Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis
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Дата
2024
Назва журналу
Номер ISSN
Назва тому
Видавець
Universidad de la Frontera
Анотація
Experimental studies devoted to the study of the mechanisms of the pathogenesis of acute peritonitis and the
development of new methods of medical and surgical treatment are becoming increasingly relevant. Today, experimental medicine knows many different ways to modeling septic peritonitis and eliminate it, but the role of the local immune system is underestimated, whereas it takes a direct part in inflammation. The objective of our work to study morphological features of results of experimental
modeling of septic peritonitis in white rats. The study included 15 sexually mature white male rats weighing 276.75±6.56 grams. A
simulation of septic peritonitis was performed by perforating the upper part of the cecum with four punctures with a G16 injection
needle. As a result of the experiment, after examination of the peritoneal cavity, all 15 animals were diagnosed with omentum tamponade
of perforated damage to the caecum. In 11 cases, the perforated wall of the caecum was covered by the greater omentum (73.34 %), and
in the other 4 animals, tamponade was performed by one of the epididymal omentum (26.66 %). The initial stage of tamponade with the
greater or epididymal omentums of a perforated caecum begins on the first day of the experiment and consists of tight interstitial
consolidation between them, as well as in the invasion of blood vessels from the omentum side to the focus of infection, which ensure the
delivery of the appropriate immunocompetent cells. As a result of this process, intensive lymphoid infiltrates are formed in this area, as
well as the growth of adipose tissue, which isolates the inflammatory focus from the peritoneal cavity with a thick layer.
Опис
Ключові слова
peritonitis, greater omentum, duodenum, stomach, caecum, testis, lymphoid nodule, lymph node, lymphocytes, immunocompetent cells, adipocytes
Бібліографічний опис
Hryn V. Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis / V. Hryn, O. Maksymenko // Int. J. Morphol. – 2024. – Vol. 42, № 2. – P. 446–451.