patients, which signi cantly reduced the cost of treatment.
Disorders of cardiac rhythm in patient with syndrome preexitation of ventricles and their pharmacological correction
(Українська медична стоматологічна академія, 2020) Lutsenko, R. V.; Kapustnick, Yu. A.; Sydorenko, A. H.; Луценко, Руслан Володимирович; Капустник, Юрій Олексійович; Сидоренко, Антоніна Григорівна
The goal of investigation was analysis of possibility of using of different antiarrhythmic agents in patients with syndrome preexitation and disorders of cardiac rhythm. Most typical disorders of cardiac rhythm in patient with syndrome preexitation are ortodromic reciprocating supraventricular tachycardia, antidromic supraventricular tachycardia, atrial fibrillation and atrial fibrillation. During attack of tachycardia in patients with syndrome of preexitation can be different clinical symptoms. They can range from mild palpitation to syncope. This tachycardia can be even reason of sudden cardiac death. Main its mechanism is macroreentrant circuit involving the AV-node, the additional pathway, the atrias, the ventricles. Attacks of atrioventricular reciprocating tachycardia in patients with WPW syndrome and with narrow complexes QRS calcium channel blocker verapamil has efficacy in 95% of patients. However, for treatment this arrhythmia with wide complexes QRS verapamil is contraindicated. Beside of, it should be taken in account that treatment of this type of cardiac arrhythmia cardiac glycosides are forbidden also. Verapamil and cardiac glycosides are contraindicated for termination of arrhythmia in patients with WPW syndrome and such disorders of cardiac rhythm as atrial fibrillation (flutter). For therapy of atrial fibrillation (flutter) in patients with WPW syndrome antiarrhythmic agents of agents of І A subclass (quinidine, procainamide, disopyramide, propafenone) and ІІІ class (amiodarone, sotalol) can be useful. For interruption of paroxysmal tachycardia in patients with syndrome preexitation antiarrhythmical preparations of plant origin (gilurytmal and allapinin) have high efficacy. Termination of paroxysmal tachycardia in patients with premature excitation of ventricles can be achieved after administration of antiarrhythmic agents of ІС subclass, in particular after using of propafenone and encainide. However, treatment with help these agents quite often bring about appearance of arrhythmogenic action. It is impossible using in preextation syndrome and cardiac arrhythmias drugs, which cause the acceleration of conductivity of nerve impulses in additional pathways (cardiac glycosides, β-blocker agents, for example propranolol). In patients with paroxysmal atrioventricular reciprocating (circular) tachycardia digitalis and calcium channel blockers should be avoided. Such agents as digoxin and verapamil in this arrhythmia can turn out to be dangerous in WPW syndrome, since they raise the conductivity through additional conductive pathways.
Examinations Of Indian Patients Who Have Diabetes Mellitus
(Journal of Pharmaceutical Negative Results, India, 2023) Jha, Sahil kumar; Rauth, Upasona; Kovalev, Serhii Volodymyrovych; Deviatkina, Nataliia Mykolayivna; Ковальов, Сергій Володимирович; Дев'яткіна, Наталія Миколаївна
Blood glucose (or blood sugar) levels that are elevated in people with diabetes are chronic metabolic conditions that over time cause substantial harm to the heart, blood vessels, eyes, kidneys, and nerves. The most prevalent type of diabetes is type 2, which often affects adults, and develops whenever the body stops producing enough insulin or becomes resistant to it. Type 2 diabetes has been much more common over the last three decades in nations of all income levels. Diabetes type 1 is a chronic condition in which the pancreas produces little or no insulin by itself. It was previously referred to as juvenile diabetes or insulin-dependent diabetes. The availability of affordable medical care, particularly insulin, is essential for the survival of individuals who have diabetes. Diabetes mellitus, which is primarily defined by hyperglycemia, polyuria, and polyphagia, has developed into a serious and persistent metabolic condition as a consequence of a dynamic interactions of hereditary and environmental variables. Numerous diabetes problems might arise from uncontrolled high blood sugar. Long-term diabetes causes severe complications, some of which are fatal. All around the world, the prevalence of diabetes patients is increasing at epidemic rates. Annually, diabetes and related disorders consume a sizable percentage of the national health budget. The etiopathogenesis of the disease and the emergence of the outbreak are both influenced by a number of adverse outcomes. According to reports, diabetes, which has no known cure, can be managed by maintaining daily self-care, receiving good diabetes education, and making significant gains.The untreatable condition of diabetes may be managed by maintaining personality in everyday life, providing appropriate diabetes education, and making significant advancements in knowledge, attitudes, skills, and management. In this scientific report, we will have presented reports which included data on the subjects' fasting, postprandial, and glycated hemoglobin blood sugar levels, lipid profile, LFT, and RFT. The data results analyzed is in table form.
Experience of using hippotherapy in complex effects on muscle spirals in children with spastic forms of cerebral palsy
("Wiadomosci Lekarkie", 2016) Strashko, Ye. Yu.; Kapustianska, A. A.; Bobyrova, L. E.; Страшко, Євген Юрійович; Капустянська, Анна Анатоліївна; Бобирьова, Людмила Єгорівна; Страшко, Евгений Юрьевич; Бобырева, Людмила Егоровна; Капустянская, Анна Анатольевна
Matters of physical and medical rehabilitation of children with organic lesions of the nervous system, in particular, with cerebral palsy, are actual in countries around the world. Hippotherapy is neurophysiologically oriented therapy using horses. Determine whether a combination of hippotherapy as a method of rehabilitation in the aftermath of outpatient comprehensive impact on MS on a stationary phase; Study of the effect of hippotherapy as securing and preparation method for learning new postures and movements in children with spastic cerebral palsy forms; The study of the possible optimization of psychophysical state, activation motivations of patients; Determination of the optimal timing of hippotherapy sessions, the number of procedures, the study of possible fatigue factor children. HT classes were conducted at the Ippotsentra "Wind of Change" in the period 2010-2013 the main group of children surveyed (36 people) with spastic forms of cerebral palsy. HT procedure took place twice a day - morning and evening - 30 minutes during 10-12 days. Thus, the proposed integration of the HT program of complex effects on muscle spirals children with spastic cerebral palsy forms is physiologically and anthropologically based on 4-5 day training children adequately transferred the full amount of lessons learned new postures and movements, HT does not cause complications in the somatic and psycho-emotional state of the children, HT enables sensorimotor and psychomotor effects, save and normalize muscle tone for a longer period (up to three months), compared with traditional methods of physiotherapy. HT can serve as a method of learning a new "postures and movements", the preparation of the locomotor apparatus to learn walking.
Experimental Study of Antispasmodic Activity of 2-Oksoindolin-3-Glyoxylic Acid Derivatives
(David publishing, 2014) Lutsenko, R.; Sydorenko, A.; Луценко, Руслан Володимирович; Сидоренко, Антоніна Григорівна
Clinical psychiatry and neurology requires a creation of new means with difficult many component range of psychotropic action, so psychoemotional disturbances “boundary type” and difficult mental disorders have high level of heterogeneity, various clinical manifestations, which are caused by different pathogenetic factors. One of the most often used preparation for the treatment of these diseases is anxiolytic medications. It is known that anxiolytic action combines with anticonvulsive. Perspective medications are simple amides and ethers of 2-oksoindolin-3-glyoxylic acid, which have not recognized and practically observed. The aim of this research is to determine anticonvulsant action in 2-oksoindolin-3-glyoxylic acid derivatives on the model of acute myoclonic pentylentetrazol, piktrotoxic, and bikukullin convulsions. In experiments on mature mice of both sex Wistar line were studied an influence of ethyl ester 4-[2-hydroxy-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetylamino]-butyric acid and 2-hydroxy-N-naphthalen-1-yl-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide on chemoinduced epileptogenesis. An intake of proconvulsants is accompanied by a development of syndrome convulsion, which was estimated by convulsion’s intensity (grades), latent period of convulsions (sec.), number of convulsions acts, and duration of convulsions (sec.) and number of survived animals in a group. It was showed that a combination of 2-hydroxy-N-naphthalen-1-yl-2-(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide (12 acetamide mg/kg) is similar to reference preparation diazepam in (2 mg/kg) which decreased a manifestation of syndrome convulsion. It demonstrated an increase of intensity of convulsions, decrease of latent period of the convulsion’s start which is caused by all blockers GАМКА-receptors, decrease of number convulsive acts on the background of korazol and pikrotoxin, a decrease of convulsive syndrome duration during an intake of korazol and bikukullin, and a decrease of animal’s mortality, which was caused by pikrotoxin intake.
Flavonoids from Erigeron annuus
(2023) Kovalev, S. V.; Golovach, A. R.; Kovalev, V. N.; Khilya, V. P.; Ковальов, Сергій Володимирович
Genetic algorithm for making pharmacotherapy decision in the patients with multimorbidity: approaches for clinicians
(Aluna, Polska, 2017) Бобирьов, Віктор Миколайович; Кулішов, Сергій Костянтинович; Вахненко, Андрій Вікторович; Власова, Олена Вікторівна; Бобырев, Виктор Николаевич; Кулишов, Сергей Константинович; Вахненко, Андрей Викторович; Власова, Елена Викторовна; Bobyriov, V. M.; Kulishov, S. K.; Vakhnenko, A. V.; Vlasova, O. V.
Purpose of our investigation was to propose and verify the algorithm for making pharmacotherapy decision in the patients with multimorbidity. Material and methods: Object of investigation: patients with multimorbidity. Observations were conducted according to European Guidelines. We proposed and tested genetic algorithm for making pharmacotherapy decision for such patients. It is necessary to mention, that each person is representing a variant of treating with certain pathology. Chromosome of this variant is composed from genes, where each gene is certain group of drugs. The sequence of solutions of this problem comes down to the selection of drugs for the di-morbid conditions as the descendants of mono-morbidity. At the next stage of selection continues the most successful combinations of drugs for multimorbid conditions as descendants di-morbid and monomorbid conditions. When breeding pairs must take into account the mutual potentiating pathogenic and / or sanogenetic effects. Results: We had optimal patient’s treatment as a result of crossing genes, groups of drugs and obtaining their offspring with the best combination without absolute contraindications and minimal relative contraindications. Conclusion: Thus, genetic algorithm for making pharmacotherapy decision in the patients with multimorbidity showed effectiveness of drugs choosing.

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