Inhibition of markers of the immune inflammation in bronchial asthma influenced by fullerene c60 nanopmaterials

Abstract

Bronchial asthma (BA) is a chronic disease associated with local tissue inflammation anc! remodeling of the airway . Inflammation is a complex immune response which involves immune cells as regulators and effectors of the immune function and, therefore, may play critical role in pathophysiological processes. Recent studies have suggested the possible effect of dysfunction immune cells and/or their products on inflammation process in BA. Fullerene C60 is the most promising nanomaterial inmodern medicine due its key properties, small size, enhanced permeability, surface modification and retention effect . Fullerene C60 and some of its derivatives as potent antioxidants are capable of effective ROS inactivation and lack of immunogenicity However, little is known about the effect of fullerene C60 on immune mechanisms in the pathogenesis of BA. Therefore, further studies of fullerene C60will be required for the development of specialized target treatment strategy in BA. The purpose of our work was to determine the effect of fullerene C60 on markers of immune inflammation in experimental model of BA.