The contribution of genetic determinants to the development of significant delay in physical development of extremely low-birth-weight infants

Abstract

Abstract. We conducted a molecular genetic study using polymerase chain reaction methods with isolation of DNA samples from peripheral blood. A reliable relationship was established between the dominant model (GG + AG vs. AA) of the glutathione-S-transferase genes family and a significant delay in the physical development of premature infants. The introduction of genetic research to determine the GG + AG genetic model of GSTP1 gene in premature infants will allow to identify the group at risk for significant delay in physical development and to approach its correction individually.